메뉴 건너뛰기




Volumn 2, Issue 1, 2010, Pages 49-58

Targeting the MDM2-p53 interaction as a therapeutic strategy for the treatment of cancer

Author keywords

MDM2; MDMX; Nutlin 3a; P53; TAp73

Indexed keywords


EID: 78449232165     PISSN: None     EISSN: 11791330     Source Type: Journal    
DOI: 10.2147/chc.s4952     Document Type: Review
Times cited : (6)

References (96)
  • 1
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • DeLeo AB, Jay G, Appella E, Dubois GC, Law LW, Old LJ. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A. 1979;76(5):2420-2424.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , Issue.5 , pp. 2420-2424
    • Deleo, A.B.1    Jay, G.2    Appella, E.3    Dubois, G.C.4    Law, L.W.5    Old, L.J.6
  • 2
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SY40- transformed cells
    • Lane DP, Crawford LV. T antigen is bound to a host protein in SY40- transformed cells. Nature. 1979;278(5701):261-263.
    • (1979) Nature , vol.278 , Issue.5701 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 3
    • 0018760324 scopus 로고
    • Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer DIH, Levine AJ. Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 1979;17(1):43-52.
    • (1979) Cell , vol.17 , Issue.1 , pp. 43-52
    • Linzer, D.I.H.1    Levine, A.J.2
  • 4
    • 2142758177 scopus 로고    scopus 로고
    • p53 is a tumor suppressor gene
    • Levine AJ, Finlay CA, Hinds PW. p53 is a tumor suppressor gene. Cell. 2004;116(S 2):S67-S70.
    • (2004) Cell , vol.116 , Issue.S 2
    • Levine, A.J.1    Finlay, C.A.2    Hinds, P.W.3
  • 5
    • 0024382760 scopus 로고
    • The p53 proto-oncogene can act as a suppressor of transformation
    • Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 1989;57(7):1083-1093.
    • (1989) Cell , vol.57 , Issue.7 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 6
    • 0020682479 scopus 로고
    • Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen
    • Oren M, Levine AJ. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natil Acad Sci U S A. 1983;80(1): 56-59.
    • (1983) Proc Natil Acad Sci U S A , vol.80 , Issue.1 , pp. 56-59
    • Oren, M.1    Levine, A.J.2
  • 7
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307-310.
    • (2000) Nature , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 9
    • 0347716455 scopus 로고    scopus 로고
    • MDM2, An Introduction
    • Iwakuma T, Lozano G. MDM2, An Introduction. Mol Cancer Res. 2003;1(14):993-1000.
    • (2003) Mol Cancer Res , vol.1 , Issue.14 , pp. 993-1000
    • Iwakuma, T.1    Lozano, G.2
  • 10
    • 0026649648 scopus 로고
    • The MDM-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The MDM-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992;69(7):1237-1245.
    • (1992) Cell , vol.69 , Issue.7 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 12
    • 0030905284 scopus 로고    scopus 로고
    • MDM2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. MDM2 promotes the rapid degradation of p53. Nature. 1997;387(6630):296-299.
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 13
    • 0027244853 scopus 로고
    • The p53-MDM-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-MDM-2 autoregulatory feedback loop. Genes Dev. 1993;7(7a):1126-1132.
    • (1993) Genes Dev , vol.7 , Issue.7 a , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 14
    • 70349437076 scopus 로고    scopus 로고
    • p53 and E2f: Partners in life and death
    • Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer. 2009;9(10):738-748.
    • (2009) Nat Rev Cancer , vol.9 , Issue.10 , pp. 738-748
    • Polager, S.1    Ginsberg, D.2
  • 15
    • 0029914660 scopus 로고    scopus 로고
    • Overexpression of the MDM2 Oncogene in Leukemia and Lymphoma
    • Watanabe T, Ichikawa A, Saito H, Hotta T. Overexpression of the MDM2 Oncogene in Leukemia and Lymphoma. Leuk Lymphoma. 1996;21(5):391-397.
    • (1996) Leuk Lymphoma , vol.21 , Issue.5 , pp. 391-397
    • Watanabe, T.1    Ichikawa, A.2    Saito, H.3    Hotta, T.4
  • 16
    • 33847308066 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans
    • Bond GL, Levine AJ. A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans. Oncogene. 2007;26(9): 1317-1323.
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1317-1323
    • Bond, G.L.1    Levine, A.J.2
  • 18
    • 14644439903 scopus 로고    scopus 로고
    • Chemosensitization by antisense oligonucleotides targeting MDM2
    • Bianco R, Ciardiello F, Tortora G. Chemosensitization by antisense oligonucleotides targeting MDM2. Curr Cancer Drug Targets. 2005;5(1):51-56.
    • (2005) Curr Cancer Drug Targets , vol.5 , Issue.1 , pp. 51-56
    • Bianco, R.1    Ciardiello, F.2    Tortora, G.3
  • 19
    • 53049108040 scopus 로고    scopus 로고
    • Targeting the MDM2-p53 interaction for cancer therapy
    • Shangary S, Wang S. Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res. 2008;14(17):5318-5324.
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5318-5324
    • Shangary, S.1    Wang, S.2
  • 20
    • 33845901313 scopus 로고    scopus 로고
    • MDM2 inhibitors for cancer therapy
    • Vassilev LT. MDM2 inhibitors for cancer therapy. Trends Mol Med. 2007;13(1):23-31.
    • (2007) Trends Mol Med , vol.13 , Issue.1 , pp. 23-31
    • Vassilev, L.T.1
  • 21
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003;3(3):203-216.
    • (2003) Nat Rev Cancer , vol.3 , Issue.3 , pp. 203-216
    • Brodeur, G.M.1
  • 22
    • 33644552409 scopus 로고    scopus 로고
    • Increased frequency of aberrations in the p53/MDM2/p14ARF pathway in neuroblastoma cell lines established at relapse
    • Carr J, Bell E, Pearson ADJ, et al. Increased frequency of aberrations in the p53/MDM2/p14ARF pathway in neuroblastoma cell lines established at relapse. Cancer Res. 2006;66(4):2138-2145.
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2138-2145
    • Carr, J.1    Bell, E.2    Pearson, A.D.J.3
  • 23
    • 76749166680 scopus 로고    scopus 로고
    • High frequency of p53/MDM2/p14ARF pathway abnormalities in relapsed neuroblastoma
    • Carr-Wilkinson J, O'Toole K, Wood KM, et al. High frequency of p53/MDM2/p14ARF pathway abnormalities in relapsed neuroblastoma. Clinl Cancer Res. 2010;16(4):1108-1118.
    • (2010) Clinl Cancer Res , vol.16 , Issue.4 , pp. 1108-1118
    • Carr-Wilkinson, J.1    O'Toole, K.2    Wood, K.M.3
  • 24
    • 0038444753 scopus 로고    scopus 로고
    • The p53 pathway and its inactivation in neuroblastoma
    • Tweddle D, Pearson A, Haber M, et al. The p53 pathway and its inactivation in neuroblastoma. Cancer Lett. 2003;197(1-2):93-98.
    • (2003) Cancer Lett , vol.197 , Issue.1-2 , pp. 93-98
    • Tweddle, D.1    Pearson, A.2    Haber, M.3
  • 25
    • 72949107687 scopus 로고    scopus 로고
    • Targeted molecular therapy for neuroblastoma: The ARF/MDM2/p53 axis
    • Kim E, Shohet J. Targeted molecular therapy for neuroblastoma: The ARF/MDM2/p53 axis. J Natl Cancer Inst. 2009;101(22): 1527-1529.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.22 , pp. 1527-1529
    • Kim, E.1    Shohet, J.2
  • 26
    • 33749564973 scopus 로고    scopus 로고
    • MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
    • Barbieri E, Mehta P, Chen Z, et al. MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death. Mol Cancer Ther. 2006;5(9):2358-2365.
    • (2006) Mol Cancer Ther , vol.5 , Issue.9 , pp. 2358-2365
    • Barbieri, E.1    Mehta, P.2    Chen, Z.3
  • 27
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88(3):323-331.
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 28
    • 0038148713 scopus 로고    scopus 로고
    • Intrasteric regulation of MDM2
    • Shimizu H, Hupp TR. Intrasteric regulation of MDM2. Trends Biochem Sci. 2003;28(7):346-349.
    • (2003) Trends Biochem Sci , vol.28 , Issue.7 , pp. 346-349
    • Shimizu, H.1    Hupp, T.R.2
  • 29
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin S, Moyal L, Shieh S-Y, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 1998;281(5383): 1674-1677.
    • (1998) Science , vol.281 , Issue.5383 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.-Y.3
  • 30
    • 0242664079 scopus 로고    scopus 로고
    • p73{alpha} Regulation by Chk1 in response to DNA damage
    • Gonzalez S, Prives C, Cordon-Cardo C. p73{alpha} Regulation by Chk1 in response to DNA damage. Mol Cell Biol. 2003;23(22): 8161-8171.
    • (2003) Mol Cell Biol , vol.23 , Issue.22 , pp. 8161-8171
    • Gonzalez, S.1    Prives, C.2    Cordon-Cardo, C.3
  • 31
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse J-P, Gu W. Modes of p53 regulation. Cell. 2009;137(4): 609-622.
    • (2009) Cell , vol.137 , Issue.4 , pp. 609-622
    • Kruse, J.-P.1    Gu, W.2
  • 32
    • 0034823780 scopus 로고    scopus 로고
    • Regulation of p53 localization
    • Liang S-H, Clarke MF. Regulation of p53 localization. Eur J Biochem. 2001;268(10):2779-2783.
    • (2001) Eur J Biochem , vol.268 , Issue.10 , pp. 2779-2783
    • Liang, S.-H.1    Clarke, M.F.2
  • 33
    • 33747819484 scopus 로고    scopus 로고
    • Divorcing ARF and p53: An unsettled case
    • Sherr CJ. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer. 2006;6(9):663-673.
    • (2006) Nat Rev Cancer , vol.6 , Issue.9 , pp. 663-673
    • Sherr, C.J.1
  • 34
    • 36048973184 scopus 로고    scopus 로고
    • Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons
    • Uo T, Kinoshita Y, Morrison RS. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/ cytoplasmic site of action in postnatal cortical neurons. J Neurosci. 2007;27(45):12198-12210.
    • (2007) J Neurosci , vol.27 , Issue.45 , pp. 12198-12210
    • Uo, T.1    Kinoshita, Y.2    Morrison, R.S.3
  • 35
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor W, Stark G. Regulation of the G2/M transition by p53. Oncogene. 2001;20(15):1803-1815.
    • (2001) Oncogene , vol.20 , Issue.15 , pp. 1803-1815
    • Taylor, W.1    Stark, G.2
  • 36
    • 33646343474 scopus 로고    scopus 로고
    • An shRNA barcode screen provides insight into cancer cell vulnerability
    • Brummelkamp T, Fabius A, Mullenders J, et al. An shRNA barcode screen provides insight into cancer cell vulnerability. Nat Chem Biol. 2006;2:202-206.
    • (2006) Nat Chem Biol , vol.2 , pp. 202-206
    • Brummelkamp, T.1    Fabius, A.2    Mullenders, J.3
  • 37
    • 0034517534 scopus 로고    scopus 로고
    • Evolution of functions within the p53/p63/p73 Family
    • Vincenzo L, Gerry M. Evolution of functions within the p53/p63/p73 Family. Ann N Y Acad Sci. 2000;926: 90-100.
    • (2000) Ann N Y Acad Sci , vol.926 , pp. 90-100
    • Vincenzo, L.1    Gerry, M.2
  • 38
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation is indispensable for p53 activation
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gul W. Acetylation is indispensable for p53 activation. Cell. 2008;133(4):612-626.
    • (2008) Cell , vol.133 , Issue.4 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gul, W.5
  • 39
    • 18244408596 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    • Costanzo A, Merlo P, Pediconi N, et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Molecular Cell. 2002;9(1):175-186.
    • (2002) Molecular Cell , vol.9 , Issue.1 , pp. 175-186
    • Costanzo, A.1    Merlo, P.2    Pediconi, N.3
  • 41
    • 72049083694 scopus 로고    scopus 로고
    • Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells
    • Hori T, Kondo T, Kanamori M, et al. Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. Cancer Lett. 2010;287(1):98-108.
    • (2010) Cancer Lett , vol.287 , Issue.1 , pp. 98-108
    • Hori, T.1    Kondo, T.2    Kanamori, M.3
  • 42
    • 34548256424 scopus 로고    scopus 로고
    • The role of ubiquitination in the direct mitochondrial death program of p53
    • Marchenko N, Moll U. The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle. 2007;6:1718-1723.
    • (2007) Cell Cycle , vol.6 , pp. 1718-1723
    • Marchenko, N.1    Moll, U.2
  • 44
    • 0032417695 scopus 로고    scopus 로고
    • Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
    • Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A. D 1998; 95(26): 15608-15612.
    • (1998) Proc Natl Acad Sci U S A. D , vol.95 , Issue.26 , pp. 15608-15612
    • Jones, S.N.1    Hancock, A.R.2    Vogel, H.3    Donehower, L.A.4    Bradley, A.5
  • 45
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
    • Kussie PH, Gorina S, Marechal V, et al. Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain. Science. 1996;274(5289):948-953.
    • (1996) Science , vol.274 , Issue.5289 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3
  • 47
    • 34250831517 scopus 로고    scopus 로고
    • Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
    • Allende-Vega N, Saville MK, Meek DW. Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. Oncogene. 2007;26(29):4234-4242.
    • (2007) Oncogene , vol.26 , Issue.29 , pp. 4234-4242
    • Allende-Vega, N.1    Saville, M.K.2    Meek, D.W.3
  • 48
    • 4143053880 scopus 로고    scopus 로고
    • Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
    • Feng J, Tamaskovic R, Yang Z, et al. Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem. 2004;279(34):35510-35517.
    • (2004) J Biol Chem , vol.279 , Issue.34 , pp. 35510-35517
    • Feng, J.1    Tamaskovic, R.2    Yang, Z.3
  • 49
    • 0037099586 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Mdm2 by c-Abl: Implications for p53 regulation
    • Goldberg Z, Sionov RV, Berger M, et al. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 2002;21(14):3715-3727.
    • (2002) EMBO J , vol.21 , Issue.14 , pp. 3715-3727
    • Goldberg, Z.1    Sionov, R.V.2    Berger, M.3
  • 50
    • 22544433198 scopus 로고    scopus 로고
    • Phosphorylation of human p53 at Serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
    • Mayo LD, Seo YR, Jackson MW, et al. Phosphorylation of human p53 at Serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem. 2005;280(28):25953-25959.
    • (2005) J Biol Chem , vol.280 , Issue.28 , pp. 25953-25959
    • Mayo, L.D.1    Seo, Y.R.2    Jackson, M.W.3
  • 51
    • 77949261518 scopus 로고    scopus 로고
    • Daxx is reciprocally regulated by Mdm2 and Hausp
    • Tang J, Qu L, Pang M, Yang X. Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Resh Commun. 2010;393(3):542-545.
    • (2010) Biochem Biophys Resh Commun , vol.393 , Issue.3 , pp. 542-545
    • Tang, J.1    Qu, L.2    Pang, M.3    Yang, X.4
  • 52
    • 0346455772 scopus 로고    scopus 로고
    • Posttranslational modification of MDM2
    • Meek DW, Knippschild U. Posttranslational modification of MDM2. Mol Cancer Res. 2003;1(14):1017-1026.
    • (2003) Mol Cancer Res , vol.1 , Issue.14 , pp. 1017-1026
    • Meek, D.W.1    Knippschild, U.2
  • 53
    • 0036311067 scopus 로고    scopus 로고
    • Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
    • Migliorini D, Lazzerini DE, Danovi D, et al. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol. 2002;22(15):5527-5538.
    • (2002) Mol Cell Biol , vol.22 , Issue.15 , pp. 5527-5538
    • Migliorini, D.1    Lazzerini, D.E.2    Danovi, D.3
  • 54
    • 14644437751 scopus 로고    scopus 로고
    • MDM2 is a central node in the p53 pathway: 12 years and counting
    • Bond GL, Hu W, Levine AJ. MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets. 2005;5(1):3-8.
    • (2005) Curr Cancer Drug Targets , vol.5 , Issue.1 , pp. 3-8
    • Bond, G.L.1    Hu, W.2    Levine, A.J.3
  • 55
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res. 2005;65(5):1918-1924.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6
  • 56
    • 34548780897 scopus 로고    scopus 로고
    • Efficient p53 Activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
    • Hu B, Gilkes DM, Chen J. Efficient p53 Activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res. 2007;67(18):8810-8817.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8810-8817
    • Hu, B.1    Gilkes, D.M.2    Chen, J.3
  • 57
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
    • Wang H, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin Cancer Res. 2001;7(11):3613-3624.
    • (2001) Clin Cancer Res , vol.7 , Issue.11 , pp. 3613-3624
    • Wang, H.1    Nan, L.2    Yu, D.3    Agrawal, S.4    Zhang, R.5
  • 58
    • 14644410433 scopus 로고    scopus 로고
    • Novel antisense anti-MDM2 mixed-backbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms
    • Zhang R, Wang H, Agrawal S. Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms. Curr Cancer Drug Targets. 2005;5(1): 43-49.
    • (2005) Curr Cancer Drug Targets , vol.5 , Issue.1 , pp. 43-49
    • Zhang, R.1    Wang, H.2    Agrawal, S.3
  • 60
    • 41649102468 scopus 로고    scopus 로고
    • Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
    • Shangary S, Qin D, McEachern D, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A. 2008; 105(10):3933-3938.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.10 , pp. 3933-3938
    • Shangary, S.1    Qin, D.2    McEachern, D.3
  • 61
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Craves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004;303(5659):844-848.
    • (2004) Science , vol.303 , Issue.5659 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Craves, B.3
  • 62
    • 32444449180 scopus 로고    scopus 로고
    • Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
    • Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy. Proc Natl Acad Sci U S A. 2006;103(6):1888-1893.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.6 , pp. 1888-1893
    • Tovar, C.1    Rosinski, J.2    Filipovic, Z.3
  • 63
    • 44849091255 scopus 로고    scopus 로고
    • Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    • Kumamoto K, Spillare EA, Fujita K, et al. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 2008;68(9):3193-3203.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3193-3203
    • Kumamoto, K.1    Spillare, E.A.2    Fujita, K.3
  • 64
    • 51649129472 scopus 로고    scopus 로고
    • Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells
    • Maimets T, Neganova I, Armstrong L, Lako M. Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. Oncogene. 2008;27(40):5277-5287.
    • (2008) Oncogene , vol.27 , Issue.40 , pp. 5277-5287
    • Maimets, T.1    Neganova, I.2    Armstrong, L.3    Lako, M.4
  • 65
    • 43449131243 scopus 로고    scopus 로고
    • Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells
    • Elisa B, Federica C, Erika R, et al. Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. J Cell Biochem. 2008;104(2):595-605.
    • (2008) J Cell Biochem , vol.104 , Issue.2 , pp. 595-605
    • Elisa, B.1    Federica, C.2    Erika, R.3
  • 66
    • 34250669968 scopus 로고    scopus 로고
    • Inhibition of p53-murine double minute 2 interaction by nutlin-3a stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma
    • Drakos E, Thomaides A, Medeiros LJ, et al. Inhibition of p53-murine double minute 2 interaction by nutlin-3a stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma. Clin Cancer Res. 2007;13(11):3380-3387.
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3380-3387
    • Drakos, E.1    Thomaides, A.2    Medeiros, L.J.3
  • 67
    • 70350371736 scopus 로고    scopus 로고
    • Nutlin-3 affects expression and function of retinoblastoma protein
    • Du W, Wu J, Walsh EM, Zhang Y, Chen CY, Xiao Z-XJ. Nutlin-3 affects expression and function of retinoblastoma protein. J Biol Chem. 2009;284(39):26315-26321.
    • (2009) J Biol Chem , vol.284 , Issue.39 , pp. 26315-26321
    • Du, W.1    Wu, J.2    Walsh, E.M.3    Zhang, Y.4    Chen, C.Y.5    Xiao, Z.-X.J.6
  • 68
    • 33749433216 scopus 로고    scopus 로고
    • p53 family members in myogenic differentiation and rhabdomyosarcoma development
    • Cam H, Griesmann H, Beitzinger M, et al. p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell. 2006;10(4):281-293.
    • (2006) Cancer Cell , vol.10 , Issue.4 , pp. 281-293
    • Cam, H.1    Griesmann, H.2    Beitzinger, M.3
  • 69
    • 0036897835 scopus 로고    scopus 로고
    • A revised picture of the E2F transcriptional network and RB function
    • Stevaux O, Dyson NJ. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol. 2002;14(6):684-691.
    • (2002) Curr Opin Cell Biol , vol.14 , Issue.6 , pp. 684-691
    • Stevaux, O.1    Dyson, N.J.2
  • 70
    • 0037711783 scopus 로고    scopus 로고
    • The yin and yang of E2F-1: Balancing life and death
    • La Thangue NB. The yin and yang of E2F-1: balancing life and death. Nat Cell Biol. 2003;5(7):587-589.
    • (2003) Nat Cell Biol , vol.5 , Issue.7 , pp. 587-589
    • la Thangue, N.B.1
  • 71
    • 0030849455 scopus 로고    scopus 로고
    • Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation
    • Knudsen ES, Wang JY. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol Cell Biol. 1997;17(10):5771-5783.
    • (1997) Mol Cell Biol , vol.17 , Issue.10 , pp. 5771-5783
    • Knudsen, E.S.1    Wang, J.Y.2
  • 72
    • 51649088367 scopus 로고    scopus 로고
    • E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonistinduced apoptosis in human tumor cell lines
    • Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonistinduced apoptosis in human tumor cell lines. Oncogene. 2008;27: 5305-5314.
    • (2008) Oncogene , vol.27 , pp. 5305-5314
    • Kitagawa, M.1    Aonuma, M.2    Lee, S.H.3    Fukutake, S.4    McCormick, F.5
  • 73
  • 74
    • 70349999409 scopus 로고    scopus 로고
    • nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1{alpha}
    • Lee Y-M, Lim J-H, Chun Y-S, et al. nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1{alpha}. Carcinogenesis. 2009;30(10):1768-1775.
    • (2009) Carcinogenesis , vol.30 , Issue.10 , pp. 1768-1775
    • Lee, Y.-M.1    Lim, J.-H.2    Chun, Y.-S.3
  • 75
    • 0038529602 scopus 로고    scopus 로고
    • Direct interactions between HIF-1alpha and Mdm2 modulate p53 function
    • Chen D, Li M, Luo J, Gu W. Direct interactions between HIF-1alpha and Mdm2 modulate p53 function. J Biol Chem. 2003;278(16): 13595-13598.
    • (2003) J Biol Chem , vol.278 , Issue.16 , pp. 13595-13598
    • Chen, D.1    Li, M.2    Luo, J.3    Gu, W.4
  • 76
    • 0036468523 scopus 로고    scopus 로고
    • On the shoulders of giants: P63, p73 and the rise of p53
    • Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: p63, p73 and the rise of p53. Trends Gene. 2002;18(2):90-95.
    • (2002) Trends Gene , vol.18 , Issue.2 , pp. 90-95
    • Yang, A.1    Kaghad, M.2    Caput, D.3    McKeon, F.4
  • 77
    • 70350707752 scopus 로고    scopus 로고
    • The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting
    • Lunghi P, Costanzo A, Mazzera L, Rizzoli V, Levrero M, Bonati A. The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting. Clini Cancer Res. 2009;15(21):6495-6502.
    • (2009) Clini Cancer Res , vol.15 , Issue.21 , pp. 6495-6502
    • Lunghi, P.1    Costanzo, A.2    Mazzera, L.3    Rizzoli, V.4    Levrero, M.5    Bonati, A.6
  • 78
    • 10744230945 scopus 로고    scopus 로고
    • p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D, Gasco M, Hiller L, et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell. 2003;3(4):387-402.
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 387-402
    • Bergamaschi, D.1    Gasco, M.2    Hiller, L.3
  • 79
    • 0036125352 scopus 로고    scopus 로고
    • Role of p73 in malignancy: Tumor suppressor or oncogene?
    • Stiewe T, Pützer BM. Role of p73 in malignancy: tumor suppressor or oncogene? Cell Death Differ. 2002;9(3):237-245.
    • (2002) Cell Death Differ , vol.9 , Issue.3 , pp. 237-245
    • Stiewe, T.1    Pützer, B.M.2
  • 80
    • 0037119631 scopus 로고    scopus 로고
    • Delta}Np73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
    • Zaika AI, Slade N, Erster SH, et al. {Delta}Np73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med. 2002;196(6):765-780.
    • (2002) J Exp Med , vol.196 , Issue.6 , pp. 765-780
    • Zaika, A.I.1    Slade, N.2    Erster, S.H.3
  • 81
    • 33644859241 scopus 로고    scopus 로고
    • Delta}TAp73 upregulation correlates with poor prognosis in human tumors: Putative in vivo network involving p73 isoforms, p53, and E2F-1
    • Dominguez G, Garcia JM, Pena C, et al. {Delta}TAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1. J Clin Oncol. 2006; 24(5):805-815.
    • (2006) J Clin Oncol , vol.24 , Issue.5 , pp. 805-815
    • Dominguez, G.1    Garcia, J.M.2    Pena, C.3
  • 82
    • 14944363263 scopus 로고    scopus 로고
    • Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology
    • Rossi M, A ES, Alessandro T, Gerry M, Richard AK. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Ann N Y Acad Sci. 2004;1028:143-149.
    • (2004) Ann N Y Acad Sci , vol.1028 , pp. 143-149
    • Rossi, M.1    Es, A.2    Alessandro, T.3    Gerry, M.4    Richard, A.K.5
  • 83
    • 38949199337 scopus 로고    scopus 로고
    • HDM2 antagonist nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
    • Lau LMS, Nugent JK, Zhao X, Irwin MS. HDM2 antagonist nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene. 2007;27(17):997-1003.
    • (2007) Oncogene , vol.27 , Issue.17 , pp. 997-1003
    • Lau, L.M.S.1    Nugent, J.K.2    Zhao, X.3    Irwin, M.S.4
  • 84
    • 67649442533 scopus 로고    scopus 로고
    • The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73
    • Peirce S, Findley H. The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73. Int J Oncology. 2009;34(5):1395-1402.
    • (2009) Int J Oncology , vol.34 , Issue.5 , pp. 1395-1402
    • Peirce, S.1    Findley, H.2
  • 85
    • 66149120695 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma
    • Lau LMS, Wolter JK, Lau JTML, et al. Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. Oncogene. 2009;28(19):2024-2033.
    • (2009) Oncogene , vol.28 , Issue.19 , pp. 2024-2033
    • Lau, L.M.S.1    Wolter, J.K.2    Lau, J.T.M.L.3
  • 86
    • 35448932303 scopus 로고    scopus 로고
    • The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts
    • Secchiero P, Zerbinati C, Melloni E, et al. The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts. Neoplasia. 2007;9(10):853-861.
    • (2007) Neoplasia , vol.9 , Issue.10 , pp. 853-861
    • Secchiero, P.1    Zerbinati, C.2    Melloni, E.3
  • 87
    • 34249295787 scopus 로고    scopus 로고
    • Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma
    • Becker K, Marchenko N, Maurice M, Moll U. Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. Cell Death Differ. 2007;14(7):1350-1360.
    • (2007) Cell Death Differ , vol.14 , Issue.7 , pp. 1350-1360
    • Becker, K.1    Marchenko, N.2    Maurice, M.3    Moll, U.4
  • 88
    • 0035947731 scopus 로고    scopus 로고
    • Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma
    • Isaacs JS, Saito Si, Neckers LM. Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma. J Biol Chem. 2001; 276(21):18497-18506.
    • (2001) J Biol Chem , vol.276 , Issue.21 , pp. 18497-18506
    • Isaacs, J.S.1    Saito, S.I.2    Neckers, L.M.3
  • 89
    • 23944445607 scopus 로고    scopus 로고
    • MDM2 as MYCN transcriptional target: Implications for neuroblastoma pathogenesis
    • Slack A, Lozano G, Shohet JM. MDM2 as MYCN transcriptional target: Implications for neuroblastoma pathogenesis. Cancer Letters. 2005;228(1-2):21-27.
    • (2005) Cancer Letters , vol.228 , Issue.1-2 , pp. 21-27
    • Slack, A.1    Lozano, G.2    Shohet, J.M.3
  • 90
    • 25444433114 scopus 로고    scopus 로고
    • MDM2 as a critical effector of the MYCN oncogene in tumorigenesis
    • Slack A, Shohet J. MDM2 as a critical effector of the MYCN oncogene in tumorigenesis. Cell Cycle. 2005;4(7):857-860.
    • (2005) Cell Cycle , vol.4 , Issue.7 , pp. 857-860
    • Slack, A.1    Shohet, J.2
  • 91
    • 34047275615 scopus 로고    scopus 로고
    • MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells
    • Slack AD, Chen Z, Ludwig AD, Hicks J, Shohet JM. MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells. Cancer Res. 2007;67(6): 2448-2455.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2448-2455
    • Slack, A.D.1    Chen, Z.2    Ludwig, A.D.3    Hicks, J.4    Shohet, J.M.5
  • 92
    • 36849067514 scopus 로고    scopus 로고
    • p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma
    • Chen L MA, Wood KM, Cole M, et al. p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. Cell Cycle. 2007;6(21):2.
    • (2007) Cell Cycle , vol.6 , Issue.21 , pp. 2
    • Chen, L.M.A.1    Wood, K.M.2    Cole, M.3
  • 93
    • 33750346173 scopus 로고    scopus 로고
    • Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma
    • Van Maerken T, Speleman F, Vermeulen J, et al. Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma. Cancer Res. 2006;66(19):9646-9655.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9646-9655
    • van Maerken, T.1    Speleman, F.2    Vermeulen, J.3
  • 94
    • 58349112761 scopus 로고    scopus 로고
    • Reversal of P-glycoproteinmediated multidrug resistance by the murine double minute 2 antagonist nutlin-3
    • Michaelis M, Rothweiler F, Klassert D, et al. Reversal of P- glycoproteinmediated multidrug resistance by the murine double minute 2 antagonist nutlin-3. Cancer Res. 2009;69(2):416-421.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 416-421
    • Michaelis, M.1    Rothweiler, F.2    Klassert, D.3
  • 95
    • 70449727603 scopus 로고    scopus 로고
    • Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53
    • Van Maerken T, Ferdinande L, Taildeman J, et al. Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. J Natl Cancer Inst. 2009;101(22):1562-1574.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.22 , pp. 1562-1574
    • van Maerken, T.1    Ferdinande, L.2    Taildeman, J.3
  • 96
    • 0034685798 scopus 로고    scopus 로고
    • Induction of neuronal differentiation by p73 in a neuroblastoma cell line
    • De Laurenzi V, Raschellà G, Barcaroli D, et al. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem. 2000;275(20):15226-15231.
    • (2000) J Biol Chem , vol.275 , Issue.20 , pp. 15226-15231
    • de Laurenzi, V.1    Raschellã, G.2    Barcaroli, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.