Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia

Best Practice and Research: Clinical Haematology

Volumn 23, Issue 3, 2010, Pages 307-318

  Meijerink, Jules P P ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Chromosomal rearrangements; Immunophenotype; Mutations; NOTCH1; T cell acute lymphoblastic leukaemia; TAL1

Indexed keywords

PROTEIN MYB; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETP; TRANSCRIPTION FACTOR HOXA; TRANSCRIPTION FACTOR TAL; TRANSCRIPTION FACTOR TLX1; TRANSCRIPTION FACTOR TLX3; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; IMMUNOPHENOTYPING; PRIORITY JOURNAL; REVIEW; T CELL LEUKEMIA;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; GENE REARRANGEMENT; HUMANS; IMMUNOPHENOTYPING; MUTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 78649516513     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2010.08.002     Document Type: Review

References (116)

1. J.P. Meijerink, M.L. den Boer, and R. Pieters New genetic abnormalities and treatment response in acute lymphoblastic leukemia Semin Hematol 46 1 2009 16 23
2. P. Van Vlierberghe, R. Pieters, and H.B. Beverloo Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia Br J Haematol 143 2 2008 153 168
3. A.A. Ferrando, D.S. Neuberg, and J. Staunton Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia Canc Cell 1 1 2002 75 87
4. J. Soulier, E. Clappier, and J.M. Cayuela HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL) Blood 106 1 2005 274 286
5. P. Van Vlierberghe, M. van Grotel, and J. Tchinda The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia Blood 111 9 2008 4668 4680
6. V. Asnafi, K. Beldjord, and M. Libura Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy Blood 104 13 2004 4173 4180
7. R. Berger, N. Dastugue, and M. Busson t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH) Leukemia 17 9 2003 1851 1857
8. O.A. Bernard, M. Busson-LeConiat, and P. Ballerini A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia Leukemia 15 10 2001 1495 1504 (Pubitemid 32994666)
9. H. Cave, S. Suciu, and C. Preudhomme Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951 Blood 103 2 2004 442 450
10. T.E. Hansen-Hagge, M. Schafer, and H. Kiyoi Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11) Leukemia 16 11 2002 2205 2212
11. X.Y. Su, M. Busson, and V. Della Valle Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia Gene Chromosome Canc 41 3 2004 243 249
12. M. van Grotel, J.P. Meijerink, and H.B. Beverloo The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols Haematologica 91 9 2006 1212 1221
13. P.D. Aplan, S.C. Raimondi, and I.R. Kirsch Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia J Exp Med 176 5 1992 1303 1310
14. R.O. Bash, W.M. Crist, and J.J. Shuster Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study Blood 81 8 1993 2110 2117
15. T.M. Breit, E.J. Mol, and I.L. Wolvers-Tettero Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes J Exp Med 177 4 1993 965 977
16. E. Carlotti, F. Pettenella, and R. Amaru Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell acute lymphoblastic leukaemia Br J Haematol 118 4 2002 1011 1018
17. M. van Grotel, J.P. Meijerink, and E.R. van Wering Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences Leukemia 22 1 2008 124 131
18. P. Van Vlierberghe, M. van Grotel, and H.B. Beverloo The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia Blood 108 10 2006 3520 3529
19. T. Boehm, L. Foroni, and Y. Kaneko The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 Proc Natl Acad Sci U S A 88 10 1991 4367 4371
20. B. Royer-Pokora, U. Loos, and W.D. Ludwig TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11) Oncogene 6 10 1991 1887 1893
21. L.R. Finger, J. Kagan, and G. Christopher Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma Proc Natl Acad Sci U S A 86 13 1989 5039 5043
22. M. Simonis, P. Klous, and I. Homminga High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology Nat Methods 6 11 2009 837 842
23. T. Boehm, R. Baer, and I. Lavenir The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15 EMBO J 7 2 1988 385 394
24. Y. Xia, L. Brown, and C.Y. Yang TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia Proc Natl Acad Sci U S A 88 24 1991 11416 11420
25. D.S. Chervinsky, X.F. Zhao, and D.H. Lam Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice Mol Cell Biol 19 7 1999 5025 5035
26. S. Herblot, A.M. Steff, and P. Hugo SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression Nat Immunol 1 2 2000 138 144
27. J. O'Neil, J. Shank, and N. Cusson TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB Canc. Cell 5 6 2004 587 596
28. V.E. Valge-Archer, H. Osada, and A.J. Warren The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells Proc Natl Acad Sci U S A 91 18 1994 8617 8621
29. A.A. Ferrando, S.A. Armstrong, and D.S. Neuberg Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation Blood 102 1 2003 262 268
30. W.A. Dik, W. Brahim, and C. Braun CALM-AF10 + T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes Leukemia 19 11 2005 1948 1957
31. Y. Okada, Q. Feng, and Y. Lin hDOT1L links histone methylation to leukemogenesis Cell 121 2 2005 167 178
32. Y. Okada, Q. Jiang, and M. Lemieux Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L Nat Cell Biol 8 9 2006 1017 1024
33. A. Batova, M.B. Diccianni, and J.C. Yu Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia Canc Res 57 5 1997 832 836
34. J.M. Cayuela, A. Madani, and L. Sanhes Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia Blood 87 6 1996 2180 2186
35. J. O'Neil, J. Grim, and P. Strack FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors J Exp Med 204 8 2007 1813 1824
36. B.J. Thompson, S. Buonamici, and M.L. Sulis The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia J Exp Med 204 8 2007 1825 1835
37. A.P. Weng, A.A. Ferrando, and W. Lee Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia Science 306 5694 2004 269 271
38. B.V. Balgobind, P. Van Vlierberghe, and A.M. van den Ouweland Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis Blood 111 8 2008 4322 4328
39. A. Gutierrez, T. Sanda, and R. Grebliunaite High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia Blood 114 3 2009 647 650
40. M. Kawamura, H. Ohnishi, and S.X. Guo Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia Leuk Res 23 2 1999 115 126
41. F.C. von Lintig, I. Huvar, and P. Law Ras activation in normal white blood cells and childhood acute lymphoblastic leukemia Clin Canc Res 6 5 2000 1804 1810
42. S. Yokota, M. Nakao, and S. Horiike Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases Int J Hematol 67 4 1998 379 387
43. T. Palomero, M. Dominguez, and A.A. Ferrando The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia Cell Cycle 7 8 2008 965 970
44. C. Graux, J. Cools, and C. Melotte Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia Nat Genet 36 10 2004 1084 1089
45. P. Raanani, L. Trakhtenbrot, and G. Rechavi Philadelphia-chromosome- positive T-lymphoblastic leukemia: acute leukemia or chronic myelogenous leukemia blastic crisis Acta Haematol 113 3 2005 181 189
46. J.G. Herman, J. Jen, and A. Merlo Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B Canc Res 56 4 1996 722 727
47. A. Merlo, J.G. Herman, and L. Mao 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 7 1995 686 692
48. M. Fasseu, P.D. Aplan, and M. Chopin p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis Blood 110 7 2007 2610 2619
49. S. Breit, M. Stanulla, and T. Flohr Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia Blood 108 4 2006 1151 1157
50. Clappier, E, Collette S, Grardel N, et al. Prognostic significance of NOTCH1 and FBXW7 mutations in childhood T-cell acute leukemia: results from the EORTC Children Leukemia Group, Leukemia [in press].
51. Kox C, Zimmermann M, Stanulla M, et al. The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL can be seperated from NOTCH pathway activation by FBXW7 loss of function, Leukemia [in press].
52. A. Larson Gedman, Q. Chen, and S. Kugel Desmoulin The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group Leukemia 23 8 2009 1417 1425
53. Zuurbier L, Homminga I, Calvert V, et al. NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell Acute Lymphoblastic Leukemia patients treated on DCOG or COALL protocols, Leukemia [in press].
54. V. Asnafi, A. Buzyn, and S. Le Noir NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study Blood 113 17 2009 3918 3924
55. A. Malyukova, T. Dohda, and N. von der Lehr The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling Canc Res 67 12 2007 5611 5616
56. M.L. Sulis, O. Williams, and T. Palomero NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL Blood 112 3 2008 733 740
57. L.W. Ellisen, J. Bird, and D.C. West TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms Cell 66 4 1991 649 661
58. W.S. Pear, J.C. Aster, and M.L. Scott Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles J Exp Med 183 5 1996 2283 2291
59. J.C. Pui, D. Allman, and L. Xu Notch1 expression in early lymphopoiesis influences B versus T lineage determination Immunity 11 3 1999 299 308
60. M.Y. Chiang, L. Xu, and O. Shestova Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia J Clin Invest 118 9 2008 3181 3194
61. A.P. Weng, Y. Nam, and M.S. Wolfe Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling Mol Cell Biol 23 2 2003 655 664
62. D.J. DeAngelo, R.M. Stone, and M.L. Heaney Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics Blood 108 12 2006 3674 3681
63. P.J. Real, V. Tosello, and T. Palomero Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia Nat Med 15 1 2009 50 58
64. C. Grabher, H. von Boehmer, and A.T. Look Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia Nat Rev Cancs 6 5 2006 347 359
65. T. Palomero, W.K. Lim, and D.T. Odom NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth Proc Natl Acad Sci U S A 103 48 2006 18261 18266
66. A.P. Weng, J.M. Millholland, and Y. Yashiro-Ohtani c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma Genes Dev 20 15 2006 2096 2109
67. H. Medyouf, X. Gao, and F. Armstrong Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss Blood 115 6 2010 1175 1184
68. M.C. Bene, G. Castoldi, and W. Knapp Proposals for the immunological classification of acute leukemias. European group for the immunological characterization of leukemias (EGIL) Leukemia 9 10 1995 1783 1786
69. R. Garand, S. Voisin, and S. Papin Characteristics of pro-T ALL subgroups: comparison with late T-ALL. The Groupe d'Etude Immunologique des Leucemies Leukemia 7 2 1993 161 167
70. E. Thiel, B.R. Kranz, and A. Raghavachar Prethymic phenotype and genotype of pre-T (CD7+/ER-)-cell leukemia and its clinical significance within adult acute lymphoblastic leukemia Blood 73 5 1989 1247 1258
71. A. Vitale, A. Guarini, and C. Ariola Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol Blood 107 2 2006 473 479
72. F.M. Uckun, P.S. Gaynon, and M.G. Sensel Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study J Clin Oncol 15 6 1997 2214 2221
73. V. Asnafi, A. Buzyn, and X. Thomas Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: a LALA-94 study Blood 105 8 2005 3072 3078
74. D.I. Marks, E.M. Paietta, and A.V. Moorman T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993) Blood 114 25 2009 5136 5145
75. E. Coustan-Smith, C.G. Mullighan, and M. Onciu Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia Lancet Oncol 10 2 2009 147 156
76. T. Niehues, P. Kapaun, and D.O. Harms A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies Leukemia 13 4 1999 614 617
77. C.H. Pui, F.G. Behm, and W.M. Crist Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia Blood 82 2 1993 343 362
78. W.D. Ludwig, J. Harbott, and C.R. Bartram Incidence and prognostic significance of immunophenotypic subgroups in childhood acute lymphoblastic leukemia: experience of the BFM study 86 Recent Results Cancer Res 131 1993 269 282
79. J. Pullen, J.J. Shuster, and M. Link Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. A Pediatric Oncology Group (POG) study Leukemia 13 11 1999 1696 1707
80. A.A. Ferrando, D.S. Neuberg, and R.K. Dodge Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia Lancet 363 9408 2004 535 536
81. U.R. Kees, N.A. Heerema, and R. Kumar Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG) Leukemia 17 5 2003 887 893
82. N.R. Schneider, A.J. Carroll, and J.J. Shuster New recurring cytogenetic] abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases Blood 96 7 2000 2543 2549
83. V. Asnafi, K. Beldjord, and E. Boulanger Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment Blood 101 7 2003 2693 2703
84. E.A. Macintyre, L. Smit, and J. Ritz Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor alpha beta lineage Blood 80 6 1992 1511 1520
85. A. Kikuchi, Y. Hayashi, and S. Kobayashi Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma Leukemia 7 7 1993 933 938
86. U. Baak, N. Gokbuget, and H. Orawa Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group Leukemia 22 6 2008 1154 1160
87. P. Ballerini, A. Blaise, and M. Busson-Le Coniat HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis Blood 100 3 2002 991 997
88. L. Mauvieux, V. Leymarie, and C. Helias High incidence of Hox11L2 expression in children with T-ALL Leukemia 16 12 2002 2417 2422
89. A.A. Ferrando, S. Herblot, and T. Palomero Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia Blood 103 5 2004 1909 1911
90. M. van Grotel, M.M. van den Heuvel-Eibrink, and E.R. van Wering CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia Pediatr Blood Canc 51 6 2008 737 740
91. M.A. Hall, D.J. Curtis, and D. Metcalf The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12 Proc Natl Acad Sci U S A 100 3 2003 992 997
92. L. Robb, I. Lyons, and R. Li Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene Proc Natl Acad Sci U S A 92 15 1995 7075 7079
93. R.A. Shivdasani, E.L. Mayer, and S.H. Orkin Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL Nature 373 6513 1995 432 434
94. Y. Yamada, A.J. Warren, and C. Dobson The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis Proc Natl Acad Sci U S A 95 7 1998 3890 3895
95. C. Capron, Y. Lecluse, and A.L. Kaushik The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation Blood 107 12 2006 4678 4686
96. A Gutierrez, SE Dahlberg, and DS Neuberg Absence of biallelic TCRg deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia J Clin Oncol 28 24 2010 3816 3823
97. N.G. Gottardo, P.A. Jacoby, and H.N. Sather Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols Leukemia 19 9 2005 1705 1708
98. B. Cauwelier, H. Cave, and C. Gervais Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogenetique Hematologique Leukemia 21 1 2007 121 128
99. V. Asnafi, I. Radford-Weiss, and N. Dastugue CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage Blood 102 3 2003 1000 1006
100. F. Speleman, B. Cauwelier, and N. Dastugue A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias Leukemia 19 3 2005 358 366
101. E. Clappier, W. Cuccuini, and A. Kalota The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) - the translocation defining a new T-ALL subtype in very young children Blood 110 4 2007 1251 1261
102. E. Clappier, W. Cuccuini, and J.M. Cayuela Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias Leukemia 20 1 2006 82 86
103. M.J. Park, T. Taki, and M. Oda FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma Br J Haematol 145 2 2009 198 206
104. Y.M. Zhu, W.L. Zhao, and J.F. Fu NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis Clin Canc Res 12 10 2006 3043 3049
105. C.D. Baldus, J. Thibaut, and N. Goekbuget Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia Haematologica 94 10 2009 1383 1390
106. M.R. Mansour, M.L. Sulis, and V. Duke Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol J Clin Oncol 27 26 2009 4352 4356
107. S. Suzuki, S. Nagel, and B. Schneider A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2) in T-cell neoplasia Leukemia 23 5 2009 1003 1006
108. P. Van Vlierberghe, T. Palomero, and Khiabanian H PHF6 mutations in T-cell acute lymphoblastic leukemia Nat Genet 42 4 2010 338 342
109. I. Lahortiga, K. De Keersmaecker, and P. Van Vlierberghe Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia Nat Genet 39 5 2007 593 595
110. J. O'Neil, J. Tchinda, and A. Gutierrez Alu elements mediate MYB gene tandem duplication in human T-ALL J Exp Med 204 13 2007 3059 3066
111. T. Burmeister, N. Gokbuget, and R. Reinhardt NUP214-ABL1 in adult T-ALL: the GMALL study group experience Blood 108 10 2006 3556 3559
112. P. Van Vlierberghe, J.P.P. Meijerink, and R.W. Stam Actvating FLT3 mutations inCD4+/CD8- pediatric T-cell acute lymphoblastic leukemias Blood 106 2006 4414 4415
113. K. De Keersmaecker, C. Graux, and M.D. Odero Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32) Blood 105 12 2005 4849 4852
114. H. Van Limbergen, H.B. Beverloo, and E. van Drunen Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia Gene Chromosome Canc 30 3 2001 274 282
115. V. Lacronique, A. Boureux, and V.D. Valle A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia Science 278 5341 1997 1309 1312
116. E. Paietta, A.A. Ferrando, and D. Neuberg Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias Blood 104 2 2004 558 560