Vitamin D: Its role in cancer prevention and treatment

Progress in Biophysics and Molecular Biology

Volumn 92, Issue 1, 2006, Pages 49-59

  Holick, Michael F ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone health; Cancer; Sunlight; Ultraviolet radiation; Vitamin D

Indexed keywords

TUMOR MARKER; VITAMIN D;

BLOOD; COMORBIDITY; HUMAN; NEOPLASM; REVIEW; RISK ASSESSMENT; RISK FACTOR; VITAMIN D DEFICIENCY;

COMORBIDITY; HUMANS; NEOPLASMS; RISK ASSESSMENT; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 33744803244     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2006.02.014     Document Type: Review

References (72)

1. Ahonen M.H., Tenkanen L., Teppo L., Hakama M., and Tuohimaa P. Prostate cancer risk and pre-diagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 11 (2000) 847-852
2. Apperly F.L. The relation of solar radiation to cancer mortality in North America. Cancer Res 1 (1941) 191-195
3. Barger-Lux M.J., Heaney R.P., Dowell S., Chen T.C., and Holick M.F. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporosis Int 8 3 (1998) 222-230
4. Bauer J.M., and Freyberg R.H. Vitamin D intoxication and metastatic calcification. J. Am. Med. Assoc. 130 (1946) 1208-1215
5. Bertone-Johnson E.R., Chen W.Y., Holick M.F., et al. Plasma 25-hydroxyvitamin D and 1,25-Dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 1991-1997
6. Bikle D.D., Nemanic M.K., Gee E., and Elias P. 1,25-Dihydroxyvitamin D3 production by human keratinocytes: kinetics and regulation. J. Clin. Invest. 78 (1986) 557-566
7. Bouillon R., Okamura W.H., and Norman A.W. Structure-function relationships in the vitamin D endocrine system. Endocrine Rev 16 (1995) 200-257
8. British Pediatric Association. Hypercalcaemia in infants and vitamin D. Br. Med. J 45 (1956) 401
9. Chapuy M.C., Preziosi P., Maamer M., et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis Int 7 (1997) 439-443
10. Chel V.G.M., Ooms M.E., Popp-Snijders C., et al. Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J. Bone Miner. Res. 13 (1998) 1238-1242
11. Chen T.C., and Holick M.F. Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol. Metab. 14 (2003) 423-430
12. Chuck A., Todd J., and Diffey B. Subliminal ultraviolet-B irradiation for the prevention of vitamin D deficiency in the elderly: a feasibility study. Photochem. Photoimmun. Photomed. 17 4 (2001) 168-171
13. Colston K., Horst M., and Feldman D. Organ distribution of the cytoplasmic 1,25-dihydroxycholecalciferol receptor in various mouse tissues. Endocrinology 107 (1981) 1916
14. Colston K., Colston M.J., and Feldman D. 1,25-Dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 108 (1981) 1083-1086
15. 3-1-α-hydroxlyase and vitamin D receptor gene expression in human colonic mucosa is elevated during early carcinogenesis. Steroids 66 (2001) 287-292
16. Dalhoff K., Dancey J., Astrup L., et al. A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma. Br. J. Cancer 89 (2003) 252-257
17. DeLuca H. Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr. 80 Suppl (2004) 1689S-1696S
18. Feldman D., Zhao X.Y., and Krishnan A.V. Editorial/Mini-review: vitamin D and prostate cancer. Endocrinology 141 (2000) 5-9
19. Freedman D.M., Dosemeci M., and McGlynn K. Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study. Occup. Environ. Med. 59 (2002) 257-262
20. Garland C., Shekelle R.B., Barrett-Connor E., Criqui M.H., Rossof A.H., and Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1 (1985) 307-309
21. Garland C.F., Comstock G.W., Garland F.C., Helsing K.J., Shaw E.K., and Gorham E.D. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 2 (1989) 1176-1178
22. Garland C.F., Garland F.C., and Gorham E.D. Can colon cancer incidence and death rates be reduced with calcium and vitamin D?. Am. J. Clin. Nutr. 54 (1991) 193S-201S
23. Garland F.C., Garland C.F., Gorham E.D., and Young J.F. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev. Med. 19 (1990) 614-622
24. Gordon C.M., DePeter K.C., Feldman H.A., Grace E., and Emans S.J. Prevalence of vitamin D deficiency among healthy adolescents. Arch. Pediatr. Adolesc. Med. 158 (2004) 531-537
25. Grant W.B. An ecologic study of the role of solar UV-B radiation in reducing the risk of cancer using cancer mortality data, dietary supply data and latitude for European countries. In: Holick M.F. (Ed). Biologic Effects of Light 2001 Proceedings of a Symposium, Boston, MA (2002), Kluwer Academic Publishing, Boston 267-276
26. Grant W.B. An estimate of premature cancer mortality in the US due to inadequate doses of solar ultraviolet-B radiation. Cancer 94 (2002) 1867-1875
27. Grant W.B. A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality. Eur. Urol. 45 (2004) 271-279
28. Grant W.B., and Holick M.F. Benefits and requirements of vitamin D for optimal health: a review. Alter. Med. Rev. 10 (2005) 94-111
29. Hanchette C.L., and Schwartz G.G. Geographic patterns of prostate cancer mortality. Cancer 70 (1992) 2861-2869
30. Heaney R.P. Invited award lecture: long latency deficiency disease-insights from calcium and vitamin D. Am. J. Clin. Nutr. 78 (2003) 912-919
31. 3 and its analogues in the treatment of psoriasis. Retinoids 14 (1998) 7-12
32. Holick M.F. Vitamin D. The underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr. Opin. Endocrinol. Diabetes 9 (2002) 87-98
33. Holick M.F. Vitamin D: Importance for bone health, cellular health and cancer prevention. In: Holick M.F. (Ed). Biologic Effects of Light 2001 Proceedings of a Symposium, Boston, MA (2002), Kluwer Academic Publishing, Boston 155-173
34. Holick M.F. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am. J. Clin. Nutr. 80 (2004) 1678S-1688S
35. Holick M.F. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am. J. Clin. Nutr. 79 (2004) 362-371
36. Janowsky E.C., Lester G.E., Weinberg C.R., et al. Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutr. 2 (1999) 283-291
37. John E.M., Schwartz G.G., Dreon D.M., and Koo J. Vitamin D and breast cancer risk: the NHANES I epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol. Biomarkers. Prev. 8 (1999) 399-406
38. Kauppinen-Mäkelin R., Tähtelä R., Löyttyniemi E., Kärkkäinen J., and Välimäki M.J. High prevalence of hypovitaminosis D in Finnish medical in- and outpatients. J. Intern. Med. 249 (2001) 559-563
39. Khosla S. The OPG/RANKL/RANK system. Endocrinology 142 12 (2001) 5050-5055
40. Kinyamu H.K., Gallagher J.C., Rafferty K.A., and Balhorn K.E. Dietary calcium and vitamin D intake in elderly women: Effect on serum parathyroid hormone and vitamin D metabolites. Am. J. Clin. Nutr. 67 (1998) 342-348
41. 3: in vivo and vitro effects on human pre-leukemic and leukemic cells. Cancer Treat. Rep. 69 (1985) 1399-1407
42. Koutkia P., Lu Z., Chen T.C., and Holick M.F. Treatment of vitamin D deficiency due to Crohn's disease with tanning bed ultraviolet B radiation. Gastroenterology 121 6 (2001) 1485-1488
43. Koutkia P., Lu Z., Chen T.C., and Holick M.F. Treatment of vitamin D deficiency due to Crohn's disease with tanning bed ultraviolet B radiation. Gastroenterology 121 (2001) 1485-1488
44. Lefkowitz E.S., and Garland C.F. Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int. J. Epidemiol. 23 (1994) 1133-1136
45. Lips P., Duong T., Oleksik A., et al. A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J. Clin. Endocrinol. Metab. 86 (2001) 1212-1221
46. Looker A.C., Dawson-Hughes B., Calvo M.S., Gunter E.W., and Sahyoun N.R. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 30 (2002) 771-777
47. Luscombe C.J., Fryer A.A., French M.E., et al. Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. Lancet 358 (2001) 641-642
48. 3. Proc. Natl. Acad. Sci. USA 52 (1985) 5409-5412
49. Malabanan A., Veronikis I.E., and Holick M.F. Redefining vitamin D insufficiency. Lancet 351 (1998) 805-806
50. Mawer E.B., Hayes M.E., Heys S.E., et al. Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cell line. J. Clin. Endocrinol. Metab. 79 (1994) 554-560
51. 3. Steroids 67 (2002) 457-466
52. Omdahl J., Morris H., and May B. Hydroxlyase enzymes of the vitamin D pathway: expression, function and regulation. Annu. Rev. Nutr. 22 (2002) 139-166
53. Outila T.A., Karkkainen M.U., and Lamberg-Allardt C.J. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am. J. Clin. Nutr. 74 (2001) 206-210
54. Reid I.R., Gallagher D.J.A., and Bosworth J. Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure. Age Ageing 15 (1985) 35-40
55. 3. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 391-395
56. Skowronski R.J., Peehl D.M., and Feldman D. Vitamin D and prostate cancer: 1,25-Dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology 132 (1993) 1952-1960
57. Spina C., Tangpricha V., Yao M., Zhou W., Wolfe M.M., Maehr H., Uskokovic M., Adorini L., and Holick M.F. Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs. J. Steroid Biochem. Mol. Biol. 97 (2005) 111-120
58. Stumpf W.E., Sar M., Reid F.A., et al. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science 206 (1979) 1188-1190
59. Suda T., Abe E., Miyaura C., et al. Induction of differentiation of human myeloid leukemia cells by 1 α,25-dihydroxyvitaminD3. In: Norman A., Schaefer K., Herrath D.V., and Grigdeit H.-G. (Eds). Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism (1982), Walter de Gruyter, New York 59-64
60. Sullivan S.S., Rosen C.J., Halteman W.A., Chen T.C., and Holick M.F. Adolescent girls in Maine at risk for vitamin D insufficiency. J. Am. Diet. Assoc. 105 (2005) 971-974
61. Tanaka H., Abe E., Miyaura C., et al. 1 alpha,25-Dihydroxycholecalciferol and human myeloid leukemia cell line (HL-60): the presence of cytosol receptor and induction of differentiation. Biochem. J. 204 (1982) 713-719
62. Tangpricha V., Flanagan J.N., Whitlatch L.W., et al. 25-Hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue. Lancet 357 (2001) 1673-1674
63. Tangpricha V., Koutkia P., Rieke S.M., Chen T.C., Perez A.A., and Holick M.F. Fortification of orange juice with vitamin D: a novel approach to enhance vitamin D nutritional health. Am. J. Clin. Nutr. 77 (2003) 1478-1483
64. Tangpricha V., Turner A., Spina C., Decastro S., Chen T., and Holick M.F. Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. Am. J. Clin. Nutr. 80 (2004) 1645-1649
65. Tangpricha V., Spina C., Yao M., Chen T.C., Wolfe M.M., and Holick M.F. Vitamin D Deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. J. Nutr. 135 (2005) 2350-2354
66. Tangrea J., Helzlsouer K., Pietinen P., et al. Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men. Cancer Causes Control 8 (1997) 615-625
67. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 69 (1999) 842-856
68. Vieth R. The pharmacology of vitamin D, including fortification strategies. In: Feldman D., Pike J.W., and Glorieux F.H. (Eds). Vitamin D, second ed (2005), Elsevier Acad. Press, Amsterdam (Chapter 61)
69. Vieth R., Pinto T.R., Reen B.S., and Wong M.M. Vitamin D poisoning by table sugar. Lancet 359 (2002) 672
70. Whitlatch L.W., Young M.V., Schwartz G.G., et al. 25-hydroxyvitamin D-1-α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer. J. Steroid Biochem. Mol. Biol. 81 (2002) 135-140
71. Woo T.C., Choo R., Jamieson M., Chander S., and Vieth R. Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy. Nutr. Cancer 51 1 (2005) 32-36
72. Zhao X.Y., and Feldman D. The role of vitamin D in prostate cancer. Steroids 66 (2001) 293-300