Screening transthyretin amyloid fibril inhibitors: Characterization of novel multiprotein, multiligand complexes by mass spectrometry

Structure

Volumn 10, Issue 6, 2002, Pages 851-863

  McCammon, Margaret G ^a,b   Scott, David J ^c   Keetch, Catherine A ^a,b   Greene, Lesley H ^b   Purkey, Hans E ^d   Petrassi, H Michael ^d   Kelly, Jeffery W ^d   Robinson, Carol V ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cooperativity; Ligand screening; Multiprotein target; Retinol binding protein; Transthyretin; Transthyretin retinol binding protein complex

Indexed keywords

AMYLOID; DICLOFENAMIC ACID; DIFLUNISAL; FENOPROFEN; FLUFENAMIC ACID; FLURBIPROFEN; INDOMETACIN; LIGAND; MECLOFENAMIC ACID; MEFENAMIC ACID; PREALBUMIN; PROTEIN INHIBITOR; PROTEIN SUBUNIT; RESVERATROL; TETRAMER; THYROXINE; UNCLASSIFIED DRUG; VITAMIN;

ARTICLE; LIGAND BINDING; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMYLOID; BINDING SITES; DRUG EVALUATION, PRECLINICAL; LIGANDS; MASS SPECTROMETRY; POLYMERS; PREALBUMIN; VITAMIN A;

EID: 0036277955     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00771-2     Document Type: Article

References (40)

1. Amyloid diseases: Abnormal protein aggregation in neurodegeneration
2. Amyloid fibril formation and protein misassembly: A structural quest for insights into amyloid and prion diseases
3. Mechanisms of transthyretin amyloidogenesis - Antigenic mapping of transthyretin purified from plasma and amyloid fibrils and within in-situ tissue localizations
4. Liver-transplantation for the treatment of type-I familial amyloidotic polyneuropathy
5. Clinical improvement after liver-transplantation for type-I familial amyloid polyneuropathy
6. A comparative analysis of 23 structures of the amyloidogenic protein transthyretin
7. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease
8. The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid
9. Computer graphics in drug design - Molecular modeling of thyroid-hormone pre-albumin interactions
10. Inhibiting transthyretin amyloid fibril formation via protein stabilization
11. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation
12. Discovering transthyretin amyloid fibril inhibitors by limited screening
13. Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors
14. Electrospray ionization mass spectrometry: A technology for studying noncovalent macromolecular complexes
15. Electrospray ionization mass spectrometry in the study of biomolecular non-covalent interactions
16. Determination of non-covalent metal ion/protein interactions using a microflow electrospray ionization mass spectrometry interface
17. Analysis of transcription complexes and effects of ligands by microelectrospray ionization mass spectrometry
18. Determining calcium-binding stoichiometry and cooperativity of parvalbumin and calmodulin by mass spectrometry
19. Mass spectrometry as a novel approach to probe cooperativity in multimeric enzymatic systems
20. Protein subunit interactions and structural integrity of amyloidogenic transthyretins: Evidence from electrospray mass spectrometry
21. Dissection of multi-protein complexes using mass spectrometry: Subunit interactions in transthyretin and retinol-binding protein complexes
22. Dissociation of heme-globin complexes by blackbody infrared radiative dissociation:Molecular specificity in the gas phase?
23. Probing the nature of noncovalent interactions by mass spectrometry. A study of protein-CoA ligand binding and assembly
24. Specificity and interactions of the protein OppA: Partitioning solvent binding effects using mass spectrometry
25. Effects of anion on the positive ion electrospray ionization mass spectra of peptides and proteins
26. Comparison of experimental binding data and theoretical models in proteins containing subunits
27. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP
28. The interactions between retinol-binding proteins and pre-albumins studied by fluorescence polarization
29. The interaction of human plasma retinol binding protein with prealbumin
30. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid
31. Rational design of potent human transthyretin amyloid disease inhibitors
32. The transthyretin-retinol-binding protein complex
33. The crystal structure of amyloidogenic Leu(55) -> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils
34. Arresting amyloidosis in-vivo using small-molecule anionic sulfonates or sulfates - implications for Alzheimers-disease
35. Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: Potential small-molecule therapeutic agents for the treatment of Alzheimer's disease
36. Controlling polymerization of beta-amyloid and prion-derived peptides with synthetic small molecule ligands
37. Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily
38. How to determine the molar absorbance coefficient of a protein
39. Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties