Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol

Journal of the American College of Cardiology

Volumn 52, Issue 8, 2008, Pages 644-651

  Sehnert, Amy J ^a   Daniels, Susan E ^a   Elashoff, Michael ^a   Wingrove, James A ^a   Burrow, Christopher R ^a   Horne, Benjamin ^b   Muhlestein, Joseph B ^b   Donahue, Mark ^c   Liggett, Stephen B ^d   Anderson, Jeffrey L ^b   Kraus, William E ^c  

^a CardioDx Inc   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

blockers; adrenergic receptors; genetics; haplotypes; heart failure

Indexed keywords

ADRENERGIC RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; METOPROLOL;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; SEX DIFFERENCE; SURVIVAL; TREATMENT RESPONSE;

ADRENERGIC BETA-ANTAGONISTS; AGED; CARBAZOLES; DISEASE PROGRESSION; FEMALE; GENOTYPE; HAPLOTYPES; HEART FAILURE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; METOPROLOL; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPANOLAMINES; RECEPTORS, ADRENERGIC; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2;

EID: 48849103604     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.05.022     Document Type: Article

References (33)

1. Rosamond W., Flegal K., Furie K., et al. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117 (2008) e25-e146
2. McMurray J.J., and Pfeffer M.A. Heart failure. Lancet 365 (2005) 1877-1889
3. Morita H., Seidman J., and Seidman C.E. Genetic causes of human heart failure. J Clin Invest 115 (2005) 518-526
4. Donahue M.P., Marchuk D.A., and Rockman H.A. Redefining heart failure: the utility of genomics. J Am Coll Cardiol 48 (2006) 1289-1298
5. Tang W.H., and Francis G.S. The year in heart failure. J Am Coll Cardiol 50 (2007) 2344-2351
6. Liggett S.B. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology 61 (2000) 167-173
7. Small K.M., McGraw D.W., and Liggett S.B. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 43 (2003) 381-411
8. Feldman D.S., Carnes C.A., Abraham W.T., and Bristow M.R. Mechanisms of disease: beta-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure. Nat Clin Pract Cardiovasc Med 2 (2005) 475-483
9. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 353 (1999) 2001-2007
10. Packer M., Fowler M.B., Roecker E.B., et al. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106 (2002) 2194-2199
11. Muthumala A., Drenos F., Elliott P.M., and Humphries S.E. Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis. Eur J Heart Fail 10 (2008) 3-13
12. Shin J., and Johnson J.A. Pharmacogenetics of β-blockers. Pharmacotherapy 27 (2007) 874-887
13. Mason D.A., Moore J.D., Green S.A., and Liggett S.B. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem 274 (1999) 12670-12674
14. de Groote P., Helbecque N., Lamblin N., et al. Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure. Pharmacogenet Genomics 15 (2005) 137-142
15. Kaye D.M., Smirk B., Williams C., Jennings G., Esler M., and Holst D. Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure. Pharmacogenetics 13 (2003) 379-382
16. Liggett S.B., Mialet-Perez J., Thaneemit-Chen S., et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure. Proc Natl Acad Sci U S A 103 (2006) 11288-11293
17. Mialet Perez J., Rathz D.A., Petrashevskaya N.N., et al. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat Med 9 (2003) 1300-1305
18. Terra S.G., Hamilton K.K., Pauly D.F., et al. Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to β-blocker therapy. Pharmacogenet Genomics 15 (2005) 227-234
19. Terra S.G., Pauly D.F., Lee C.R., et al. beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure. Clin Pharmacol Ther 77 (2005) 127-137
20. Morgan T.M., Krumholz H.M., Lifton R.P., and Spertus J.A. Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA 297 (2007) 1551-1561
21. Shin J., Lobmeyer M.T., Gong Y., et al. Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure. Am J Cardiol 99 (2007) 250-255
22. Duke University School of Medicine, Division of Cardiovascular Medicine. Cardiovascular Genetic and Genomic Sciences. http://cardiology.duke.edu/modules/div_cv_rsch_cggs/ Accessed December 2005 to July 2006
23. ClinicalTrials.gov. Database Registry of the Intermountain Heart Collaborative Study. http://www.clinicaltrials.gov/ct2/show/NCT00406185?term=NCT00406185&rank=1 Accessed April 2006 to July 2006
24. The Social Security Death Master File. http://www.ssdmf.com Accessed March 2007
25. Small K.M., Mialet-Perez J., Seman C.A., Theiss C.T., Brown K.M., and Liggett S.B. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: diverse intragenic variability with haplotype-specific functional effects. Proc Natl Acad Sci U S A 101 (2004) 13020-13025
26. Dempster A., Laird N., and Rubin D. Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc B 39 (1977) 1-38
27. Team RDC. R: A Language and Environment for Statistical Computing (2007), R Foundation for Statistical Computing, Vienna, Austria
28. Levy W.C., Mozaffarian D., Linker D.T., et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation 113 (2006) 1424-1433
29. de Groote P., Lamblin N., Helbecque N., et al. The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure. Eur J Heart Fail 7 (2005) 966-973
30. White H.L., de Boer R.A., Maqbool A., et al. An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. Eur J Heart Fail 5 (2003) 463-468
31. Tang W.H., Tong W., Jain A., Francis G.S., Harris C.M., and Young J.B. Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J Am Coll Cardiol 51 (2008) 569-576
32. Hawkins G.A., Tantisira K., Meyers D.A., et al. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med 174 (2006) 1101-1109
33. Small K.M., Mialet-Perez J., and Liggett S.B. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. J Cardiovasc Pharmacol 51 (2008) 106-110