메뉴 건너뛰기




Volumn 370, Issue 9602, 2007, Pages 1861-1874

New therapies for treatment of rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; ATLIZUMAB; BISPHOSPHONIC ACID DERIVATIVE; CERTOLIZUMAB PEGOL; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; NATALIZUMAB; PREDNISONE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; UNCLASSIFIED DRUG;

EID: 35648988128     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(07)60784-3     Document Type: Review
Times cited : (837)

References (155)
  • 1
    • 0035012803 scopus 로고    scopus 로고
    • The epidemiology of rheumatoid arthritis
    • Gabriel S. The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27 (2001) 269-281
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 269-281
    • Gabriel, S.1
  • 2
    • 0037029418 scopus 로고    scopus 로고
    • Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study
    • Choi H., Hernan M., Seeger J., Robins J., and Wolfe F. Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet 359 (2002) 1173-1177
    • (2002) Lancet , vol.359 , pp. 1173-1177
    • Choi, H.1    Hernan, M.2    Seeger, J.3    Robins, J.4    Wolfe, F.5
  • 3
    • 0028105830 scopus 로고
    • Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count measures
    • Pincus T., Brooks R., and Callahan L. Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count measures. Ann Intern Med 120 (1994) 26-34
    • (1994) Ann Intern Med , vol.120 , pp. 26-34
    • Pincus, T.1    Brooks, R.2    Callahan, L.3
  • 4
    • 0023500817 scopus 로고
    • The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen P., Silver J., and Winchester R. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30 (1987) 1205-1213
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.1    Silver, J.2    Winchester, R.3
  • 5
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller D., Jenkins M., and Schwartz R. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7 (1989) 445-480
    • (1989) Annu Rev Immunol , vol.7 , pp. 445-480
    • Mueller, D.1    Jenkins, M.2    Schwartz, R.3
  • 6
    • 0036170440 scopus 로고    scopus 로고
    • Activation and inhibition of lymphocytes by costimulation
    • Frauwirth K., and Thompson C. Activation and inhibition of lymphocytes by costimulation. J Clin Invest 109 (2002) 295-299
    • (2002) J Clin Invest , vol.109 , pp. 295-299
    • Frauwirth, K.1    Thompson, C.2
  • 7
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein M., Evans J., Singh A., et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200 (2004) 277-285
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.1    Evans, J.2    Singh, A.3
  • 8
    • 4444355794 scopus 로고    scopus 로고
    • Regulatory/suppressor T cells in health and disease
    • Shevach E. Regulatory/suppressor T cells in health and disease. Arthritis Rheum 50 (2004) 2721-2724
    • (2004) Arthritis Rheum , vol.50 , pp. 2721-2724
    • Shevach, E.1
  • 9
    • 33746369415 scopus 로고    scopus 로고
    • Regulatory T-cell physiology and application to treat autoimmunity
    • Tang Q., and Bluestone J. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev 212 (2006) 217-237
    • (2006) Immunol Rev , vol.212 , pp. 217-237
    • Tang, Q.1    Bluestone, J.2
  • 10
    • 0027486150 scopus 로고
    • Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines
    • Bombara M., Webb D., Conrad P., et al. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J Leukoc Biol 54 (1993) 399-406
    • (1993) J Leukoc Biol , vol.54 , pp. 399-406
    • Bombara, M.1    Webb, D.2    Conrad, P.3
  • 11
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong Y., Feige U., Sarosi I., et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402 (1999) 304-309
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.1    Feige, U.2    Sarosi, I.3
  • 12
    • 36548999949 scopus 로고    scopus 로고
    • Autoantibodies in rheumatoid arthritis
    • Firestein G., Panayi G., and Wollheim F. (Eds), Oxford University Press, Oxford
    • Steiner G., and Smolen J. Autoantibodies in rheumatoid arthritis. In: Firestein G., Panayi G., and Wollheim F. (Eds). Rheumatoid arthritis. 2nd edn. (2006), Oxford University Press, Oxford 194-198
    • (2006) Rheumatoid arthritis. 2nd edn. , pp. 194-198
    • Steiner, G.1    Smolen, J.2
  • 13
    • 0023752553 scopus 로고
    • Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes
    • Debets J., Van der Linden C., Dieteren I., Leeuwenberg J., and Buurman W. Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. J Immunol 141 (1988) 1197-1201
    • (1988) J Immunol , vol.141 , pp. 1197-1201
    • Debets, J.1    Van der Linden, C.2    Dieteren, I.3    Leeuwenberg, J.4    Buurman, W.5
  • 14
    • 18844370436 scopus 로고    scopus 로고
    • Diagnostic and prognostic significance of autoantibodies in early rheumatoid arthritis
    • Rantapaa-Dahlqvist S. Diagnostic and prognostic significance of autoantibodies in early rheumatoid arthritis. Scand J Rheumatol 34 (2005) 83-96
    • (2005) Scand J Rheumatol , vol.34 , pp. 83-96
    • Rantapaa-Dahlqvist, S.1
  • 15
    • 27744497998 scopus 로고    scopus 로고
    • Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis
    • Nell V., Machold K., Stamm T., et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis 64 (2005) 1731-1736
    • (2005) Ann Rheum Dis , vol.64 , pp. 1731-1736
    • Nell, V.1    Machold, K.2    Stamm, T.3
  • 16
    • 33646036416 scopus 로고    scopus 로고
    • B cells as antigen presenting cells
    • Rodriguez-Pinto D. B cells as antigen presenting cells. Cell Immunol 238 (2005) 67-75
    • (2005) Cell Immunol , vol.238 , pp. 67-75
    • Rodriguez-Pinto, D.1
  • 18
    • 24944472774 scopus 로고    scopus 로고
    • B cells: a fundamental role in the pathogenesis of rheumatoid arthritis?
    • Panayi G. B cells: a fundamental role in the pathogenesis of rheumatoid arthritis?. Rheumatology (Oxford) 44 suppl 2 (2005) ii3-ii7
    • (2005) Rheumatology (Oxford) , vol.44 , Issue.SUPPL. 2
    • Panayi, G.1
  • 19
    • 0029914194 scopus 로고    scopus 로고
    • Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors?
    • Firestein G. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors?. Arthritis Rheum 39 (1996) 1781-1790
    • (1996) Arthritis Rheum , vol.39 , pp. 1781-1790
    • Firestein, G.1
  • 20
    • 36549036868 scopus 로고    scopus 로고
    • Fibroblasts
    • Smolen J., and Lipsky P. (Eds), Martin Dunitz, London
    • Lee Z., and Firestein G. Fibroblasts. In: Smolen J., and Lipsky P. (Eds). Targeted therapies in rheumatology (2003), Martin Dunitz, London 133-146
    • (2003) Targeted therapies in rheumatology , pp. 133-146
    • Lee, Z.1    Firestein, G.2
  • 21
    • 0043123379 scopus 로고    scopus 로고
    • Osteoclast-independent bone resorption by fibroblast-like cells
    • Pap T., Claus A., Ohtsu S., et al. Osteoclast-independent bone resorption by fibroblast-like cells. Arthritis Res Ther 5 (2003) R163-R173
    • (2003) Arthritis Res Ther , vol.5
    • Pap, T.1    Claus, A.2    Ohtsu, S.3
  • 22
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner U., Kriegsmann J., Franklin B., et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 149 (1996) 1607-1615
    • (1996) Am J Pathol , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1    Kriegsmann, J.2    Franklin, B.3
  • 23
    • 0031894140 scopus 로고    scopus 로고
    • Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis
    • Gravallese E., Harada Y., Wang J., Gorn A., Thornhill T., and Goldring S. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 152 (1998) 943-951
    • (1998) Am J Pathol , vol.152 , pp. 943-951
    • Gravallese, E.1    Harada, Y.2    Wang, J.3    Gorn, A.4    Thornhill, T.5    Goldring, S.6
  • 24
    • 0036853902 scopus 로고    scopus 로고
    • Osteoclasts are essential for TNF-α-mediated joint destruction
    • Redlich K., Hayer S., Ricci R., et al. Osteoclasts are essential for TNF-α-mediated joint destruction. J Clin Invest 110 (2002) 1419-1427
    • (2002) J Clin Invest , vol.110 , pp. 1419-1427
    • Redlich, K.1    Hayer, S.2    Ricci, R.3
  • 25
    • 0025255530 scopus 로고
    • Quantitative analysis of cytokine gene expression in rheumatoid arthritis
    • Firestein G., Alvaro-Gracia J., and Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol 144 (1990) 3347-3353
    • (1990) J Immunol , vol.144 , pp. 3347-3353
    • Firestein, G.1    Alvaro-Gracia, J.2    Maki, R.3
  • 26
    • 0032703306 scopus 로고    scopus 로고
    • Cytokine production by synovial T cells in rheumatoid arthritis
    • Steiner G., Tohidast-Akrad M., Witzmann G., et al. Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford) 38 (1999) 202-213
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 202-213
    • Steiner, G.1    Tohidast-Akrad, M.2    Witzmann, G.3
  • 27
    • 0026091413 scopus 로고
    • Localization of tumor-necrosis factor-alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis
    • Chu C., Field M., Feldmann M., and Maini R. Localization of tumor-necrosis factor-alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 34 (1991) 1125-1132
    • (1991) Arthritis Rheum , vol.34 , pp. 1125-1132
    • Chu, C.1    Field, M.2    Feldmann, M.3    Maini, R.4
  • 30
    • 0032743708 scopus 로고    scopus 로고
    • A proinflammatory role for IL-18 in rheumatoid arthritis
    • Gracie J., Forsey R., Chan W., et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 104 (1999) 1393-1401
    • (1999) J Clin Invest , vol.104 , pp. 1393-1401
    • Gracie, J.1    Forsey, R.2    Chan, W.3
  • 31
    • 0031042456 scopus 로고    scopus 로고
    • Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
    • McInnes I., Leung B., Sturrock R., Field M., and Liew F. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat Med 3 (1997) 189-195
    • (1997) Nat Med , vol.3 , pp. 189-195
    • McInnes, I.1    Leung, B.2    Sturrock, R.3    Field, M.4    Liew, F.5
  • 32
    • 25444508411 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis: targeting cytokines
    • Zwerina J., Redlich K., Schett G., and Smolen J. Pathogenesis of rheumatoid arthritis: targeting cytokines. Ann N Y Acad Sci 1051 (2005) 716-729
    • (2005) Ann N Y Acad Sci , vol.1051 , pp. 716-729
    • Zwerina, J.1    Redlich, K.2    Schett, G.3    Smolen, J.4
  • 33
    • 0242293743 scopus 로고    scopus 로고
    • Chemokines
    • Smolen J., and Lipsky P. (Eds), Martin Dunitz, London
    • Szekanecz Z., Kim J., and Koch A. Chemokines. In: Smolen J., and Lipsky P. (Eds). Targeted therapies in rheumatology (2003), Martin Dunitz, London 345-357
    • (2003) Targeted therapies in rheumatology , pp. 345-357
    • Szekanecz, Z.1    Kim, J.2    Koch, A.3
  • 34
    • 18844382644 scopus 로고    scopus 로고
    • Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis
    • Haringman J., Oostendorp R., and Tak P. Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis. Expert Opin Emerg Drugs 10 (2005) 299-310
    • (2005) Expert Opin Emerg Drugs , vol.10 , pp. 299-310
    • Haringman, J.1    Oostendorp, R.2    Tak, P.3
  • 35
    • 0038131975 scopus 로고    scopus 로고
    • Therapeutic strategies for rheumatoid arthritis
    • Smolen J., and Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2 (2003) 473-488
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 473-488
    • Smolen, J.1    Steiner, G.2
  • 36
    • 0036780681 scopus 로고    scopus 로고
    • Toll-like receptors as potential therapeutic targets for multiple diseases
    • Zuany-Amorim C., Hastewell J., and Walker C. Toll-like receptors as potential therapeutic targets for multiple diseases. Nat Rev Drug Discov 1 (2002) 797-807
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 797-807
    • Zuany-Amorim, C.1    Hastewell, J.2    Walker, C.3
  • 37
    • 0027471714 scopus 로고
    • Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patients and trial profiles
    • Goldsmith C., Boers M., Bombardier C., and Tugwell P. Criteria for clinically important changes in outcomes: development, scoring and evaluation of rheumatoid arthritis patients and trial profiles. J Rheumatol 20 (1993) 561-565
    • (1993) J Rheumatol , vol.20 , pp. 561-565
    • Goldsmith, C.1    Boers, M.2    Bombardier, C.3    Tugwell, P.4
  • 39
    • 33344470277 scopus 로고    scopus 로고
    • The definition and measurement of disease modification in inflammatory rheumatic diseases
    • Aletaha D., and Smolen J. The definition and measurement of disease modification in inflammatory rheumatic diseases. Rheum Dis Clin North Am 32 (2006) 9-44
    • (2006) Rheum Dis Clin North Am , vol.32 , pp. 9-44
    • Aletaha, D.1    Smolen, J.2
  • 40
    • 0029044362 scopus 로고
    • American College of Rheumatology: preliminary definition of improvement in rheumatoid arthritis
    • Felson D., Anderson J., Boers M., et al. American College of Rheumatology: preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 38 (1995) 727-735
    • (1995) Arthritis Rheum , vol.38 , pp. 727-735
    • Felson, D.1    Anderson, J.2    Boers, M.3
  • 41
    • 0033019626 scopus 로고    scopus 로고
    • ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials
    • van Gestel A., Anderson J., van Riel P., et al. ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. J Rheumatol 26 (1999) 705-711
    • (1999) J Rheumatol , vol.26 , pp. 705-711
    • van Gestel, A.1    Anderson, J.2    van Riel, P.3
  • 42
    • 0344127554 scopus 로고    scopus 로고
    • A simplified disease activity index for rheumatoid arthritis for use in clinical practice
    • Smolen J., Breedveld F., Schiff M., et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology 42 (2003) 244-257
    • (2003) Rheumatology , vol.42 , pp. 244-257
    • Smolen, J.1    Breedveld, F.2    Schiff, M.3
  • 43
    • 23944478301 scopus 로고    scopus 로고
    • Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score
    • Aletaha D., Nell V., Stamm T., et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther 7 (2005) R796-R806
    • (2005) Arthritis Res Ther , vol.7
    • Aletaha, D.1    Nell, V.2    Stamm, T.3
  • 44
    • 25444481274 scopus 로고    scopus 로고
    • Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states
    • Aletaha D., Ward M., Machold K., Nell V., Stamm T., and Smolen J. Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states. Arthritis Rheum 52 (2005) 2625-2636
    • (2005) Arthritis Rheum , vol.52 , pp. 2625-2636
    • Aletaha, D.1    Ward, M.2    Machold, K.3    Nell, V.4    Stamm, T.5    Smolen, J.6
  • 45
    • 27744532112 scopus 로고    scopus 로고
    • Is DAS28 an appropriate tool to assess remission in rheumatoid arthritis?
    • Makinen H., Kautiainen H., Hannonen P., and Sokka T. Is DAS28 an appropriate tool to assess remission in rheumatoid arthritis?. Ann Rheum Dis 64 (2005) 1410-1413
    • (2005) Ann Rheum Dis , vol.64 , pp. 1410-1413
    • Makinen, H.1    Kautiainen, H.2    Hannonen, P.3    Sokka, T.4
  • 46
    • 27444447706 scopus 로고    scopus 로고
    • Comparison of different definitions to classify remission and sustained remission: 1 year TEMPO results
    • van der Heijde D., Klareskog L., Boers M., et al. Comparison of different definitions to classify remission and sustained remission: 1 year TEMPO results. Ann Rheum Dis 64 (2005) 1582-1587
    • (2005) Ann Rheum Dis , vol.64 , pp. 1582-1587
    • van der Heijde, D.1    Klareskog, L.2    Boers, M.3
  • 48
    • 33750699312 scopus 로고    scopus 로고
    • What should be our treatment goal in rheumatoid arthritis today?
    • Smolen J., and Aletaha D. What should be our treatment goal in rheumatoid arthritis today?. Clin Exp Rheumatol 24 6 suppl 43 (2006) S007-S013
    • (2006) Clin Exp Rheumatol , vol.24 , Issue.6 SUPPL. 43
    • Smolen, J.1    Aletaha, D.2
  • 49
    • 0015151774 scopus 로고
    • Methods of scoring the progression of radiologic changes in rheumatoid arthritis: correlation of radiologic, clinical and laboratory abnormalities
    • Sharp J., Lidsky M., Collins L., and Moreland J. Methods of scoring the progression of radiologic changes in rheumatoid arthritis: correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum 14 (1971) 706-720
    • (1971) Arthritis Rheum , vol.14 , pp. 706-720
    • Sharp, J.1    Lidsky, M.2    Collins, L.3    Moreland, J.4
  • 50
    • 0022397174 scopus 로고
    • How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?
    • Sharp J., Young D., Bluhm G., et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis?. Arthritis Rheum 28 (1985) 1326-1335
    • (1985) Arthritis Rheum , vol.28 , pp. 1326-1335
    • Sharp, J.1    Young, D.2    Bluhm, G.3
  • 51
    • 0021078901 scopus 로고
    • Methods of assessing radiographic change in rheumatoid arthritis
    • Genant H. Methods of assessing radiographic change in rheumatoid arthritis. Am J Med 75 (1983) 35-47
    • (1983) Am J Med , vol.75 , pp. 35-47
    • Genant, H.1
  • 52
    • 0024604643 scopus 로고
    • Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis
    • van der Heijde D., van Riel P., Nuver-Zwart I., Gribnau F., and van de Putte L. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet 1 (1989) 1036-1038
    • (1989) Lancet , vol.1 , pp. 1036-1038
    • van der Heijde, D.1    van Riel, P.2    Nuver-Zwart, I.3    Gribnau, F.4    van de Putte, L.5
  • 53
    • 0037236618 scopus 로고    scopus 로고
    • Radiographic data from recent randomized controlled trials in rheumatoid arthritis: what have we learned?
    • Strand V., and Sharp J. Radiographic data from recent randomized controlled trials in rheumatoid arthritis: what have we learned?. Arthritis Rheum 48 (2003) 21-34
    • (2003) Arthritis Rheum , vol.48 , pp. 21-34
    • Strand, V.1    Sharp, J.2
  • 54
    • 33749319744 scopus 로고    scopus 로고
    • Measuring function in rheumatoid arthritis: identifying reversible and irreversible components
    • Aletaha D., Smolen J., and Ward M. Measuring function in rheumatoid arthritis: identifying reversible and irreversible components. Arthritis Rheum 54 (2006) 2784-2792
    • (2006) Arthritis Rheum , vol.54 , pp. 2784-2792
    • Aletaha, D.1    Smolen, J.2    Ward, M.3
  • 55
    • 1342322755 scopus 로고    scopus 로고
    • Patients with rheumatoid arthritis in clinical care
    • Smolen J., and Aletaha D. Patients with rheumatoid arthritis in clinical care. Ann Rheum Dis 63 (2004) 221-225
    • (2004) Ann Rheum Dis , vol.63 , pp. 221-225
    • Smolen, J.1    Aletaha, D.2
  • 57
    • 0026877917 scopus 로고
    • The MOS 36-item short-form health survey (SF-36): I-conceptual framework and item selection
    • Ware Jr. J., and Sherbourne C. The MOS 36-item short-form health survey (SF-36): I-conceptual framework and item selection. Med Care 30 (1992) 473-483
    • (1992) Med Care , vol.30 , pp. 473-483
    • Ware Jr., J.1    Sherbourne, C.2
  • 58
    • 0142124934 scopus 로고    scopus 로고
    • Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis
    • Pincus T., Yazici Y., Sokka T., Aletaha D., and Smolen J. Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol 21 5 suppl 31 (2003) S179-S185
    • (2003) Clin Exp Rheumatol , vol.21 , Issue.5 SUPPL. 31
    • Pincus, T.1    Yazici, Y.2    Sokka, T.3    Aletaha, D.4    Smolen, J.5
  • 59
    • 0142218522 scopus 로고    scopus 로고
    • Rheumatoid arthritis in 2003: where are we now with treatment?
    • Weinblatt M. Rheumatoid arthritis in 2003: where are we now with treatment?. Ann Rheum Dis 62 suppl 2 (2003) ii94-ii96
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL. 2
    • Weinblatt, M.1
  • 60
    • 84960582159 scopus 로고
    • Efficacy of methotrexate in rheumatoid arthritis
    • Weinblatt M. Efficacy of methotrexate in rheumatoid arthritis. Br J Rheumatol 34 suppl 2 (1995) 43-48
    • (1995) Br J Rheumatol , vol.34 , Issue.SUPPL. 2 , pp. 43-48
    • Weinblatt, M.1
  • 61
    • 0036021133 scopus 로고    scopus 로고
    • Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis: an observational study
    • Aletaha D., and Smolen J. Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis: an observational study. J Rheumatol 29 (2002) 1631-1638
    • (2002) J Rheumatol , vol.29 , pp. 1631-1638
    • Aletaha, D.1    Smolen, J.2
  • 62
    • 10744223002 scopus 로고    scopus 로고
    • Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    • Klareskog L., van der Heijde D., de Jager J., et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363 (2004) 675-681
    • (2004) Lancet , vol.363 , pp. 675-681
    • Klareskog, L.1    van der Heijde, D.2    de Jager, J.3
  • 63
    • 8444239359 scopus 로고    scopus 로고
    • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized controlled trial
    • St Clair E., van der Heijde D., Smolen J., et al. Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized controlled trial. Arthritis Rheum 50 (2004) 3432-3443
    • (2004) Arthritis Rheum , vol.50 , pp. 3432-3443
    • St Clair, E.1    van der Heijde, D.2    Smolen, J.3
  • 64
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • Breedveld F., Weisman M., Kavanaugh A., et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 54 (2006) 26-37
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.1    Weisman, M.2    Kavanaugh, A.3
  • 65
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Lipsky P., van der Heijde D., St Clair E., et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 343 (2000) 1594-1602
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.1    van der Heijde, D.2    St Clair, E.3
  • 66
    • 2342658406 scopus 로고    scopus 로고
    • Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial
    • Keystone E., Kavanaugh A., Sharp J., et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum 50 (2004) 1400-1411
    • (2004) Arthritis Rheum , vol.50 , pp. 1400-1411
    • Keystone, E.1    Kavanaugh, A.2    Sharp, J.3
  • 67
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt M., Kremer J., Bankhurst A., et al. A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340 (1999) 253-259
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.1    Kremer, J.2    Bankhurst, A.3
  • 68
    • 36549018273 scopus 로고    scopus 로고
    • The relevance of sub-clinical synovitis in the longitudinal assessment of RA: MRI-detected inflammation predicts structural progression in patients in apparent clinical remission
    • Brown A., Conaghan P., Karim Z., et al. The relevance of sub-clinical synovitis in the longitudinal assessment of RA: MRI-detected inflammation predicts structural progression in patients in apparent clinical remission. Arthritis Rheum 54 suppl (2006) 4034
    • (2006) Arthritis Rheum , vol.54 , Issue.SUPPL , pp. 4034
    • Brown, A.1    Conaghan, P.2    Karim, Z.3
  • 69
    • 34249089498 scopus 로고    scopus 로고
    • One-year results of golimumab compared with placebo in patients with active RA despite treatment with methotrexate: a phase II, randomized, double-blind, placebo-controlled, dose-ranging trial
    • (abstr)
    • Kay J., Matteson E., Dasgubpta B., et al. One-year results of golimumab compared with placebo in patients with active RA despite treatment with methotrexate: a phase II, randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum 54 suppl (2006) S833 (abstr)
    • (2006) Arthritis Rheum , vol.54 , Issue.SUPPL
    • Kay, J.1    Matteson, E.2    Dasgubpta, B.3
  • 70
    • 0036796777 scopus 로고    scopus 로고
    • Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial
    • Choy E., Hazleman B., Smith M., et al. Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology 41 (2002) 1133-1137
    • (2002) Rheumatology , vol.41 , pp. 1133-1137
    • Choy, E.1    Hazleman, B.2    Smith, M.3
  • 71
    • 34447300492 scopus 로고    scopus 로고
    • Study of Active Controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of Tocilizumab
    • published online May 7. DOI:10.1136/ard.2006.068064
    • Nishimoto N., Hashimoto J., Miyasaka N., et al. Study of Active Controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of Tocilizumab. Ann Rheum Dis (2007). published online May 7. DOI:10.1136/ard.2006.068064
    • (2007) Ann Rheum Dis
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3
  • 72
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a mulitcenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen S., Emery P., Greenwald M., et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a mulitcenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 54 (2006) 2793-2806
    • (2006) Arthritis Rheum , vol.54 , pp. 2793-2806
    • Cohen, S.1    Emery, P.2    Greenwald, M.3
  • 73
    • 33745291091 scopus 로고    scopus 로고
    • Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial
    • Kremer J., Genant H., Moreland L., et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med 144 (2006) 865-876
    • (2006) Ann Intern Med , vol.144 , pp. 865-876
    • Kremer, J.1    Genant, H.2    Moreland, L.3
  • 74
    • 17244364098 scopus 로고    scopus 로고
    • Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study
    • Smolen J., Han C., Bala M., et al. Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheum 52 (2005) 1020-1030
    • (2005) Arthritis Rheum , vol.52 , pp. 1020-1030
    • Smolen, J.1    Han, C.2    Bala, M.3
  • 75
    • 33644895018 scopus 로고    scopus 로고
    • Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial
    • Smolen J., van der Heijde D., St Clair E., et al. Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial. Arthritis Rheum 54 (2006) 702-710
    • (2006) Arthritis Rheum , vol.54 , pp. 702-710
    • Smolen, J.1    van der Heijde, D.2    St Clair, E.3
  • 76
    • 27744514865 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial
    • Goekoop-Ruiterman Y., de Vries-Bouwstra J., Allaart C., et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 52 (2005) 3381-3390
    • (2005) Arthritis Rheum , vol.52 , pp. 3381-3390
    • Goekoop-Ruiterman, Y.1    de Vries-Bouwstra, J.2    Allaart, C.3
  • 77
    • 0142124926 scopus 로고    scopus 로고
    • A proposed treatment algorithm for rheumatoid arthritis: aggressive therapy, methotrexate, and quantitative measures
    • Smolen J., Sokka T., Pincus T., and Breedveld F. A proposed treatment algorithm for rheumatoid arthritis: aggressive therapy, methotrexate, and quantitative measures. Clin Exp Rheumatol 21 suppl 21 (2003) S209-S210
    • (2003) Clin Exp Rheumatol , vol.21 , Issue.SUPPL. 21
    • Smolen, J.1    Sokka, T.2    Pincus, T.3    Breedveld, F.4
  • 78
    • 3242677099 scopus 로고    scopus 로고
    • Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial
    • Grigor C., Capell H., Stirling A., et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364 (2004) 263-269
    • (2004) Lancet , vol.364 , pp. 263-269
    • Grigor, C.1    Capell, H.2    Stirling, A.3
  • 79
    • 0018949401 scopus 로고
    • Characterization of a human B lymphocyte-specific antigen
    • Stashenko P., Nadler L., Hardy R., and Schlossman S. Characterization of a human B lymphocyte-specific antigen. J Immunol 125 (1980) 1678-1685
    • (1980) J Immunol , vol.125 , pp. 1678-1685
    • Stashenko, P.1    Nadler, L.2    Hardy, R.3    Schlossman, S.4
  • 80
    • 0024410224 scopus 로고
    • Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes: regulation by protein kinase C
    • Valentine M., Meier K., Rossie S., and Clark E. Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes: regulation by protein kinase C. J Biol Chem 264 (1989) 11282-11287
    • (1989) J Biol Chem , vol.264 , pp. 11282-11287
    • Valentine, M.1    Meier, K.2    Rossie, S.3    Clark, E.4
  • 81
    • 0023976470 scopus 로고
    • Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains
    • Einfeld D., Brown J., Valentine M., Clark E., and Ledbetter J. Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains. EMBO J 7 (1988) 711-717
    • (1988) EMBO J , vol.7 , pp. 711-717
    • Einfeld, D.1    Brown, J.2    Valentine, M.3    Clark, E.4    Ledbetter, J.5
  • 82
    • 33745662565 scopus 로고    scopus 로고
    • B cells move to centre stage: novel opportunities for autoimmune disease treatment
    • Browning J. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nat Rev Drug Discov 5 (2006) 564-576
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 564-576
    • Browning, J.1
  • 83
    • 0028057250 scopus 로고
    • Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
    • Reff M., Carner K., Chambers K., et al. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 83 (1994) 435-445
    • (1994) Blood , vol.83 , pp. 435-445
    • Reff, M.1    Carner, K.2    Chambers, K.3
  • 84
    • 0036177919 scopus 로고    scopus 로고
    • Rituximab: mechanism of action and resistance
    • Maloney D., Smith B., and Rose A. Rituximab: mechanism of action and resistance. Semin Oncol 29 suppl 2 (2002) 2-9
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 2 , pp. 2-9
    • Maloney, D.1    Smith, B.2    Rose, A.3
  • 85
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Clynes R., Towers T., Presta L., and Ravetch J. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6 (2000) 443-446
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.1    Towers, T.2    Presta, L.3    Ravetch, J.4
  • 86
    • 0035977173 scopus 로고    scopus 로고
    • Rituximab: mechanisms and applications
    • Johnson P., and Glennie M. Rituximab: mechanisms and applications. Br J Cancer 85 (2001) 1619-1623
    • (2001) Br J Cancer , vol.85 , pp. 1619-1623
    • Johnson, P.1    Glennie, M.2
  • 87
    • 0034959580 scopus 로고    scopus 로고
    • Combination chemotherapy and rituximab
    • Czuczman M. Combination chemotherapy and rituximab. Anticancer Drugs 12 suppl 2 (2001) S15-S19
    • (2001) Anticancer Drugs , vol.12 , Issue.SUPPL. 2
    • Czuczman, M.1
  • 88
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards J., Szczepanski L., Szechinski J., et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350 (2004) 2572-2581
    • (2004) N Engl J Med , vol.350 , pp. 2572-2581
    • Edwards, J.1    Szczepanski, L.2    Szechinski, J.3
  • 89
    • 33646483031 scopus 로고    scopus 로고
    • The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
    • Emery P., Fleischmann R., Filipowicz-Sosnowska A., et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum 54 (2006) 1390-1400
    • (2006) Arthritis Rheum , vol.54 , pp. 1390-1400
    • Emery, P.1    Fleischmann, R.2    Filipowicz-Sosnowska, A.3
  • 90
    • 0035093233 scopus 로고    scopus 로고
    • Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
    • Edwards J., and Cambridge G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 40 (2001) 205-211
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 205-211
    • Edwards, J.1    Cambridge, G.2
  • 91
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer J., Westhovens R., Leon M., et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 349 (2003) 1907-1915
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.1    Westhovens, R.2    Leon, M.3
  • 92
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
    • Genovese M., Becker J., Schiff M., et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N Engl J Med 353 (2005) 1114-1123
    • (2005) N Engl J Med , vol.353 , pp. 1114-1123
    • Genovese, M.1    Becker, J.2    Schiff, M.3
  • 93
    • 33846869910 scopus 로고    scopus 로고
    • Prevention of joint structural damage at 1 year with rituximab in rheumatoid arthritis patients with an inadequate response to one or more TNF inhibitors (REFLEX study)
    • Keystone E., Emery P., Peterfy C., et al. Prevention of joint structural damage at 1 year with rituximab in rheumatoid arthritis patients with an inadequate response to one or more TNF inhibitors (REFLEX study). Ann Rheum Dis 65 suppl II (2006) 58
    • (2006) Ann Rheum Dis , vol.65 , Issue.SUPPL. II , pp. 58
    • Keystone, E.1    Emery, P.2    Peterfy, C.3
  • 94
    • 32444447885 scopus 로고    scopus 로고
    • Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    • Leandro M., Cambridge G., Ehrenstein M., and Edwards J. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum 54 (2006) 613-620
    • (2006) Arthritis Rheum , vol.54 , pp. 613-620
    • Leandro, M.1    Cambridge, G.2    Ehrenstein, M.3    Edwards, J.4
  • 96
    • 0036669785 scopus 로고    scopus 로고
    • The interaction properties of costimulatory molecules revisited
    • Collins A., Brodie D., Gilbert R., et al. The interaction properties of costimulatory molecules revisited. Immunity 17 (2002) 201-210
    • (2002) Immunity , vol.17 , pp. 201-210
    • Collins, A.1    Brodie, D.2    Gilbert, R.3
  • 97
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B., and Bluestone J. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 19 (2001) 225-252
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.2
  • 98
    • 0029849012 scopus 로고    scopus 로고
    • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2
    • Webb L., Walmsley M., and Feldmann M. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur J Immunol 26 (1996) 2320-2328
    • (1996) Eur J Immunol , vol.26 , pp. 2320-2328
    • Webb, L.1    Walmsley, M.2    Feldmann, M.3
  • 99
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion
    • Moreland L., Alten R., Van den Bosch F., et al. Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum 46 (2002) 1470-1479
    • (2002) Arthritis Rheum , vol.46 , pp. 1470-1479
    • Moreland, L.1    Alten, R.2    Van den Bosch, F.3
  • 100
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial
    • Kremer J., Dougados M., Emery P., et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum 52 (2005) 2263-2271
    • (2005) Arthritis Rheum , vol.52 , pp. 2263-2271
    • Kremer, J.1    Dougados, M.2    Emery, P.3
  • 101
    • 33645806121 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis patients with abatacept and methotrexate significantly improved health-related quality of life
    • Emery P., Kosinski M., Li T., et al. Treatment of rheumatoid arthritis patients with abatacept and methotrexate significantly improved health-related quality of life. J Rheumatol 33 (2006) 681-689
    • (2006) J Rheumatol , vol.33 , pp. 681-689
    • Emery, P.1    Kosinski, M.2    Li, T.3
  • 102
    • 36448937307 scopus 로고    scopus 로고
    • The efficacy and safety of abatacept or infliximab in RA patients with an inadequate response to MTX: results from a 1-year double-blind, randomized, placebo-controlled trial
    • (abstr)
    • Schiff M., Keiserman M., Codding C., et al. The efficacy and safety of abatacept or infliximab in RA patients with an inadequate response to MTX: results from a 1-year double-blind, randomized, placebo-controlled trial. Arthritis Rheum 54 suppl (2006) 4117 (abstr)
    • (2006) Arthritis Rheum , vol.54 , Issue.SUPPL , pp. 4117
    • Schiff, M.1    Keiserman, M.2    Codding, C.3
  • 103
    • 33846853779 scopus 로고    scopus 로고
    • Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial
    • Weinblatt M., Schiff M., Goldman A., et al. Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann Rheum Dis 66 (2007) 228-234
    • (2007) Ann Rheum Dis , vol.66 , pp. 228-234
    • Weinblatt, M.1    Schiff, M.2    Goldman, A.3
  • 104
    • 33749365296 scopus 로고    scopus 로고
    • Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: a one-year randomized, placebo-controlled study
    • Weinblatt M., Combe B., Covucci A., Aranda R., Becker J., and Keystone E. Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: a one-year randomized, placebo-controlled study. Arthritis Rheum 54 (2006) 2807-2816
    • (2006) Arthritis Rheum , vol.54 , pp. 2807-2816
    • Weinblatt, M.1    Combe, B.2    Covucci, A.3    Aranda, R.4    Becker, J.5    Keystone, E.6
  • 105
    • 0001419395 scopus 로고    scopus 로고
    • Safety of combination therapy of anakinra with etanercept in patients with rheumatoid arthritis
    • (abstr)
    • Schiff M., Bulpitt K., Weaver A., et al. Safety of combination therapy of anakinra with etanercept in patients with rheumatoid arthritis. Arthritis Rheum 44 suppl (2001) S79 (abstr)
    • (2001) Arthritis Rheum , vol.44 , Issue.SUPPL
    • Schiff, M.1    Bulpitt, K.2    Weaver, A.3
  • 106
    • 0027402917 scopus 로고
    • Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody
    • Wendling D., Racadot E., and Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol 20 (1993) 259-262
    • (1993) J Rheumatol , vol.20 , pp. 259-262
    • Wendling, D.1    Racadot, E.2    Wijdenes, J.3
  • 107
    • 0027199126 scopus 로고
    • IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
    • Murakami M., Hibi M., Nakagawa N., et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260 (1993) 1808-1810
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1    Hibi, M.2    Nakagawa, N.3
  • 108
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S., Sato K., Kim K., et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11 (1996) 88-95
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.3
  • 109
    • 0035090840 scopus 로고    scopus 로고
    • Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
    • Mihara M., Kotoh M., Nishimoto N., et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 98 (2001) 319-326
    • (2001) Clin Immunol , vol.98 , pp. 319-326
    • Mihara, M.1    Kotoh, M.2    Nishimoto, N.3
  • 110
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N., Mihara M., Moriya Y., et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum 41 (1998) 2117-2121
    • (1998) Arthritis Rheum , vol.41 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3
  • 112
    • 27144488346 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    • Nishimoto N., Kanakura Y., Aozasa K., et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106 (2005) 2627-2632
    • (2005) Blood , vol.106 , pp. 2627-2632
    • Nishimoto, N.1    Kanakura, Y.2    Aozasa, K.3
  • 113
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial
    • Choy E., Isenberg D., Garrood T., et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 46 (2002) 3143-3150
    • (2002) Arthritis Rheum , vol.46 , pp. 3143-3150
    • Choy, E.1    Isenberg, D.2    Garrood, T.3
  • 114
    • 0038166958 scopus 로고    scopus 로고
    • Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis: phase I/II clinical study
    • Nishimoto N., Yoshizaki K., Maeda K., et al. Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis: phase I/II clinical study. J Rheumatol 30 (2003) 1426-1435
    • (2003) J Rheumatol , vol.30 , pp. 1426-1435
    • Nishimoto, N.1    Yoshizaki, K.2    Maeda, K.3
  • 115
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial
    • Nishimoto N., Yoshizaki K., Miyasaka N., et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 50 (2004) 1761-1769
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 116
    • 13244261140 scopus 로고    scopus 로고
    • Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis
    • De Rycke L., Verhelst X., Kruithof E., et al. Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis. Ann Rheum Dis 64 (2005) 299-302
    • (2005) Ann Rheum Dis , vol.64 , pp. 299-302
    • De Rycke, L.1    Verhelst, X.2    Kruithof, E.3
  • 117
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini R., Taylor P., Szechinski J., et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54 (2006) 2817-2829
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.1    Taylor, P.2    Szechinski, J.3
  • 118
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • Maini R., Breedveld F., Kalden J., et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 41 (1998) 1552-1563
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.1    Breedveld, F.2    Kalden, J.3
  • 119
    • 36549041138 scopus 로고    scopus 로고
    • Genentech (accessed April 27, 2006)
    • Genentech. Full prescribing information: rituxan (rituximab). http://www.gene.com/gene/products/information/oncology/rituxan/insert.jsp (accessed April 27, 2006)
    • Full prescribing information: rituxan (rituximab)
  • 120
    • 36549023620 scopus 로고    scopus 로고
    • US Food and Drug Administration (accessed April 15, 2007)
    • US Food and Drug Administration. Rituxan (rituximab) label information. http://www.fda.gov/cder/foi/label/2007/103705s5247Lbl.pdf (accessed April 15, 2007)
    • Rituxan (rituximab) label information
  • 121
    • 36549051807 scopus 로고    scopus 로고
    • European Medicines Agency (accessed March 6, 2007)
    • European Medicines Agency. Authorised medicines for human use: mabthera. http://www.emea.eu.int/humandocs/Humans/EPAR/mabthera/mabthera.htm (accessed March 6, 2007)
    • Authorised medicines for human use: mabthera
  • 123
    • 33644910398 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus
    • Itoh K., Kano T., Nagashio C., Mimori A., Kinoshita M., and Sumiya M. Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus. Arthritis Rheum 54 (2006) 1020-1022
    • (2006) Arthritis Rheum , vol.54 , pp. 1020-1022
    • Itoh, K.1    Kano, T.2    Nagashio, C.3    Mimori, A.4    Kinoshita, M.5    Sumiya, M.6
  • 124
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry T., Major E., Ryschkewitsch C., et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 354 (2006) 924-933
    • (2006) N Engl J Med , vol.354 , pp. 924-933
    • Yousry, T.1    Major, E.2    Ryschkewitsch, C.3
  • 125
    • 33750327259 scopus 로고    scopus 로고
    • Natalizumab and progressive multifocal leukoencephalopathy
    • iii2-15
    • Berger J. Natalizumab and progressive multifocal leukoencephalopathy. Ann Rheum Dis 65 suppl 3 (2006) iii2-15
    • (2006) Ann Rheum Dis , vol.65 , Issue.SUPPL. 3
    • Berger, J.1
  • 126
    • 33746942234 scopus 로고    scopus 로고
    • Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis
    • Roll P., Palanichamy A., Kneitz C., Dorner T., and Tony H. Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis. Arthritis Rheum 54 (2006) 2377-2386
    • (2006) Arthritis Rheum , vol.54 , pp. 2377-2386
    • Roll, P.1    Palanichamy, A.2    Kneitz, C.3    Dorner, T.4    Tony, H.5
  • 127
    • 36549034988 scopus 로고    scopus 로고
    • US Food and Drug Administration (accessed April 15, 2007)
    • US Food and Drug Administration. Abatacept label information. http://www.fda.gov/cder/foi/label/2007/125118s0016lbl.pdf (accessed April 15, 2007)
    • Abatacept label information
  • 128
    • 33644892763 scopus 로고    scopus 로고
    • Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
    • Baecklund E., Iliadou A., Askling J., et al. Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54 (2006) 692-701
    • (2006) Arthritis Rheum , vol.54 , pp. 692-701
    • Baecklund, E.1    Iliadou, A.2    Askling, J.3
  • 129
    • 25444519432 scopus 로고    scopus 로고
    • Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study
    • Baslund B., Tvede N., Danneskiold-Samsoe B., et al. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 52 (2005) 2686-2692
    • (2005) Arthritis Rheum , vol.52 , pp. 2686-2692
    • Baslund, B.1    Tvede, N.2    Danneskiold-Samsoe, B.3
  • 130
    • 13444254086 scopus 로고    scopus 로고
    • Interleukin-18: a therapeutic target in rheumatoid arthritis?
    • McInnes I., Liew F., and Gracie J. Interleukin-18: a therapeutic target in rheumatoid arthritis?. Arthritis Res Ther 7 (2005) 38-41
    • (2005) Arthritis Res Ther , vol.7 , pp. 38-41
    • McInnes, I.1    Liew, F.2    Gracie, J.3
  • 131
    • 34247155347 scopus 로고    scopus 로고
    • Emerging cytokine targets in rheumatoid arthritis
    • Asquith D., and McInnes I. Emerging cytokine targets in rheumatoid arthritis. Curr Opin Rheumatol 19 (2007) 246-251
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 246-251
    • Asquith, D.1    McInnes, I.2
  • 132
    • 36549085254 scopus 로고    scopus 로고
    • The biology of human interleukin-32
    • Smolen J., and Lipsky P. (Eds), Martin Dunitz, London (in press)
    • Dinarello C., and Kim S. The biology of human interleukin-32. In: Smolen J., and Lipsky P. (Eds). Contemporary targeted therapies in rheumatology (2007), Martin Dunitz, London (in press)
    • (2007) Contemporary targeted therapies in rheumatology
    • Dinarello, C.1    Kim, S.2
  • 133
    • 33747871712 scopus 로고    scopus 로고
    • Inhibiting toll-like receptors in inflammatory disease
    • Emery P., and Ponchel F. Inhibiting toll-like receptors in inflammatory disease. Lancet 368 (2006) 821-822
    • (2006) Lancet , vol.368 , pp. 821-822
    • Emery, P.1    Ponchel, F.2
  • 134
    • 33747881274 scopus 로고    scopus 로고
    • Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial
    • Vanags D., Williams B., Johnson B., et al. Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial. Lancet 368 (2006) 855-863
    • (2006) Lancet , vol.368 , pp. 855-863
    • Vanags, D.1    Williams, B.2    Johnson, B.3
  • 135
    • 33750333226 scopus 로고    scopus 로고
    • Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis
    • Barksby H., Milner J., Patterson A., et al. Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis. Arthritis Rheum 54 (2006) 3244-3253
    • (2006) Arthritis Rheum , vol.54 , pp. 3244-3253
    • Barksby, H.1    Milner, J.2    Patterson, A.3
  • 136
    • 0036838574 scopus 로고    scopus 로고
    • Treatments no longer in development for rheumatoid arthritis
    • Keystone E. Treatments no longer in development for rheumatoid arthritis. Ann Rheum Dis 61 suppl 2 (2002) ii43-ii45
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2
    • Keystone, E.1
  • 137
  • 138
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M., and Lin A. NF-κB at the crossroads of life and death. Nat Immunol 3 (2002) 221-227
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 139
    • 34249276510 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of 3 dose levels of CP-690,550 versus placebo in the treatment of active rheumatoid arthritis
    • (abstr)
    • Kremer J., Bloom B., Breedveld F., et al. A randomized, double-blind, placebo-controlled trial of 3 dose levels of CP-690,550 versus placebo in the treatment of active rheumatoid arthritis. Arthritis Rheum 54 (2006) 4116 (abstr)
    • (2006) Arthritis Rheum , vol.54 , pp. 4116
    • Kremer, J.1    Bloom, B.2    Breedveld, F.3
  • 140
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial
    • Cohen S., Hurd E., Cush J., et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46 (2002) 614-624
    • (2002) Arthritis Rheum , vol.46 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3
  • 141
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung M., Lewiecki E., Cohen S., et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354 (2006) 821-831
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.1    Lewiecki, E.2    Cohen, S.3
  • 142
    • 34249337867 scopus 로고    scopus 로고
    • RANKL inhibition with denosumab reduces progression of bone erosions in patients with rheumatoid arthritis: month 6 MRI results
    • Cohen S., Valen P., Ritchlin C., et al. RANKL inhibition with denosumab reduces progression of bone erosions in patients with rheumatoid arthritis: month 6 MRI results. Arthritis Rheum 54 (2006) S831
    • (2006) Arthritis Rheum , vol.54
    • Cohen, S.1    Valen, P.2    Ritchlin, C.3
  • 143
    • 0036185343 scopus 로고    scopus 로고
    • Tumor necrosis factor α-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin
    • Redlich K., Hayer S., Maier A., et al. Tumor necrosis factor α-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum 46 (2002) 785-792
    • (2002) Arthritis Rheum , vol.46 , pp. 785-792
    • Redlich, K.1    Hayer, S.2    Maier, A.3
  • 144
    • 33646484359 scopus 로고    scopus 로고
    • Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis
    • Jarrett S., Conaghan P., Sloan V., et al. Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis. Arthritis Rheum 54 (2006) 1410-1414
    • (2006) Arthritis Rheum , vol.54 , pp. 1410-1414
    • Jarrett, S.1    Conaghan, P.2    Sloan, V.3
  • 145
    • 17144405306 scopus 로고    scopus 로고
    • Emerging and potential therapies for osteoporosis
    • Grey A., and Reid I. Emerging and potential therapies for osteoporosis. Expert Opin Investig Drugs 14 (2005) 265-278
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 265-278
    • Grey, A.1    Reid, I.2
  • 146
    • 33846949349 scopus 로고    scopus 로고
    • Dickkopf-1 is a master regulator of joint remodeling
    • Diarra D., Stolina M., Polzer K., et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 13 (2007) 156-163
    • (2007) Nat Med , vol.13 , pp. 156-163
    • Diarra, D.1    Stolina, M.2    Polzer, K.3
  • 147
    • 0242388249 scopus 로고    scopus 로고
    • Angiogenesis
    • Smolen J., and Lipsky P. (Eds), Martin Dunitz, London
    • Folkman J. Angiogenesis. In: Smolen J., and Lipsky P. (Eds). Targeted therapies in rheumatology (2003), Martin Dunitz, London 111-131
    • (2003) Targeted therapies in rheumatology , pp. 111-131
    • Folkman, J.1
  • 148
    • 0028866438 scopus 로고
    • Early rheumatoid arthritis: time to aim for remission?
    • Emery P., and Salmon M. Early rheumatoid arthritis: time to aim for remission?. Ann Rheum Dis 54 (1995) 944-947
    • (1995) Ann Rheum Dis , vol.54 , pp. 944-947
    • Emery, P.1    Salmon, M.2
  • 149
    • 19944431840 scopus 로고    scopus 로고
    • Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial
    • Quinn M., Conaghan P., O'Connor P., et al. Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum 52 (2005) 27-35
    • (2005) Arthritis Rheum , vol.52 , pp. 27-35
    • Quinn, M.1    Conaghan, P.2    O'Connor, P.3
  • 150
    • 33750307231 scopus 로고    scopus 로고
    • Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2005
    • iii2-15
    • Furst D., Breedveld F., Kalden J., et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2005. Ann Rheum Dis 65 suppl 3 (2005) iii2-15
    • (2005) Ann Rheum Dis , vol.65 , Issue.SUPPL. 3
    • Furst, D.1    Breedveld, F.2    Kalden, J.3
  • 151
    • 33846877022 scopus 로고    scopus 로고
    • Consensus statement on the use of rituximab in patients with rheumatoid arthritis
    • Smolen J., Keystone E., Emery P., et al. Consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann Rheum Dis 66 (2007) 143-150
    • (2007) Ann Rheum Dis , vol.66 , pp. 143-150
    • Smolen, J.1    Keystone, E.2    Emery, P.3
  • 152
    • 0345490890 scopus 로고    scopus 로고
    • Treatment with infliximab (Remicade) when etanercept (Enbrel) has failed or vice versa: data from the STURE registry showing that switching tumour necrosis factor α blockers can make sense
    • van Vollenhoven R., Harju A., Brannemark S., and Klareskog L. Treatment with infliximab (Remicade) when etanercept (Enbrel) has failed or vice versa: data from the STURE registry showing that switching tumour necrosis factor α blockers can make sense. Ann Rheum Dis 62 (2003) 1195-1198
    • (2003) Ann Rheum Dis , vol.62 , pp. 1195-1198
    • van Vollenhoven, R.1    Harju, A.2    Brannemark, S.3    Klareskog, L.4
  • 153
    • 12344317731 scopus 로고    scopus 로고
    • C-reactive protein as a predictor of infliximab treatment outcome in patients with rheumatoid arthritis: defining subtypes of nonresponse and subsequent response to etanercept
    • Buch M., Seto Y., Bingham S., et al. C-reactive protein as a predictor of infliximab treatment outcome in patients with rheumatoid arthritis: defining subtypes of nonresponse and subsequent response to etanercept. Arthritis Rheum 52 (2005) 42-48
    • (2005) Arthritis Rheum , vol.52 , pp. 42-48
    • Buch, M.1    Seto, Y.2    Bingham, S.3
  • 154
    • 33745030280 scopus 로고    scopus 로고
    • The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction
    • Geusens P., Landewe R., Garnero P., et al. The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis Rheum 54 (2006) 1772-1777
    • (2006) Arthritis Rheum , vol.54 , pp. 1772-1777
    • Geusens, P.1    Landewe, R.2    Garnero, P.3
  • 155
    • 36549062161 scopus 로고    scopus 로고
    • Aletaha D, Funovits J, Keystone EC, Smolen JS. Disease activity in the early course of treatment predicts response to therapy after one year in rheumatoid arthritis patients. Arthritis Rheum (in press).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.