Comparison of chromatographically determined values of the lipophilicity of anticonvulsant active N-substituted amides of α-arylalkylamine-γ-hydroxybutyric acid with values estimated by computational methods

Journal of Planar Chromatography - Modern TLC

Volumn 16, Issue 5, 2003, Pages 390-395

  Malawska, Barbara ^a   Kulig, Katarzyna ^a   Bendieck, Eva ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

hydroxybutyric acid derivatives anticonvulsant activity; Calculated partition coefficient, log P; Relative lipophilicity (RM0)

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; COMPUTATIONAL METHODS; METHANOL; PH EFFECTS; THIN LAYER CHROMATOGRAPHY;

LIPOPHILICITY; PARTITION COEFFICIENTS;

ACETIC ACID;

4 HYDROXYBUTYRIC ACID; ACETIC ACID; AMIDE; ANTICONVULSIVE AGENT; METHANOL; PENTETRAZOLE; TROMETAMOL;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CHROMATOGRAPHY; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG STRUCTURE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; LIPOPHILICITY; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PH;

EID: 0344308307     PISSN: 09334173     EISSN: None     Source Type: Journal    
DOI: 10.1556/JPC.16.2003.5.12     Document Type: Article

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