메뉴 건너뛰기




Volumn 396, Issue 2, 2007, Pages 358-368

Functional analysis on the 5′-flanking region of human FXR gene in HepG2 cells

Author keywords

Farnesoid X receptor; Hepatic nuclear factor 1 ; Promoter analysis

Indexed keywords

FARNESOID X RECEPTOR; HEPATIC NUCLEAR FACTOR 1ALPHA; NUCLEOTIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 34250687888     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2007.04.011     Document Type: Article
Times cited : (11)

References (30)
  • 1
    • 0025785990 scopus 로고
    • Two members of an HNF1 homeoprotein family are expressed in mouse liver
    • Bach I., Mattei M.G., Cereghini S., and Yaniv M. Two members of an HNF1 homeoprotein family are expressed in mouse liver. Nucleic Acids Res. 19 (1991) C3553-C3559
    • (1991) Nucleic Acids Res. , vol.19
    • Bach, I.1    Mattei, M.G.2    Cereghini, S.3    Yaniv, M.4
  • 2
    • 0025253275 scopus 로고
    • HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF
    • Baumhueter S., et al. HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes Dev. 4 (1990) C372-C379
    • (1990) Genes Dev. , vol.4
    • Baumhueter, S.1
  • 4
    • 0035807902 scopus 로고    scopus 로고
    • A transcription factor regulatory circuit in differentiated pancreatic cells
    • Boj S., Parrizas M., Maestro M., and Ferrer J. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc. Natl. Acad Sci. U. S. A. 98 (2001) C14481-C14486
    • (2001) Proc. Natl. Acad Sci. U. S. A. , vol.98
    • Boj, S.1    Parrizas, M.2    Maestro, M.3    Ferrer, J.4
  • 5
    • 22544474215 scopus 로고    scopus 로고
    • Transient impairment of the adaptive response to fasting in FXR-deficient mice
    • Cariou B., et al. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett. 579 (2005) C4076-C4080
    • (2005) FEBS Lett. , vol.579
    • Cariou, B.1
  • 6
    • 0036218724 scopus 로고    scopus 로고
    • Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
    • 10.1172/JCI200214505
    • Claudel T., et al. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J. Clin. Invest. 109 (2002) C961-C971 10.1172/JCI200214505
    • (2002) J. Clin. Invest. , vol.109
    • Claudel, T.1
  • 7
    • 0042666932 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    • Claudel T., et al. Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. Gastroenterology. 125 (2003) C544-C555
    • (2003) Gastroenterology. , vol.125
    • Claudel, T.1
  • 8
    • 26244441014 scopus 로고    scopus 로고
    • The farnesoid X receptor. A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T., Staels B., and Kuipers F. The farnesoid X receptor. A molecular link between bile acid and lipid and glucose metabolism. Arterioscler. Thromb. Vasc. Biol. 25 (2005) C2020-C2031
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 9
    • 1842527650 scopus 로고    scopus 로고
    • Glucose regulates the expression of the farnesoid X receptor in liver
    • Duran-Sandoval D., et al. Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes 53 (2004) C890-C898
    • (2004) Diabetes , vol.53
    • Duran-Sandoval, D.1
  • 10
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6 (2000) C517-C526
    • (2000) Mol. Cell , vol.6
    • Goodwin, B.1
  • 13
    • 0031944313 scopus 로고    scopus 로고
    • Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse
    • Lee Y.H., Saue R.B., and Gonzalez F.J. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol. Cell. Biol. 18 (1998) C3059-C3068
    • (1998) Mol. Cell. Biol. , vol.18
    • Lee, Y.H.1    Saue, R.B.2    Gonzalez, F.J.3
  • 14
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K., Saha P.K., Chan L., and Moore D.D. Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116 (2006) C1102-C1109
    • (2006) J. Clin. Invest. , vol.116
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 15
    • 0033591297 scopus 로고    scopus 로고
    • Identification of a nuclear receptor for bile acids
    • Makishima M., et al. Identification of a nuclear receptor for bile acids. Science 284 (1999) C1362-C1365
    • (1999) Science , vol.284
    • Makishima, M.1
  • 16
    • 0026328713 scopus 로고
    • vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression
    • Ott M.O., Rey-Campos J., Cereghini S., and Yaniv M. vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech. Dev. 36 (1991) C47-C58
    • (1991) Mech. Dev. , vol.36
    • Ott, M.O.1    Rey-Campos, J.2    Cereghini, S.3    Yaniv, M.4
  • 17
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: natural ligands for an orphan nuclear receptor
    • Parks D.J., et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 284 (1999) C1365-C1368
    • (1999) Science , vol.284
    • Parks, D.J.1
  • 18
    • 0033765528 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis
    • Pontoglio M. Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis. J. Am. Soc. Nephrol. 11 Suppl 16 (2000) CS140-CS143
    • (2000) J. Am. Soc. Nephrol. , vol.11 , Issue.SUPPL. 16
    • Pontoglio, M.1
  • 19
    • 0030031453 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 inactivation results in hepaticdysfunction, phenylketonuria, and renal Fanconi syndrome
    • Pontoglio M., et al. Hepatocyte nuclear factor 1 inactivation results in hepaticdysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84 (1996) C575-C585
    • (1996) Cell , vol.84
    • Pontoglio, M.1
  • 20
    • 0030740208 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene
    • Pontoglio M., Faust D.M., Doyen A., Yaniv M., and Weiss M.C. Hepatocyte nuclear factor 1alpha gene inactivation impairs chromatin remodeling and demethylation of the phenylalanine hydroxylase gene. Mol. Cell. Biol. 17 (1997) C4948-C4956
    • (1997) Mol. Cell. Biol. , vol.17
    • Pontoglio, M.1    Faust, D.M.2    Doyen, A.3    Yaniv, M.4    Weiss, M.C.5
  • 21
    • 33748940093 scopus 로고    scopus 로고
    • FXR promotes adipocyte differentiation and regulates adipose cell function in vivo. Pharmacology and experimental therapeutics
    • Rizzo G., et al. FXR promotes adipocyte differentiation and regulates adipose cell function in vivo. Pharmacology and experimental therapeutics. Mol. Pharmacol. 70 (2006) C1164-C1173
    • (2006) Mol. Pharmacol. , vol.70
    • Rizzo, G.1
  • 22
    • 0034892164 scopus 로고    scopus 로고
    • Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences
    • Ryffel G.U. Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J. Mol. Endocrinol. 27 (2001) C11-C29
    • (2001) J. Mol. Endocrinol. , vol.27
    • Ryffel, G.U.1
  • 23
    • 0035072875 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 is an essential regulator of bile acid and plasma cholesterol metabolism
    • Shih D.Q., et al. Hepatocyte nuclear factor-1 is an essential regulator of bile acid and plasma cholesterol metabolism. Nat. Genet. 27 (2001) C375-C382
    • (2001) Nat. Genet. , vol.27
    • Shih, D.Q.1
  • 24
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., and Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102 (2000) C731-C744
    • (2000) Cell , vol.102
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 25
    • 0034671526 scopus 로고    scopus 로고
    • The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
    • Urizar N.L., Dowhan D.H., and Moore D.D. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J. Biol. Chem. 275 (2000) C39313-C39317
    • (2000) J. Biol. Chem. , vol.275
    • Urizar, N.L.1    Dowhan, D.H.2    Moore, D.D.3
  • 26
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H., Chen J., Hollister K., Sowers L.C., and Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 3 (1999) C543-C553
    • (1999) Mol. Cell , vol.3
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 27
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M., et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J. Clin. Invest. 113 (2004) C1408-C1418
    • (2004) J. Clin. Invest. , vol.113
    • Watanabe, M.1
  • 28
    • 10544249874 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
    • Yamataga K., et al. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384 (1996) C455-C458
    • (1996) Nature , vol.384
    • Yamataga, K.1
  • 29
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y., Kast-Woelbern H.R., and Edwards P.A. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J. Biol. Chem. 278 (2003) C104-C110
    • (2003) J. Biol. Chem. , vol.278
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 30
    • 15844383382 scopus 로고    scopus 로고
    • Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells
    • Zhou D., Clark P., Wang F., and Chen S. Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells. J. Biol. Chem. 271 (1996) C15194-C15202
    • (1996) J. Biol. Chem. , vol.271
    • Zhou, D.1    Clark, P.2    Wang, F.3    Chen, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.