-
1
-
-
0035881581
-
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines
-
Keshelava N, Zuo JJ, Chen P, et al. Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines. Cancer Res 2001;61:6185-93.
-
(2001)
Cancer Res
, vol.61
, pp. 6185-6193
-
-
Keshelava, N.1
Zuo, J.J.2
Chen, P.3
-
2
-
-
0027109075
-
Cancer. p53, guardian of the genome
-
Lane DP. Cancer. p53, guardian of the genome. Nature 1992;358: 15-6.
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
4
-
-
0027459198
-
mdm2 expression is induced by wild type p53 activity
-
Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J 1993;12:461-8.
-
(1993)
EMBO J
, vol.12
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
5
-
-
0029060657
-
Complex structure and regulation of the P16 (MTS1) locus
-
Stone S, Jiang P, Dayananth P, et al. Complex structure and regulation of the P16 (MTS1) locus. Cancer Res 1995;55:2988-94.
-
(1995)
Cancer Res
, vol.55
, pp. 2988-2994
-
-
Stone, S.1
Jiang, P.2
Dayananth, P.3
-
6
-
-
0033521621
-
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
-
Honda R, Yasuda H. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J 1999;18:22-7.
-
(1999)
EMBO J
, vol.18
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
8
-
-
0031771497
-
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
-
Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 1998;18:6457-73.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6457-6473
-
-
Robertson, K.D.1
Jones, P.A.2
-
9
-
-
0038444753
-
The p53 pathway and its inactivation in neuroblastoma
-
Tweddle DA, Pearson AD, Haber M, et al. The p53 pathway and its inactivation in neuroblastoma. Cancer Lett 2003;197:93-8.
-
(2003)
Cancer Lett
, vol.197
, pp. 93-98
-
-
Tweddle, D.A.1
Pearson, A.D.2
Haber, M.3
-
10
-
-
0035132847
-
Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line
-
Tweddle DA, Malcolm AJ, Bown N, Pearson AD, Lunec J. Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line. Cancer Res 2001;61:8-13.
-
(2001)
Cancer Res
, vol.61
, pp. 8-13
-
-
Tweddle, D.A.1
Malcolm, A.J.2
Bown, N.3
Pearson, A.D.4
Lunec, J.5
-
11
-
-
33644552409
-
Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse
-
Carr J, Bell E, Pearson AD, et al. Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse. Cancer Res 2006;66:2138-45.
-
(2006)
Cancer Res
, vol.66
, pp. 2138-2145
-
-
Carr, J.1
Bell, E.2
Pearson, A.D.3
-
12
-
-
0027239723
-
Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment
-
Brodeur GM, Pritchard J, Berthold F, et al. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 1993;11:1466-77.
-
(1993)
J Clin Oncol
, vol.11
, pp. 1466-1477
-
-
Brodeur, G.M.1
Pritchard, J.2
Berthold, F.3
-
13
-
-
0037601662
-
Quality assessment of genetic markers used for therapy stratification
-
Ambros IM, Benard J, Boavida M, et al. Quality assessment of genetic markers used for therapy stratification. J Clin Oncol 2003; 21:2077-84.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2077-2084
-
-
Ambros, I.M.1
Benard, J.2
Boavida, M.3
-
14
-
-
4143081483
-
Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
-
Lamont JM, McManamy CS, Pearson AD, Clifford SC, Ellison DW. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 2004;10:5482-93.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5482-5493
-
-
Lamont, J.M.1
McManamy, C.S.2
Pearson, A.D.3
Clifford, S.C.4
Ellison, D.W.5
-
15
-
-
33845965035
-
High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays
-
Carr J, Bown NP, Case MC, Hall AG, Lunec J, Tweddle DA. High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays. Cancer Genet Cytogenet 2007;172:127-38.
-
(2007)
Cancer Genet Cytogenet
, vol.172
, pp. 127-138
-
-
Carr, J.1
Bown, N.P.2
Case, M.C.3
Hall, A.G.4
Lunec, J.5
Tweddle, D.A.6
-
16
-
-
36849067514
-
p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma
-
Chen L, Malcolm AJ, Wood KM, et al. p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. Cell Cycle 2007;6:2685-96.
-
(2007)
Cell Cycle
, vol.6
, pp. 2685-2696
-
-
Chen, L.1
Malcolm, A.J.2
Wood, K.M.3
-
17
-
-
0028224658
-
Low frequency of the p53 gene mutations in neuroblastoma
-
Hosoi G, Hara J, Okamura T, et al. Low frequency of the p53 gene mutations in neuroblastoma. Cancer 1994;73:3087-93.
-
(1994)
Cancer
, vol.73
, pp. 3087-3093
-
-
Hosoi, G.1
Hara, J.2
Okamura, T.3
-
18
-
-
0027274781
-
Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification
-
Imamura J, Bartram CR, Berthold F, Harms D, Nakamura H, Koeffler HP. Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification. Cancer Res 1993;53:4053-8.
-
(1993)
Cancer Res
, vol.53
, pp. 4053-4058
-
-
Imamura, J.1
Bartram, C.R.2
Berthold, F.3
Harms, D.4
Nakamura, H.5
Koeffler, H.P.6
-
20
-
-
0035187023
-
p16/p14 (ARF) cell cycle regulatory pathways in primary neuroblastoma: P16 expression is associated with advanced stage disease
-
Omura-Minamisawa M, Diccianni MB, Chang RC, et al. p16/p14 (ARF) cell cycle regulatory pathways in primary neuroblastoma: p16 expression is associated with advanced stage disease. Clin Cancer Res 2001;7:3481-90.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3481-3490
-
-
Omura-Minamisawa, M.1
Diccianni, M.B.2
Chang, R.C.3
-
21
-
-
0029013621
-
Role of cysteine residues in regulation of p53 function
-
Rainwater R, Parks D, Anderson ME, Tegtmeyer P, Mann K. Role of cysteine residues in regulation of p53 function. Mol Cell Biol 1995;15: 3892-903.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3892-3903
-
-
Rainwater, R.1
Parks, D.2
Anderson, M.E.3
Tegtmeyer, P.4
Mann, K.5
-
22
-
-
0037418548
-
Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain
-
Butler JS, Loh SN. Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain. Biochemistry 2003;42: 2396-403.
-
(2003)
Biochemistry
, vol.42
, pp. 2396-2403
-
-
Butler, J.S.1
Loh, S.N.2
-
23
-
-
0026569818
-
Clonal expansion of p53 mutant cells is associated with brain tumour progression
-
Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavanee W, Vogelstein B. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 1992;355:846-7.
-
(1992)
Nature
, vol.355
, pp. 846-847
-
-
Sidransky, D.1
Mikkelsen, T.2
Schwechheimer, K.3
Rosenblum, M.L.4
Cavanee, W.5
Vogelstein, B.6
-
24
-
-
0033592666
-
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor
-
Ishii N, Tada M, Hamou MF, et al. Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor. Oncogene 1999;18:5870-8.
-
(1999)
Oncogene
, vol.18
, pp. 5870-5878
-
-
Ishii, N.1
Tada, M.2
Hamou, M.F.3
-
25
-
-
0029967254
-
Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells
-
Pollock RE, Lang A, Luo J, El-Naggar AK, Yu D. Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells. Oncogene 1996;12:2035-9.
-
(1996)
Oncogene
, vol.12
, pp. 2035-2039
-
-
Pollock, R.E.1
Lang, A.2
Luo, J.3
El-Naggar, A.K.4
Yu, D.5
-
26
-
-
0027976389
-
Clonal expansion of p53 mutant cells in leukemia progression in vitro
-
Wada H, Asada M, Nakazawa S, et al. Clonal expansion of p53 mutant cells in leukemia progression in vitro. Leukemia 1994;8:53-9.
-
(1994)
Leukemia
, vol.8
, pp. 53-59
-
-
Wada, H.1
Asada, M.2
Nakazawa, S.3
-
27
-
-
0032803707
-
Emergence of p53 mutant cisplatin-resistant ovarian carcinoma cells following drug exposure: Spontaneously mutant selection
-
Righetti SC, Perego P, Corna E, Pierotti MA, Zunino F. Emergence of p53 mutant cisplatin-resistant ovarian carcinoma cells following drug exposure: spontaneously mutant selection. Cell Growth Differ 1999; 10:473-8.
-
(1999)
Cell Growth Differ
, vol.10
, pp. 473-478
-
-
Righetti, S.C.1
Perego, P.2
Corna, E.3
Pierotti, M.A.4
Zunino, F.5
-
28
-
-
0037022606
-
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
-
de Vries A, Flores ER, Miranda B, et al. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A 2002;99:2948-53.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 2948-2953
-
-
de Vries, A.1
Flores, E.R.2
Miranda, B.3
-
29
-
-
34250334567
-
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage
-
Wijnhoven SW, Speksnijder EN, Liu X, et al. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res 2007;67:4648-56.
-
(2007)
Cancer Res
, vol.67
, pp. 4648-4656
-
-
Wijnhoven, S.W.1
Speksnijder, E.N.2
Liu, X.3
-
30
-
-
35948967957
-
p53 determines multidrug sensitivity of childhood neuroblastoma
-
Xue C, Haber M, Flemming C, et al. p53 determines multidrug sensitivity of childhood neuroblastoma. Cancer Res 2007;67:10351-60.
-
(2007)
Cancer Res
, vol.67
, pp. 10351-10360
-
-
Xue, C.1
Haber, M.2
Flemming, C.3
-
31
-
-
7144250518
-
Role of a p53 polymorphism in the development of human papillomavirus-associated cancer
-
Storey A, Thomas M, Kalita A, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998;393:229-34.
-
(1998)
Nature
, vol.393
, pp. 229-234
-
-
Storey, A.1
Thomas, M.2
Kalita, A.3
-
32
-
-
0037372005
-
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
-
Dumont P, Leu JI, Della Pietra AC III, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 2003;33:357-65.
-
(2003)
Nat Genet
, vol.33
, pp. 357-365
-
-
Dumont, P.1
Leu, J.I.2
Della Pietra III, A.C.3
George, D.L.4
Murphy, M.5
-
33
-
-
5144225768
-
Positional gene expression analysis identifies 12q overexpression and amplification in a subset of neuroblastomas
-
Su WT, Alaminos M, Mora J, Cheung NK, La Quaglia MP, Gerald WL. Positional gene expression analysis identifies 12q overexpression and amplification in a subset of neuroblastomas. Cancer Genet Cytogenet 2004;154:131-7.
-
(2004)
Cancer Genet Cytogenet
, vol.154
, pp. 131-137
-
-
Su, W.T.1
Alaminos, M.2
Mora, J.3
Cheung, N.K.4
La Quaglia, M.P.5
Gerald, W.L.6
-
34
-
-
33751092280
-
Oligonucleotide array-based comparative genomic hybridization (aCGH) of 90 neuroblastomas reveals aberration patterns closely associated with relapse pattern and outcome
-
Spitz R, Oberthuer A, Zapatka M, et al. Oligonucleotide array-based comparative genomic hybridization (aCGH) of 90 neuroblastomas reveals aberration patterns closely associated with relapse pattern and outcome. Genes Chromosomes Cancer 2006;45:1130-42.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 1130-1142
-
-
Spitz, R.1
Oberthuer, A.2
Zapatka, M.3
-
35
-
-
50349103248
-
Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: Results of a pilot study on 239 patients
-
Cattelani S, Defferrari R, Marsilio S, et al. Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients. Clin Cancer Res 2008;14:3248-53.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3248-3253
-
-
Cattelani, S.1
Defferrari, R.2
Marsilio, S.3
-
36
-
-
69849106415
-
MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma
-
Perfumo C, Parodi S, Mazzocco K, et al. MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma. Pediatr Blood Cancer 2009;53:576-83.
-
(2009)
Pediatr Blood Cancer
, vol.53
, pp. 576-583
-
-
Perfumo, C.1
Parodi, S.2
Mazzocco, K.3
-
37
-
-
0037784207
-
Aberrant methylation of multiple genes in neuroblastic tumours. Relationship with MYCN amplification and allelic status at 1p
-
Gonzalez-Gomez P, Bello MJ, Lomas J, et al. Aberrant methylation of multiple genes in neuroblastic tumours. Relationship with MYCN amplification and allelic status at 1p. Eur J Cancer 2003;39:1478-85.
-
(2003)
Eur J Cancer
, vol.39
, pp. 1478-1485
-
-
Gonzalez-Gomez, P.1
Bello, M.J.2
Lomas, J.3
-
38
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
39
-
-
9244241061
-
Lack of evidence for mutations or deletions in the CDKN2A/p16 and CDKN2B/p15 genes of Brazilian neuroblastoma patients
-
Bassi CL, Martelli L, Cipolotti R, Scrideli CA, Defavery R, Tone LG. Lack of evidence for mutations or deletions in the CDKN2A/p16 and CDKN2B/p15 genes of Brazilian neuroblastoma patients. Braz J Med Biol Res 2004;37:1683-7.
-
(2004)
Braz J Med Biol Res
, vol.37
, pp. 1683-1687
-
-
Bassi, C.L.1
Martelli, L.2
Cipolotti, R.3
Scrideli, C.A.4
Defavery, R.5
Tone, L.G.6
-
40
-
-
1842339876
-
Mutational analysis of the p16 gene in human neuroblastomas
-
Castresana JS, Gomez L, Garcia-Miguel P, Queizan A, Pestana A. Mutational analysis of the p16 gene in human neuroblastomas. Mol Carcinog 1997;18:129-33.
-
(1997)
Mol Carcinog
, vol.18
, pp. 129-133
-
-
Castresana, J.S.1
Gomez, L.2
Garcia-Miguel, P.3
Queizan, A.4
Pestana, A.5
-
41
-
-
0029943442
-
The p16 and p18 tumor suppressor genes in neuroblastoma: Implications for drug resistance
-
Diccianni MB, Chau LS, Batova A, Vu TQ, Yu AL. The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance. Cancer Lett 1996;104:183-92.
-
(1996)
Cancer Lett
, vol.104
, pp. 183-192
-
-
Diccianni, M.B.1
Chau, L.S.2
Batova, A.3
Vu, T.Q.4
Yu, A.L.5
-
42
-
-
0035863312
-
Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
-
Thompson PM, Maris JM, Hogarty MD, et al. Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma. Cancer Res 2001;61:679-86.
-
(2001)
Cancer Res
, vol.61
, pp. 679-686
-
-
Thompson, P.M.1
Maris, J.M.2
Hogarty, M.D.3
-
43
-
-
67650457657
-
Mdm2 deficiency suppresses MYCN-driven neuroblastoma tumorigenesis in vivo
-
Chen Z, Lin Y, Barbieri E, et al. Mdm2 deficiency suppresses MYCN-driven neuroblastoma tumorigenesis in vivo. Neoplasia 2009;11:753-62.
-
(2009)
Neoplasia
, vol.11
, pp. 753-762
-
-
Chen, Z.1
Lin, Y.2
Barbieri, E.3
-
44
-
-
33750346173
-
Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma
-
Van Maerken T, Speleman F, Vermeulen J, et al. Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma. Cancer Res 2006;66:9646-55.
-
(2006)
Cancer Res
, vol.66
, pp. 9646-9655
-
-
Van Maerken, T.1
Speleman, F.2
Vermeulen, J.3
-
45
-
-
33749564973
-
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
-
Barbieri E, Mehta P, Chen Z, et al. MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death. Mol Cancer Ther 2006;5:2358-65.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2358-2365
-
-
Barbieri, E.1
Mehta, P.2
Chen, Z.3
-
46
-
-
70449727603
-
Antitumor activity of the selective MDM2 antagonist Nutlin-3 against chemoresistant neuroblastoma with wild-type p53
-
Van Maerken T, Ferdinande L, Taildeman J, et al. Antitumor activity of the selective MDM2 antagonist Nutlin-3 against chemoresistant neuroblastoma with wild-type p53. J Natl Cancer Inst 2009;101: 1562-74.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1562-1574
-
-
Van Maerken, T.1
Ferdinande, L.2
Taildeman, J.3
-
47
-
-
40749114771
-
High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: A randomised trial
-
Pearson AD, Pinkerton CR, Lewis IJ, Imeson J, Ellershaw C, Machin D. High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. Lancet Oncol 2008;9:247-56.
-
(2008)
Lancet Oncol
, vol.9
, pp. 247-256
-
-
Pearson, A.D.1
Pinkerton, C.R.2
Lewis, I.J.3
Imeson, J.4
Ellershaw, C.5
Machin, D.6
-
48
-
-
0035171143
-
OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age
-
Tweddle DA, Pinkerton CR, Lewis IJ, Ellershaw C, Cole M, Pearson AD. OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age. Med Pediatr Oncol 2001;36:239-42.
-
(2001)
Med Pediatr Oncol
, vol.36
, pp. 239-242
-
-
Tweddle, D.A.1
Pinkerton, C.R.2
Lewis, I.J.3
Ellershaw, C.4
Cole, M.5
Pearson, A.D.6
-
49
-
-
0035174256
-
N7:a novel multimodality therapy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age
-
Cheung NK, Kushner BH, LaQuaglia M, et al. N7:a novel multimodality therapy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age. Med Pediatr Oncol 2001;36:227-30.
-
(2001)
Med Pediatr Oncol
, vol.36
, pp. 227-230
-
-
Cheung, N.K.1
Kushner, B.H.2
LaQuaglia, M.3
-
50
-
-
0037767946
-
Long-term results and risk profiles of patients in five consecutive trials (1979-1997) with stage 4 neuroblastoma over 1 year of age
-
Berthold F, Hero B, Kremens B, et al. Long-term results and risk profiles of patients in five consecutive trials (1979-1997) with stage 4 neuroblastoma over 1 year of age. Cancer Lett 2003;197:11-7.
-
(2003)
Cancer Lett
, vol.197
, pp. 11-17
-
-
Berthold, F.1
Hero, B.2
Kremens, B.3
|