(Aryloxy)aryl semicarbazones and related compounds: A novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen

Journal of Medicinal Chemistry

Volumn 39, Issue 20, 1996, Pages 3984-3997

  Dimmock, Jonathan R ^a   Puthucode, Ramanan N ^a   Smith, Jennifer M ^a   Hetherington, Mark ^a   Quail, J Wilson ^a   Pugazhenthi, Uma ^a   Lechler, Terry ^a   Stables, James P ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; PENTETRAZOLE; SEMICARBAZONE DERIVATIVE;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; HYDROGEN BOND; HYDROPHOBICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEIZURE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTICONVULSANTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; RATS; SEIZURES; SEMICARBAZONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029817837     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9603025     Document Type: Article

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