Intrakines - Evidence for a Trans-Cellular Mechanism of Action

Molecular Therapy

Volumn 1, Issue 2, 2000, Pages 165-170

  Engel, Barbara C ^a   Bauer, Gerhard ^a   Pepper, Karen A ^a   Bockstoce, David C ^a   Yu, Xiao Jin ^a   Chen, Si Yi ^b   Kohn, Donald B ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

CXCR4; Gene therapy; HIV; Intrakines

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; GREEN FLUORESCENT PROTEIN; PHOTOPROTEIN; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CELL LINE; CHEMOTAXIS; DOSE RESPONSE; DOWN REGULATION; FLOW CYTOMETRY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HUMAN; LEUKEMIA CELL LINE; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; RETROVIRUS; SOUTHERN BLOTTING; T LYMPHOCYTE; TRANSACTIVATION;

BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CELL LINE; CHEMOKINES; CHEMOKINES, CXC; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLOW CYTOMETRY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; JURKAT CELLS; LUMINESCENT PROTEINS; RECEPTORS, CXCR4; RETROVIRIDAE; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSDUCTION, GENETIC;

EID: 0034137837     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0026     Document Type: Article

References (26)

1. Finzi D., Blankson J., Siliciano J. D., Margolick J. B., Chadwick K., Pierson T., Smith K., Lisziewicz J., Lori F., Flexner C., Quinn T. C., Chaisson R. E., Rosenberg E., Walker B., Gange S., Gallant J., Siliciano R. F. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat. Med. 5:1999;512-517.
2. Zhang L., Ramratnam B., Tenner-Racz K., He Y., Vesanen M., Lewin S., Talal A., Racz P., Perelson A. S., Korber B. T., Markowitz M., Ho D. D. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. New Engl. J. Med. 340:1999;1605-1613.
3. Saag M. S., Kilby J. M. HIV-1 and HAART: A time to cure, a time to kill. Nat. Med. 5:1999;609-611.
4. Michael N. L., Moore J. P. HIV-entry inhibitors: Evading the issue. Nat. Med. 5:1999;740-741.
5. Deng H. K., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R. E., Hill C. M., Davis C. B., Peiper S. C., Schall T. J., Littman D. R., Landau N. R. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 381:1996;661-667.
6. Dragic T., Litwin V., Allaway G. P., Martin S. R., Huang Y., Nagashima K. A., Cayanan C., Maddon P. J., Koup R. A., Moore J. P., Paxton W. A. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 381:1996;667-673.
7. Feng Y., Broder C. C., Kennedy P. E., Berger E. A. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 272:1996;872-877.
8. Cairns J. S., D'Souza M. P. Chemokines and HIV-1 second receptors: The therapeutic connection. Nat. Med. 4:1998;563-568.
9. Cocchi F., DeVico A. L., Garzino-Demo A., Arya S. K., Gallo R. C., Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 270:1995;1811-1815.
10. Bleul C. C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., Springer T. A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 382:1996;829-833.
11. Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J. L., Arenzana-Seisdedos F., Schwartz O., Heard J. M., Clark-Lewis I., Legler D. F., Loetscher M., Baggiolini M., Moser B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature. 382:1996;833-835.
12. Murakami T., Zhang T. Y., Koyanagi Y., Tanaka Y., Kim J., Suzuki Y., Minoguchi S., Tamamura H., Waki M., Matsumoto A., Fujii N., Shida H., Hoxie J. A., Peiper S. C., Yamamoto N. Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection. J. Virol. 73:1999;7489-7496.
13. Doranz B. J., Grovit-Ferbas K., Sharron M. P., Mao S. H., Goetz M. B., Daar E. S., Doms R. W., O'Brien W. A. A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J. Exp. Med. 186:1997;1395-1400.
14. Schols D., Struyf S., Van Damme J., Este J. A., Henson G., De Clercq E. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J. Exp. Med. 186:1997;1383-1388.
15. Chen J. D., Bai X., Yang A. G., Cong Y., Chen S. Y. Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy. Nature Med. 3:1997;1110-1116.
16. Robbins P. B., Yu X. J., Skelton D. M., Pepper K. A., Wasserman R. M., Zhu L., Kohn D. B. Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells. J. Virol. 71:1997;9466-9474.
17. Challita P.-M., Skelton D. M., el-Khoueiry A., Yu X. J., Weinberg K., Kohn D. B. Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J. Virol. 69:1995;748-755.
18. Markowitz D., Goff S., Bank A. A safe packaging line for gene transfer: Separating viral genes on two different plasmids. J. Virol. 62:1988;1120-1124.
19. Miller A. D., Garcia J. V., von Suhr N., Lynch C. M., Wilson C., Eiden M. V. Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J. Virol. 65:1991;2220-2224.
20. - human hematopoietic cells by HIV-1-based lentiviral vectors. Proc. Natl. Acad. Sci. USA. 96:1999;2988-2993.
21. Lewis M. J., Pelham H. R. B. Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Cell. 68:1992;353-364.
22. Bu G., Rennke S., Geuze H. J. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). J. Cell Sci. 110:1997;65-73.
23. Llewellyn D. H., Roderick H. L., Rose S. KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells. Biochem. Biophys. Res. Commun. 240:1997;36-40.
24. Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H., Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 382:1996;635-638.
25. Ma Q., Jones D., Borghesani P. R., Segal R. A., Nagasawa T., Kishimoto T., Bronson R. T., Springer T. A. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Natl. Acad. Sci. USA. 95:1998;9448-9453.
26. Peled A., Petit I., Kollet O., Magid M., Ponomaryov T., Byk T., Nagler A., Ben-Hur H., Many A., Shultz L., Lider O., Alon R., Zipori D., Lapidot T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 283:1999;845-848.