A serotonin-1A receptor agonist and an N-methyl-D-aspartate receptor antagonist oppose each others effects in a genetic rat epilepsy model

Neuroscience Letters

Volumn 261, Issue 1-2, 1999, Pages 89-92

  Filakovszky, Janos ^a   Gerber, Katalin ^a   Bagdy, Gyorgy ^a  

^a NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Hungary)

Author keywords

(+) 5 methyl 10,11 dihydro 5H dibenzo a,d cyclohepten 5,10 imine maleate (MK 801); 5 HT(1A) receptor; 8 Hydrox 2 (di n propylamino) tetralin; Absence epilepsy; Serotonin; Spike wave discharge; WAG RIJ rats

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SEROTONIN 1 AGONIST;

ABSENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; GABAERGIC TRANSMISSION; GENETIC MODEL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RAT; SEROTONINERGIC TRANSMISSION; SPIKE WAVE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ACTION POTENTIALS; ANIMALS; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EPILEPSY, ABSENCE; EXCITATORY AMINO ACID ANTAGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS;

EID: 0033548027     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00015-4     Document Type: Article

References (20)

1. Avanzini G., Vergnes M., Spreafico R., Marescaux C. Calcium-dependent regulation of genetically determined spike and waves by the reticular thalamic nucleus of rats. Epilepsia. 34:1993;1-7.
2. Bagdy G., To C.T. Comparison of relative potencies of i.v. and i.c.v. administered 8-OH DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks. Eur. J. Pharmacol. 323:1997;53-58.
3. Banerjee P.K., Snead III O.C. Thalamic NMDA receptors in the γ-hydroxybutyrate model of absence seizures: a cerebral microinjection study in rats. Neuropharmacology. 34:1995;43-53.
4. 1A binding in rat brain: a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res. 561:1991;51-60.
5. Depaulis A., Vergnes M., Marescaux C., Lannes B., Warter J.M. Evidence that activation of GABA receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat. Brain Res. 448:1988;20-29.
6. Freund F.T., Gulyás A.I. Inhibitory control of GABAergic interneurons in the hippocampus. Can. J. Physiol. Pharmacol. 75:1997;479-487.
7. 1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy. Brain Res. 807:1998;243-245.
8. Hamon, M., Gozlan, H., El Mestikawy, S., Emerit, M.B., Cossery, J.M. and Lutz, O., Biochemical properties of central serotonin receptors. In N.N. Osborne and M. Hamon (Eds.), Neuronal Serotonin, Wiley, Chichester, 1988, pp. 393-447.
9. 2 receptor subtype specific drugs. Eur. J. Pharmacol. 282:1995;39-55.
10. Löscher W., Czuczwar J.S. Evaluation of the 5-hydroxytryptamine receptor agonist 8-hydroxy-2 (di-n-propylamino)tetralin in different rodent models of epilepsy. Neurosci. Lett. 60:1985;201-206.
11. Löscher W., Hönack D. The behavioural effects of MK801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems. Eur. J. Pharmacol. 215:1992;199-208.
12. Löscher W., Annies R., Hönack D. The N-methyl-D-aspartate receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions of rats. Neurosci. Lett. 128:1991;191-194.
13. Luhmann H.J., Mittmann T., van Luijtelaar G., Heinemann U. Impairment of intracortical GABA-ergic inhibition in rat model of absence epilepsy. Epilepsy Res. 22:1995;43-51.
14. Pape H.C., McCormick D.A. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature. 340:1989;715-718.
15. Peeters B.W.M.M., Rijn van C.M., Luijtelaar van E.L.J.M., Coenen A.M.L. Antiepileptic and behavioural actions of MK-801 in animal model of spontaneous absence epilepsy. Epilepsy Res. 3:1989;178-181.
16. Pumain R., Louvel J., Gastard M., Kurcewicz I., Vergnes M. Responses to N-methyl-D-aspartate are enhanced in rats with Petit Mal-like seizures. J. Neural. Transm. 35:1992;97-108.
17. Snead III O.C. Basic mechanisms of generalized absence seizures. Ann. Neurol. 37:1995;146-157.
18. Statnick M.A., Dailey J.W., Jobe P.C., Browning R.A. Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats. Epilepsia. 37:1996;311-321.
19. Steriade M. Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance. Cerebral Cortex. 7:1997;583-604.
20. Van Luijtelaar, E.L.J.M. and Coenen, A.M.L., The WAG/Rij model for generalized absence seizures. In E.B. Manelis, J.N. Loeber and F.E. Dreifuss (Eds.), Advances in Epileptology, Vol. 17, Raven Press, New York, 1989, pp. 78-83.