Synthesis, anticonvulsant activity and 5-HT1A, 5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione

European Journal of Medicinal Chemistry

Volumn 41, Issue 7, 2006, Pages 874-881

  Obniska, J ^a   Kolaczkowski M ^a   Bojarski, A J ^b   Duszynska B ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

2 Azaspiro 4.4 nonane and 4.5 decane 1,3 diones; 4 Arylpiperazine derivatives; 5 HT1A; 5 HT2A receptor affinity; Anticonvulsant activity

Indexed keywords

ALKANE DERIVATIVE; KETONE DERIVATIVE; PENTETRAZOLE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MOUSE; NEUROTOXICITY; NONHUMAN; RECEPTOR AFFINITY; ROTAROD TEST; SEIZURE;

ANTICONVULSANTS; AZA COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIMIDES;

EID: 33745746948     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.03.001     Document Type: Article

References (30)

1. Davies J.A. Seizure 4 (1995) 267-272
2. Filakovszky J., Gerber K., and Bagdy G. Neurosci. Lett. 261 (1999) 89-92
3. Salgado-Commissariat D., and Alkadhi K.A. Brain Res. 743 (1996) 212-216
4. Graf M., Jakus R., Kantor S., Levay G., and Bagdy G. Neurosci. Lett. 359 (2004) 45-48
5. Yan Q.S., Jobe P.C., and Dailey J.W. Br. J. Pharmacol. 115 (1995) 1314-1318
6. Gariboldi M., Tutka P., Samanin R., and Vezzani A. Br. J. Pharmacol. 119 (1996) 813-818
7. Lindstrom S.I., Gulyas P., Halldin B., Andree C., and Farde L. Neurology 62 (2004) 1343-1351
8. Marlet I., Ryvlin P., Dufournel D., Isnard J., Faillenot I., Ostrowsky K., Lavenne F., Le Bars D., and Mauguiere F. Neuroimage 22 (2004) 886-896
9. Stean T.O., Atkins A.R., Heidbreder C.A., Quinn L.P., Trail B.K., and Upton N. Br. J. Pharmacol. 144 (2005) 628-635
10. Przegaliński E., Baran L., and Siwanowicz J. Epilepsia 35 (1994) 889-894
11. Upton N., Stean T.O., Middlemiss D., Blackburn T., and Kennett G. Eur. J. Pharmacol. 359 (1998) 33-40
12. Obniska J., and Zagórska A. Farmaco 58 (2003) 1227-1234
13. Obniska J., Jurczyk S., Zejc A., Kamiński K., Tatarczyńska E., and Stachowicz K. Pharmacol. Rep. 57 (2005) 170-175
14. Scott K.R., Moore J.A., Zalusky T.B., Nicholson J.M., Lee J.A.M., and Chinko C.N. J. Med. Chem. 28 (1985) 413-417
15. Edafiogho I.O., Scott K.R., Moore J.A., Farrar V.A., and Nicholson J.M. J. Med. Chem. 34 (1991) 387-392
16. Farrar V.A., Ciechanowska-Rutkowska M., Grochowski J., Serda P., Pilati T., Filippini G., Hinko C.N., El-Assadi A., Moore J., Edafiogho I.O., Andrews C.A., Cory M., Nicolson J.M., and Scott K.R. J. Med. Chem. 36 (1993) 3517-3525
17. Alexander M.S., Stables J.P., Ciechanowicz-Rutkowska M., Hursthouse M.B., Hibbs D.E., Edafiogho I.O., Moore V.A., and Scott K.R. Eur. J. Med. Chem. 31 (1996) 787-795
18. Obniska J., Kołaczkowski M., Charakieva-Minol S., Ne{ogonek}dza K., Dybała M., and Bojarski A.J. Pharmacol. Rep. 57 (2005) 336-344
19. Obniska J., Pawłowski M., Chojnacka-Wójcik E., Kołaczkowski M., Czopek A., Duszyńska B., Tatarczyńska E., and Wesołowska Pol A. J. Pharmcol. 55 (2003) 553-557
20. Pawłowski M., Chłoń G., Obniska J., Zejc A., Charakchieva-Minol S., and Mokrosz M.J. Farmaco 55 (2000) 461-468
21. Obniska J., Kulig K., and Zejc A. Acta Polon. Pharm. Drug Res. 55 (1998) 223-231
22. Smart B.E. J. Fluorine Chem. 109 (2001) 3-11
23. Ismail F. J. Fluorine Chem. 118 (2002) 27-33
24. Lopez-Rodriguez M.L., Rosado M.L., Benhamu B., Morcillo M.J., Sanz A.M., Orensanz L., Beneytez M.E., Fuentes J.A., and Manzanares J. J. Med. Chem. 39 (1996) 4439-4450
25. Glennon R.A., Naiman N.A., Lyon R.A., and Titeler M. J. Med. Chem. 31 (1988) 1968-1971
26. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Epilepsia 19 (1978) 409-428
27. Kupferberg H.J. Epilepsia 30 Suppl. (1989) 51-56
28. Bojarski A.J., Cegła M.T., Charakiewa-Minol S., Mokrosz M.J., Maćkowiak M., and Mokrosz J.L. Pharmazie 48 (1993) 289-294
29. Cheng Y., and Prusoff W.H. Biochem. Pharmacol. 22 (1973) 3099-3108
30. Yogeeswari P., Sriram D., Saraswat V., Vaigunda-Ragavendran J., Mohan M., Kumar M., Murugesan S., Thirumurugan R., and Stables J.P. Eur. J. Pharm. Sci. 20 (2003) 341-346