Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid

Drug Metabolism and Disposition

Volumn 38, Issue 1, 2010, Pages 143-149

  Owen, Bryn M ^a   Milona, Alexandra ^a   Van Mil, Saskia ^b   Clements, Peter ^c   Holder, Julie ^c   Boudjelal, Mohamed ^c   Cairns, William ^c   Parker, Malcolm ^a   White, Roger ^a   Williamson, Catherine ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; ENZYME; LITHOCHOLIC ACID; PREGNANE X RECEPTOR; SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE URINE LEVEL; CONTROLLED STUDY; DETOXIFICATION; DIET; DRUG METABOLISM; FEEDING; FEMALE; FIRST PASS EFFECT; GENE EXPRESSION REGULATION; INTESTINE; INTESTINE TRANSIT TIME; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILE ACIDS AND SALTS; BODY WEIGHT; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; INJECTIONS, INTRAPERITONEAL; INTESTINES; LITHOCHOLIC ACID; LIVER; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIENZYME COMPLEXES; RECEPTORS, STEROID; STEROID HYDROXYLASES; SULFATE ADENYLYLTRANSFERASE; SULFOTRANSFERASES;

MUS;

EID: 73149105298     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029306     Document Type: Article

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