메뉴 건너뛰기




Volumn 30, Issue 5, 2010, Pages 449-461

A CCL2-based fusokine as a novel biopharmaceutical for the treatment of CCR2-driven autoimmune diseases

Author keywords

CCL2; Fusokines; GMME1; GPCRs; Multiple sclerosis; Rheumatoid arthritis

Indexed keywords

CHEMOKINE RECEPTOR CCR2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1;

EID: 78650053726     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevimmunol.v30.i5.40     Document Type: Review
Times cited : (9)

References (80)
  • 1
    • 0035260881 scopus 로고    scopus 로고
    • Chemokines and disease
    • Feb
    • Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol. 2001 Feb;2(2):108-15.
    • (2001) Nat Immunol , vol.2 , Issue.2 , pp. 108-115
    • Gerard, C.1    Rollins, B.J.2
  • 2
    • 0017607124 scopus 로고
    • Purification and characterization of human and bovine platelet factor 4
    • Wu VY, Walz DA, McCoy LE. Purification and characterization of human and bovine platelet factor 4. Prep Biochem. 1977;7(6):479-93.
    • (1977) Prep Biochem , vol.7 , Issue.6 , pp. 479-493
    • Wu, V.Y.1    Walz, D.A.2    McCoy, L.E.3
  • 3
    • 34250186076 scopus 로고    scopus 로고
    • Manipulating the chemokine-chemokine receptor network to treat cancer
    • Jun 15
    • Ruffini PA, Morandi P, Cabioglu N, Altundag K, Cristofanilli M. Manipulating the chemokine-chemokine receptor network to treat cancer. Cancer. 2007 Jun 15;109(12):2392-404.
    • (2007) Cancer , vol.109 , Issue.12 , pp. 2392-2404
    • Ruffini, P.A.1    Morandi, P.2    Cabioglu, N.3    Altundag, K.4    Cristofanilli, M.5
  • 4
    • 35348826635 scopus 로고    scopus 로고
    • Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors
    • Oct
    • Wagner W, Roderburg C, Wein F, Diehlmann A, Frankhauser M, Schubert R, Eckstein V, Ho AD. Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors. Stem Cells. 2007 Oct;25(10):2638-47.
    • (2007) Stem Cells , vol.25 , Issue.10 , pp. 2638-2647
    • Wagner, W.1    Roderburg, C.2    Wein, F.3    Diehlmann, A.4    Frankhauser, M.5    Schubert, R.6    Eckstein, V.7    Ho, A.D.8
  • 5
    • 0028084818 scopus 로고
    • Regulation of monocyte chemoattractant protein- 1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor
    • Feb
    • Barna BP, Pettay J, Barnett GH, Zhou P, Iwasaki K, Estes ML. Regulation of monocyte chemoattractant protein- 1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor. J Neuroimmunol. 1994 Feb;50(1):101-7.
    • (1994) J Neuroimmunol , vol.50 , Issue.1 , pp. 101-107
    • Barna, B.P.1    Pettay, J.2    Barnett, G.H.3    Zhou, P.4    Iwasaki, K.5    Estes, M.L.6
  • 6
    • 3543118899 scopus 로고    scopus 로고
    • Glycosaminoglycan disaccharide alters the dimer dissociation constant of the chemokine MIP-1 beta
    • Aug 10
    • McCornack MA, Boren DM, LiWang PJ. Glycosaminoglycan disaccharide alters the dimer dissociation constant of the chemokine MIP-1 beta. Biochemistry. 2004 Aug 10;43(31):10090-101.
    • (2004) Biochemistry , vol.43 , Issue.31 , pp. 10090-10101
    • McCornack, M.A.1    Boren, D.M.2    LiWang, P.J.3
  • 7
    • 0032571360 scopus 로고    scopus 로고
    • Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection
    • Mar 27
    • Proost P, De M, I, Schols D, Struyf S, Lambeir AM, Wuyts A, Opdenakker G, De CE, Scharpe S, Van DJ. Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. J Biol Chem. 1998 Mar 27;273(13):7222-7.
    • (1998) J Biol Chem , vol.273 , Issue.13 , pp. 7222-7227
    • Proost, P.1    De, M.I.2    Schols, D.3    Struyf, S.4    Lambeir, A.M.5    Wuyts, A.6    Opdenakker, G.7    De, C.E.8    Scharpe, S.9    Van, D.J.10
  • 8
  • 9
    • 0032538522 scopus 로고    scopus 로고
    • Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    • Oct 16
    • Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science. 1998 Oct 16;282(5388):480-3.
    • (1998) Science , vol.282 , Issue.5388 , pp. 480-483
    • Randolph, G.J.1    Beaulieu, S.2    Lebecque, S.3    Steinman, R.M.4    Muller, W.A.5
  • 11
  • 13
    • 0034231216 scopus 로고    scopus 로고
    • CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells
    • Jul
    • Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.Nat Immunol. 2000 Jul;1(1):83-7.
    • (2000) Nat Immunol , vol.1 , Issue.1 , pp. 83-87
    • Aliberti, J.1    Reis E Sousa, C.2    Schito, M.3    Hieny, S.4    Wells, T.5    Huffnagle, G.B.6    Sher, A.7
  • 14
    • 0029946021 scopus 로고    scopus 로고
    • Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family
    • May 1
    • Mohamadzadeh M, Poltorak AN, Bergstressor PR, Beutler B, Takashima A. Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. J Immunol. 1996 May 1;156(9):3102-6.
    • (1996) J Immunol , vol.156 , Issue.9 , pp. 3102-3106
    • Mohamadzadeh, M.1    Poltorak, A.N.2    Bergstressor, P.R.3    Beutler, B.4    Takashima, A.5
  • 15
  • 17
    • 0034682885 scopus 로고    scopus 로고
    • Inflammation dampened by gelatinase a cleavage of monocyte chemoattractant protein-3
    • Aug 18
    • McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science. 2000 Aug 18;289(5482):1202-6.
    • (2000) Science , vol.289 , Issue.5482 , pp. 1202-1206
    • McQuibban, G.A.1    Gong, J.H.2    Tam, E.M.3    McCulloch, C.A.4    Clark-Lewis, I.5    Overall, C.M.6
  • 18
    • 0037103183 scopus 로고    scopus 로고
    • Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
    • Aug 15
    • McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood. 2002 Aug 15;100(4):1160-7.
    • (2002) Blood , vol.100 , Issue.4 , pp. 1160-1167
    • McQuibban, G.A.1    Gong, J.H.2    Wong, J.P.3    Wallace, J.L.4    Clark-Lewis, I.5    Overall, C.M.6
  • 19
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • Aug 1
    • Rollins BJ. Chemokines. Blood. 1997 Aug 1;90(3):909-28.
    • (1997) Blood , vol.90 , Issue.3 , pp. 909-928
    • Rollins, B.J.1
  • 20
    • 0037458614 scopus 로고    scopus 로고
    • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation
    • Feb 21
    • Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem. 2003 Feb 21;278(8):6258-67.
    • (2003) J Biol Chem , vol.278 , Issue.8 , pp. 6258-6267
    • Tohgo, A.1    Choy, E.W.2    Gesty-Palmer, D.3    Pierce, K.L.4    Laporte, S.5    Oakley, R.H.6    Caron, M.G.7    Lefkowitz, R.J.8    Luttrell, L.M.9
  • 21
    • 0035793059 scopus 로고    scopus 로고
    • Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus
    • Jan 2
    • Barak LS, Oakley RH, Laporte SA, Caron MG. Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):93-8.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.1 , pp. 93-98
    • Barak, L.S.1    Oakley, R.H.2    Laporte, S.A.3    Caron, M.G.4
  • 22
    • 0036780743 scopus 로고    scopus 로고
    • G-protein-coupled receptor oligomerization and its potential for drug discovery
    • Oct
    • George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov. 2002 Oct;1(10):808-20.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.10 , pp. 808-820
    • George, S.R.1    O'Dowd, B.F.2    Lee, S.P.3
  • 23
    • 34247855761 scopus 로고    scopus 로고
    • Chemokine: Receptor structure, interactions, and antagonism
    • Allen SJ, Crown SE, Handel TM. Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol. 2007;25:787-820.
    • (2007) Annu Rev Immunol , vol.25 , pp. 787-820
    • Allen, S.J.1    Crown, S.E.2    Handel, T.M.3
  • 24
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    • Dec 15
    • Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995 Dec 15;270(5243):1811-5.
    • (1995) Science , vol.270 , Issue.5243 , pp. 1811-1815
    • Cocchi, F.1    DeVico, A.L.2    Garzino-Demo, A.3    Arya, S.K.4    Gallo, R.C.5    Lusso, P.6
  • 26
    • 70350165412 scopus 로고    scopus 로고
    • Novel drug classes: Entry inhibitors [enfuvirtide, chemokine (C- C motif) receptor 5 antagonists]
    • Nov
    • McKinnell JA, Saag MS. Novel drug classes: entry inhibitors [enfuvirtide, chemokine (C- C motif) receptor 5 antagonists]. Curr Opin HIV AIDS. 2009 Nov;4(6):513-7.
    • (2009) Curr Opin HIV AIDS , vol.4 , Issue.6 , pp. 513-517
    • McKinnell, J.A.1    Saag, M.S.2
  • 27
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines--chemotactic cytokines that mediate inflammation
    • Feb 12
    • Luster AD. Chemokines--chemotactic cytokines that mediate inflammation. N Engl J Med. 1998 Feb 12;338(7):436-45.
    • (1998) N Engl J Med , vol.338 , Issue.7 , pp. 436-445
    • Luster, A.D.1
  • 28
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Apr 9
    • Baggiolini M. Chemokines and leukocyte traffic. Nature. 1998 Apr 9;392(6676):565-8.
    • (1998) Nature , vol.392 , Issue.6676 , pp. 565-568
    • Baggiolini, M.1
  • 30
    • 0032800758 scopus 로고    scopus 로고
    • CCR2: From cloning to the creation of knockout mice
    • Charo IF. CCR2: from cloning to the creation of knockout mice. Chem Immunol. 1999;72:30-41.
    • (1999) Chem Immunol , vol.72 , pp. 30-41
    • Charo, I.F.1
  • 31
    • 0029112239 scopus 로고
    • In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation
    • Oct 1
    • Chensue SW, Ruth JH, Warmington K, Lincoln P, Kunkel SL. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J Immunol. 1995 Oct 1;155(7):3546-51.
    • (1995) J Immunol , vol.155 , Issue.7 , pp. 3546-3551
    • Chensue, S.W.1    Ruth, J.H.2    Warmington, K.3    Lincoln, P.4    Kunkel, S.L.5
  • 32
    • 0031131879 scopus 로고    scopus 로고
    • Differential CC chemokine-induced enhancement of T helper cell cytokine production
    • May 1
    • Karpus WJ, Lukacs NW, Kennedy KJ, Smith WS, Hurst SD, Barrett TA. Differential CC chemokine-induced enhancement of T helper cell cytokine production. J Immunol. 1997 May 1;158(9):4129-36.
    • (1997) J Immunol , vol.158 , Issue.9 , pp. 4129-4136
    • Karpus, W.J.1    Lukacs, N.W.2    Kennedy, K.J.3    Smith, W.S.4    Hurst, S.D.5    Barrett, T.A.6
  • 34
    • 0034704593 scopus 로고    scopus 로고
    • Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
    • Mar 23
    • Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature. 2000 Mar 23;404(6776):407-11.
    • (2000) Nature , vol.404 , Issue.6776 , pp. 407-411
    • Gu, L.1    Tseng, S.2    Horner, R.M.3    Tam, C.4    Loda, M.5    Rollins, B.J.6
  • 35
    • 54049106148 scopus 로고    scopus 로고
    • Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: Potential role of the macrophage in terminating polymorphonuclear leukocyte influx
    • Oct 15
    • Dean RA, Cox JH, Bellac CL, Doucet A, Starr AE, Overall CM. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood. 2008 Oct 15;112(8):3455-64.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3455-3464
    • Dean, R.A.1    Cox, J.H.2    Bellac, C.L.3    Doucet, A.4    Starr, A.E.5    Overall, C.M.6
  • 37
    • 0028316908 scopus 로고
    • Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails
    • Mar 29
    • Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2752-6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.7 , pp. 2752-2756
    • Charo, I.F.1    Myers, S.J.2    Herman, A.3    Franci, C.4    Connolly, A.J.5    Coughlin, S.R.6
  • 38
    • 0034832211 scopus 로고    scopus 로고
    • CCR2A and CCR2B, the two isoforms of the monocyte chemoattractant protein-1 receptor are up-regulated and expressed by different cell subsets in idiopathic inflammatory myopathies
    • Oct
    • Bartoli C, Civatte M, Pellissier JF, Figarella-Branger D. CCR2A and CCR2B, the two isoforms of the monocyte chemoattractant protein-1 receptor are up-regulated and expressed by different cell subsets in idiopathic inflammatory myopathies. Acta Neuropathol. 2001 Oct;102(4):385-92.
    • (2001) Acta Neuropathol , vol.102 , Issue.4 , pp. 385-392
    • Bartoli, C.1    Civatte, M.2    Pellissier, J.F.3    Figarella-Branger, D.4
  • 39
    • 0034327802 scopus 로고    scopus 로고
    • Functional differences between monocyte chemotactic protein-1 receptor A and monocyte chemotactic protein-1 receptor B expressed in a Jurkat T cell
    • Nov 1
    • Sanders SK, Crean SM, Boxer PA, Kellner D, LaRosa GJ, Hunt SW 3rd. Functional differences between monocyte chemotactic protein-1 receptor A and monocyte chemotactic protein-1 receptor B expressed in a Jurkat T cell. J Immunol. 2000 Nov 1;165(9):4877-83.
    • (2000) J Immunol , vol.165 , Issue.9 , pp. 4877-4883
    • Sanders, S.K.1    Crean, S.M.2    Boxer, P.A.3    Kellner, D.4    LaRosa, G.J.5    Hunt III, S.W.6
  • 40
    • 34548856205 scopus 로고    scopus 로고
    • Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA
    • Aug 31
    • Cho ML, Yoon BY, Ju JH, Jung YO, Jhun JY, Park MK, Park SH, Cho CS, Kim HY. Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA. Exp Mol Med. 2007 Aug 31;39(4):499-507.
    • (2007) Exp Mol Med , vol.39 , Issue.4 , pp. 499-507
    • Cho, M.L.1    Yoon, B.Y.2    Ju, J.H.3    Jung, Y.O.4    Jhun, J.Y.5    Park, M.K.6    Park, S.H.7    Cho, C.S.8    Kim, H.Y.9
  • 42
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • Sep
    • McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007 Sep;8(9):913-9.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 43
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Mar 19
    • Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med. 2001 Mar 19;193(6):713-26.
    • (2001) J Exp Med , vol.193 , Issue.6 , pp. 713-726
    • Huang, D.R.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 44
    • 0036295472 scopus 로고    scopus 로고
    • Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats
    • Jul
    • Jee Y, Yoon WK, Okura Y, Tanuma N, Matsumoto Y. Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol. 2002 Jul;128(1-2):49-57.
    • (2002) J Neuroimmunol , vol.128 , Issue.1-2 , pp. 49-57
    • Jee, Y.1    Yoon, W.K.2    Okura, Y.3    Tanuma, N.4    Matsumoto, Y.5
  • 45
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    • Oct 2
    • Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med. 2000 Oct 2;192(7):1075-80.
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 46
    • 0034665652 scopus 로고    scopus 로고
    • Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine
    • Sep 15
    • Onai N, Zhang Y, Yoneyama H, Kitamura T, Ishikawa S, Matsushima K. Impairment of lymphopoiesis and myelopoiesis in mice reconstituted with bone marrow-hematopoietic progenitor cells expressing SDF-1-intrakine. Blood. 2000 Sep 15;96(6):2074-80.
    • (2000) Blood , vol.96 , Issue.6 , pp. 2074-2080
    • Onai, N.1    Zhang, Y.2    Yoneyama, H.3    Kitamura, T.4    Ishikawa, S.5    Matsushima, K.6
  • 47
    • 0242290924 scopus 로고    scopus 로고
    • A genetic approach to inactivating chemokine receptors using a modified viral protein
    • Nov
    • Coffield VM, Jiang Q, Su L. A genetic approach to inactivating chemokine receptors using a modified viral protein. Nat Biotechnol. 2003 Nov;21(11):1321-7.
    • (2003) Nat Biotechnol , vol.21 , Issue.11 , pp. 1321-1327
    • Coffield, V.M.1    Jiang, Q.2    Su, L.3
  • 49
    • 0030909913 scopus 로고    scopus 로고
    • The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats
    • May
    • Ogata H, Takeya M, Yoshimura T, Takagi K, Takahashi K. The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats. J Pathol. 1997 May;182(1):106-14.
    • (1997) J Pathol , vol.182 , Issue.1 , pp. 106-114
    • Ogata, H.1    Takeya, M.2    Yoshimura, T.3    Takagi, K.4    Takahashi, K.5
  • 50
    • 0030748047 scopus 로고    scopus 로고
    • Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice
    • DOI 10.1016/S0165-2478(97)00075-8, PII S0165247897000758
    • Plater-Zyberk C, Hoogewerf AJ, Proudfoot AE, Power CA, Wells TN. Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice. Immunol Lett. 1997 Jun 1;57(1-3):117-20. (Pubitemid 27319323)
    • (1997) Immunology Letters , vol.57 , Issue.1-3 , pp. 117-120
    • Plater-Zyberk, C.1    Hoogewerf, A.J.2    Proudfoot, A.E.I.3    Power, C.A.4    Wells, T.N.C.5
  • 52
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • Jun
    • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007 Jun;7(6):429-42.
    • (2007) Nat Rev Immunol , vol.7 , Issue.6 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 53
    • 35648988128 scopus 로고    scopus 로고
    • New therapies for treatment of rheumatoid arthritis
    • DOI 10.1016/S0140-6736(07)60784-3, PII S0140673607607843
    • Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P. New therapies for treatment of rheumatoid arthritis. Lancet. 2007 Dec 1;370(9602):1861-74. (Pubitemid 350180008)
    • (2007) Lancet , vol.370 , Issue.9602 , pp. 1861-1874
    • Smolen, J.S.1    Aletaha, D.2    Koeller, M.3    Weisman, M.H.4    Emery, P.5
  • 54
    • 0033120514 scopus 로고    scopus 로고
    • Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling
    • Rabin RL, Park MK, Liao F, Swofford R, Stephany D, Farber JM. Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. J Immunol. 1999 Apr 1;162(7):3840-50. (Pubitemid 29314761)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3840-3850
    • Rabin, R.L.1    Park, M.K.2    Liao, F.3    Swofford, R.4    Stephany, D.5    Farber, J.M.6
  • 55
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • DOI 10.1016/S1074-7613(03)00174-2
    • Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003 Jul;19(1):71-82. (Pubitemid 36859902)
    • (2003) Immunity , vol.19 , Issue.1 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 57
    • 47249107343 scopus 로고    scopus 로고
    • Is CCR2 the right chemokine receptor to target in rheumatoid arthritis?
    • Jul
    • Proudfoot AE. Is CCR2 the right chemokine receptor to target in rheumatoid arthritis? Arthritis Rheum. 2008 Jul;58(7):1889-91.
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 1889-1891
    • Proudfoot, A.E.1
  • 58
    • 0029131699 scopus 로고
    • A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer
    • Sep
    • Zhang Y, Rollins BJ. A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer. Mol Cell Biol. 1995 Sep;15(9):4851-5.
    • (1995) Mol Cell Biol , vol.15 , Issue.9 , pp. 4851-4855
    • Zhang, Y.1    Rollins, B.J.2
  • 61
    • 0030612473 scopus 로고    scopus 로고
    • An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model
    • Jul 7
    • Gong JH, Ratkay LG, Waterfield JD, Clark-Lewis I. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med. 1997 Jul 7;186(1):131-7.
    • (1997) J Exp Med , vol.186 , Issue.1 , pp. 131-137
    • Gong, J.H.1    Ratkay, L.G.2    Waterfield, J.D.3    Clark-Lewis, I.4
  • 63
    • 0033564824 scopus 로고    scopus 로고
    • Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines
    • DOI 10.1042/0264-6021:3400803
    • Reckless J, Grainger DJ. Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines. Biochem J. 1999 Jun 15;340(Pt 3):803-11. (Pubitemid 29312880)
    • (1999) Biochemical Journal , vol.340 , Issue.3 , pp. 803-811
    • Reckless, J.1    Grainger, D.J.2
  • 65
    • 0034637218 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes
    • DOI 10.1016/S0014-2999(00)00461-1, PII S0014299900004611
    • Kintscher U, Goetze S, Wakino S, Kim S, Nagpal S, Chandraratna RA, Graf K, Fleck E, Hsueh WA, Law RE. Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes. Eur J Pharmacol. 2000 Aug 11;401(3):259-70. (Pubitemid 30608710)
    • (2000) European Journal of Pharmacology , vol.401 , Issue.3 , pp. 259-270
    • Kintscher, U.1    Goetze, S.2    Wakino, S.3    Kim, S.4    Nagpal, S.5    Chandraratna, R.A.S.6    Graf, K.7    Fleck, E.8    Hsueh, W.A.9    Law, R.E.10
  • 67
    • 0035888090 scopus 로고    scopus 로고
    • Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis
    • Oct 15
    • Stanislaus R, Singh AK, Singh I. Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis. J Neurosci Res. 2001 Oct 15;66(2):155-62.
    • (2001) J Neurosci Res , vol.66 , Issue.2 , pp. 155-162
    • Stanislaus, R.1    Singh, A.K.2    Singh, I.3
  • 68
    • 33847351791 scopus 로고    scopus 로고
    • A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex
    • Mar 1
    • Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood. 2007 Mar 1;109(5):2234-42.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2234-2242
    • Rafei, M.1    Wu, J.H.2    Annabi, B.3    Lejeune, L.4    Francois, M.5    Galipeau, J.6
  • 69
    • 0036636094 scopus 로고    scopus 로고
    • Apoptosis as a therapeutic tool in rheumatoid arthritis
    • Jul
    • Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol. 2002 Jul;2(7):527-35.
    • (2002) Nat Rev Immunol , vol.2 , Issue.7 , pp. 527-535
    • Pope, R.M.1
  • 70
    • 64849099402 scopus 로고    scopus 로고
    • Selective inhibition of CCR2 expressing lymphomyeloid cells in experimental autoimmune encephalomyelitis by a GM-CSF-MCP1 fusokine
    • Mar 1
    • Rafei M, Campeau PM, Wu JH, Birman E, Forner K, Boivin MN, Galipeau J. Selective inhibition of CCR2 expressing lymphomyeloid cells in experimental autoimmune encephalomyelitis by a GM-CSF-MCP1 fusokine. J Immunol. 2009 Mar 1;182(5):2620-7.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 2620-2627
    • Rafei, M.1    Campeau, P.M.2    Wu, J.H.3    Birman, E.4    Forner, K.5    Boivin, M.N.6    Galipeau, J.7
  • 71
    • 4644228075 scopus 로고    scopus 로고
    • Human-compatible collagen matrix for prolonged and reversible systemic delivery of erythropoietin in mice from gene-modified marrow stromal cells
    • Oct
    • Eliopoulos N, Lejeune L, Martineau D, Galipeau J. Human-compatible collagen matrix for prolonged and reversible systemic delivery of erythropoietin in mice from gene-modified marrow stromal cells. Mol Ther. 2004 Oct;10(4):741-8.
    • (2004) Mol Ther , vol.10 , Issue.4 , pp. 741-748
    • Eliopoulos, N.1    Lejeune, L.2    Martineau, D.3    Galipeau, J.4
  • 74
    • 0038131975 scopus 로고    scopus 로고
    • Therapeutic strategies for rheumatoid arthritis
    • Jun
    • Smolen JS, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003 Jun;2(6):473-88.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.6 , pp. 473-488
    • Smolen, J.S.1    Steiner, G.2
  • 75
    • 0033696206 scopus 로고    scopus 로고
    • The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis
    • Sep
    • Rodenburg RJ, Ganga A, van Lent PL, van de Putte LB, van Venrooij WJ. The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis. Arthritis Rheum. 2000 Sep;43(9):1941-50.
    • (2000) Arthritis Rheum , vol.43 , Issue.9 , pp. 1941-1950
    • Rodenburg, R.J.1    Ganga, A.2    Van Lent, P.L.3    Van De Putte, L.B.4    Van Venrooij, W.J.5
  • 77
    • 68149160827 scopus 로고    scopus 로고
    • An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis
    • Aug 1
    • Rafei M, Berchiche YA, Birman E, Boivin MN, Young YK, Wu JH, Heveker N, Galipeau J. An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis. J Immunol. 2009 Aug 1;183(3):1759-66.
    • (2009) J Immunol , vol.183 , Issue.3 , pp. 1759-1766
    • Rafei, M.1    Berchiche, Y.A.2    Birman, E.3    Boivin, M.N.4    Young, Y.K.5    Wu, J.H.6    Heveker, N.7    Galipeau, J.8
  • 80
    • 52949104096 scopus 로고    scopus 로고
    • Investigational C-C chemokine receptor 2 antagonists for the treatment of autoimmune diseases
    • Sep
    • Kalinowska A, Losy J. Investigational C-C chemokine receptor 2 antagonists for the treatment of autoimmune diseases. Expert Opin Investig Drugs. 2008 Sep;17(9):1267-79.
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.9 , pp. 1267-1279
    • Kalinowska, A.1    Losy, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.