Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 26039-26045

  Sanishvili, Ruslan ^a   Yakunin, Alexander F ^b   Laskowski, Roman A ^d   Skarina, Tatiana ^c   Evdokimova, Elena ^c   Doherty Kirby, Amanda ^e   Lajoie, Gilles A ^e   Thornton, Janet M ^d   Arrowsmith, Cheryl H ^b,c   Savchenko, Alexei ^c   Joachimiak, Andrzej ^a   Edwards, Aled M ^b,c  

^a ARGONNE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; ESCHERICHIA COLI; HYDROLYSIS; MOLECULAR STRUCTURE;

BIOINFORMATICS;

BIOCHEMISTRY;

ASPARTIC ACID; CARBOXYLESTERASE; CARBOXYLESTERASE BIOH; HISTIDINE; HYDROLASE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYMOLOGY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEOMICS;

BIOTIN; CARBOXYLIC ESTER HYDROLASES; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0038168191     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303867200     Document Type: Article

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