Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma

Journal of Biological Chemistry

Volumn 276, Issue 21, 2001, Pages 18497-18506

  Isaacs, Jennifer S ^a   Saito, Shin'ichi ^b   Neckers, Leonard M ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DNA; ENZYME KINETICS; NEUROLOGY; PROTEINS; TOXICITY; TUMORS;

GENOTOXIC STRESSES; PHOSPHORYLATION;

BIOCHEMISTRY;

DOXORUBICIN; PROTEASOME; PROTEIN MDM2; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; TUMOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; WILD TYPE; CELL CULTURE; METABOLISM;

ANTINEOPLASTIC AGENTS; DOXORUBICIN; HUMANS; NEOPLASM PROTEINS; NEUROBLASTOMA; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035947731     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100638200     Document Type: Article

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