Live cell monitoring of μ-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors

Journal of Biological Chemistry

Volumn 282, Issue 37, 2007, Pages 27126-27132

  Nikolaev, Viacheslav O ^a   Boettcher, Chotima ^b,c   Dees, Christian ^a   Bünemann, Moritz ^a   Lohse, Martin J ^a   Zenk, Meinhart H ^b,c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MONITORING; FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); G-PROTEIN ACTIVATION; MORPHINE BIOSYNTHETIC PRECURSORS;

BINDING SITES; BIOACTIVITY; BIOSYNTHESIS; CELL MEMBRANES; ENERGY TRANSFER; MAMMALS;

PROTEINS;

CODEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; ORIPAVINE; RETICULINE; SALUTARIDIN; SALUTARIDINOL; THEBAINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; ENZYME ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MORPHINE; RECEPTORS, OPIOID, MU;

ANIMALIA; MAMMALIA;

EID: 34848863094     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703272200     Document Type: Article

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