Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 15, 2008, Pages 5768-5773

  Killilea, David W ^a   Ames, Bruce N ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Oxygen tension; Telomeres; Tumor suppressor

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ARTICLE; CELL CULTURE; CELL DIVISION; CELL FUNCTION; CELL IMMORTALIZATION; CELL POPULATION; CELL VIABILITY; FIBROBLAST; GROWTH RATE; HUMAN; HUMAN CELL; LIFESPAN; LONG TERM EXPOSURE; MAGNESIUM DEFICIENCY; OXYGEN TENSION; PLATING MEDIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; TELOMERE;

CELL AGING; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FIBROBLASTS; HUMANS; MAGNESIUM DEFICIENCY; OXYGEN; TELOMERE;

EID: 44449167577     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712401105     Document Type: Article

References (60)

1. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997) in Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (Natl Acad Press, Washington, DC), pp 190-249.
2. Ford ES, Mokdad AH (2003) Dietary magnesium intake in a national sample of US adults. J Nutr 133:2879-2882.
3. Moshfegh A, Goldman J, Cleveland L (2005) What We Eat in America, NHANES 2001-2002: Usual Nutrient Intakes from Food Compared to Dietary Reference Intakes. (US Department of Agriculture, Agriculture Research Service, Washington, DC).
4. Bowman S (2007) Low economic status is associated with suboptimal intakes of nutritious foods by adults in the National Health and Nutrition Examination Survey 1999-2002. Nutr Res 27:513-523.
5. Kant AK, Graubard BI (2007) Ethnicity is an independent correlate of biomarkers of micronutrient intake and status in American adults. J Nutr 137:2456-2463.
6. Hartwig A (2001) Role of magnesium in genomic stability. Mutat Res 475:113-121.
7. Larsson SC, Bergkvist L, Wolk A (2005) Magnesium intake in relation to risk of colorectal cancer in women. J Am Med Assoc 293:86-89.
8. Barbagallo M, Dominguez LJ, Resnick LM (2007) Magnesium metabolism in hypertension and type 2 diabetes mellitus. Am J Ther 14:375-385.
9. Turlapaty PD, Altura BM (1978) Extracellular magnesium ions control calcium exchange and content of vascular smooth muscle. Eur J Pharmacol 52:421-423.
10. Altura BM, Altura BT, Gebrewold A, Ising H, Gunther T (1984) Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ. Science 223:1315-1317.
11. Goto Y, Nakamura M, Abe S, Kato M, Fukui M (1993) Physiological correlates of abnormal behaviors in magnesium-deficient rats. Epilepsy Res 15:81-89.
12. Altura BM, Altura BT (1995) Magnesium and cardiovascular biology: An important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res 41:347-359.
13. Wolf FI, Torsello A, Fasanella S, Cittadini A (2003) Cell physiology of magnesium. Mol Aspects Med 24:11-26.
14. Rude RK, Gruber HE (2004) Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem 15:710-716.
15. Blache D, et al. (2006) Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats. Free Radic Biol Med 41:277-284.
16. He K, Song Y, Belin RJ, Chen Y (2006) Magnesium intake and the metabolic syndrome: Epidemiologic evidence to date. J Cardiometab Syndr 1:351-355.
17. Rude RK, et al. (2006) Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism. Osteoporos Int 17:1022-1032.
18. Mazur A, et al. (2007) Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 458:48-56.
19. McKeehan WL, Ham RG (1978) Calcium and magnesium ions and the regulation of multiplication in normal and transformed cells. Nature 275:756-758.
20. Dickens BF, Weglicki WB, Li YS, Mak IT (1992) Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett 311:187-191.
21. Sgambato A, Wolf FI, Faraglia B, Cittadini A (1999) Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells. J Cell Physiol 180:245-254.
22. Maier JA, Malpuech-Brugere C, Zimowska W, Rayssiguier Y, Mazur A (2004) Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta 1689:13-21.
23. Martin H, et al. (2006) N-acetylcysteine partially reverses oxidative stress and apoptosis exacerbated by Mg-deficiency culturing conditions in primary cultures of rat and human hepatocytes. J Am Coll Nutr 25:363-369.
24. Yang Y, et al. (2006) Magnesium deficiency enhances hydrogen peroxide production and oxidative damage in chick embryo hepatocyte in vitro. Biometals 19:71-81.
25. Altura BM, et al. (2003) Expression of the nuclear factor-kappaB and proto-oncogenes c-fos and c-jun are induced by low extracellular Mg2+ in aortic and cerebral vascular smooth muscle cells: possible links to hypertension, atherogenesis, and stroke. Am J Hypertens 16:701-707.
26. Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120:513-522.
27. Guyton A, Hall J (1966) in Textbook of Medical Physiology (Saunders, Philadelphia, PA), pp 513-523.
28. Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN (1995) Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 92:4337-4341.
29. Shay JW, Pereira-Smith OM, Wright WE (1991) A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196:33-39.
30. Hara E, Tsurui H, Shinozaki A, Nakada S, Oda K (1991) Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem Biophys Res Commun 179:528-534.
31. Itahana K, Dimri G, Campisi J (2001) Regulation of cellular senescence by p53. Eur J Biochem 268:2784-2791.
32. Dimri GP, et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367.
33. Alcorta DA, et al. (1996) Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93:13742-13747.
34. McConnell BB, Starborg M, Brookes S, Peters G (1998) Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 8:351-354.
35. Stein GH, Drullinger LF, Soulard A, Dulic V (1999) Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19:2109-2117.
36. Romani A, Marfella C, Scarpa A (1993) Regulation of magnesium uptake and release in the heart and in isolated ventricular myocytes. Circ Res 72:1139-1148.
37. Altura BM, Zhang A, Altura BT (1993) Magnesium, hypertensive vascular diseases, atherogenesis, subcellular compartmentation of Ca2+ and Mg2+ and vascular contractility. Miner Electrolyte Metab 19:323-336.
38. Altura BM, Zhang A, Cheng TP, Altura BT (2001) Extracellular magnesium regulates nuclear and perinuclear free ionized calcium in cerebral vascular smooth muscle cells: Possible relation to alcohol and central nervous system injury. Alcohol 23:83-90.
39. Chen H, Campisi J, Padmanabhan R (1996) SV40 large T antigen transactivates the human cdc2 promoter by inducing a CCAAT box binding factor. J Biol Chem 271:13959-13967.
40. Ali SH, DeCaprio JA (2001) Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 11:15-23.
41. Ribeiro SM, Armelin HA (1984) Ca2+ and Mg2+ requirements for growth are not concomitantly reduced during cell transformation. Mol Cell Biochem 59:173-181.
42. Ames BN, Atamna H, Killilea DW (2005) Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med 26:363-378.
43. Ames BN (2006) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103:17589-17594.
44. 1 arrest but not cell replication. Biochem J 332:43-50.
45. Killilea DW, Atamna H, Liao C, Ames BN (2003) Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal 5:507-516.
46. von Zglinicki T, Pilger R, Sitte N (2000) Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med 28:64-74.
47. Rubio MA, Davalos AR, Campisi J (2004) Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res 298:17-27.
48. Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N (1998) Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63:935-948.
49. Kang HT, Lee HI, Hwang ES (2006) Nicotinamide extends replicative lifespan of human cells. Aging Cell 5:423-436.
50. Tanaka Y, Moritoh Y, Miwa N (2007) Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes. J Cell Biochem 102:689-703.
51. Forsyth N, Evans A, Shay J, Wright W (2003) Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2:235-243.
52. Gilley D, Tanaka H, Herbert BS (2005) Telomere dysfunction in aging and cancer. Int J Biochem Cell Biol 37:1000-1013.
53. Nielsen FH, Milne DB, Gallagher S, Johnson L, Hoverson B (2007) Moderate magnesium deprivation results in calcium retention and altered potassium and phosphorus excretion by postmenopausal women. Magnes Res 20:19-31.
54. George GA, Heaton FW (1975) Changes in cellular composition during magnesium deficiency. Biochem J 152:609-615.
55. Lemke MR (1995) Plasma magnesium decrease and altered calcium/magnesium ratio in severe dementia of the Alzheimer type. Biol Psychiatry 37:341-343.
56. Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN (2007) Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. J Nutr 137:25-30.
57. Dimri GP, Campisi J (1994) Molecular and cell biology of replicative senescence. Cold Spring Harb Symp Quant Biol 59:67-73.
58. Yang NC, Hu ML (2005) The limitations and validities of senescence associated-beta-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells. Exp Gerontol 40:813-819.
59. Killilea AN, Downing KH, Killilea DW (2007) Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells. Cancer Lett 258:70-79.
60. Ferre S, Mazur A, Maier JAM (2007) Low magnesium induces senescent features in cultured human endothelial cells. Magnes Res 20:66-71.