Molecular and secretory profiles of human mesenchymal stromal cells and their abilities to maintain primitive hematopoietic progenitors

Stem Cells

Volumn 25, Issue 10, 2007, Pages 2638-2647

  Wagner, Wolfgang ^a   Roderburg, Christoph ^a   Wein, Frederik ^a   Diehlmann, Anke ^a   Frankhauser, Maria ^b   Schubert, Ralf ^c   Eckstein, Volker ^a   Ho, Anthony D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Cytonet GmbH   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Adhesion; Feeder layer; Hematopoietic progenitor cells; Mesenchymal stromal cells; Molecular profile; Secretory profile

Indexed keywords

CADHERIN; CADHERIN 11; CD38 ANTIGEN; CYTOKINE ANTIBODY; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE L1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADIPOSE TISSUE; ARTICLE; BONE MARROW CELL; CD34 SELECTION; CELL ADHESION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MESENCHYME CELL; PROTEIN EXPRESSION; STEM CELL; STROMA CELL; UMBILICAL CORD BLOOD;

ADIPOSE TISSUE; ANTIGENS, CD34; ANTIGENS, CD38; CELL ADHESION; CELL ADHESION MOLECULES; CELL COMMUNICATION; CELL CULTURE TECHNIQUES; CELL SEPARATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; FETAL BLOOD; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INTERCELLULAR JUNCTIONS; MESODERM; ORGAN SPECIFICITY; STROMAL CELLS;

EID: 35348826635     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0280     Document Type: Article

References (51)

1. Zhang J, Niu C, Ye L et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-841.
2. Wilson A, Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 2006;6:93-106.
3. Forsberg EC, Prohaska SS, Katzman S et al. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet 2005;1:e28.
4. Punzel M, Liu D, Zhang T et al. The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment. Exp Hematol 2003;31:339-347.
5. Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977;91:335-344.
6. Kadereit S, Deeds LS, Haynesworth SE et al. Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(-) early progenitors cultured over human MSCs as a feeder layer. STEM CELLS 2002;20:573-582.
7. Yamaguchi M, Hirayama F, Murahashi H et al. Ex vivo expansion of human UC blood primitive hematopoietic progenitors and transplantable stem cells using human primary BM stromal cells and human AB serum. Cytotherapy 2002;4:109 -118.
8. Horwitz EM, Le BK, Dominici M et al. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 2005;7:393-395.
9. Wineman J, Moore K, Lemischka I et al. Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain longterm repopulating stem cells. Blood 1996;87:4082-4090.
10. Gan OI, Murdoch B, Larochelle A et al. Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells. Blood 1997;90:641-650.
11. Jang YK, Jung DH, Jung MH et al. Mesenchymal stem cells feeder layer from human umbilical cord blood for ex vivo expanded growth and proliferation of hematopoietic progenitor cells. Ann Hematol 2006;85:212-225.
12. Robinson SN, Ng J, Niu T et al. Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant 2006;37:359-366.
13. Freund D, Bauer N, Boxberger S et al. Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: Effects on proliferation and clonogenicity. Stem Cells Dev 2006;15:815-829.
14. Goncalves R, Lobato da SC, Cabral JM et al. A Stro-1(+) human universal stromal feeder layer to expand/maintain human bone marrow hematopoietic stem/progenitor cells in a serum-free culture system. Exp Hematol 2006;34:1353-1359.
15. Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 1966;16:381-390.
16. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
17. Zuk PA, Zhu M, Mizuno H et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001;7:211-228.
18. Bieback K, Kern S, Kluter H et al. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. STEM CELLS 2004;22:625-634.
19. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000;109:235-242.
20. Goodwin HS, Bicknese AR, Chien SN et al. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 2001;7:581-588.
21. Kogler G, Sensken S, Airey JA et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004;200:123-135.
22. Wagner W, Wein F, Seckinger A et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005;33:1402-1416.
23. Wagner W, Feldmann RE, Jr., Seckinger A et al. The heterogeneity of human mesenchymal stem cell preparations - Evidence from simultaneous analysis of proteomes and transcriptomes. Exp Hematol 2006;34:536-548.
24. Kern S, Eichler H, Stoeve J et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. STEM CELLS 2006;24:1294-1301.
25. Reyes M, Lund T, Lenvik T et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001;98:2615-2625.
26. Hou L, Cao H, Wang D et al. Induction of umbilical cord blood mesenchymal stem cells into neuron-like cells in vitro. Int J Hematol 2003;78:256-261.
27. Thiemann FT, Moore KA, Smogorzewska EM et al. The murine stromal cell line AFT024 acts specifically on human CD34+CD38- progenitors to maintain primitive function and immunophenotype in vitro. Exp Hematol 1998;26:612-619.
28. Wagner W, Wein F, Roderburg C et al. Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction. Exp Hematol 2007;35:314-325.
29. Sutherland HJ, Eaves CJ, Eaves AC et al. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 1989;74:1563-1570.
30. Punzel M, Gupta P, Roodell M et al. Factor(s) secreted by AFT024 fetal liver cells following stimulation with human cytokines are important for human LTC-IC growth. Leukemia 1999;13:1079-1084.
31. Wagner W, Ansorge A, Wirkner U et al. Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood 2004;104:675-686.
32. Faber A, Roderburg C, Wein F et al. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J Biomed Biotechnol 2007;2007:26065.
33. Gottschling S, Saffrich R, Seckinger A et al. Human mesenchymal stroma cells regulate initial self-renewing divisions of hematopoietic progenitor cells by a beta1-integrin-dependent mechanism. STEM CELLS 2007;25:798-806.
34. Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69-80.
35. Gronthos S, Franklin DM, Leddy HA et al. Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 2001;189:54-63.
36. Aust L, Devlin B, Foster SJ et al. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy 2004;6:7-14.
37. Tocci A, Forte L. Mesenchymal stem cell: Use and perspectives. Hematol J 2003;4:92-96.
38. Zuk PA, Zhu M, Ashjian P et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295.
39. Jiang Y, Vaessen B, Lenvik T et al. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 2002;30:896-904.
40. Lee RH, Kim B, Choi I et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 2004;14:311-324.
41. Corre J, Barreau C, Cousin B et al. Human subcutaneous adipose cells support complete differentiation but not self-renewal of hematopoietic progenitors. J Cell Physiol 2006;208:282-288.
42. Ho AD. Kinetics and symmetry of divisions of hematopoietic stem cells. Exp Hematol 2005;33:1-8.
43. Hackney JA, Charbord P, Brunk BP et al. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A 2002;99:13061-13066.
44. Oostendorp RA, Robin C, Steinhoff C et al. Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures. STEM CELLS 2005;23:842-851.
45. Weisel KC, Gao Y, Shieh JH et al. Stromal cell lines from the aortagonado-mesonephros region are potent supporters of murine and human hematopoiesis. Exp Hematol 2006;34:1505-1516.
46. Charbord P, Moore K. Gene expression in stem cell-supporting stromal cell lines. Ann N Y Acad Sci 2005;1044:159-167.
47. Kogler G, Radke TF, Lefort A et al. Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells. Exp Hematol 2005;33:573-583.
48. Taguchi T, Takenouchi H, Matsui J et al. Involvement of insulin-like growth factor-I and insulin-like growth factor binding proteins in pro-B-cell development. Exp Hematol 2006;34:508-518.
49. Foll JL, Dannecker L, Zehrer C et al. Activation-dependent expression of the insulin-like growth factor binding protein-2 in human lymphocytes. Immunology 1998;94:173-180.
50. Liu LQ, Sposato M, Liu HY et al. Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its novel role in promoting proliferation of primitive CD34+CD38- hematopoietic cells in vitro. Oncol Res 2003;13:359-371.
51. Wilson HM, Lesnikov V, Plymate SR et al. High IGFBP-3 levels in marrow plasma in early-stage MDS: Effects on apoptosis and hemopoiesis. Leukemia 2005;19:580-585.