Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations

BMC Bioinformatics

Volumn 7, Issue , 2006, Pages

  Hallén, Kristofer ^a   Björkegren, Johan ^b,c   Tegnér, Jesper ^a,b,c  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Clinical Gene Networks AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DEVELOPMENT; EXPRESSION MEASUREMENTS; EXPRESSION PROFILE; PRIOR INFORMATION; REGULATORY NETWORK; SEARCH STRATEGIES; SHORT INTERFERING RNA (SIRNA); TARGET IDENTIFICATION;

CHEMICAL COMPOUNDS; ITERATIVE METHODS; NETWORK ARCHITECTURE; PERTURBATION TECHNIQUES;

GENE EXPRESSION;

CHEMICAL COMPOUND; GALACTOSE; SMALL INTERFERING RNA; PROTEOME;

ALGORITHM; ARTICLE; COMPUTER MODEL; DATA BASE; DRUG DESIGN; DRUG MECHANISM; DRUG TARGETING; GENE DELETION; GENE LIBRARY; GENE MAPPING; GENOME; MAMMAL CELL; NONHUMAN; PHARMACOGENETICS; PREDICTION; VALIDATION PROCESS; YEAST; CHROMOSOME MAP; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENETICS; METABOLISM; PROCEDURES; SYSTEM ANALYSIS;

MAMMALIA;

ALGORITHMS; CHROMOSOME MAPPING; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG EVALUATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VARIATION; PROTEOME; SYSTEMS INTEGRATION;

EID: 33645038950     PISSN: 14712105     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-7-51     Document Type: Article

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