Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds

European Journal of Medicinal Chemistry

Volumn 35, Issue 2, 2000, Pages 241-248

  Dimmock, Jonathan R ^a   Vashishtha, Sarvesh C ^a   Stables, James P ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Acetylhydrazones; Anticonvulsant; Atomic charges; Oxamoylhydrazones; Semicarbazones

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; HYDRAZONE DERIVATIVE; PHENYTOIN; SEMICARBAZONE DERIVATIVE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ARTICLE; CONTROLLED STUDY; CONVULSION; DOSE TIME EFFECT RELATION; DRUG BINDING SITE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MOUSE; NEUROTOXICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; TOXICITY TESTING;

EID: 0034099495     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00123-9     Document Type: Article

References (23)

1. Sanders J.W. Epilepsia. 34:1993;1007-1016.
2. Edafiogho I.O., Scott K.R. Wolf M.E. Burger's Medicinal Chemistry and Drug Discovery. 1996;175 John Wiley and Sons Inc., NY.
3. Dimmock J.R., Sidhu K.K., Thayer R.S., Mack P., Duffy M.S., Reid R.S., et al. J. Med. Chem. 36:1993;2243-2252.
4. Dimmock J.R., Sidhu K.K., Tumber S.D., Basran S.K., Chen M., Quail J.W., et al. Eur. J. Med. Chem. 30:1995;287-301.
5. Dimmock J.R., Pandeya S.N., Quail J.W., Pugazhenthi U., Allen T.M., Kao G.Y., Balzarini J., De Clercq E. Eur. J. Med. Chem. 30:1995;303-314.
6. Dimmock J.R., Vashishtha S.C., Stables J.P. Pharmazie. 50:1995;823-824.
7. Scovill J.P., Klayman D.L., Franchino C.F. J. Med. Chem. 25:1982;1261-1264.
8. Stables J.P., Kupferberg H.J. Avanzini G, Tanganelli P, Avoli M. Molecular and Cellular Targets for Antiepileptic Drugs. 1997;191-198 John Libbey & Co. Ltd., London.
9. Dunham M.S., Miya T.A. J. Am. Pharm. Ass. Sci. 46:1957;208-209.
10. Topliss J.G. J. Med. Chem. 20:1977;463-469.
11. Dimmock J.R., Baker G.B. Epilepsia. 35:1994;648-655.
12. Dimmock J.R., Puthucode R.N., Lo M.S., Quail J.W., Yang J., Stables J.P. Pharmazie. 51:1996;83-88.
13. Horner L., Fernekess H. Chem. Ber. 94:1961;712-724.
14. Gillis B.T., Schimmel K.F. J. Org. Chem. 27:1962;413-417.
15. Grammatakis P. Bull. Soc. Chim. France. 1950;690-698.
16. Turner R.A. J. Am. Chem. Soc. 69:1947;875-877.
17. Moshchitskee S.O., Sologub L.S., Pavlenko A.F., Akkerman V.P. Zh. Org. Chem. 2:1966;2164-2167 Chem. Abstr. 2:1967;. 75960j.
18. Moshchitskee S.O., Sologub L.S., Pavlenko A.F., Akkerman V.P. Zh. Org. Chem. 2:1966;2164-2167 Chem. Abstr. 2:1967;. 75960j.
19. Buckingham J. 5th edition Dictionary of Organic Compounds. volume 5:1982;4849 Chapman and Hall, NY.
20. Buckingham J. 5th edition Dictionary of Organic Compounds. volume 5:1982;6449 Chapman and Hall, NY.
21. Romburgh P.V. Rec. Trav. Chim. 57:1938;494-499.
22. Braude E.A., Evans E.A. J. Chem. Soc. 1955;334-337.
23. HyperChem Release 5.0 for Windows (1996), Hypercube, Inc., Waterloo, Ontario, Canada.