The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 80-90

  Khan, Ansar A ^a   Chow, Edwin C Y ^b   Porte, Robert J ^c   Pang, K Sandy ^b   Groothuis, Geny M M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Bile acid; Cytochrome P450; FXR; GR; Induction; Intestinal slices; Lithocholic acid; Liver slices; PXR; Transporters; VDR

Indexed keywords

BILE ACID; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A9; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LITHOCHOLIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; PROTEIN BSEP; PROTEIN FXR; PROTEIN LXR ALPHA; PROTEIN NTCP; PROTEIN PXR; PROTEIN TYROSINE PHOSPHATASE SHP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; COLON; CONTROLLED STUDY; DETOXIFICATION; HUMAN; HUMAN CELL; ILEUM; INTESTINE; JEJUNUM; LIVER; METABOLIC REGULATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

ADULT; AGED; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; LITHOCHOLIC ACID; LIVER; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGAN SPECIFICITY; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; RATS, WISTAR; RNA, MESSENGER; SIGNAL TRANSDUCTION; SYMPORTERS;

RATTUS;

EID: 78650517954     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.09.011     Document Type: Article

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