Expression signatures for a model androgen and antiandrogen in the fathead minnow (Pimephales promelas) ovary

Environmental Science and Technology

Volumn 43, Issue 7, 2009, Pages 2614-2619

  Garcia Reyero, Natália ^a   Villeneuve, Daniel L ^b   Kroll, Kevin J ^a   Liu, Li ^a   Orlando, Edward F ^c   Watanabe, Karen H ^d   Sepulveda, María S ^e   Ankley, Gerald T ^b   Denslow, Nancy D ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTORS; APOPTOSIS REGULATORS; CORTICOTROPIN-RELEASING HORMONES; FATHEAD MINNOWS; GENE MICROARRAYS; HYDROXYSTEROID DEHYDROGENASE; INTERFERON-; MODEL COMPOUNDS; MOLECULAR SWITCHES; PHENOTYPIC CHANGES; PIMEPHALES PROMELAS; TISSUE ARCHITECTURES; TRANSCRIPTIONAL REGULATORS; TRENBOLONE;

BIOACTIVITY; CELL DEATH; GENE EXPRESSION;

MICROARRAYS;

3 BETA HYDROXYSTEROID DEHYDROGENASE DERIVATIVE; ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN; CORTICOTROPIN RELEASING FACTOR; FLUTAMIDE; HYDROXYSTEROID DEHYDROGENASE; INTERFERON REGULATORY FACTOR 1; TRANSCRIPTION FACTOR YY1; TRENBOLONE; UNCLASSIFIED DRUG;

ANDROGEN; BIOMARKER; CONCENTRATION (COMPOSITION); CYPRINID; GENE EXPRESSION; HORMONE; MODELING; REPRODUCTIVE BIOLOGY;

ANIMAL TISSUE; ARTICLE; CASP 8 AND FADD LIKE APOPTOSIS REGULATOR GENE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE; GENE EXPRESSION; MUTATION; NONHUMAN; ONCOGENE MYC; OVARY; PIMEPHALES PROMELAS; SPERM ASSOCIATED ANTIGEN 8 GENE; STEROIDOGENESIS;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; CYPRINIDAE; FEMALE; GENE EXPRESSION PROFILING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARY; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

PIMEPHALES PROMELAS;

EID: 64349098479     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es8024484     Document Type: Article

References (39)

1. Denslow, N. D.; Sepúlveda, M. S., Ecotoxicological effects of endocrine disrupting compounds on fish reproduction. In The Fish Oocyte: From Basic Studies to BiotechnologicalApplications; Babin, P. J., Cerda, J., Lubzens, E., Eds.; Springer Publishing Co: Dordrecht, The Netherlands, 2007; pp 255-322.
2. Safe, S. H.; Pallaroni, L.; Yoon, K.; Gaido, K.; Ross, S.; McDonnell, D. Problems for risk assessment of endocrine-active estrogenic compounds. Environ Health Perspect 2002, 110 (6), 925-929.
3. Durhan, E. J.; Lambright, C. S.; Makynen, E. A.; Lazorchak, J.; Hartig, P. C.; Wilson, V. S.; Gray, L. E.; Ankley, G. T. Identification of metabolites of trenbolone acetate in androgenic runoff from a beef feedlot. Environ Health Perspect 2006, 114 (1), 65-68.
4. Ankley, G. T.; Jensen, K. M.; Makynen, E. A.; Kahl, M. D.; Korte, J. J.; Hornung, M. W.; Henry, T. R.; Denny, J. S.; Leino, R. L.; Wilson, V. S.; Cardon, M. C.; Hartig, P. C.; Gray, L. E. Effects of the androgenic growth promoter 17β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Environ. Toxicol. Chem. 2003, 22, 1350-1360.
5. Wilson, V. S.; Lambright, C.; Ostby, J.; Gray, L. E., Jr. In vitro and in vivo effects of 17β-trenbolone: Afeedlot effluent contaminant. Toxicol. Sci. 2002, 70, 202-211.
6. Singh, S. M.; Gauthier, S.; Labrie, F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Curr. Med. Chem. 2000, 7, 211-247.
7. Jensen, K. M.; Kahl, M. D.; Makynen, E. A.; Korte, J. J.; Leino, R. L.; Butterworth, B. C.; Ankley, G. T. Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow. Aquat. Toxicol. 2004, 70, 99-110.
8. A short-term test method for assessing the reproductive toxicity of endocrine disrupting chemicals using the fathead minnow (Pimephales promelas), EPA/600/R-01/067; U.S. Environmental Protection Agency: Washington, DC, 2002.
9. Ankley, G. T.; Defoe, D. L.; Kahl, M. D.; Jensen, K. M.; Makynen, E. A.; Miracle, A.; Hartig, P.; Gray, L. E.; Cardon, M.; Wilson, V. Evaluation of the model anti-androgen flutamide for assessing the mechanistic basis of responses to an androgen in the fathead minnow (Pimephales promelas). Environ. Sci. Technol. 2004, 38, 6322-6327.
10. Hemming, J. M.; Waller, W. T.; Chow, M. C.; Denslow, N. D.; Venables, B. Assessment of the estrogenicity and toxicity of a domestic wastewater effluent flowing through a constructed wetland system using biomarkers in male fathead minnows (Pimephalespromelasrafinesque, 1820). Environ. Toxicol. Chem. 2001, 20, 2268-2275.
11. Jensen, K. M.; Korte, J. J.; Kahl, M. D.; Pasha, M. S.; Ankley, G. T. Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas). Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol. 2001, 128, 127-141.
12. Garcia-Reyero, N.; Barber, D. S.; Gross, T. S.; Johnson, K. G.; Sepulveda, M. S.; Szabo, N. J.; Denslow, N. D. Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction. Aquat. Toxicol. 2006, 78, 358-369.
13. Villeneuve, D. L.; Knoebl, I.; Kahl, M. D.; Jensen, K. M.; Hammermeister, D. E.; Greene, K. J.; Blake, L. S.; Ankley, G. T. Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA expression in the fathead minnow (Pimephales promelas). Aquat. Toxicol. 2006, 76, 353-368.
14. Villeneuve, D. L.; Blake, L. S.; Brodin, J. D.; Greene, K. J.; Knoebl, I.; Miracle, A. L.; Martinovic, D.; Ankley, G. T. Transcription of key genes regulating gonadal steroidogenesis in control and ketoconazole- or vinclozolin-exposed fathead minnows. Toxicol. Sci. 2007, 98, 395-407.
15. Zahurak, M.; Parmigiani, G.; Yu, W.; Scharpf, R. B.; Berman, D.; Schaeffer, E.; Shabbeer, S.; Cope, L. Pre-processing Agilent microarray data. BMC Bioinf. 2007, 8, 142.
16. Benjamini, Y.; Hochberg, Y Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R Stat. Soc., Ser. B 1995, 57, 289-300.
17. Nikitin, A.; Egorov, S.; Daraselia, N.; Mazo, I. Pathway studio-the analysis and navigation of molecular networks. Bioinformatics 2003, 19, 2155-2157.
18. Martyniuk, C.; Alvarez, S.; McClung, S.; Villeneuve, D.; Ankley, G.; Denslow, N. Quantitative proteomic profiles of androgen receptor signaling in the liver of fathead minnows (Pimephalus promelas). J. Proteome Res. (accepted).
19. Wang, Y.; Ge, W. Developmental profiles of activinbetaA, betaB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biol. Reprod. 2004, 71, 2056-2064.
20. Kim, H. H.; Kwak, D. H.; Yon, J. M.; Baek, I. J.; Lee, S. R.; Lee, J. E.; Nahm, S. S.; Jeong, J. H.; Lee, B. J.; Yun, Y. W.; Nam, S. Y. Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors. J Reprod. Dev. 2007, 53, 465-471.
21. Filby, A L.; Thorpe, K. L.; Maack, G.; Tyler, C. R. Gene expression profiles revealing the mechanisms of anti-androgen- and estrogen-induced feminization in fish. Aquat. Toxicol. 2007, 81, 219-231.
22. Fukuzawa, N. H.; Ohsako, S.; Wu, Q.; Sakaue, M.; Fujii-Kuriyama, Y.; Baba, T.; Tohyama, C. Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse. Mol. Cell. Endocrinol. 2004, 221, 87-96.
23. Hu, W.; Sorrentino, C.; Denison, M. S.; Kolaja, K.; Fielden, M. R. Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol. Pharmacol. 2007, 71, 1475-1486.
24. Hook, S. E.; Skillman, A. D.; Small, J. A.; Schultz, I. R. Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants. Aquat. Toxicol. 2006, 77, 372-385.
25. Moens, L. N.; van der Ven, K.; Van Remortel, P.; Del-Favero, J.; De Coen, W. M. Expression profiling of endocrine-disrupting compounds using a customized Cyprinus carpio cDNA microarray. Toxicol. Sci. 2006, 93, 298-310.
26. Nguyen, T. V.; Yao, M.; Pike, C. J. Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology 2007, 148, 2936-2943.
27. Miyamoto, H.; Yeh, S.; Lardy, H.; Messing, E.; Chang, C. Delta5-androstenediol is a natural hormone with androgenic activity in human prostate cancer cells. Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 11083-11088.
28. Rahman, M. M.; Miyamoto, H.; Lardy, H.; Chang, C. Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 5124-5129.
29. Wong, C.; Kelce, W. R.; Sar, M.; Wilson, E. M. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J. Biol. Chem. 1995, 270, 19998-20003.
30. Coe, K. J.; Nelson, S. D.; Ulrich, R. G.; He, Y.; Dai, X.; Cheng, O.; Caguyong, M.; Roberts, C. J.; Slatter, J. G. Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYPIA inducers. Drug Metab. Dispos. 2006, 34, 1266-1275.
31. Thackray, V. G.; McGillivray, S. M.; Mellon, P. L. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol. Endocrinol. 2006, 20, 2062-2079.
32. Harada, H.; Fujita, T.; Miyamoto, M.; Kimura, Y.; Maruyama, M.; Furia, A.; Miyata, T.; Taniguchi, T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 1989, 58, 729-739.
33. Madge, B.; Geisen, C.; Moroy, T.; Schwab, M. Yaf2 inhibits Myc biological function. Cancer Lett 2003, 193, 171-176.
34. Nackley, A. C.; Shea-Eaton, W.; Lopez, D.; McLean, M. P. Repression of the steroidogenic acute regulatory gene by the multifunctional transcription factor Yin Yang 1. Endocrinology 2002, 143, 1085-1096.
35. Watanabe, T. K.; Suzuki, M.; Omori, Y.; Hishigaki, H.; Horie, M.; Kanemoto, N.; Fujiwara, T.; Nakamura, Y.; Takahashi, E. Cloning and characterization of a novel member of the human Mad gene family (MADH6). Genomics 1997, 42, 446-451.
36. Shrivastava, A.; Saleque, S.; Kalpana, G. V.; Artandi, S.; Goff, S. P.; Calame, K. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 1993, 262, 1889-1892.
37. Tremblay, J. J.; Viger, R. S. Novel roles for GATA transcription factors in the regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 2003, 85, 291-298.
38. Ericsson, J.; Usheva, A.; Edwards, P. A. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. J. Biol. Chem. 1999, 274, 14508-14513.
39. Cheng, G. Y.; Shi, J. L.; Wang, M.; Hu, Y Q.; Liu, C. M.; Wang, Y. F.; Xu, C. Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane protein 1 antibody. Asian J. Androl. 2007, 9, 23-29.