Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals

Toxicological Sciences

Volumn 110, Issue 2, 2009, Pages 449-462

  Goetz, Amber K ^a,b   Dix, David J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Myclobutanil; Propiconazole; Steroid metabolism; Toxicogenomics; Triadimefon

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; MYCLOBUTANIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PREGNANE X RECEPTOR; PROPICONAZOLE; TRIADIMEFON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID METABOLISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GESTATION PERIOD; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; REPRODUCTIVE TOXICITY; SIGNAL TRANSDUCTION; STEROID METABOLISM; STEROL SYNTHESIS; TESTIS; TOXICOGENETICS;

AGING; ANIMALS; ANTIFUNGAL AGENTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GESTATIONAL AGE; INFERTILITY, MALE; LIVER; LIVER DISEASES; MALE; NITRILES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; REPRODUCTION; TESTIS; TESTOSTERONE; TRIAZOLES;

RATTUS;

EID: 67650760524     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp098     Document Type: Article

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