Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats

Journal of Neuroimmunology

Volumn 128, Issue 1-2, 2002, Pages 49-57

  Jee, Youngheun ^a   Yoon, Won Kee ^a   Okura, Yoshio ^a   Tanuma, Naoyuki ^a   Matsumoto, Yoh ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

CCR2; Experimental autoimmune encephalomyelitis; MCP 1; Relapse

Indexed keywords

CHEMOKINE RECEPTOR CCR2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; RELAPSE; REMISSION; SPINAL CORD; T LYMPHOCYTE;

ACUTE DISEASE; ANIMALS; ASTROCYTES; CENTRAL NERVOUS SYSTEM; CHEMOKINE CCL2; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; CHRONIC DISEASE; CYTOKINES; ECTODYSPLASINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOTHELIUM; MACROPHAGES; MEMBRANE PROTEINS; MULTIPLE SCLEROSIS; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CHEMOKINE; RNA, MESSENGER; T-LYMPHOCYTES; UP-REGULATION;

EID: 0036295472     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00147-9     Document Type: Article

References (33)

1. Characterization of binding sites for chemokines MCP-1 and MIP-1α on human brain microvessels
2. Expression of binding sites for beta chemokines on human astrocytes
3. Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat
4. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
5. Flow cytometric analysis of infiltrating cells in the peripheral nerves in experimental allergic neuritis
6. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
7. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages
8. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats
9. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
10. MIP-1α and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation
11. Acute and relapsing experimental encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1α and monocyte chemotactic protein-1
12. MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner
13. Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: Implications for tubulointerstitial injury in chronic glomerulonephritides
14. The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats: Part 1. Immunohistochemical examination of developing lesion of EAE
15. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: An immunohistochemical and in situ hybridization study
16. In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ
17. Contact with T cells modulates monocyte IL10 production. Role of T cell membrane TNF-α
18. Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat
19. Chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation
20. The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2
21. The role of chemokine receptors in primary, effector, and memory immune responses
22. Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions
23. Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue
24. Multiple sclerosis: A two-stage disease
25. Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis
26. Differential effects of TNF-α and IFN-γ in chronic relapsing autoimmune encephalomyelitis
27. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice
28. Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1α or its CCR5 receptor
29. Axonal transection in the lesions of multiple sclerosis
30. α4 Integrin-VCAM-binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
31. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family
32. Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions
33. Long-lasting protective immunity to experimental autoimmune encephalomyelitis following vaccination with naked DNA encoding C-C chemokines