-
1
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein B., et al. Surfing the p53 network. Nature. 408:2000;307-310.
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
-
2
-
-
0001837570
-
Functions of the MDM2 oncoprotein
-
Freedman A., et al. Functions of the MDM2 oncoprotein. Cell. Mol. Life Sci. 55:1999;96-107.
-
(1999)
Cell. Mol. Life Sci.
, vol.55
, pp. 96-107
-
-
Freedman, A.1
-
3
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R., et al. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:1997;25-27.
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
-
4
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
Sakaguchi K., et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. Gene Dev. 12:1998;2831-2841.
-
(1998)
Gene Dev.
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
-
5
-
-
0033593199
-
Role for p300 in stabilization of p53 in the response to DNA damage
-
Yuan Z.M., et al. Role for p300 in stabilization of p53 in the response to DNA damage. J. Biol. Chem. 274:1999;1883-1886.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1883-1886
-
-
Yuan, Z.M.1
-
6
-
-
0037432773
-
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
-
Grossman S.R., et al. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science. 300:2003;342-344.
-
(2003)
Science
, vol.300
, pp. 342-344
-
-
Grossman, S.R.1
-
7
-
-
0037452725
-
Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
-
McCoy M.A., et al. Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation. Proc. Natl. Acad. Sci. U. S. A. 100:2003;1645-1648.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 1645-1648
-
-
McCoy, M.A.1
-
8
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S., et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281:1998;1674-1677.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
-
9
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh S.Y., et al. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14:2000;289-300.
-
(2000)
Genes Dev.
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
-
10
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh S.Y., et al. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91:1997;325-334.
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
-
11
-
-
0033523777
-
Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation
-
Craig A.L., et al. Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation. Oncogene. 18:1999;6305-6312.
-
(1999)
Oncogene
, vol.18
, pp. 6305-6312
-
-
Craig, A.L.1
-
12
-
-
85031157974
-
Questioning the role of Chk2 in the p53 DNA damage response
-
in press
-
Ahn, A. et al. Questioning the role of Chk2 in the p53 DNA damage response. J. Biol. Chem. (in press).
-
J. Biol. Chem.
-
-
Ahn, A.1
-
13
-
-
0034737438
-
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
-
Sakaguchi K., et al. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J. Biol. Chem. 275:2000;9278-9283.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9278-9283
-
-
Sakaguchi, K.1
-
14
-
-
0036407644
-
Molecular mechanism of the interaction between MDM2 and p53
-
Schon O., et al. Molecular mechanism of the interaction between MDM2 and p53. J. Mol. Biol. 323:2002;491-501.
-
(2002)
J. Mol. Biol.
, vol.323
, pp. 491-501
-
-
Schon, O.1
-
15
-
-
0035092598
-
Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300
-
Dornan D., Hupp T.R. Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300. EMBO Rep. 2:2001;139-144.
-
(2001)
EMBO Rep.
, vol.2
, pp. 139-144
-
-
Dornan, D.1
Hupp, T.R.2
-
16
-
-
0038508864
-
DNA-dependent acetylation of p53 by the transcription coactivator p300
-
Dornan D., et al. DNA-dependent acetylation of p53 by the transcription coactivator p300. J. Biol. Chem. 278:2003;13431-13441.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13431-13441
-
-
Dornan, D.1
-
17
-
-
0033567340
-
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 protein are modified in human cancers
-
Craig A.L., et al. Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 protein are modified in human cancers. Biochem. J. 342:1999;133-141.
-
(1999)
Biochem. J.
, vol.342
, pp. 133-141
-
-
Craig, A.L.1
-
18
-
-
0027258466
-
Thymocyte apoptosis induced by p53-dependent and independent pathways
-
Clarke A.R., et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
-
(1993)
Nature
, vol.362
, pp. 849-852
-
-
Clarke, A.R.1
-
19
-
-
0037112844
-
Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao I., et al. Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21:2002;6225-6235.
-
(2002)
EMBO J.
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
-
20
-
-
0035903157
-
Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization
-
Lai Z., et al. Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J. Biol. Chem. 276:2001;31357-31367.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31357-31367
-
-
Lai, Z.1
-
21
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Kussie P.H., et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science. 274:1996;948-953.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
-
22
-
-
0037047345
-
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
-
Shimizu H., et al. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J. Biol. Chem. 277:2002;28446-28458.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28446-28458
-
-
Shimizu, H.1
-
23
-
-
0030665146
-
Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
-
Mayo L.D., et al. Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res. 57:1997;5013-5016.
-
(1997)
Cancer Res.
, vol.57
, pp. 5013-5016
-
-
Mayo, L.D.1
-
24
-
-
0033604499
-
Active site-directed protein regulation
-
Kobe B., Kemp B.E. Active site-directed protein regulation. Nature. 402:1999;373-376.
-
(1999)
Nature
, vol.402
, pp. 373-376
-
-
Kobe, B.1
Kemp, B.E.2
-
26
-
-
0030348261
-
Intrasteric regulation of calmodulin-dependent protein kinases
-
Kemp B.E., et al. Intrasteric regulation of calmodulin-dependent protein kinases. Adv. Pharmacol. 36:1996;221-249.
-
(1996)
Adv. Pharmacol.
, vol.36
, pp. 221-249
-
-
Kemp, B.E.1
-
27
-
-
0032941139
-
Structural basis of autoregulation of phenylalanine hydroxylase
-
Kobe B., et al. Structural basis of autoregulation of phenylalanine hydroxylase. Nat. Struct. Biol. 6:1999;442-448.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 442-448
-
-
Kobe, B.1
-
28
-
-
0034881964
-
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
-
Espinosa J.M., Emerson B.M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell. 8:2001;57-69.
-
(2001)
Mol. Cell
, vol.8
, pp. 57-69
-
-
Espinosa, J.M.1
Emerson, B.M.2
-
29
-
-
0035694469
-
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
-
Barlev N.A., et al. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell. 8:2001;1243-1254.
-
(2001)
Mol. Cell
, vol.8
, pp. 1243-1254
-
-
Barlev, N.A.1
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