메뉴 건너뛰기




Volumn 7, Issue 9, 2010, Pages 694-706

Recent advancement in the field of anticonvulsants: A review

Author keywords

Anticonvulsant agent; Epilepsy; Maximal electroshock seizure; Pentylenetetrazole

Indexed keywords

1 PHENYLPIPERAZINE; 3 CHLORO 2 METHYLPHENYL; 4 AMINOBENZANILIDE DERIVATIVE; 4 HYDROXYBUTYRIC ACID; ACETAZOLAMIDE; AMIDE; AMINO ACID DERIVATIVE; ANTICONVULSIVE AGENT; CAPROLACTAM; CARBONATE DEHYDRATASE INHIBITOR; INDOLE DERIVATIVE; ISOINDOLINEDIONE DERIVATIVE; ISOINDOLINONE; ISOTRYPTAMINE DERIVATIVE; LACTAM; METHAZOLAMIDE; QUINAZOLIN 4(3H) ONE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; SEMICARBAZONE; SEMICARBAZONE DERIVATIVE; SEROTONIN; TETRAHYDROISOQUINOLINE; TOPIRAMATE; TRYPTAMINE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG; ZONISAMIDE;

EID: 77958505561     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018010792929487     Document Type: Article
Times cited : (9)

References (109)
  • 1
    • 43149120671 scopus 로고    scopus 로고
    • Proceedings of the National Academy of Sciences, USA
    • Prinz, A.A. In Understanding epilepsy through network modeling, Proceedings of the National Academy of Sciences, USA, 2008; 105(16), pp. 5953-5954.
    • (2008) Understanding Epilepsy Through Network Modeling , vol.105 , Issue.16 , pp. 5953-5954
    • Prinz, A.A.1
  • 2
    • 0034954068 scopus 로고    scopus 로고
    • Major system toxicities and side effects of anticonvulsants
    • Swann, A.C. Major system toxicities and side effects of anticonvulsants. J. Clin. Psychiatry, 2001, 62(14), 16-21.
    • (2001) J. Clin. Psychiatry , vol.62 , Issue.14 , pp. 16-21
    • Swann, A.C.1
  • 3
    • 0034840412 scopus 로고    scopus 로고
    • Adverse effects of antiepileptic drugs on bone structure: Epidemiology, mechanisms and therapeutic implications
    • Pack, A.M.; Morrell, M.J. Adverse effects of antiepileptic drugs on bone structure: Epidemiology, mechanisms and therapeutic implications. CNS Drugs, 2001, 15(8), 633-642(10).
    • (2001) CNS Drugs , vol.15 , Issue.8 , pp. 633-642
    • Pack, A.M.1    Morrell, M.J.2
  • 4
    • 0001592694 scopus 로고
    • Laidlaw J, Richens A, Chadwick D, Ed.; A Textbook of Epilepsy. Churchill Livingston: Edinburgh
    • Richens, A.; Perucca, E. In Clinical pharmacology and medical treatment; Laidlaw J, Richens A, Chadwick D, Ed.; A Textbook of Epilepsy. Churchill Livingston: Edinburgh, 1993; pp. 495-559.
    • (1993) Clinical Pharmacology and Medical Treatment , pp. 495-559
    • Richens, A.1    Perucca, E.2
  • 5
    • 0022565563 scopus 로고
    • Anticonvulsant drugs: Mechanisms of action
    • Macdonald, R.L.; McLean, M.J. Anticonvulsant drugs: Mechanisms of action. Adv. Neurol, 1986, 44, 713-736.
    • (1986) Adv. Neurol , vol.44 , pp. 713-736
    • Macdonald, R.L.1    McLean, M.J.2
  • 7
    • 0029057901 scopus 로고
    • Antiepilaptic drug mechanism of action
    • Macdonald, R.L.; Kelly, K.M. Antiepilaptic drug mechanism of action. Epilapsia, 1995, 36, S2-S12.
    • (1995) Epilapsia , vol.36
    • Macdonald, R.L.1    Kelly, K.M.2
  • 9
    • 0028220347 scopus 로고
    • Strategies in antiepileptic drug development: Is rational drug design superior to random drug screening and structural variation
    • Loscher, W.; Schmidt, D. Strategies in antiepileptic drug development: Is rational drug design superior to random drug screening and structural variation? Epilepsy Res., 1994, 17, 95-134.
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Loscher, W.1    Schmidt, D.2
  • 10
    • 0036202214 scopus 로고    scopus 로고
    • Effect of antiepileptic drugs on cognitive function in individuals with epilepsy: A comparative review of newer versus older agents
    • Brunbech, L.; Sabers, A. Effect of antiepileptic drugs on cognitive function in individuals with epilepsy: A comparative review of newer versus older agents. Drugs, 2002, 62(4), 593-604.
    • (2002) Drugs , vol.62 , Issue.4 , pp. 593-604
    • Brunbech, L.1    Sabers, A.2
  • 11
    • 33646911656 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs: Innovative strategies
    • Löscher, W.; Schmidt, D. New horizons in the development of antiepileptic drugs: Innovative strategies. Epilepsy Res., 2006, 69(3), 183-272.
    • (2006) Epilepsy Res , vol.69 , Issue.3 , pp. 183-272
    • Löscher, W.1    Schmidt, D.2
  • 12
    • 0026593032 scopus 로고
    • Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats
    • Dailey, J.W.; Mishra, P.K.; Ko, K.H.; Penny, J.E.; Jobe, P.C. Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Life Sci., 1992, 50, 319-326.
    • (1992) Life Sci , vol.50 , pp. 319-326
    • Dailey, J.W.1    Mishra, P.K.2    Ko, K.H.3    Penny, J.E.4    Jobe, P.C.5
  • 13
    • 0027958856 scopus 로고
    • Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats
    • Yan, Q.S.; Jobe, P.C; Cheong, J.H.; Ko, K.H.; Dailey, J.W. Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. Naunyn-Schmiedebergs Arch. Pharmacol, 1994, 350, 149-152.
    • (1994) Naunyn-Schmiedebergs Arch. Pharmacol , vol.350 , pp. 149-152
    • Yan, Q.S.1    Jobe, P.C.2    Cheong, J.H.3    Ko, K.H.4    Dailey, J.W.5
  • 14
    • 84965089022 scopus 로고
    • Anticonvulsant compounds and 5-hydroxytryptamine in rat brain
    • Bonnycastle, D.D.; Giarman, N.J.; Paasonen, M.K. Anticonvulsant compounds and 5-hydroxytryptamine in rat brain. Br. J. Pharmacol, 1957, 12, 228-231.
    • (1957) Br. J. Pharmacol , vol.12 , pp. 228-231
    • Bonnycastle, D.D.1    Giarman, N.J.2    Paasonen, M.K.3
  • 16
    • 0842299485 scopus 로고    scopus 로고
    • 2C Receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy
    • Jakus, R.; Graf, M.; Juhasz, G.; Gerber, K.; Levay, G.; Halasz, P.; Bagdy, G. 5-HT2C Receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy. Exp. Neurol, 2003, 184, 964-972.
    • (2003) Exp. Neurol , vol.184 , pp. 964-972
    • Jakus, R.1    Graf, M.2    Juhasz, G.3    Gerber, K.4    Levay, G.5    Halasz, P.6    Bagdy, G.7
  • 17
    • 0033548027 scopus 로고    scopus 로고
    • A serotonin-1A receptor agonist and N-methyl-D-aspartate receptor antagonist oppose each other's effects in a genetic rat epilepsy model
    • Filakovszky, J.; Gerber, K.; Bagdy, G. A serotonin-1A receptor agonist and N-methyl-D-aspartate receptor antagonist oppose each other's effects in a genetic rat epilepsy model. Neurosci. Lett., 1999, 261, 89-92.
    • (1999) Neurosci. Lett , vol.261 , pp. 89-92
    • Filakovszky, J.1    Gerber, K.2    Bagdy, G.3
  • 18
    • 0035372334 scopus 로고    scopus 로고
    • 8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance
    • Filakovszky, J.; Kantor, S.; Halasz, P.; Bagdy, G. 8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance. Neurochem. Int., 2001, 38, 551-556.
    • (2001) Neurochem. Int , vol.38 , pp. 551-556
    • Filakovszky, J.1    Kantor, S.2    Halasz, P.3    Bagdy, G.4
  • 22
    • 13444272080 scopus 로고    scopus 로고
    • 2C receptors as a potential therapeutic target for the design antiepileptic drugs
    • Isaac, M. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Curr. Top. Med. Chem., 2005, 5, 59-67.
    • (2005) Curr. Top. Med. Chem , vol.5 , pp. 59-67
    • Isaac, M.1
  • 23
    • 33745746948 scopus 로고    scopus 로고
    • 2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro [4.4] nonane and [4.5] decane-1, 3-dione
    • Obniska, J.; Kolaczkowski, M.; Bojarski, A.J.; Duszyhska, B. Synthesis, anticonvulsant activity and 5-HT1A, 5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro [4.4] nonane and [4.5] decane-1, 3-dione. Eur. J. Med. Chem., 2006, 41(7), 874-881.
    • (2006) Eur. J. Med. Chem , vol.41 , Issue.7 , pp. 874-881
    • Obniska, J.1    Kolaczkowski, M.2    Bojarski, A.J.3    Duszyhska, B.4
  • 24
    • 0242551675 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione
    • Obniska, J.; Zagorska, A. Synthesis and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl)-methyl] derivatives of 3-aryl pyrrolidine-2,5-dione and 2-aza-spiro[4.4]nonane-1,3-dione. IlFarmaco, 2003, 58(12), 1227-1234.
    • (2003) IlFarmaco , vol.58 , Issue.12 , pp. 1227-1234
    • Obniska, J.1    Zagorska, A.2
  • 25
    • 33745812748 scopus 로고    scopus 로고
    • Synthesis and structural characterization of N-benzoyl-tryptamine and its new analogue N-salicyloyltryptamine, A potential anticonvulsant agent
    • Oliveira, F.A.; Silva, D.A.; Quintans-Junior, L.J.; Gutierrez, S.J.C; Almeida, R.N.; Barbosa-Filho, J.M.; Souza, M.F.V. Synthesis and structural characterization of N-benzoyl-tryptamine and its new analogue N-salicyloyltryptamine, A potential anticonvulsant agent. J. Chil Chem. Soc, 2006, 51(2), 919-922.
    • (2006) J. Chil Chem. Soc , vol.51 , Issue.2 , pp. 919-922
    • Oliveira, F.A.1    Silva, D.A.2    Quintans-Junior, L.J.3    Gutierrez, S.J.C.4    Almeida, R.N.5    Barbosa-Filho, J.M.6    Souza, M.F.V.7
  • 26
    • 0025349117 scopus 로고
    • Comparative anticonvulsant activity of 4-chlorobenzene sulfonamide and prototype antiepileptic drugs in rodents
    • Clark, C.R.; McMillian, C.L. Comparative anticonvulsant activity of 4-chlorobenzene sulfonamide and prototype antiepileptic drugs in rodents. Epilepsia, 1990, 31(4), 474-479.
    • (1990) Epilepsia , vol.31 , Issue.4 , pp. 474-479
    • Clark, C.R.1    McMillian, C.L.2
  • 27
    • 37349003751 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of some N-phenyl-2-phtalimidoethanesulfonamide derivatives
    • Akgul, O.; Kilic, F.S.; Erol, K.; Pabuccuoglu, V. Synthesis and anticonvulsant activity of some N-phenyl-2-phtalimidoethanesulfonamide derivatives. Arch. Pharm., 2007, 340(12), 656-660.
    • (2007) Arch. Pharm , vol.340 , Issue.12 , pp. 656-660
    • Akgul, O.1    Kilic, F.S.2    Erol, K.3    Pabuccuoglu, V.4
  • 28
    • 0029886374 scopus 로고    scopus 로고
    • Synthesis and evaluation of N-(phenylacetyl) trifluoromethane sulfonamides as anticonvulsant
    • Flaherty, A.P.T.; Greenwood, T.D.; Manheim, A.L.; Wolfe, J.F. Synthesis and evaluation of N-(phenylacetyl) trifluoromethane sulfonamides as anticonvulsant. J. Med. Chem., 1996, 39, 1509-1513.
    • (1996) J. Med. Chem , vol.39 , pp. 1509-1513
    • Flaherty, A.P.T.1    Greenwood, T.D.2    Manheim, A.L.3    Wolfe, J.F.4
  • 30
    • 2142808112 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity
    • Ilies, M.A.; Masereel, B.; Rolin, S.; Scozzafava, A.; Câmpeanu, G.; Cîmpeanu, V.; Supuran, C.T. Carbonic anhydrase inhibitors: Aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. Bioorg. Med. Chem., 2004, 12(10), 2717-2726.
    • (2004) Bioorg. Med. Chem , vol.12 , Issue.10 , pp. 2717-2726
    • Ilies, M.A.1    Masereel, B.2    Rolin, S.3    Scozzafava, A.4    Câmpeanu, G.5    Cîmpeanu, V.6    Supuran, C.T.7
  • 31
    • 77952708293 scopus 로고    scopus 로고
    • Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide
    • Hen, N.; Bialer, M.; Wlodarczyk, B.; Finnell, R.H.; Yagen, B. Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide. J. Med. Chem., 2010, 53, 4177-4186.
    • (2010) J. Med. Chem , vol.53 , pp. 4177-4186
    • Hen, N.1    Bialer, M.2    Wlodarczyk, B.3    Finnell, R.H.4    Yagen, B.5
  • 32
    • 0033984914 scopus 로고    scopus 로고
    • Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice
    • Sarro, G.D.; Gratteri, S.; Bonacci, F.; Musumeci, S.A.; Elia, M.; Sarro, A.D. Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice. Eur. J. Pharmacol, 2000, 388(2), 163-170.
    • (2000) Eur. J. Pharmacol , vol.388 , Issue.2 , pp. 163-170
    • Sarro, G.D.1    Gratteri, S.2    Bonacci, F.3    Musumeci, S.A.4    Elia, M.5    Sarro, A.D.6
  • 33
    • 0038666152 scopus 로고    scopus 로고
    • Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy
    • Borowicz, K.K.; Luszczki, J.J.; Duda, A.M.; Czuczwar, S.J. Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsy. Epilepsia, 2003, 44(5), 640-646.
    • (2003) Epilepsia , vol.44 , Issue.5 , pp. 640-646
    • Borowicz, K.K.1    Luszczki, J.J.2    Duda, A.M.3    Czuczwar, S.J.4
  • 34
    • 0032487644 scopus 로고    scopus 로고
    • Multiple actions of the novel anticonvulsant drug topiramate in the rat subiculum
    • Kawasaki, H.; Tancredi, V.; D'Arcangelo, G.; Avoli, M. Multiple actions of the novel anticonvulsant drug topiramate in the rat subiculum In-vitro. Brain Res., 1998, 807, 125-134.
    • (1998) In-vitro. Brain Res , vol.807 , pp. 125-134
    • Kawasaki, H.1    Tancredi, V.2    D'arcangelo, G.3    Avoli, M.4
  • 35
    • 0037122779 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties
    • Masereel, B.; Rolin, S.; Abbate, F.; Scozzafava, A.; Supuran, C.T. Carbonic anhydrase inhibitors: Anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J. Med. Chem., 2002, 45, 312-320.
    • (2002) J. Med. Chem , vol.45 , pp. 312-320
    • Masereel, B.1    Rolin, S.2    Abbate, F.3    Scozzafava, A.4    Supuran, C.T.5
  • 37
    • 0023115854 scopus 로고
    • Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy
    • Conley, J.D.; Kohn, H. Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy. J. Med. Chem., 1987, 30, 567-574.
    • (1987) J. Med. Chem , vol.30 , pp. 567-574
    • Conley, J.D.1    Kohn, H.2
  • 38
    • 0023690669 scopus 로고
    • Marked stereo specificity in a new class of anticonvulsants
    • Kohn, H.; Conley, J.D.; Leander, J.D. Marked stereo specificity in a new class of anticonvulsants. Brain Res., 1988, 457, 371-375.
    • (1988) Brain Res , vol.457 , pp. 371-375
    • Kohn, H.1    Conley, J.D.2    Leander, J.D.3
  • 39
    • 0025238774 scopus 로고
    • Preparation and anticonvulsant activity of a series of functionalized a-aromatic and α-heteroaromatic amino acids
    • Kohn, H.; Sawhney, K.N.; LeGall, P.; Conley, J.D.; Robertson, D.W.; Leander, J.D. Preparation and anticonvulsant activity of a series of functionalized a-aromatic and α-heteroaromatic amino acids. J. Med. Chem., 1990, 33, 919-926.
    • (1990) J. Med. Chem , vol.33 , pp. 919-926
    • Kohn, H.1    Sawhney, K.N.2    Legall, P.3    Conley, J.D.4    Robertson, D.W.5    Leander, J.D.6
  • 40
    • 0026077751 scopus 로고
    • Preparation and anticonvulsant activity of a series of functionalized a-heteroaromatic-substituted amino acids
    • Kohn, H.; Sawhney, K.N.; LeGall, P.; Robertson, D.W.; Leander, J.D. Preparation and anticonvulsant activity of a series of functionalized a-heteroaromatic-substituted amino acids. J. Med. Chem., 1991, 34, 2444-2452.
    • (1991) J. Med. Chem , vol.34 , pp. 2444-2452
    • Kohn, H.1    Sawhney, K.N.2    Legall, P.3    Robertson, D.W.4    Leander, J.D.5
  • 41
    • 0027443545 scopus 로고
    • Synthesis and anticonvulsant activities of α-heteroaromatic- α-acetamido-N-benzylacetamide derivatives
    • Kohn, H.; Sawhney, K.H.; Bardel, P.; Robertson, D.W.; Leander, J.D. Synthesis and anticonvulsant activities of α-heteroaromatic- α-acetamido-N-benzylacetamide derivatives. J. Med. Chem., 1993, 36, 3350-3360.
    • (1993) J. Med. Chem , vol.36 , pp. 3350-3360
    • Kohn, H.1    Sawhney, K.H.2    Bardel, P.3    Robertson, D.W.4    Leander, J.D.5
  • 42
    • 0028579819 scopus 로고
    • Synthesis and anticonvulsant activities of a-acetamido-N-benzylacetamide derivatives containing an electron-deficient a-heteroaromatic substituent
    • Bardel, P.; Bolanos, A.; Kohn, H. Synthesis and anticonvulsant activities of a-acetamido-N-benzylacetamide derivatives containing an electron-deficient a-heteroaromatic substituent. J. Med. Chem., 1994, 37, 4567-4571.
    • (1994) J. Med. Chem , vol.37 , pp. 4567-4571
    • Bardel, P.1    Bolanos, A.2    Kohn, H.3
  • 43
    • 0028307689 scopus 로고
    • Anticonvulsant properties of N-substituted α, α-diamino acid derivatives
    • Kohn, H.; Sawhney, K.N.; Robertson, D.W.; Leander, J.D. Anticonvulsant properties of N-substituted α, α-diamino acid derivatives. J. Pharm. Sci., 1994, 83, 689-691.
    • (1994) J. Pharm. Sci , vol.83 , pp. 689-691
    • Kohn, H.1    Sawhney, K.N.2    Robertson, D.W.3    Leander, J.D.4
  • 44
    • 0029898015 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives
    • Choi, D.; Stables, J.P.; Kohn, H. Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives. J. Med. Chem., 1996, 39, 1907-1916.
    • (1996) J. Med. Chem , vol.39 , pp. 1907-1916
    • Choi, D.1    Stables, J.P.2    Kohn, H.3
  • 45
    • 0033492029 scopus 로고    scopus 로고
    • The anticonvulsant activities of N-benzyl-3-methoxypropionamides
    • Andurkar, S.V.; Stables J.P.; Kohn, H. The anticonvulsant activities of N-benzyl-3-methoxypropionamides. Bioorg. Med. Chem., 1999, 7, 2381-2389.
    • (1999) Bioorg. Med. Chem , vol.7 , pp. 2381-2389
    • Andurkar, S.V.1    Stables, J.P.2    Kohn, H.3
  • 46
    • 0034841551 scopus 로고    scopus 로고
    • Functionalized amino acid anticonvulsants: Synthesis and pharmacological evaluation of conformationally restricted analogues
    • Le Tiran, A.; Stables, J.P.; Kohn, H. Functionalized amino acid anticonvulsants: Synthesis and pharmacological evaluation of conformationally restricted analogues. Bioorg. Med. Chem., 2001, 9, 2693-2708.
    • (2001) Bioorg. Med. Chem , vol.9 , pp. 2693-2708
    • Le Tiran, A.1    Stables, J.P.2    Kohn, H.3
  • 47
    • 0035953311 scopus 로고    scopus 로고
    • Synthesis and structural studies of aza analogues of funcionalized amino acids: New anticonvulsant agents
    • Andurkar, S.V.; Béguin, C; Stables, J.P.; Kohn, H. Synthesis and structural studies of aza analogues of funcionalized amino acids: New anticonvulsant agents. J. Med. Chem., 2001, 44, 1475-1478.
    • (2001) J. Med. Chem , vol.44 , pp. 1475-1478
    • Andurkar, S.V.1    Béguin, C.2    Stables, J.P.3    Kohn, H.4
  • 48
  • 49
    • 0037057588 scopus 로고    scopus 로고
    • Design and evaluation of affinity labels of functionalized amino acid anticonvulsants
    • Le Tiran, A.; Stables, J.P.; Kohn, H. Design and evaluation of affinity labels of functionalized amino acid anticonvulsants. J. Med. Chem., 2002, 45, 4762-4773.
    • (2002) J. Med. Chem , vol.45 , pp. 4762-4773
    • Le Tiran, A.1    Stables, J.P.2    Kohn, H.3
  • 50
    • 0037142302 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships analysis of functionalized amino acid anticonvulsant agents using K nearest neighbor and simulated annealing PLS methods
    • Shen, M.; Le Tiran, A.; Xiao, Y.; Golbraikh, A.; Kohn, H.; Trop-sha, A. Quantitative structure-activity relationships analysis of functionalized amino acid anticonvulsant agents using K nearest neighbor and simulated annealing PLS methods. J. Med. Chem., 2002, 45, 2811-2823.
    • (2002) J. Med. Chem , vol.45 , pp. 2811-2823
    • Shen, M.1    Le Tiran, A.2    Xiao, Y.3    Golbraikh, A.4    Kohn, H.5    Trop-Sha, A.6
  • 52
    • 18244431460 scopus 로고    scopus 로고
    • N-Substituted amino acid N'-benzylamides: Synthesis, anticonvulsant, and metabolic activities
    • Béguin, C; Le Tiran, A.; Stables, J.P.; Voyksner, R.D.; Kohn, H. N-Substituted amino acid N'-benzylamides: Synthesis, anticonvulsant, and metabolic activities. Bioorg. Med. Chem., 2004, 12, 3079-3096.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 3079-3096
    • Béguin, C.1    Le Tiran, A.2    Stables, J.P.3    Voyksner, R.D.4    Kohn, H.5
  • 53
    • 0029881622 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of some amino amide derivatives. Part 1: Alanine derivatives
    • Paruszewski, R.; Rostafińska-Suchar, G.; Strupińska, M.; Jawor-ski, P.; Stables, J.P. Synthesis and anticonvulsant activity of some amino amide derivatives. Part 1: Alanine derivatives. Pharmazie, 1996, 51, 145-148.
    • (1996) Pharmazie , vol.51 , pp. 145-148
    • Paruszewski, R.1    Rostafińska-Suchar, G.2    Strupińska, M.3    Jawor-Ski, P.4    Stables, J.P.5
  • 54
    • 0029936701 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of some amino amide derivatives. Part 2: Derivatives of Gly, Ala, Leu, Pro, Trp, Phe (4Cl), Ala (a-Me)
    • Paruszewski, R.; Rostafińska-Suchar, G.; Strupińska, M.; Jawor-ski, P.; Winiecka, I.; Stables, J.P. Synthesis and anticonvulsant activity of some amino amide derivatives. Part 2: Derivatives of Gly, Ala, Leu, Pro, Trp, Phe (4Cl), Ala (a-Me). Pharmazie, 1996, 51, 212-215.
    • (1996) Pharmazie , vol.51 , pp. 212-215
    • Paruszewski, R.1    Rostafińska-Suchar, G.2    Strupińska, M.3    Jawor-Ski, P.4    Winiecka, I.5    Stables, J.P.6
  • 55
    • 0342514579 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of some amino amide derivatives. Part 3: Derivatives of Ala. Arg, Tzl, Gly and cAbu
    • Paruszewski, R.; Rostafińska-Suchar, G.; Strupińska, M.; Winiecka, I.; Stables, J.P. Synthesis and anticonvulsant activity of some amino amide derivatives. Part 3: Derivatives of Ala. Arg, Tzl, Gly and cAbu. Pharmazie, 2000, 55, 27-30.
    • (2000) Pharmazie , vol.55 , pp. 27-30
    • Paruszewski, R.1    Rostafińska-Suchar, G.2    Strupińska, M.3    Winiecka, I.4    Stables, J.P.5
  • 58
    • 0038695659 scopus 로고    scopus 로고
    • Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors
    • Kieć-Kononowicz, K.; Karolak-Wojciechowska, J.; Handzlik, J. Glycine derivatives of imidazolones as potential ligands of glycine binding site of NMDA receptors. Acta Pol. Pharm.-Drug Res., 1998, 55, 381-388.
    • (1998) Acta Pol. Pharm.-Drug Res , vol.55 , pp. 381-388
    • Kieć-Kononowicz, K.1    Karolak-Wojciechowska, J.2    Handzlik, J.3
  • 59
    • 0345646399 scopus 로고    scopus 로고
    • Structure and activity studies on glycine receptor ligands. Diphenyl imidazolin-4-one glycinamides
    • Kieć-Kononowicz, K.; Karolak-Wojciechowska, J. Structure and activity studies on glycine receptor ligands. Diphenyl imidazolin-4-one glycinamides. Acta Pol. Pharm.- Drug Res., 1998, 55, 389-397.
    • (1998) Acta Pol. Pharm.- Drug Res , vol.55 , pp. 389-397
    • Kieć-Kononowicz, K.1    Karolak-Wojciechowska, J.2
  • 60
    • 0035802403 scopus 로고    scopus 로고
    • Structure and activity studies of glycine receptor ligands. Structural remarks on arylidene-imidazoline-4-one glycinates and glycinamides
    • Karolak-Wojciechowska, J.; Kieć-Kononowicz, K.; Mrozek, A. Structure and activity studies of glycine receptor ligands. Structural remarks on arylidene-imidazoline-4-one glycinates and glycinamides. J. Mol. Srtuct., 2001, 597, 73-81.
    • (2001) J. Mol. Srtuct , vol.597 , pp. 73-81
    • Karolak-Wojciechowska, J.1    Kieć-Kononowicz, K.2    Mrozek, A.3
  • 61
    • 0037445897 scopus 로고    scopus 로고
    • Structure and activity studies of glycine receptor ligands. Arylidene-imidazoline-4-one amino acids
    • Karolak-Wojciechowska, J.; Mrozek, A.; Kieć-Kononowicz, K.; Handzlik, J. Structure and activity studies of glycine receptor ligands. Arylidene-imidazoline-4-one amino acids. J. Mol. Srtuct., 2003, 649, 25-36.
    • (2003) J. Mol. Srtuct , vol.649 , pp. 25-36
    • Karolak-Wojciechowska, J.1    Mrozek, A.2    Kieć-Kononowicz, K.3    Handzlik, J.4
  • 62
    • 0037413350 scopus 로고    scopus 로고
    • N-, α-, and β-Substituted 3-aminopropionic acids: Design, syntheses and antiseizure activities
    • Tan, C.Y.K.; Wainman, D.; Weaver, D.F. N-, α-, and β-Substituted 3-aminopropionic acids: Design, syntheses and antiseizure activities. Bioorg. Med. Chem., 2003, 11, 113-121.
    • (2003) Bioorg. Med. Chem , vol.11 , pp. 113-121
    • Tan, C.Y.K.1    Wainman, D.2    Weaver, D.F.3
  • 63
    • 16544388584 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant evaluation of N-substituted-isoindolinedione derivatives
    • Monem, A.A.; Hafez, A. Synthesis and anticonvulsant evaluation of N-substituted-isoindolinedione derivatives. Arch. Pharm. Res., 2004, 27(5), 495-501.
    • (2004) Arch. Pharm. Res , vol.27 , Issue.5 , pp. 495-501
    • Monem, A.A.1    Hafez, A.2
  • 64
    • 42949179669 scopus 로고    scopus 로고
    • Design synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones
    • Kamihski, K.; Obniska, J. Design synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones. Bioorg. Med. Chem., 2008, 16(9), 4921-4931.
    • (2008) Bioorg. Med. Chem , vol.16 , Issue.9 , pp. 4921-4931
    • Kamihski, K.1    Obniska, J.2
  • 65
    • 0019987297 scopus 로고
    • α-Substituted y-Butyrolactones: New class of anticonvulsant drugs
    • Klunk, W.E.; McKeon, A.C.; Covey, D.F.; Ferrendelli, J.A. α-Substituted y-Butyrolactones: New class of anticonvulsant drugs. Science, 1982, 217, 1040-1042.
    • (1982) Science , vol.217 , pp. 1040-1042
    • Klunk, W.E.1    McKeon, A.C.2    Covey, D.F.3    Ferrendelli, J.A.4
  • 66
    • 0019943406 scopus 로고
    • Anticonvulsant properties of α-, γ-, and α-γ-substituted γ-butyrolactones
    • Klunk, W.E.; Covey, D.F.; Ferrendelli, J.A. Anticonvulsant properties of α-, γ-, and α-γ-substituted γ-butyrolactones. Mol. Pharmacol, 1982, 22, 438-443.
    • (1982) Mol. Pharmacol , vol.22 , pp. 438-443
    • Klunk, W.E.1    Covey, D.F.2    Ferrendelli, J.A.3
  • 67
    • 72849179721 scopus 로고
    • Anticonvulsant and toxicologic properties of some benzilic amides and the physiological disposition of the N-ethyl derivative
    • Albert, J.R.; Boxill, G.C.; Weikel, J. H. Jr. Anticonvulsant and toxicologic properties of some benzilic amides and the physiological disposition of the N-ethyl derivative. J. Pharmacol. Exp. Ther., 1961, 131, 85-90.
    • (1961) J. Pharmacol. Exp. Ther , vol.131 , pp. 85-90
    • Albert, J.R.1    Boxill, G.C.2    Weikel Jr., J.H.3
  • 68
    • 0346957333 scopus 로고    scopus 로고
    • Synthesis, physicochemical and anticonvulsant properties of some N-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione
    • Obniska, J.; Zejc, A. Synthesis, physicochemical and anticonvulsant properties of some N-substituted amides of 3-spirocycloalkylpyrrolidine-2,5-dione. Acta. Pol. Pharm., 2003, 60(5), 383-390.
    • (2003) Acta. Pol. Pharm , vol.60 , Issue.5 , pp. 383-390
    • Obniska, J.1    Zejc, A.2
  • 69
    • 2942701907 scopus 로고    scopus 로고
    • Characterization of the anticonvulsant profile of valpromide derivatives
    • Tasso, S.M.; Moon, S.C.; Bruno-Blanch, L.E.; Estiu, G.L. Characterization of the anticonvulsant profile of valpromide derivatives. Bioorg. Med. Chem., 2004, 12, 3857-3869.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 3857-3869
    • Tasso, S.M.1    Moon, S.C.2    Bruno-Blanch, L.E.3    Estiu, G.L.4
  • 70
    • 0022118918 scopus 로고
    • Anticonvulsant activity of some 4-aminobenzanilides
    • Clark, C.R.; Sansom, R.T.; Lin, CM.; Norris, G.N. Anticonvulsant activity of some 4-aminobenzanilides. J. Med. Chem., 1985, 28, 1259-1262.
    • (1985) J. Med. Chem , vol.28 , pp. 1259-1262
    • Clark, C.R.1    Sansom, R.T.2    Lin, C.M.3    Norris, G.N.4
  • 71
    • 0021340965 scopus 로고
    • Synthesis and anticonvulsant activity of some substituted lactams and amides
    • Brouillettet, W.J.; Grunewald, G.L. Synthesis and anticonvulsant activity of some substituted lactams and amides. J. Med. Chem., 1984, 27, 202-206.
    • (1984) J. Med. Chem , vol.27 , pp. 202-206
    • Brouillettet, W.J.1    Grunewald, G.L.2
  • 72
    • 0032862374 scopus 로고    scopus 로고
    • Effects of anticonvulsant lactams on in-vitro seizures in the hippocampal slice preparation
    • Hill, M.W.; De la Cruz, M.A.M.; Covey, D.F.; Rothman, S.M. Effects of anticonvulsant lactams on in-vitro seizures in the hippocampal slice preparation. Epilepsy Res., 1999, 37, 121-131.
    • (1999) Epilepsy Res , vol.37 , pp. 121-131
    • Hill, M.W.1    de la Cruz, M.A.M.2    Covey, D.F.3    Rothman, S.M.4
  • 73
    • 0033957622 scopus 로고    scopus 로고
    • A close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats
    • Potschka, H.; Feuerstein, T.J.; Löscher, W. Gabapentin-lactam, A close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats. Arch. Pharmacol, 2000, 361, 200-205.
    • (2000) Arch. Pharmacol , vol.361 , pp. 200-205
    • Potschka, H.1    Feuerstein, T.J.2    Löscher, W.3    Gabapentin-Lactam, A.4
  • 75
    • 0031022027 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activities of 3,3-dialkyl and 3-alkyl-3-benzyl-2-piperidinones (S-Valerolactams) and hexahydro-2H-azepin-2-ones (£-Caprolactams)
    • Reddy, P.A.; Woodward, K.E.; McIlheran, S.M.; Hsiang, B.C.H.; Latifi, T. N.; Hill, M.W.; Rothman, S.M.; Ferrendelli, J.A.; Covey, D.F. Synthesis and anticonvulsant activities of 3,3-dialkyl and 3-alkyl-3-benzyl-2-piperidinones (S-Valerolactams) and hexahydro-2H-azepin-2-ones (£-Caprolactams). J. Med. Chem., 1997, 40, 44-49.
    • (1997) J. Med. Chem , vol.40 , pp. 44-49
    • Reddy, P.A.1    Woodward, K.E.2    McIlheran, S.M.3    Hsiang, B.C.H.4    Latifi, T.N.5    Hill, M.W.6    Rothman, S.M.7    Ferrendelli, J.A.8    Covey, D.F.9
  • 76
    • 0042591180 scopus 로고    scopus 로고
    • Design, synthesis, and development of novel caprolactam anticonvulsants
    • Grimm, J.B.; Stables, J.P.; Brown, M.L. Design, synthesis, and development of novel caprolactam anticonvulsants. Bioorg. Med. Chem., 2003, 11, 4133-4141.
    • (2003) Bioorg. Med. Chem , vol.11 , pp. 4133-4141
    • Grimm, J.B.1    Stables, J.P.2    Brown, M.L.3
  • 77
    • 55249110578 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of some quinazolin-4-(3H)-one derivatives
    • Georgey, H.; Gawad, N.A.; Abbas, S. Synthesis and anticonvulsant activity of some quinazolin-4-(3H)-one derivatives. Molecules, 2008, 13, 2557-2569.
    • (2008) Molecules , vol.13 , pp. 2557-2569
    • Georgey, H.1    Gawad, N.A.2    Abbas, S.3
  • 78
    • 0025157161 scopus 로고
    • Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones
    • Wolfe, J.F.; Rathman, T.L.; Sleevi, M.C.; Campbell, J.A.; Greenwood, T.D. Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones. J. Med. Chem., 1990, 33, 161-166.
    • (1990) J. Med. Chem , vol.33 , pp. 161-166
    • Wolfe, J.F.1    Rathman, T.L.2    Sleevi, M.C.3    Campbell, J.A.4    Greenwood, T.D.5
  • 79
    • 0020506475 scopus 로고
    • Synthesis of 3,4-dihydro-4-oxoquinazolin derivatives as potential anticonvulsants
    • Vaidya, N.A.; Panos, C.H.; Kite, A.; Iturrian W.B.; Blanton, DeWitt. C. Synthesis of 3,4-dihydro-4-oxoquinazolin derivatives as potential anticonvulsants. J. Med. Chem., 1983, 26, 1422-1425.
    • (1983) J. Med. Chem , vol.26 , pp. 1422-1425
    • Vaidya, N.A.1    Panos, C.H.2    Kite, A.3    Iturrian, W.B.4    de Witt, C.B.5
  • 80
    • 1842858323 scopus 로고    scopus 로고
    • Synthesis of newer thiadiazolyl and thiazolidinonyl quinazolin-4(3H) - ones as potential anticonvulsant agents
    • Archana Srivastava, V.K, Kumar, A. Synthesis of newer thiadiazolyl and thiazolidinonyl quinazolin-4(3H) - ones as potential anticonvulsant agents. Eur. J. Med. Chem., 2002, 37, 873-882.
    • (2002) Eur. J. Med. Chem , vol.37 , pp. 873-882
    • Archana, S.V.K.1    Kumar, A.2
  • 81
    • 0038166026 scopus 로고    scopus 로고
    • Design and synthesis of some new derivatives of 3H-quinazolin-4-one with promising anticonvulsant activity
    • El-Helby, A.G.; Wahab, M.H. Design and synthesis of some new derivatives of 3H-quinazolin-4-one with promising anticonvulsant activity. Acta. Pharm., 2003, 53(2), 127-138.
    • (2003) Acta. Pharm , vol.53 , Issue.2 , pp. 127-138
    • El-Helby, A.G.1    Wahab, M.H.2
  • 82
    • 0042668312 scopus 로고    scopus 로고
    • Newer substituted benzoxazepinyl-quinazolinones as potent antipsychotic and anticonvulsant agents
    • Bajaj, K.; Srivastava, V.K.; Kumar, A. Newer substituted benzoxazepinyl-quinazolinones as potent antipsychotic and anticonvulsant agents. Arzneimittelforschung, 2003, 53(7), 480-485.
    • (2003) Arzneimittelforschung , vol.53 , Issue.7 , pp. 480-485
    • Bajaj, K.1    Srivastava, V.K.2    Kumar, A.3
  • 83
    • 1942452736 scopus 로고    scopus 로고
    • γ-Hydroxybutyric acid (GHB) and its chemical modifications: A review of the GHBergic system
    • Waszkielewicz, A.; Bojarski, J. γ-Hydroxybutyric acid (GHB) and its chemical modifications: A review of the GHBergic system. Pol. J. Pharmacol, 2004, 56, 43-49.
    • (2004) Pol. J. Pharmacol , vol.56 , pp. 43-49
    • Waszkielewicz, A.1    Bojarski, J.2
  • 84
    • 0029035245 scopus 로고
    • Synthesis, physicochemical and pharmacological properties of new N-substituted amides of α-piperazine-γ-hydroxybutyric acid
    • Malawska, B.; Gobaille, S. Synthesis, physicochemical and pharmacological properties of new N-substituted amides of α-piperazine-γ-hydroxybutyric acid. Pharmazie, 1995, 50, 390-393.
    • (1995) Pharmazie , vol.50 , pp. 390-393
    • Malawska, B.1    Gobaille, S.2
  • 85
    • 0028828388 scopus 로고
    • Search for new anticonvulsant compounds, Part 1: Synthesis, physicochemical and anticonvulsant properties of new derivatives of a-amino-y--phthalimidobutyric acid
    • Malawska, B.; Zejc, A. Search for new anticonvulsant compounds, Part 1: Synthesis, physicochemical and anticonvulsant properties of new derivatives of a-amino-y--phthalimidobutyric acid. Pharmazie, 1995, 50, 722-755.
    • (1995) Pharmazie , vol.50 , pp. 722-755
    • Malawska, B.1    Zejc, A.2
  • 86
    • 0035695262 scopus 로고    scopus 로고
    • Influence of new γ-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice
    • Mendyk, A.; Salat, K.; Librowski, T.; Czarnecki, T.; Malawska, B. Influence of new γ-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice. Pol. J. Pharmacol, 2001, 53, 689-693.
    • (2001) Pol. J. Pharmacol , vol.53 , pp. 689-693
    • Mendyk, A.1    Salat, K.2    Librowski, T.3    Czarnecki, T.4    Malawska, B.5
  • 87
    • 0030790189 scopus 로고    scopus 로고
    • Search for new anticonvulsant compounds, Part 2: Structure-activity relationship studies of new N-substituted amides of α-piperazine-y-hydroxybutyric acid as active anticonvulsants
    • Malawska, B.; Kulig, K.; Ciechanowicz-Rutkowska, M. Search for new anticonvulsant compounds, Part 2: Structure-activity relationship studies of new N-substituted amides of α-piperazine-y-hydroxybutyric acid as active anticonvulsants. Arch. Pharm., 1997, 330, 91-99.
    • (1997) Arch. Pharm , vol.330 , pp. 91-99
    • Malawska, B.1    Kulig, K.2    Ciechanowicz-Rutkowska, M.3
  • 88
    • 0033055547 scopus 로고    scopus 로고
    • Search for new anticonvulsant compounds, Part 3. Synthesis, physicochemical properties, anticonvulsant activities and voltage-sensitive calcium channels affinity of N-substituted amides of a-(4-phenylpiperazine)-GABA
    • Malawska, B.; Antkiewicz-Michaluk, L. Search for new anticonvulsant compounds, Part 3. Synthesis, physicochemical properties, anticonvulsant activities and voltage-sensitive calcium channels affinity of N-substituted amides of a-(4-phenylpiperazine)-GABA. Pharmazie, 1999, 54, 239-243.
    • (1999) Pharmazie , vol.54 , pp. 239-243
    • Malawska, B.1    Antkiewicz-Michaluk, L.2
  • 89
    • 0033052762 scopus 로고    scopus 로고
    • Anticonvulsant activities and voltage-sensitive calcium channels receptor affinity of substituted N-benzylamides of y-amino- and γ-hydroxybutyric acid
    • Malawska, B.; Kulig, K.; Antkiewicz-Michaluk, L.; Cliffe, I.; Porter, R.; Misra, A. Anticonvulsant activities and voltage-sensitive calcium channels receptor affinity of substituted N-benzylamides of y-amino- and γ-hydroxybutyric acid. Arch. Pharm., 1999, 332(5), 167-174.
    • (1999) Arch. Pharm , vol.332 , Issue.5 , pp. 167-174
    • Malawska, B.1    Kulig, K.2    Antkiewicz-Michaluk, L.3    Cliffe, I.4    Porter, R.5    Misra, A.6
  • 90
    • 0036968741 scopus 로고    scopus 로고
    • Influence of new γ-hydroxybutyric acid amide analogues on the central nervous system activity in mice
    • Salat, K.; Mendyk, A.; Librowski, T.; Czarnecki, R.; Malawska, B. Influence of new γ-hydroxybutyric acid amide analogues on the central nervous system activity in mice. Pol. J. Pharmacol, 2002, 54, 731-736.
    • (2002) Pol. J. Pharmacol , vol.54 , pp. 731-736
    • Salat, K.1    Mendyk, A.2    Librowski, T.3    Czarnecki, R.4    Malawska, B.5
  • 91
    • 0344308307 scopus 로고    scopus 로고
    • Comparison of chromatographically determined values of the lipophilicity of anticonvulsant active N-substituted amides of a-arylalkylamine-γ-hydroxybutyric acid with values estimated by computational methods
    • Malawska, B.; Kulig, K.; Bendieck, E. Comparison of chromatographically determined values of the lipophilicity of anticonvulsant active N-substituted amides of a-arylalkylamine-γ-hydroxybutyric acid with values estimated by computational methods. J. Planar Chromatogr., 2003, 16, 390-395.
    • (2003) J. Planar Chromatogr , vol.16 , pp. 390-395
    • Malawska, B.1    Kulig, K.2    Bendieck, E.3
  • 92
    • 4243308002 scopus 로고    scopus 로고
    • Searching of γ-amino- and γ-hydroxybutyric acid analogues with expected anticonvulsant activity
    • Malawska, B. Searching of γ-amino- and γ-hydroxybutyric acid analogues with expected anticonvulsant activity. (Polish). Wiad. Chem., 2001, 55, 377-402.
    • (2001) (Polish). Wiad. Chem , vol.55 , pp. 377-402
    • Malawska, B.1
  • 93
    • 35048836884 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of α-substituted N-benzylamides of β-hydroxybutyric acid with potential GABA-ergic activity, Part 6: Search for new anticonvulsant compounds
    • Malawska, B.; Kulig, k.; Gajda, J.; Szczeblewski, D.; Musial, A.; Wieckowski, K.; Maciag D.; Stables, J. P. Design, synthesis and pharmacological evaluation of α-substituted N-benzylamides of β-hydroxybutyric acid with potential GABA-ergic activity, Part 6: Search for new anticonvulsant compounds. Acta Pol. Pharm. -Drug Res., 2007, 64(2), 127-137.
    • (2007) Acta Pol. Pharm. -Drug Res , vol.64 , Issue.2 , pp. 127-137
    • Malawska, B.1    Kulig, K.2    Gajda, J.3    Szczeblewski, D.4    Musial, A.5    Wieckowski, K.6    Maciag, D.7    Stables, J.P.8
  • 94
    • 0347761409 scopus 로고    scopus 로고
    • Investigation into new anticonvulsant derivatives of a-substituted N-benzylamides of -hydroxy- and γ-acetoxybutyric acid, Part 5: Search for new anticonvulsant compounds
    • Malawska, B.; Kulig, K.; piewak, A.; Stables, J.P. Investigation into new anticonvulsant derivatives of a-substituted N-benzylamides of -hydroxy- and γ-acetoxybutyric acid, Part 5: Search for new anticonvulsant compounds. Bioorg. Med. Chem., 2004, 12, 625-632.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 625-632
    • Malawska, B.1    Kulig, K.2    Piewak, A.3    Stables, J.P.4
  • 96
    • 0029053795 scopus 로고
    • Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicyclic ketones for anticonvulsant and other biological properties
    • Dimmock, J.R.; Pandeya, S.N.; Quail, J.W.; Pugazhenthi, U.; Allen, T.M.; Kao, G.Y.; Balzarini, J.; DeClercq, E. Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicyclic ketones for anticonvulsant and other biological properties. Eur. J. Med. Chem., 1995, 30, 303-314.
    • (1995) Eur. J. Med. Chem , vol.30 , pp. 303-314
    • Dimmock, J.R.1    Pandeya, S.N.2    Quail, J.W.3    Pugazhenthi, U.4    Allen, T.M.5    Kao, G.Y.6    Balzarini, J.7    Declercq, E.8
  • 97
    • 0029817837 scopus 로고    scopus 로고
    • (Aryloxy)aryl semicarbazones and related compounds: A novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen
    • Dimmock, J.R.; Puthucode, R.N.; Smith, J.M.; Hetherington, M.; Quail, J.W.; Pugazhenthi, U.; Lecher, T.; Stables, J.P. (Aryloxy)aryl semicarbazones and related compounds: A novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen. J. Med. Chem., 1996, 39, 3984-3997.
    • (1996) J. Med. Chem , vol.39 , pp. 3984-3997
    • Dimmock, J.R.1    Puthucode, R.N.2    Smith, J.M.3    Hetherington, M.4    Quail, J.W.5    Pugazhenthi, U.6    Lecher, T.7    Stables, J.P.8
  • 99
    • 0032763055 scopus 로고    scopus 로고
    • Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties
    • Pandeya, S.N.; Ponnilavarasan, I.; Pandey, A.; Lakhan, R.; Stables, J.P. Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties. Pharmazie, 1999, 54, 923-925.
    • (1999) Pharmazie , vol.54 , pp. 923-925
    • Pandeya, S.N.1    Ponnilavarasan, I.2    Pandey, A.3    Lakhan, R.4    Stables, J.P.5
  • 100
    • 0034099495 scopus 로고    scopus 로고
    • Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds
    • Dimmock, J.R.; Vashishtha, S.C.; Stables, J.P. Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds. Eur. J. Med. Chem., 2000, 35, 241-248.
    • (2000) Eur. J. Med. Chem , vol.35 , pp. 241-248
    • Dimmock, J.R.1    Vashishtha, S.C.2    Stables, J.P.3
  • 101
    • 0033748227 scopus 로고    scopus 로고
    • Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones
    • Pandeya, S.N.; Yogeeswari, P.; Stables, J.P. Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones. Eur. J. Med. Chem., 2000, 35, 879-886.
    • (2000) Eur. J. Med. Chem , vol.35 , pp. 879-886
    • Pandeya, S.N.1    Yogeeswari, P.2    Stables, J.P.3
  • 102
    • 0033754195 scopus 로고    scopus 로고
    • Anticonvulsant activity of p-chlorophenyl substituted aryl semicarbazones: The role of primary terminal amino group
    • Pandeya, S.N.; Mishra, V.; Ponnilavarasan, I.; Stables, J.P. Anticonvulsant activity of p-chlorophenyl substituted aryl semicarbazones: The role of primary terminal amino group. Pol. J. Pharmacol., 2000, 52, 283-290.
    • (2000) Pol. J. Pharmacol , vol.52 , pp. 283-290
    • Pandeya, S.N.1    Mishra, V.2    Ponnilavarasan, I.3    Stables, J.P.4
  • 103
    • 0033942293 scopus 로고    scopus 로고
    • Ureylene anticonvulsants and related compounds
    • Dimmock, J.R.; Vashishtha, S.C.; Stables, J.P. Ureylene anticonvulsants and related compounds. Pharmazie, 2000, 55, 490-494.
    • (2000) Pharmazie , vol.55 , pp. 490-494
    • Dimmock, J.R.1    Vashishtha, S.C.2    Stables, J.P.3
  • 104
    • 0035109635 scopus 로고    scopus 로고
    • Design of semicarbazones and their bio-isosteric analogues as potential anticonvulsants
    • Pandeya, S.N.; Manjula, H.; Stables, J.P. Design of semicarbazones and their bio-isosteric analogues as potential anticonvulsants. Pharmazie, 2001, 56, 121-124.
    • (2001) Pharmazie , vol.56 , pp. 121-124
    • Pandeya, S.N.1    Manjula, H.2    Stables, J.P.3
  • 105
    • 0036501108 scopus 로고    scopus 로고
    • Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones
    • Yogeeswari, P.; Sriram, D.; Sunil Jit, L.R.; Kumar, S.S.; Stables, J.P. Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones. Eur. J. Med. Chem., 2002, 37, 231-236.
    • (2002) Eur. J. Med. Chem , vol.37 , pp. 231-236
    • Yogeeswari, P.1    Sriram, D.2    Sunil, J.L.R.3    Kumar, S.S.4    Stables, J.P.5
  • 106
    • 0037367011 scopus 로고    scopus 로고
    • Design and synthesis of semicarbazones and their bio-isosteric analogues as potent anticonvulsants: The role of hydrogen bonging
    • Pandeya, S.N.; Agarwal, A.K.; Singh, A.; Stables, J.P. Design and synthesis of semicarbazones and their bio-isosteric analogues as potent anticonvulsants: The role of hydrogen bonging. Acta Pharm., 2003, 53, 15-24.
    • (2003) Acta Pharm , vol.53 , pp. 15-24
    • Pandeya, S.N.1    Agarwal, A.K.2    Singh, A.3    Stables, J.P.4
  • 109
    • 33644982586 scopus 로고    scopus 로고
    • 2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: Synthesis and pharmacological evaluation
    • Thirumurugan, R.; Sriram, D.; Saxena, A.; Stables, J.P.; Yogeeswari, P. 2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: Synthesis and pharmacological evaluation. Bioorg. Med. Chem., 2006, 14, 3106-3112.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 3106-3112
    • Thirumurugan, R.1    Sriram, D.2    Saxena, A.3    Stables, J.P.4    Yogeeswari, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.