Design, synthesis, and anticonvulsant activity of N-phenylamino derivatives of 3,3-dialkyl-pyrrolidine-2,5-diones and hexahydro-isoindole-1,3-diones

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 4921-4931

  Kamiński, Krzysztof ^a   Obniska, Jolanta ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Anticonvulsant activity; In vivo studies; Pyrrolidine 2,5 diones; Succinimides

Indexed keywords

ANILINE DERIVATIVE; N (2 CHLOROPHENYL)AMINO 3 BUTYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (2 CHLOROPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (2 CHLOROPHENYL)AMINO 3 METHYL 3 PROPYL PYRROLIDINE 2,5 DIONE; N (2 CHLOROPHENYL)AMINO 3,3 DIETHYL PYRROLIDINE 2,5 DIONE; N (2 CHLOROPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N (2 METHYLPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (2,4 DICHLOROPHENYL)AMINO 3 BUTYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (2,4 DICHLOROPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (2,4 DICHLOROPHENYL)AMINO 3 METHYL 3 PROPYL PYRROLIDINE 2,5 DIONE; N (2,4 DICHLOROPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N (3 CHLOROPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (3 CHLOROPHENYL)AMINO 3 METHYL 3 PROPYL PYRROLIDINE 2,5 DIONE; N (3 CHLOROPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N (4 BROMOPHENYL)AMINO 3 BUTYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (4 BROMOPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (4 BROMOPHENYL)AMINO 3 METHYL 3 PROPYL PYRROLIDINE 2,5 DIONE; N (4 BROMOPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N (4 CHLOROPHENYL)AMINO 3 BUTYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (4 CHLOROPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (4 CHLOROPHENYL)AMINO 3 METHYL 3 PROPYL PYRROLIDINE 2,5 DIONE; N (4 CHLOROPHENYL)AMINO 3,3 DIETHYL PYRROLIDINE 2,5 DIONE; N (4 CHLOROPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N (4 METHYLPHENYL)AMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N (4 METHYLPHENYL)AMINO 3,3 DIETHYL PYRROLIDINE 2,5 DIONE; N (4 METHYLPHENYL)AMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; N PHENYLAMINO 3 ETHYL 3 METHYL PYRROLIDINE 2,5 DIONE; N PHENYLAMINO 3,3 DIETHYL PYRROLIDINE 2,5 DIONE; N PHENYLAMINO 3,3 DIMETHYLPYRROLIDINE 2,5 DIONE; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTRIC SHOCK; IN VIVO STUDY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACODYNAMICS; RAT; SEIZURE;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; ISOINDOLES; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; PILOCARPINE; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 42949179669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.037     Document Type: Article

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