Reverse engineering adverse outcome pathways

Environmental Toxicology and Chemistry

Volumn 30, Issue 1, 2011, Pages 22-38

  Perkins, Edward J ^a   Chipman, J Kevin ^b   Edwards, Stephen ^c   Habib, Tanwir ^d   Falciani, Francesco ^b   Taylor, Ronald ^e   Van Aggelen, Graham ^f   Vulpe, Chris ^g   Antczak, Philipp ^b   Loguinov, Alexandre ^g  

^a US ARMY ENGINEER RESEARCH AND DEVELOPMENT CENTER   (United States)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d UNIVERSITY OF SOUTHERN MISSISSIPPI   (United States)

^e PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^f ENVIRONMENT CANADA   (Canada)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adverse outcome pathway; Mechanism of action; Microarray; Network inference; Toxicology

Indexed keywords

ADVERSE OUTCOMES; BIOLOGICAL PROCESS; CHEMICAL TREATMENTS; COMPLEX INTERACTION; ECO-TOXICOLOGY; FATHEAD MINNOW; GENE REGULATORY NETWORKS; HIGH-DIMENSIONAL; IN-VITRO; IN-VIVO; LARGE DATA; MECHANISM OF ACTION; MUTUAL INFORMATIONS; NETWORK INFERENCE; NETWORK PATHS; PIMEPHALES PROMELAS; ROAD-MAPS; TOXICOLOGICAL EFFECTS; TOXICOLOGY;

ECOLOGY; INDICATORS (CHEMICAL); REVERSE ENGINEERING;

GENE EXPRESSION;

BIOLOGICAL MARKER; CYCLONITE; FADROZOLE; FLUTAMIDE; KETOCONAZOLE; PROCHLORAZ; TRENBOLONE; TRINITROTOLUENE;

BIOMARKER; GENE EXPRESSION; GENETIC ENGINEERING; HYPOTHESIS TESTING; MAP; REGULATORY APPROACH; ROAD; TOXICOLOGY;

ADVERSE OUTCOME; ARTICLE; BIOENGINEERING; ECOTOXICOLOGY; GENE EXPRESSION; GENE REGULATORY NETWORK; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PIMEPHALES PROMELAS; PREDICTION; PRIORITY JOURNAL; REVERSE ENGINEERING;

ANIMALS; CYPRINIDAE; ENVIRONMENTAL MONITORING; FEMALE; GENE EXPRESSION; MODELS, BIOLOGICAL; MODELS, CHEMICAL; OVARY; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

PIMEPHALES PROMELAS;

EID: 78650494068     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.374     Document Type: Article

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