The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor α expression in macrophages by inducing apoptosis

Arthritis and Rheumatism

Volumn 43, Issue 9, 2000, Pages 1941-1950

  Rodenburg, Richard J T ^a,b   Ganga, Anuradha ^a   Van Lent, Peter L E M ^a   Van De Putte, Leo B A ^a   Van Venrooij, Walther J ^a,c  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b TNO   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CROHN DISEASE; CYTOKINE PRODUCTION; DRUG MECHANISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ADENOSINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CASPASES; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, PERITONEAL; METHOTREXATE; MICE; MICE, INBRED C57BL; SULFASALAZINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033696206     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200009)43:9<1941::AID-ANR4>3.0.CO;2-O     Document Type: Article

References (39)

1. Sulphasalazine: Mechanism of action in rheumatoid arthritis
2. Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
3. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'nucleotidase-mediated conversion of adenine nucleotides
4. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFκB
5. Monoclonal anti-TNFα antibody as a probe of pathogenesis and therapy of rheumatoid disease
6. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
7. Expression of macrophage-derived chemokine (MDC) mRNA in macrophages is enhanced by interleukin-1β, tumor necrosis factor α, and lipopolysaccharide
8. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes
9. Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
10. Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines
11. A functional Sp1 binding site is essential for the activity of the adult liver-specific human insulin-like growth factor II promoter
12. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages
13. Rapid induction of neutrophil apoptosis by sulfasalazine: Implications of reactive oxygen species in the apoptotic process
14. Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine
15. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death
16. Salicylazosulfapyridine (Salazopyrin) effect on endotoxin-induced production of interleukin-1-like factor from human monocytes in vitro
17. Cleavage of lamin A by Mch2 α but not CPP32: Multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
18. Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death
19. Caspases: The executioners of apoptosis
20. Immunosuppressive effects of apoptotic cells
21. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
22. Apoptosis induced by adenosine in human leukemia HL-60 cells
23. Adenosine induces apoptosis by inhibiting mRNA and protein synthesis in chick embryonic sympathetic neurons
24. NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
25. Lipopolysaccharide inhibits TNF-induced apoptosis: Role of nuclear factor-κB activation and reactive oxygen intermediates
26. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
27. Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop
28. Apoptosis promotes a caspase-induced amino-terminal truncation of Ikappa-Bα that functions as a stable inhibitor of NF-κB
29. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
30. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
31. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
32. Distribution studies of salicylazosulfapyridine and its metabolites
33. Absorption, metabolism and excretion of salicylazosulfapyridine in man
34. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis
35. Phagocytic synovial lining cells in experimental arthritis: Down-regulation of synovitis by CL2MDP-liposomes
36. LPS-binding proteins and receptors
37. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
38. NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis