Regulation of gene expression in the intestinal epithelium

Progress in Molecular Biology and Translational Science

Volumn 96, Issue C, 2010, Pages 207-229

  Richmond, Camilla A ^a   Breault, David T ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

BMP; Ephrins; Epithelium; Forkhead; Gene expression; Hedgehog; Intestine; Notch; Parahox; Wnt

Indexed keywords

EID: 78649231440     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-381280-3.00009-9     Document Type: Chapter

References (118)

1. A.P. Monaghan, K.H. Kaestner, E. Grau, and G. Schutz Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm Development 119 1993 567 578
2. J. Totafurno, M. Bjerknes, and H. Cheng The crypt cycle. Crypt and villus production in the adult intestinal epithelium Biophys J 52 1987 279 294
3. K.N. Wallace, S. Akhter, E.M. Smith, K. Lorent, and M. Pack Intestinal growth and differentiation in zebrafish Mech Dev 122 2005 157 173
4. E. Sancho, E. Batlle, and H. Clevers Signaling pathways in intestinal development and cancer Annu Rev Cell Dev Biol 20 2004 695 723
5. H. Cheng, and C.P. Leblond Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types Am J Anat 141 1974 537 561
6. C.S. Potten Stem cells in gastrointestinal epithelium: numbers, characteristics and death Philos Trans R Soc Lond B Biol Sci 353 1998 821 830
7. C.S. Potten, G. Owen, and D. Booth Intestinal stem cells protect their genome by selective segregation of template DNA strands J Cell Sci 115 2002 2381 2388
8. M. Bjerknes, and H. Cheng Clonal analysis of mouse intestinal epithelial progenitors Gastroenterology 116 1999 7 14
9. K.A. Moore, and I.R. Lemischka Stem cells and their niches Science 311 2006 1880 1885
10. V.B.N. Korinek, P. Moerer, E. van Donselaar, G. Huls, P.J. Peters, and H. Clevers Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 Nat Genet 19 1998 379 383
11. S. Fre, M. Huyghe, P. Mourikis, S. Robine, D. Louvard, and S. Artavanis-Tsakonas Notch signals control the fate of immature progenitor cells in the intestine Nature 435 2005 964 968
12. B.Z. Stanger, R. Datar, L.C. Murtaugh, and D.A. Melton Direct regulation of intestinal fate by Notch Proc Natl Acad Sci USA 102 2005 12443 12448
13. J.H. van Es, M.E. van Gijn, O. Riccio, M. van den Born, M. Vooijs, and H. Begthel Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Nature 435 2005 959 963
14. X.C. He, J. Zhang, W.G. Tong, O. Tawfik, J. Ross, and D.H. Scoville BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling Nat Genet 36 2004 1117 1121
15. A. Gregorieff, D. Pinto, H. Begthel, O. Destree, M. Kielman, and H. Clevers Expression pattern of Wnt signaling components in the adult intestine Gastroenterology 129 2005 626 638
16. A.P. Haramis, H. Begthel, M. van den Born, J. van Es, S. Jonkheer, and G.J. Offerhaus De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine Science 303 2004 1684 1686
17. D.W. Powell, P.A. Adegboyega, J.F. Di Mari, and R.C. Mifflin Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer Am J Physiol Gastrointest Liver Physiol 289 2005 G2 7
18. M. Bjerknes, and H. Cheng Modulation of specific intestinal epithelial progenitors by enteric neurons Proc Natl Acad Sci USA 98 2001 12497 12502
19. B.B. Madison, K. Braunstein, E. Kuizon, K. Portman, X.T. Qiao, and D.L. Gumucio Epithelial hedgehog signals pattern the intestinal crypt-villus axis Development 132 2005 279 289
20. T. Narita, Y. Ishii, T. Nohno, S. Noji, and S. Yasugi Sonic hedgehog expression in developing chicken digestive organs is regulated by epithelial-mesenchymal interactions Dev Growth Differ 40 1998 67 74
21. D.J. Roberts, D.M. Smith, D.J. Goff, and C.J. Tabin Epithelial- mesenchymal signaling during the regionalization of the chick gut Development 125 1998 2791 2801
22. Y. Litingtung, L. Lei, H. Westphal, and C. Chiang Sonic hedgehog is essential to foregut development Nat Genet 20 1998 58 61
23. D. Weigel, G. Jurgens, F. Kuttner, E. Seifert, and H. Jackle The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo Cell 57 1989 645 658
24. P. Carlsson, and M. Mahlapuu Forkhead transcription factors: key players in development and metabolism Dev Biol 250 2002 1 23
25. K.H. Kaestner, W. Knochel, and D.E. Martinez Unified nomenclature for the winged helix/forkhead transcription factors Genes Dev 14 2000 142 146
26. L.A. Cirillo, F.R. Lin, I. Cuesta, D. Friedman, M. Jarnik, and K.S. Zaret Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4 Mol Cell 9 2002 279 289
27. S. Filosa, J.A. Rivera-Perez, A.P. Gomez, A. Gansmuller, H. Sasaki, and R.R. Behringer Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis Development 124 1997 2843 2854
28. W. Shen, L.M. Scearce, J.E. Brestelli, N.J. Sund, and K.H. Kaestner Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast J Biol Chem 276 2001 42812 42817
29. C.S. Lee, J.R. Friedman, J.T. Fulmer, and K.H. Kaestner The initiation of liver development is dependent on Foxa transcription factors Nature 435 2005 944 947
30. D.Z. Ye, and K.H. Kaestner Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice Gastroenterology 137 2009 2052 2062
31. J.R. Friedman, and K.H. Kaestner The Foxa family of transcription factors in development and metabolism Cell Mol Life Sci 63 2006 2317 2328
32. P.H. Holmqvist, S. Belikov, K.S. Zaret, and O. Wrange FoxA1 binding to the MMTV LTR modulates chromatin structure and transcription Exp Cell Res 304 2005 593 603
33. C. Kappen, K. Schughart, and F.H. Ruddle Two steps in the evolution of Antennapedia-class vertebrate homeobox genes Proc Natl Acad Sci USA 86 1989 5459 5463
34. R. Krumlauf Hox genes in vertebrate development Cell 78 1994 191 201
35. J. Deschamps, E. van den Akker, S. Forlani, W. De Graaff, T. Oosterveen, and B. Roelen Initiation, establishment and maintenance of Hox gene expression patterns in the mouse Int J Dev Biol 43 1999 635 650
36. O. Pabst, R. Zweigerdt, and H.H. Arnold Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen Development 126 1999 2215 2225
37. S. Desai, Z. Loomis, A. Pugh-Bernard, J. Schrunk, M.J. Doyle, and A. Minic Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine Dev Biol 313 2008 58 66
38. N.M. Brooke, J. Garcia-Fernandez, and P.W. Holland The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster Nature 392 1998 920 922
39. B.I. Meyer, and P. Gruss Mouse Cdx-1 expression during gastrulation Development 117 1993 191 203
40. F. Beck Homeobox genes in gut development Gut 51 2002 450 454
41. L.W. Gamer, and C.V. Wright Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern Mech Dev 43 1993 71 81
42. R. James, and J. Kazenwadel Homeobox gene expression in the intestinal epithelium of adult mice J Biol Chem 266 1991 3246 3251
43. F. Beck, T. Erler, A. Russell, and R. James Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes Dev Dyn 204 1995 219 227
44. K. Chawengsaksophak, R. James, V.E. Hammond, F. Kontgen, and F. Beck Homeosis and intestinal tumours in Cdx2 mutant mice Nature 386 1997 84 87
45. F. Beck, K. Chawengsaksophak, P. Waring, R.J. Playford, and J.B. Furness Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice Proc Natl Acad Sci USA 96 1999 7318 7323
46. H. Mutoh, Y. Hakamata, K. Sato, A. Eda, I. Yanaka, and S. Honda Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice Biochem Biophys Res Commun 294 2002 470 479
47. D.G. Silberg, J. Sullivan, E. Kang, G.P. Swain, J. Moffett, and N.J. Sund Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice Gastroenterology 122 2002 689 696
48. F. Beck The role of Cdx genes in the mammalian gut Gut 53 2004 1394 1396
49. N. Gao, P. White, and K.H. Kaestner Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2 Dev Cell 16 2009 588 599
50. Y. Guz, M.R. Montminy, R. Stein, J. Leonard, L.W. Gamer, and C.V. Wright Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny Development 121 1995 11 18
51. M.F. Offield, T.L. Jetton, P.A. Labosky, M. Ray, R.W. Stein, and M.A. Magnuson PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum Development 122 1996 983 995
52. C. Chen, R. Fang, C. Davis, C. Maravelias, and E. Sibley Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells Am J Physiol Gastrointest Liver Physiol 297 2009 G1126 G1137
53. J.D. Molkentin, Q. Lin, S.A. Duncan, and E.N. Olson Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis Genes Dev 11 1997 1061 1072
54. M. Koutsourakis, A. Langeveld, R. Patient, R. Beddington, and F. Grosveld The transcription factor GATA6 is essential for early extraembryonic development Development 126 1999 723 732
55. R. Fang, L.C. Olds, and E. Sibley Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development Gene Expr Patterns 6 2006 426 432
56. E. Beuling, T. Bosse, D.J. aan de Kerk, C.M. Piaseckyj, Y. Fujiwara, and S.G. Katz GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors Dev Biol 322 2008 179 189
57. M.R. Dusing, and D.A. Wiginton Epithelial lineages of the small intestine have unique patterns of GATA expression J Mol Histol 36 2005 15 24
58. M.T. Veeman, J.D. Axelrod, and R.T. Moon A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling Dev Cell 5 2003 367 377
59. C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 20 2004 781 810
60. D.H. Scoville, T. Sato, X.C. He, and L. Li Current view: intestinal stem cells and signaling Gastroenterology 134 2008 849 864
61. P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, and B. Vogelstein Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 1997 1787 1790
62. F. Kuhnert, C.R. Davis, H.T. Wang, P. Chu, M. Lee, and J. Yuan Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Proc Natl Acad Sci USA 101 2004 266 271
63. T. Fevr, S. Robine, D. Louvard, and J. Huelsken Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells Mol Cell Biol 27 2007 7551 7559
64. E.V. Prochownik c-Myc: linking transformation and genomic instability Curr Mol Med 8 2008 446 458
65. V. Muncan, O.J. Sansom, L. Tertoolen, T.J. Phesse, H. Begthel, and E. Sancho Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc Mol Cell Biol 26 2006 8418 8426
66. J.H. van Es, P. Jay, A. Gregorieff, M.E. van Gijn, S. Jonkheer, and P. Hatzis Wnt signalling induces maturation of Paneth cells in intestinal crypts Nat Cell Biol 7 2005 381 386
67. P. Bastide, C. Darido, J. Pannequin, R. Kist, S. Robine, and C. Marty-Double Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium J Cell Biol 178 2007 635 648
68. Y. Mori-Akiyama, M. van den Born, J.H. van Es, S.R. Hamilton, H.P. Adams, and J. Zhang SOX9 is required for the differentiation of paneth cells in the intestinal epithelium Gastroenterology 133 2007 539 546
69. N. Barker, J.H. van Es, J. Kuipers, P. Kujala, M. van den Born, and M. Cozijnsen Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 2007 1003 1007
70. O.J. Sansom, K.R. Reed, A.J. Hayes, H. Ireland, H. Brinkmann, and I.P. Newton Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration Genes Dev 18 2004 1385 1390
71. P. Andreu, S. Colnot, C. Godard, S. Gad, P. Chafey, and M. Niwa-Kawakita Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine Development 132 2005 1443 1451
72. L.K. Su, K.W. Kinzler, B. Vogelstein, A.C. Preisinger, A.R. Moser, and C. Luongo Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene Science 256 1992 668 670
73. D. Pinto, A. Gregorieff, H. Begthel, and H. Clevers Canonical Wnt signals are essential for homeostasis of the intestinal epithelium Genes Dev 17 2003 1709 1713
74. Q. Xu, G. Mellitzer, V. Robinson, and D.G. Wilkinson In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins Nature 399 1999 267 271
75. E. Batlle, J.T. Henderson, H. Beghtel, M.M. van den Born, E. Sancho, and G. Huls Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB Cell 111 2002 251 263
76. M. van de Wetering, E. Sancho, C. Verweij, W. de Lau, I. Oving, and A. Hurlstone The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111 2002 241 250
77. E. Batlle, J. Bacani, H. Begthel, S. Jonkheer, A. Gregorieff, and M. van de Born EphB receptor activity suppresses colorectal cancer progression Nature 435 2005 1126 1130
78. A.M. Jubb, F. Zhong, S. Bheddah, H.I. Grabsch, G.D. Frantz, and W. Mueller EphB2 is a prognostic factor in colorectal cancer Clin Cancer Res 11 2005 5181 5187
79. P. Blache, M. van de Wetering, I. Duluc, C. Domon, P. Berta, and J.N. Freund SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes J Cell Biol 166 2004 37 47
80. A.D. Gracz, S. Ramalingam, and S.T. Magness Sox9-Expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro Am J Physiol Gastrointest Liver Physiol 298 2010 G590 G600
81. X. Li, B.B. Madison, W. Zacharias, A. Kolterud, D. States, and D.L. Gumucio Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk Physiol Genomics 29 2007 290 301
82. J.R. Howe, S. Roth, J.C. Ringold, R.W. Summers, H.J. Jarvinen, and P. Sistonen Mutations in the SMAD4/DPC4 gene in juvenile polyposis Science 280 1998 1086 1088
83. T. Brabletz, A. Jung, S. Reu, M. Porzner, F. Hlubek, and L.A. Kunz-Schughart Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment Proc Natl Acad Sci USA 98 2001 10356 10361
84. J.R. Howe, J.L. Bair, M.G. Sayed, M.E. Anderson, F.A. Mitros, and G.M. Petersen Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis Nat Genet 28 2001 184 187
85. F. Hlubek, T. Brabletz, J. Budczies, S. Pfeiffer, A. Jung, and T. Kirchner Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer Int J Cancer 121 2007 1941 1948
86. B.A. Auclair, Y.D. Benoit, N. Rivard, Y. Mishina, and N. Perreault Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage Gastroenterology 133 2007 887 896
87. G.L. Mutter Pten, a protean tumor suppressor Am J Pathol 158 2001 1895 1898
88. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
89. D.W. Parsons, T.L. Wang, Y. Samuels, A. Bardelli, J.M. Cummins, and L. DeLong Colorectal cancer: mutations in a signalling pathway Nature 436 2005 792
90. M. Cully, H. You, A.J. Levine, and T.W. Mak Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis Nat Rev Cancer 6 2006 184 192
91. D. Liaw, D.J. Marsh, J. Li, P.L. Dahia, S.I. Wang, and Z. Zheng Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nat Genet 16 1997 64 67
92. A. Hemminki, D. Markie, I. Tomlinson, E. Avizienyte, S. Roth, and A. Loukola A serine/threonine kinase gene defective in Peutz-Jeghers syndrome Nature 391 1998 184 187
93. D.E. Jenne, H. Reimann, J. Nezu, W. Friedel, S. Loff, and R. Jeschke Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase Nat Genet 18 1998 38 43
94. A.F. Baas, J. Kuipers, N.N. van der Wel, E. Batlle, H.K. Koerten, and P.J. Peters Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD Cell 116 2004 457 466
95. J.L. Watts, D.G. Morton, J. Bestman, and K.J. Kemphues The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry Development 127 2000 1467 1475
96. S.G. Martin, and D. St Johnston A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity Nature 421 2003 379 384
97. N. Bardeesy, M. Sinha, A.F. Hezel, S. Signoretti, N.A. Hathaway, and N.E. Sharpless Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation Nature 419 2002 162 167
98. H. Miyoshi, M. Nakau, T.O. Ishikawa, M.F. Seldin, M. Oshima, and M.M. Taketo Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice Cancer Res 62 2002 2261 2266
99. A.F. Baas, J. Boudeau, G.P. Sapkota, L. Smit, R. Medema, and N.A. Morrice Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD EMBO J 22 2003 3062 3072
100. S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, and T.P. Makela Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J Biol 2 2003 28
101. J.F. Hancock Ras proteins: different signals from different locations Nat Rev Mol Cell Biol 4 2003 373 384
102. N. Schroder, and A. Gossler Expression of Notch pathway components in fetal and adult mouse small intestine Gene Expr Patterns 2 2002 247 250
103. J.H. van Es, and H. Clevers Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease Trends Mol Med 11 2005 496 502
104. M. Itoh, C.H. Kim, G. Palardy, T. Oda, Y.J. Jiang, and D. Maust Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by delta Dev Cell 4 2003 67 82
105. C. Crosnier, N. Vargesson, S. Gschmeissner, L. Ariza-McNaughton, A. Morrison, and J. Lewis Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine Development 132 2005 1093 1104
106. J. Jensen, E.E. Pedersen, P. Galante, J. Hald, R.S. Heller, and M. Ishibashi Control of endodermal endocrine development by Hes-1 Nat Genet 24 2000 36 44
107. A. D'Angelo, O. Bluteau, M.A. Garcia-Gonzalez, L. Gresh, A. Doyen, and S. Garbay Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium Development 137 2010 1573 1582
108. S. Cereghini Liver-enriched transcription factors and hepatocyte differentiation FASEB J 10 1996 267 282
109. M. Pontoglio, M. Pausa, A. Doyen, B. Viollet, M. Yaniv, and F. Tedesco Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes J Exp Med 194 2001 1683 1689
110. E. Barbacci, M. Reber, M.O. Ott, C. Breillat, F. Huetz, and S. Cereghini Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification Development 126 1999 4795 4805
111. Q. Yang, N.A. Bermingham, M.J. Finegold, and H.Y. Zoghbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine Science 294 2001 2155 2158
112. V. Zecchini, R. Domaschenz, D. Winton, and P. Jones Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells Genes Dev 19 2005 1686 1691
113. C. Crosnier, D. Stamataki, and J. Lewis Organizing cell renewal in the intestine: stem cells, signals and combinatorial control Nat Rev Genet 7 2006 349 359
114. M.Y. Choi, A.I. Romer, M. Hu, M. Lepourcelet, A. Mechoor, and A. Yesilaltay A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development Development 133 2006 4119 4129
115. L. Zeng, A.D. Carter, and S.J. Childs miR-145 directs intestinal maturation in zebrafish Proc Natl Acad Sci USA 106 2009 17793 17798
116. K. Hino, K. Tsuchiya, T. Fukao, K. Kiga, R. Okamoto, and T. Kanai Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation RNA 14 2008 1433 1442
117. L.B. McKenna, J. Schug, A. Vourekas, J.B. McKenna, N. Bramswig, and J.R. Friedman MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function Gastroenterology 2010 [Epub ahead of Print]
118. K.S. Zaret, and M. Grompe Generation and regeneration of cells of the liver and pancreas Science 322 2008 1490 1494