Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology

Biochemistry

Volumn 49, Issue 49, 2010, Pages 10553-10564

  Zhang, Aming ^a   Jordan, Jacob L ^a   Ivanova, Magdalena I ^b   Weiss, William F ^c,d   Roberts, Christopher J ^c   Fernandez, Erik J ^a  

^a University of Virginia   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Delaware   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE MORPHOLOGY; AGGREGATION MECHANISM; BIOPHARMACEUTICALS; COLLOIDAL STABILITY; CONGO RED; DISORDERED STRUCTURES; GRANULOCYTE-COLONY STIMULATING FACTOR; HYDROGEN EXCHANGE; MOLECULAR CONFORMATION; MOLECULAR-LEVEL INSIGHTS; MORPHOLOGICAL FEATURES; PROTEIN AGGREGATION; STRUCTURAL MECHANISMS; THERMALLY INDUCED;

AZO DYES; BIOCHEMISTRY; GLYCOPROTEINS; IONIC STRENGTH; MORPHOLOGY; PEPTIDES; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

AGGREGATES;

AMYLOID; AMYLOID BETA PROTEIN; CHYMOTRYPSINOGEN; CONGO RED; POLYPEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; AMYLOID; AMYLOIDOSIS; ANIMALS; CATTLE; CHYMOTRYPSINOGEN; CONGO RED; HOT TEMPERATURE; MOLECULAR SEQUENCE DATA; PLIABILITY; X-RAY DIFFRACTION;

BOVINAE;

EID: 78650154417     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1014216     Document Type: Article

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