Modulation of sodium channel inactivation gating by a novel lactam: Implications for seizure suppression in chronic limbic epilepsy

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 1, 2009, Pages 201-212

  Jones, Paulianda J ^a   Merrick, Ellen C ^a   Batts, Timothy W ^a   Hargus, Nicholas J ^a   Wang, Yuesheng ^a   Stables, James P ^c   Bertram, Edward H ^a   Brown, Milton L ^b   Patel, Manoj K ^a,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c ASP Program   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 (4 METHOXYPHENYL) 1 METHYL 1,3 DIHYDROINDOL 2 ONE; ANTICONVULSIVE AGENT; LACTAM; LAMOTRIGINE; SODIUM CHANNEL; UNCLASSIFIED DRUG; YW 192; 3-HYDROXY-3-(4-METHOXYPHENYL)-1-METHYL-1,3-DIHYDROINDOL-2-ONE; INDOLE DERIVATIVE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTRIC SHOCK; ELECTROPHYSIOLOGY; EPILEPSY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; MEMBRANE DEPOLARIZATION; NEUROLOGIC DISEASE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SEDATION; SEIZURE; SODIUM CURRENT; STEADY STATE; TEMPORAL LOBE; TEMPORAL LOBE EPILEPSY; ANIMAL; DISEASE MODEL; DRUG EFFECT; KIDNEY; LIMBIC SYSTEM; NERVE CELL; PATCH CLAMP; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; EPILEPSY; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; HUMANS; INDOLES; KIDNEY; LACTAMS; LIMBIC SYSTEM; MALE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SODIUM CHANNELS;

EID: 59149094738     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144709     Document Type: Article

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