PTEN, a protean tumor suppressor

American Journal of Pathology

Volumn 158, Issue 6, 2001, Pages 1895-1898

  Mutter, George L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

CARCINOGENESIS; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC VARIABILITY; HETEROZYGOSITY LOSS; METASTASIS; NOTE; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0034978311     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64656-1     Document Type: Note

References (47)

1. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
2. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
3. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease
4. The role of MMAC1 mutations in early-onset breast cancer: Causative in association with Cowden syndrome and excluded in BRCA1-negative cases
5. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
6. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
7. Immunocytochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
8. Identification of PTEN mutations in metastatic melanoma specimens
9. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
10. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
11. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
12. Somatic mutations of PTEN in glioblastoma multiforme
13. Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q
14. Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme
15. PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas
16. PTEN/MMAC1 mutations in endometrial cancers
17. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
18. PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
19. PTEN mutations in endometrial cancers with 10q LOH: Additional evidence for the involvement of multiple tumor suppressors
20. PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases
21. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
22. Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers
23. Allelic imbalance and mutations of the PTEN gene in ovarian cancer
24. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
25. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
26. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
27. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
28. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
29. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
30. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
31. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130Cas
32. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
33. Will the real Cowden syndrome please stand up: Revised diagnostic criteria
34. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
35. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
36. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
37. Changes in endometrial PTEN expression throughout the human menstrual cycle
38. The epidemiology of endometrial cancer
39. PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
40. Gatekeeper for endometrium: The PTEN tumor suppressor gene
41. Common genetic changes between endometriosis and ovarian cancer
42. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary
43. 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,NO) prostate cancer
44. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
45. Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN
46. PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
47. Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer