Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells

Cancer Letters

Volumn 287, Issue 1, 2010, Pages 98-108

  Hori, Takeshi ^a   Kondo, Takashi ^a   Kanamori, Masahiko ^a   Tabuchi, Yoshiaki ^b   Ogawa, Ryohei ^a   Zhao, Qing Li ^a   Ahmed, Kanwal ^a   Yasuda, Taketoshi ^a   Seki, Shoji ^a   Suzuki, Kayo ^a   Kimura, Tomoatsu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Apoptosis; DR5; MDM2; Nutlin 3; TRAIL

Indexed keywords

DEATH RECEPTOR 5; FLICE INHIBITORY PROTEIN; MESSENGER RNA; NUTLIN 3; PROTEIN BID; PROTEIN P53; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HCT116; COLON CANCER; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CELL SURVIVAL; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG SYNERGISM; HCT116 CELLS; HUMANS; IMIDAZOLES; METALLOPROTEASES; PIPERAZINES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 72049083694     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.06.002     Document Type: Article

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