Bioanalytical methods for the determination of cocaine and metabolites in human biological samples

Bioanalysis

Volumn 1, Issue 5, 2009, Pages 977-1000

  Barroso, M ^a   Gallardo, E ^b   Queiroz, J A ^b  

^a INSTITUTO NACIONAL DE MEDICINA LEGAL E CIÊNCIAS FORENSES   (Portugal)

^b UNIVERSITY OF BEIRA INTERIOR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE;

BODY FLUID; CHEMISTRY; ENZYME IMMUNOASSAY; HUMAN; LABORATORY DIAGNOSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; REVIEW; SUBSTANCE ABUSE;

BODY FLUIDS; CHROMATOGRAPHY, LIQUID; COCAINE; HUMANS; IMMUNOENZYME TECHNIQUES; MASS SPECTROMETRY; SPECIMEN HANDLING; SUBSTANCE ABUSE DETECTION;

EID: 77958472582     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.09.72     Document Type: Review

References (223)

1. Kolbrich EA, Barnes AJ, Gorelick DA et al. Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration. J. Anal. Toxicol. 30, 501-510 (2006).
2. Boghdadi MS, Henning RJ. Cocaine: pathophysiology and clinical toxicology. Heart Lung 26, 466-483 (1997).
3. Goldstein RA, DesLauries C, Burda MA. Cocaine: history, social implications, and toxicity-a review. Dis. Mon. 55, 6-38 (2009).
4. Spihler V. Drugs in saliva. In: Clarke's Analysis of Drugs and Poisons. Pharmaceutical Press, London, UK 109-123 (2004).
5. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man (7th Edition). Biomedical Publications, CA, USA 256-262 (2004).
6. Cognard E, Bouchonnet S, Staub C. Validation of a gas chromatography-ion trap tandem mass spectrometry for simultaneous analyse of cocaine and its metabolites in saliva. J. Pharm. Biomed. Anal. 41, 925-934 (2006).
7. Huestis MA, Darwin WD, Shimomura E et al. Cocaine and metabolites urinary excretion after controlled smoked administration. J. Anal. Toxicol. 31, 462-468 (2007).
8. Scheidweiler KB, Cone EJ, Moolchan ET, Huestis MA. Dose-related distribution of codeine, cocaine, and metabolites into human hair following controlled oral codeine and subcutaneous cocaine administration. J. Pharmacol. Exp. Ther. 313, 909-915 (2005).
9. Zuo Y, Zhang K, Wu J, Rego C, Fritz J. An accurate and non-destructive GC method for determination of cocaine on US paper currency. J. Sep. Sci. 31, 2444-2450 (2008).
10. Bones J, Macka M, Paull B. Evaluation of monolithic and sub 2 μ m particle packed columns for the rapid screening for illicit drugs-application to the determination of drug contamination on Irish euro banknotes. Analyst 132, 208-17 (2007).
11. Jenkins AJ. Drug contamination of US paper currency. Forensic Sci. Int. 121, 189-193 (2001).
12. Sergi M, Bafle E, Compagnone D, Curini R, D'Ascenzo G, Romolo FS. Multiclass analysis of illicit drugs in plasma and oral fuids by LC-MS/MS. Anal. Bioanal. Chem. 393, 709-718 (2009).
13. Verstraete AG. Detection times of drugs of abuse in blood, urine, and oral fuid. Ther. Drug. Monit. 26, 200-205 (2004).
14. Keller T, Keller A, Tutsch-Bauer E, Monticelli F. Driving under the infuence of drugs and alcohol in Salzburg and Uppper Austria during the years 2003-2007. Leg. Med. 11, S98-S99 (2009).
15. Tóth AR, Varga T, Molnár A, Hideg Z, Somogi G. The role of licit and illicit drugs in traffc (Hungary 2000-2007). Leg. Med. 11, S419-S422 (2009).
16. Jones AW, Holmgren A, Kugelberg FC. Concentrations of cocaine and its major metabolite benzoylecgonine in blood samples from apprehended drivers in Sweden. Forensic Sci. Int. 177, 133-139 (2008).
17. Yonamine M, Saviano AM. Determination of cocaine and cocaethylene in urine by solid-phase microextraction and gas chromatography-mass spectrometry. Biomed. Chromatogr. 20, 1071-1075 (2006).
18. Dolan K, Rouen D, Kimber J. An overview of the use of urine, hair, sweat and saliva to detect drug use. Drug Alcohol Rev. 23, 213-217 (2004).
19. Farell LJ, Kerrigan S, Logan BK. Recommendations for toxicological investigation of drug impaired driving. J. Forensic Sci. 52, 1214-1218 (2007).
20. Jaffee WB, Trucco E, Teter C, Levy S, Weiss RD. Focus on alcohol and drug abuse: ensuring validity in urine drug testing. Psychiatr. Serv. 59, 140-142 (2008).
21. Cook JD, Caplan YH, LoDico CP, Bush DM. The characterization of human urine for specimen validity determination in workplace drug testing: a review. J. Anal. Toxicol. 24, 579-588 (2000).
22. Gallardo E, Queiroz JA. The role of alternative specimens in toxicological analysis. Biomed. Chromatogr. 22, 795-821 (2008).
23. Barroso M, Dias M, Vieira DN, Queiroz JA, López-Rivadulla M. Development and validation of an analytical method for the simultaneous determination of cocaine and its main metabolite, benzoylecgonine, in human hair by gas chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 22, 3320-3326 (2008).
24. Musshoff F, Madea B. Analytical pitfalls in hair testing. Anal. Bioanal. Chem. 388, 1475-1494 (2007)
25. Society of Hair Testing: Recommendations for hair testing in forensic cases. Forensic Sci. Int. 145, 83-84 (2004).
26. Hill V, Cairns T, Schaffer M. Hair analysis for cocaine: factors in laboratory contamination studies and their relevance to profciency sample preparation and hair testing practices. Forensic Sci. Int. 176, 23-33 (2008).
27. Hill V, Cairns T, Schaffer M. Hair analysis for cocaine: the requirement for effective wash procedures and effects of drug concentration and hair porosity in contamination and decontamination. J. Anal. Toxicol. 29, 319-326 (2005).
28. Blank DL, Kidwell DA. Decontamination procedures for drugs of abuse in hair: are they suffcient? Forensic Sci. Int. 70, 13-38 (1995).
29. Hoelzle C, Scheufer F, Uhl M, Sachs H, Thieme D. Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination. Forensic Sci. Int. 176, 13-18 (2008).
30. Toennes SW, Kauert GF, Steinmeyer S, Moeller MR. Driving under the infuence of drugs-evaluation of analytical data of drugs in oral fuid, serum and urine, and correlation with impairment symptoms. Forensic Sci. Int. 152, 149-155 (2005).
31. Ramaekers JG, Moeller MR, van Ruitenbeek P, Theunissen EL, Schneider E, Kauert G. Cognition and motor control as a function of D9-THC concentration in serum and oral fuid: Limits of impairment. Drug Alcohol Depend. 85, 114-122 (2006).
32. Drummer OH. Review: pharmacokinetics of illicit drugs in oral fuid. Forensic Sci. Int. 150, 133-142 (2005).
33. Huestis MA, Oyler JM, Cone EJ, Wstadik AT, Schoendorfer D, Joseph RE. Sweat testing for cocaine, codeine and metabolites by gas chromatography-mass spectrometry. J. Chromatogr. B 733, 247-264 (1999).
34. Kidwell DA, Smith FP. Susceptibility of PharmChek™ drugs of abuse patch to environmental contamination. Forensic Sci. Int. 116, 89-106 (2001).
35. Gray T, Huestis M. Bioanalytical procedures for monitoring in utero drug exposure. Anal. Bioanal. Chem. 388, 1455-1465 (2007).
36. Lozano J, García-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S. Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther. Drug Monit. 29, 711-734 (2007).
37. Huestis MA, Choo RE. Drug abuse's smallest victims: in utero drug exposure. Forensic Sci. Int. 128, 20-30 (2002).
38. Gareri J, Klein J, Koren G. Drugs of abuse testing in meconium. Clin. Chim. Acta 366, 101-111 (2006).
39. Ostrea EM Jr: Testing for exposure to illicit drugs and other agents in the neonate: a review of laboratory methods and the role of meconium analysis. Curr. Probl. Pediatr. 29, 37-56 (1999).
40. Moore C, Negrusz A, Lewis D. Determination of drugs of abuse in meconium. J. Chromatogr. B 713, 137-146 (1998).
41. Montgomery DP, Plate CA, Jones M et al. Using umbilical cord tissue to detect fetal exposure to illicit drugs: a multicentered stuffy in Utah and New Jersey. J. Perionatol. 28, 750-753 (2008).
42. Eyler FD, Behnke M, Wobie K, Garvan CW, Tebbett I. Relative ability of biologic specimens and interviews to detect prenatal cocaine use. Neurotoxicol. Teratol. 27, 677-687 (2005).
43. Kim E, Brion LP, Meenan G, Lehrer M, Suresh BR. Perinatal toxicology screening: comparison of various maternal and neonatal samples. J. Perinatol. 18, 116-121 (1998).
44. Winecker RE, Goldberger BA, Tebbett I et al. Detection of cocaine and its metabolites in amniotic fuid and umbilical cord tissue. J. Anal. Toxicol. 21, 97-104 (1997).
45. Moore C, Browne S, Tebbett I, Negruzs A, Meyer W, Jain L. Determination of cocaine and benzoylecgonine in human aminiotic fuid using high fow solid-phase extraction columns and HPLC. Forensic Sci. Int. 56, 177-181 (1992).
46. Moore C, Dempsey D, Deitermann D, Lewis D, Leikin J. Fetal cocaine exposure: analysis of vernix caseosa. J. Anal. Toxicol. 20, 509-511 (1992).
47. Contreras MT, González M, González S et al. Validation of a procedure for the gas chromatography-mass spectrometry analysis of cocaine and metabolites in pericardial fuid. J. Anal. Toxicol. 31, 75-80 (2007).
48. Contreras MT, Hernández AF, González M. Application of pericardial fuid to the analysis of morphine (heroin) and cocaine in forensic toxicology. Forensic Sci. Int.164, 168-171 (2006).
49. Duer WC, Spitz DJ, McFarland S. Relationships between concentrations of cocaine and its hydrolysates in peripheral blood, heart blood, vitreous humor and urine. J. Forensic Sci. 51, 421-425 (2006).
50. ® RapiScan system as an on-site screening tool for drugs of abuse in a non-conventional biological matrix: vitreous humor. Forensic Sci. Int. 156, 102-105 (2006).
51. Fernández P, Aldonza M, Bouzas A, Lema M, Bermejo AM, Tabernero MJ. GC-FID determination of cocaine and its metabolites in human bile and vitreous humor. J. Appl. Toxicol. 26, 253-257 (2006).
52. Furnari C, Ottaviano V, Sacchetti G, Mancini M. A fatal case of cocaine poisoning in a body packer. J. Forensic Sci. 47, 208-210 (2002).
53. Chronister CW, Walrath JC, Goldberger BA. Rapid detection of benzoylecgonine in vitreous humor by enzyme immunoassay. J. Anal. Toxicol. 25, 621-624 (2001).
54. Mackey-Bojack S, Kloss J, Apple F. Cocaine, cocaine metabolite, and ethanol concentrations in postmortem blood and vitreous humor. J. Anal. Toxicol. 24, 59-65 (2000).
55. McKinney PE, Phillips S, Gomez HF, Brent J, MacIntyre M, Watson WA. Vitreous humor cocaine and metabolite concentrations: do postmortem specimens refect blood levels at the time of death?. J. Forensic Sci. 40, 102-107 (1995).
56. Logan BK, Stafford DT. High-performance liquid chromatography with column switching for the determination of cocaine and benzoylecgonine concentrations in vitreous humor. J. Forensic Sci. 35, 1303-1309 (1990).
57. Mari F, Politi L, Bertol E. Nails of newborns in monitoring drug exposure during pregnancy. Forensic Sci. Int. 179, 176-180 (2008).
58. Ragoucy-Sengler C, Kintz P. Detection of smoked cocaine marker (anhydroecgonine methylester) in nails. J. Anal. Toxicol. 29, 765-768 (2005).
59. Valente-Campos S, Yonamine M, de Moraes Moreau RL, Silva AO. Validation of a method to detect cocaine and its metabolites in nails by gas chromatography-mass spectrometry. Forensic Sci. Int. 159, 218-222 (2006).
60. Cingolani M, Scavella S, Mencarelli R, Mirtella D, Froldi R, Rodriguez D. Simultaneous detection and quantitation of morphine, 6-acetylmorphine, and cocaine in toenails: comparison with hair analysis. J. Anal. Toxicol. 28, 128-131 (2004).
61. Engelhart DA, Jenkins AJ. Detection of cocaine analytes and opiates in nails from postmortem cases. J. Anal. Toxicol. 26, 489-492 (2002).
62. Ropero-Miller JD, Goldberger BA, Cone EJ, Joseph RE Jr. The disposition of cocaine and opiate analytes in hair and fngernails of humans following cocaine and codeine administration. J. Anal. Toxicol. 24, 496-508 (2000).
63. Garside D, Ropero-Miller JD, Goldberger BA, Hamilton WF, Maples WR. Identifcation of cocaine analytes in fngernail and toenail specimens. Forensic Sci. 43, 974-979 (1998).
64. Engelhart DA, Lavins ES, Sutheimer CA. Detection of drugs of abuse in nails. J. Anal. Toxicol. 22, 314-318 (1998).
65. Skopp G, Pötsch L. A case report on drug screening of nail clippings to detect prenatal drug exposure. Ther. Drug Monit. 19, 386-389 (1997).
66. McGrath KK, Jenkins AJ. Detection of drugs of forensic importance in postmortem bone. Am. J. Forensic Med. Pathol. 30, 40-44 (2009).
67. Poklis A, Maginn D, Barr JL. Tissue disposition of cocaine in man: a report of fve fatal poisonings. Forensic Sci. Int. 33, 83-88 (1987).
68. Giroud C, Michaud K, Sporkert F et al. A fatal overdose of cocaine associated with coingestion of marijuana, buprenorphine, and fuoxetine. Body fuid and tissue distribution of cocaine and its metabolites determined by hydrophilic interaction chromatography-mass spectrometry (HILIC-MS). J. Anal. Toxicol. 28, 464-474 (2004).
69. Vanbinst R, Koenig J, Di Fazio V, Hassoun A. Bile analysis of drugs in postmortem cases. Forensic Sci. Int. 128, 35-40 (2002).
70. Soriano T, Jurado C, Menéndez M, Repetto M. Improved solid-phase extraction method for systematic toxicological analysis in biological fuids. J. Anal. Toxicol. 25, 137-143 (2001).
71. Shakleya DM, Huestis MA. Simultaneous quantifcation of nicotine, opioids, cocaine, and metabolites in human fetal postmortem brain by liquid chromatography tandem mass. Anal. Bioanal. Chem. 394(2), 513-522 (2009).
72. Yang W, Barnes AJ, Ripple MG et al. Simultaneous quantifcation of methamphetamine, cocaine, codeine, and metabolites in skin by positive chemical ionization gas chromatography-mass spectrometry. J. Chromatogr. B 833, 210-218 (2006).
73. Lester L, Uemura N, Ademola J et al. Disposition of cocaine in skin, interstitial fuid, sebum, and stratum corneum. J. Anal. Toxicol. 26, 547-553 (2002).
74. Levisky JA, Bowerman DL, Jenkins W W, Karch SB. Drug deposition in adipose tissue and skin: evidence for an alternative source of positive sweat patch tests. Forensic Sci. Int. 110, 35-46 (2000).
75. Burillo-Putze G, López B, León JM et al. Undisclosed cocaine use and chest pain in emergency departments of Spain. Scand. J. Trauma Resusc. Emerg. Med. 17, 11 (2009).
76. Holmgren A, Holmgren P, Kugelberg FC, Jones AW, Ahlner J. Predominance of illicit drugs and poly-drug use among drug-impaired drivers in Sweden. Traffc Inj. Prev. 8, 361-367 (2007).
77. Garcia-Jimenez S, Heredia-Lezama K, Bilbao-Marcos F, Fuentes-Lara G, Monroy-Noyola A, Deciga-Campos M. Screening for marijuana and cocaine abuse by immunoanalysis and gas chromatography. Ann. NY Acad. Sci. 1139, 422-425 (2008).
78. Baker JE, Jenkins AJ. Screening for cocaine metabolite fails to detect an intoxication. Am. J. Forensic Med. Pathol. 29, 141-144 (2008).
79. Farrell LJ, Kerrigan S, Logan BK. Recommendations for toxicological investigation of drug impaired driving. Forensic Sci. 52, 1214-1218 (2007).
80. Labat L, Fontaine B, Delzenne C et al. Prevalence of psychoactive substances in truck drivers in the Nord-Pas-de-Calais region (France). Forensic Sci. Int. 174, 90-94 (2008).
81. Lu NT, Taylor BG. Drug screening and confrmation by GC-MS: comparison of EMIT II and Online KIMS against 10 drugs between US and England laboratories. Forensic Sci. Int. 157, 106-116 (2006).
82. Cone EJ, Sampson-Cone AH, Darwin WD, Huestis MA, Oyler JM. Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results. J. Anal. Toxicol. 27, 386-401 (2003).
83. Feldman M, Kuntz D, Botelho K et al. Evaluation of Roche Diagnostics ONLINE DAT II, a new generation of assays for the detection of drugs of abuse. J. Anal. Toxicol. 28, 593-598 (2004).
84. Ch'ng C W, Fitzgerald M, Gerostamoulos J et al. Drug use in motor vehicle drivers presenting to an Australian, adult major trauma centre. Emerg. Med. Australas. 19, 359-365 (2007).
85. Spiehler V, Isenschmid DS, Matthews P, Kemp P, Kupiec T. Performance of a microtiter plate ELISA for screening of postmortem blood for cocaine and metabolites. J. Anal Toxicol. 27, 587-591 (2003).
86. Lillsunde P, Michelson L, Forsstrom T et al. Comprehensive drug screening in blood for detecting abused drugs or drugs potentially hazardous for traffc safety. Forensic Sci. Int.77, 191-210 (1996).
87. Poklis A, Jortani S, Edinboro LE, Saady JJ. Direct determination of benzoylecgonine in serum by EMIT d.a.u. cocaine metabolite immunoassay. J. Anal Toxicol. 18, 419-422 (1994).
88. Bogusz M, Aderjan R, Schmitt G, Nadler E, Neureither B. The determination of drugs of abuse in whole blood by means of FPIA and EMIT-dau immunoassays-a comparative study. Forensic Sci. Int. 48, 27-37 (1990).
89. Pujol ML, Cirimele V, Tritsch PJ, Villain M, Kintz P. Evaluation of the IDS One-step ELISA kits for the detection of illicit drugs in hair. Forensic Sci. Int. 170, 189-192 (2007).
90. Tsanaclis L, Wicks JF. Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample. Forensic Sci. Int. Aug 170, 121-128 (2007).
91. Lachenmeier K, Musshoff F, Madea B. Determination of opiates and cocaine in hair using automated enzyme immunoassay screening methodologies followed by gas chromatographic-mass spectrometric (GC-MS) confrmation. Forensic Sci. Int. 159, 189-199 (2006).
92. Garcia-Bournissen F, Nesterenko M, Karaskov T, Koren G. Passive environmental exposure to cocaine in Canadian children. Paediatr. 11, 30-32 (2009).
93. Quintela O, Bermejo AM, Tabernero MJ, Strano-Rossi S, Chiarotti M, Lucas AC. Evaluation of cocaine, amphetamines and cannabis use in university students through hair analysis: preliminary results. Forensic Sci. Int. 107, 273-279 (2000).
94. Tagliaro F, Valentini R, Manetto G, Crivellente F, Carli G, Marigo M. Hair analysis by using radioimmunoassay, high-performance liquid chromatography and capillary electrophoresis to investigate chronic exposure to heroin, cocaine and/or ecstasy in applicants for driving licences. Forensic Sci. Int. 107, 121-128 (2000).
95. Moore C, Deitermann D, Lewis D, Feeley B, Niedbala RS. The detection of cocaine in hair specimens using micro-plate enzyme immunoassay. J. Forensic Sci. 44, 609-612 (1999).
96. Segura J, Stramesi C, Redón A et al. Immunological screening of drugs of abuse and gas chromatographic-mass spectrometric confrmation of opiates and cocaine in hair. J. Chromatogr. B 724, 9-21 (1999).
97. Niedbala RS, Kardos K, Fries T, Cannon A, Davis A. Immunoassay for detection of cocaine/metabolites in oral fuids. J. Anal. Toxicol. 25, 62-68 (2001).
98. ® RapiScan drug test system for opiates and cocaine in oral fuid. Forensic Sci. Int. 150, 239-243 (2005).
99. Kim I, Barnes AJ, Schepers R et al. Sensitivity and specifcity of the Cozart microplate EIA cocaine oral fuid at proposed screening and confrmation cutoffs. Clin. Chem. 49, 498-1503 (2003).
100. ® microplate EIA for cocaine and metabolites in oral fuid. J. Anal. Toxicol. 28, 498-503 (2004).
101. ® RapiScan oral fuid drug testing system: an evaluation of sensitivity, specifcity, and effciency for cocaine detection compared with ELISA and GC-MS following controlled cocaine administration. J. Anal. Toxicol. 27, 407-411(2003).
102. Grönholm M, Lillsunde P. A comparison between on-site immunoassay drug-testing devices and laboratory results. Forensic Sci. Int. 121, 37-46 (2001).
103. Peace MR, Tarnai LD, Poklis A. Performance evaluation of four on-site drug-testing devices for detection of drugs of abuse in urine. J. Anal. Toxicol. 24, 589-594 (2000).
104. Verstraete AG. Oral fuid testing for driving under the infuence of drugs: history, recent progress and remaining challenges. Forensic Sci. Int. 150, 143-150 (2005).
105. Biermann T, Schwarze B, Zedler B, Betz P. On-site testing of illicit drugs: the use of the drug-testing device 'Toxiquick'. Forensic Sci. Int. 143, 21-25 (2004).
106. ® RapiScan Oral Fluid Drug Testing System for opiates in comparison to ELISA and GC/MS following controlled codeine administration. Forensic Sci. Int. 141, 41-48 (2004).
107. Barrett C, Good C, Moore C. Comparison of point of collection screening of drugs of abuse in oral fuid with a laboratory based urine screen. Forensic Sci. Int. 122, 163-166 (2001).
108. Walsh JM, Flegel R, Crouch DJ, Cangianelli L, Baudys J. An evaluation of rapid point-of collection oral fuid drug-testing devices. J. Anal. Toxicol. 27, 429-439 (2003).
109. Gray TR, Shakleya DM, Huestis MA. A liquid chromatography tandem mass spectrometry method for the simultaneous quantifcation of 20 drugs of abuse and metabolites in human meconium. Anal. Bioanal. Chem. in press (2009).
110. Antonides HM, Kiely ER, Marinetti LJ. Vitreous fuid quantifcation of opiates, cocaine, and benzoylecgonine: comparison of calibration curves in both blood and vitreous matrices with corresponding concentrations in blood. J. Anal. Toxicol. 31, 469-476 (2007).
111. Pehrsson A, Gunnar T, Engblom C, Seppä H, Jama A, Lillsunde P. Roadside oral fuid testing: comparison of the results of drugwipe 5 and drugwipe benzodiazepines on-site tests with laboratory confrmation results of oral fuid and whole blood. Forensic Sci. Int. 175, 140-148 (2008).
112. Concheiro M, de Castro A, Quintela O, López-Rivadulla M, Cruz A. Determination of drugs of abuse and their metabolites in human plasma by liquid chromatography-mass spectrometry. An application to 156 road fatalities. J. Chromatogr. B 832, 81-89 (2006).
113. Maralikova B, Weinmann W. Confrmatory analysis for drugs of abuse in plasma and urine by high-performance liquid chromatography-tandem mass spectrometry with respect to criteria for compound identifcation. J. Chromatogr B 8111, 21-30 (2004).
114. Brunet BR, Barnes AJ, Scheidweiler KB, Mura P, Huestis MA. Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantifcation of methadone, heroin, cocaine and metabolites in sweat. Anal. Bioanal. Chem. 392, 115-127 (2008).
115. Robandt PP, Reda LJ, Klette KL. Complete automation of solid-phase extraction with subsequent liquid chromatography-tandem mass spectrometry for the quantifcation of benzoylecgonine, m-hydroxybenzoylecgonine, p-hydroxybenzoylecgonine, and norbenzoylecgonine in urine-application to a high-throughput urine analysis laboratory. J. Anal. Toxicol. 32, 577-585 (2008).
116. Cone EJ, Caplan YH, Black DL, Robert T, Moser F. Urine drug testing of chronic pain patients: licit and illicit drug patterns. J. Anal. Toxicol. 32, 530-543 (2008).
117. Gunnar T, Ariniemi K, Lillsunde P. Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fuid by long column fast gas chromatography/electron impact mass spectrometry. J. Mass Spectrom. 40, 739-753 (2005).
118. Saito T, Mase H, Takeichi S, Inokuchi S. Rapid simultaneous determination of ephedrines, amphetamines, cocaine, cocaine metabolites, and opiates in human urine by GC-MS. J. Pharm. Biomed. Anal. 43, 358-363 (2007).
119. Strano-Rossi S, Colamonici C, Botre F. Parallel analysis of stimulants in saliva and urine by gas chromatography/mass spectrometry: perspectives for 'in competition' anti-doping analysis. Anal. Chim. Acta 606, 217-222 (2008).
120. Kala SV, Harris SE, Freijo TD, Gerlich S. Validation of analysis of amphetamines, opiates, phencyclidine, cocaine, and benzoylecgonine in oral fuids by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 32, 605-611 (2008).
121. Gottardo R, Bortolotti F, De Paoli G, Pascali JP, Miksík I, Tagliaro F. Hair analysis for illicit drugs by using capillary zone electrophoresis-electrospray ionization-ion trap mass spectrometry. J. Chromatogr. A 1159, 185-189 (2007)
122. Øiestad EL, Johansen U, Christophersen AS. Drug screening of preserved oral fuid by liquid chromatography-tandem mass spectrometry. Clin. Chem. 53, 300-309 (2007).
123. Bermejo AM, López P, Alvarez I, Tabernero MJ, Fernández P. Solid-phase microextraction for the determination of cocaine and cocaethylene in human hair by gas chromatography-mass spectrometry. Forensic Sci. Int. 156, 2-8 (2006).
124. de Toledo FC, Yonamine M, de Moraes Moreau RL, Silva OA. Determination of cocaine, benzoylecgonine and cocaethylene in human hair by solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B 798, 361-365 (2003).
125. Alvarez I, Bermejo AM, Tabernero MJ, Fernández P, López P. Determination of cocaine and cocaethylene in plasma by solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B 845, 90-94 (2007).
126. Follador MJ, Yonamine M, de Moraes Moreau RL, Silva OA. Detection of cocaine and cocaethylene in sweat by solid-phase microextraction and gas chromatography/mass spectrometry. J. Chromatogr. B 811, 37-40 (2004).
127. Gentili S, Cornetta M, Macchia T. Rapid screening procedure based on headspace solid-phase microextraction and gas chromatography-mass spectrometry for the detection of many recreational drugs in hair. J. Chromatogr. B 801, 289-296 (2004).
128. Pragst F. Application of solid-phase microextraction in analytical toxicology. Anal. Bioanal. Chem. 388, 1393-414 (2007).
129. Radcliffe C, Maguire K, Lockwood B. Applications of supercritical fuid extraction and chromatography in forensic science. J. Biochem. Biophys. Methods 43, 261-272 (2000).
130. Allen DL, Oliver JS. The application of supercritical fuid extraction to cocaine and its metabolites in blood and urine. J. Anal. Toxicol. 24, 228-232 (2000).
131. Kintz P. Bioanalytical procedures for detection of chemical agents in hair in the case of drug-facilitated crimes. Anal. Bioanal. Chem. 388, 1467-1474 (2007).
132. Pragst F, Balikova MA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta 370, 17-49 (2006).
133. Huang DK, Liu C, Huang MK, Chien CS. Simultaneous determination of morphine, codeine, 6-acetylmorphine, cocaine and benzoylecgonine in hair by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 23, 957-962 (2009).
134. Musshoff F, Lachenmeier K, Lichtermann D, Madea B. Cocaine and opiate concentrations in hair from subjects in a heroin maintenance program in comparison to a methadone substituted group. Int. J. Legal Med. (2008) (Epub ahead of print).
135. Moore C, Coulter C, Crompton K. Determination of cocaine, benzoylecgonine, cocaethylene and norcocaine in human hair using solid-phase extraction and liquid chromatography with tandem mass spectrometric detection. J. Chromatogr. B 859, 208-212 (2007).
136. Gottardo R, Polettini A, Sorio D et al. Capillary zone electrophoresis (CZE) coupled to time-of-fight mass spectrometry (TOF-MS) applied to the analysis of illicit and controlled drugs in blood. Electrophoresis 29, 4078-4087 (2008).
137. Jagerdeo E, Montgomery MA, Lebeau MA, Sibum M. An automated SPE/LC/MS/MS method for the analysis of cocaine and metabolites in whole blood. J. Chromatogr. B 874, 15-20 (2008).
138. Bertol E, Trignano C, Di Milia MG, Di Padua M, Mari F. Cocaine-related deaths: An enigma still under investigation. Forensic Sci. Int. 176, 121-123 (2008).
139. Fernández P, Lago M, Lorenzo RA, Carro AM, Bermejo AM, Tabernero MJ. Microwave-Assisted Extraction and HPLC-DAD determination of drugs of Abuse in human plasma. J. Anal. Toxicol. 31, 388-393 (2007).
140. Johansen SS, Bhatia HM. Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B 852, 338-344 (2007).
141. Alvarez I, Bermejo AM, Tabernero MJ, Fernández P, López P. Determination of cocaine and cocaethylene in plasma by solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B 845, 90-94 (2007).
142. Cardona PS, Chaturvedi AK, Soper JW, Canfeld DV. Simultaneous analyses of cocaine, cocaethylene, and their possible metabolic and pyrolytic products. Forensic Sci. Int. 157, 46-56 (2006).
143. Fernández P, Morales L, Vázquez C, Bermejo AM, Tabernero MJ. HPLC-DAD determination of opioids, cocaine and their metabolites in plasma. Forensic Sci. Int. 161, 31-35 (2006).
144. Jagerdeo E, Abdel-Rehim M. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-fight mass spectrometry after anline preconcentration utilizing microextraction by packed sorbent. J. Am. Soc. Mass Spectrom. 20(5), 891-899 (2009).
145. Berg T, Lundanes E, Christophersen AS, Strand DH. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. J. Chromatogr. B 877, 421-432 (2009).
146. Aturki Z, D'Orazio G, Fanali S et al. Capillary electrochromatographic separation of illicit drugs employing a cyano stationary phase. J. Chromatogr. A (2008) (In press).
147. Jagerdeo E, Montgomery MA, Sibum M, Sasaki TA, LeBeau MA. Rapid analysis of cocaine and metabolites in urine using a completely automated solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry method. J. Anal. Toxicol. 32, 570-576 (2008).
148. Su HL, Feng LI, Jen HP, Hsieh YZ. Determination of cocaine and its metabolites using cation-selective exhaustive injection and sweeping-MEKC. Electrophoresis 29, 4270-4276 (2008).
149. Marchei E, Colone P, Nastasi GG et al. On-site screening and GC-MS analysis of cocaine and heroin metabolites in body-packers urine. J. Pharm. Biomed. Anal. 48, 383-387 (2008).
150. Concheiro M, De Castro A, Quintela O, Cruz A, López-Rivadulla M. Determination of illicit drugs and their metabolites in human urine by liquid chromatography tandem mass spectrometry including relative ion intensity criterion. J. Anal. Toxicol. 31, 573-580 (2007).
151. Feng J, Wang L, Dai I, Harmon T, Bernet JT. Simultaneous determination of multiple drugs of abuse and relevant metabolites in urine by LC-MS-MS. J. Anal. Toxicol. 31, 359-368 (2007).
152. Schönberg L, Grobosch T, Lampe D, Kloft C. Toxicological Screening in Urine: Comparison of Two Automated HPLC Screening Systems, Toxicological Identifcation System (TOX.I.S.*) versus REMEDITM-HS. J. Anal. Toxicol. 31, 321-327 (2007).
153. Znaleziona J, Petr J, Maier V et al. Capillary electrophoresis as a verifcation tool for immunochemical drug screening. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 151, 31-36 (2007).
154. Zaitsu K, Miki A, Katagi M, Tsuchihashi H. Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to fltration sterilization. Forensic Sci. Int. 174, 189-196 (2008).
155. Fernández P, Lago M, Lorenzo RA, Carro AM, Bermejo AM, Tabernero MJ. Microwave assisted extraction of drugs of abuse from human urine. J. Appl. Toxicol. 27, 373-379 (2007).
156. Romberg RW, Jamerson MH, Klette KL. Rapid analysis of benzoylecgonine in urine by fast gas chromatography-mass spectrometry. J. Anal. Toxicol. 30, 554-558 (2006).
157. Jufer R, Walsh SL, Cone EJ, Sampson-Cone A. Effect of repeated cocaine administration on detection times in oral fuid and urine. J. Anal. Toxicol. 30, 458-462 (2006).
158. Saito T, Mase H, Takeichi S, Inokuchi S. Rapid simultaneous determination of ephedrines, amphetamines, cocaine, cocaine metabolites, and opiates in human urine by GC-MS. J. Pharm. Biomed. Anal. 43, 358-363 (2007).
159. Moody DE, Fang WB, Andrenyak DM, Monti KM, Jones C. A comparative evaluation of the instant-view 5-panel test card with onTrak TesTcup pro 5: comparison with gas chromatography-mass spectrometry. J. Anal. Toxicol. 30, 50-56 (2006).
160. Yonamine M, Sampaio MC. A high-performance thin-layer chromatographic technique to screen cocaine in urine samples. Leg. Med. 8, 184-187 (2006).
161. Fang H, Zeng Z, Liu L, Pang D. On-line back-extraction feld-amplifed sample injection method for directly analyzing cocaine and thebaine in the extractants by solvent microextraction. Anal. Chem. 78, 1257-1263 (2006).
162. Miller EI, Wylie FM, Oliver JS. Simultaneous detection and quantifcation of amphetamines, diazepam and its metabolites, cocaine and its metabolites, and opiates in hair by LC-ESI-MS-MS using a single extraction method. J. Anal. Toxicol. 32, 457-469 (2008).
163. Vogliardi S, Favretto D, Frison G, Ferrara SD, Seraglia R, Traldi P. A fast screening MALDI method for the detection of cocaine and its metabolites in hair. J. Mass Spectrom. 44, 18-24 (2009).
164. Hegstad S, Khiabani HZ, Kristoffersen L, Kunøe N, Lobmaier PP, Christophersen AS. Drug screening of hair by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 32, 364-372 (2008).
165. Mercolini L, Mandrioli R, Saladini B, Conti M, Baccini C, Raggi MA. Quantitative analysis of cocaine in human hair by HPLC with fuorescence
166. Stramesi C, Polla M, Vignali C, Zucchella A, Groppi A. Segmental hair analysis in order to evaluate driving performance. Forensic Sci. Int. 176, 34-37 (2008).
167. Tsanaclis L, Wicks JF. Differentiation between drug use and environmental contamination when testing for drugs in hair. Forensic Sci. Int. 176, 19-22 (2008).
168. Míguez-Framil M, Moreda-Piñeiro A, Bermejo-Barrera P, López P, Tabernero MJ, Bermejo AM. Improvements on enzymatic hydrolysis of human hair for illicit drug determination by gas chromatography/mass spectrometry. Anal. Chem. 79, 8564-8570 (2007).
169. Gottardo R, Fanigliulo A, Bortolotti F, De Paoli G, Pascali JP, Tagliaro F. Broad-spectrum toxicological analysis of hair based on capillary zone electrophoresis-time-of-fight mass spectrometry. J. Chromatogr. A 1159, 190-197 (2007).
170. Kłys M, Rojek S, Kulikowska J, Bozek E, Scisłowski M.Usefulness of multi-parameter opiates-amphetamines-cocainics analysis in hair of drug users for the evaluation of an abuse profle by means of LC-APCI-MS-MS. J. Chromatogr. B 854, 299-307 (2007).
171. Garcia-Bournissen F, Rokach B, Karaskov T, Koren G. Cocaine detection in maternal and neonatal hair: implications to fetal toxicology. Ther. Drug Monit. 29, 71-76 (2007).
172. Gambelunghe C, Sommavilla M, Ferranti C et al. Analysis of anabolic steroids in hair by GC/MS/MS. Biomed. Chromatogr. 21, 369-375 (2007).
173. Mieczkowski T, Kruger M. Interpreting the color effect of melanin on cocaine and benzoylecgonine assays for hair analysis: brown and black samples compared. J. Forensic Leg. Med. 14, 7-15 (2007).
174. Politi L, Zucchella A, Morini L, Stramesi C, Polettini A. Markers of chronic alcohol use in hair: comparison of ethyl glucuronide and cocaethylene in cocaine users. Forensic Sci. Int. Oct 172, 23-27 (2007).
175. Cristoni S, Basso E, Gerthoux P et al. Surface-activated chemical ionization ion trap mass spectrometry for the analysis of cocaine and benzoylecgonine in hair after extraction and sample dilution. Rapid Commun. Mass Spectrom. 21, 2515-2523 (2007).
176. Cordero R, Paterson S. Simultaneous quantifcation of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS. J. Chromatogr. B 850, 423-431 (2007).
177. Langel K, Engblom C, Pehrsson A, Gunnar T, Ariniemi K, Lillsunde P. Drug testing oral fuid-evaluation of sample devices. J. Anal. Toxicol. 32, 393-401 (2008).
178. Fernández P, Morales L, Vázquez C, Lago M, Bermejo AM. Comparison of two extraction procedures for determination of drugs of abuse in human saliva by high-performance liquid chromatography. J. Appl. Toxicol. 28, 998-1003 (2008).
179. Concheiro M, de Castro A, Quintela O, Cruz A, López-Rivadulla M. Determination of illicit and medicinal drugs and their metabolites in oral fuid and preserved oral fuid by liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 391, 2329-2338 (2008).
180. Cone EJ, Clarke J, Tsanaclis L. Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fuid. J. Anal. Toxicol. 31, 424-433 (2007).
181. Concheiro M, de Castro A, Quintela O, Cruz A, López-Rivadulla M. Confrmation by LC-MS of drugs in oral fuid obtained from roadside testing. Forensic Sci. Int. 170, 156-162 (2007).
182. Pujadas M, Pichini S, Civit E, Santamariña E, Perez K, de la Torre R. A simple and reliable procedure for the determination of psychoactive drugs in oral fuid by gas chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 44, 594-601(2007).
183. Quintela O, Crouch DJ, Andrenyak DM. Recovery of drugs of abuse from the immunalysis Quantisal™ oral fuid collection device. J. Anal. Toxicol. 30, 614-616 (2006).
184. Dams R, Choo RE, Lambert WE, Jones H, Huestis MA. Oral fuid as an alternative matrix to monitor opiate and cocaine use in substance-abuse treatment patients. Drug Alcohol Depend. 87, 258-267 (2007).
185. Toennes SW, Steinmeyer S, Maurer HJ, Moeller MR, Kauert GF. Screening for drugs of abuse in oral fuid-correlation of analysis results with serum in forensic cases. J. Anal. Toxicol. 29, 22-27 (2005).
186. Wylie FM, Torrance H, Anderson RA, Oliver JS. Drugs in oral fuid: part I. Validation of an analytical procedure for licit and illicit drugs in oral fuid. Forensic Sci. Int. 150, 191-198 (2005).
187. Wood M, Laloup M, Ramirez Fernandez M del M et al. Quantitative analysis of multiple illicit drugs preserved in oral fuid by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Forensic Sci. Int. 150, 227-238 (2005).
188. Bernhoft IM, Steentoft A, Johansen SS, Klitgaard NA, Larsen LB, Hansen LB. Drugs in injured drivers in Denmark. Forensic Sci. Int. 150, 181-189 (2005).
189. Clauwaert K, Decaestecker T, Mortier K et al. The determination of cocaine, benzoylecgonine, and cocaethylene in small-volume oral fuid samples by liquid chromatography-quadrupole-time of-fight mass spectrometry. J. Anal. Toxicol. 28, 655-659 (2004).
190. Cámpora P, Bermejo AM, Tabernero MJ, Fernández P. Quantitation of cocaine and its major metabolites in human saliva using gas chromatography-positive chemical ionization-mass spectrometry (GC-PCI-MS). J. Anal. Toxicol. 27, 270-274 (2003).
191. Fucci N, De Giovanni N, Chiarotti M. Simultaneous detection of some drugs of abuse in saliva samples by SPME technique. Forensic Sci. Int. 134, 40-45 (2003).
192. Yonamine M, Tawil N, Moreau RL, Silva AO. Solid-phase micro-extraction-gas chromatography-mass spectrometry and headspace-gas chromatography of tetrahydrocannabinol, amphetamine, methamphetamine, cocaine and ethanol in saliva samples. J. Chromatogr. B 789, 73-78 (2003).
193. Dams R, Murphy CM, Choo RE, Lambert WE, De Leenheer AP, Huestis MA. LC-atmospheric pressure chemical ionization-MS/MS analysis of multiple illicit drugs, methadone, and their metabolites in oral fuid following protein precipitation. Anal. Chem. 75, 798-804 (2003).
194. Cone EJ, Presley L, Lehrer M et al.Oral fuid testing for drugs of abuse: Positive prevalence rates by Intercept™ immunoassay screening and GC-MS-MS confrmation and suggested cutoff concentrations. J. Anal. Toxicol. 26, 541-546 (2002).
195. Samyn N, De Boeck G, Verstraete A. The use of oral fuid and sweat wipes for the detection of drugs of abuse in drivers. J. Forensic Sci. 47, 1380-1387 (2002).
196. Mortier KA, Maudens KE, Lambert WE et al. Simultaneous, quantitative determination of opiates, amphetamines, cocaine and benzoylecgonine in oral fuid by liquid chromatography quadrupole-time-of-fight mass spectrometry. J. Chromatogr. B. 779, 321-330 (2002).
197. Samyn N, van Haeren C. On-site testing of saliva and sweat with Drugwipe and determination of concentrations of drugs of abuse in saliva, plasma and urine of suspected users. Int. J. Legal Med. 113, 150-154 (2000).
198. Fucci N, De Giovanni N, Scarlata S. Sweat testing in addicts under methadone treatment: an Italian experience. Forensic Sci. Int. 174, 107-110 (2008).
199. Keller T, Keller A, Tutsch-Bauer E, Monticelli F. Application of ion mobility spectrometry in cases of forensic interest. Forensic Sci. Int. 161, 130-140 (2006).
200. Kacinko SL, Barnes AJ, Schwilke EW, Cone EJ, Moolchan ET, Huestis MA. Disposition of cocaine and its metabolites in human sweat after controlled cocaine administration. Clin. Chem. 51, 2085-2094 (2005).
201. Liberty HJ, Johnson BD, Fortner N. Detecting cocaine use through sweat testing: multilevel modeling of sweat patch length-of-wear data. J. Anal. Toxicol. 28, 667-673 (2004).
202. Uemura N, Nath RP, Harkey MR, Henderson GL, Mendelson J, Jones RT. Cocaine levels in sweat collection patches vary by location of patch placement and decline over time. J. Anal. Toxicol. 28, 253-259 (2004).
203. Moody DE, Spanbauer AC, Taccogno JL, Smith EK. Comparative analysis of sweat patches for cocaine (and metabolites) by radioimmunoassay and gas chromatography-positive ion chemical ionization-mass spectrometry. J. Anal. Toxicol. 28, 86-93 (2004).
204. Liberty HJ, Johnson BD, Fortner N, Randolph D. Detecting crack and other cocaine use with fastpatches. Addict. Biol. 8, 191-200 (2003).
205. Kidwell DA, Kidwell JD, Shinohara F et al. Comparison of daily urine, sweat, and skin swabs among cocaine users. Forensic Sci. Int. 133, 63-78 (2003).
206. Winhusen TM, Somoza EC, Singal B, Kim S, Horn PS, Rotrosen J. Measuring outcome in cocaine clinical trials: a comparison of sweat patches with urine toxicology and participant self-report. Addiction 98, 317-324 (2003).
207. Moody DE, Cheever ML. Evaluation of immunoassays for semiquantitative detection of cocaine and metabolites or heroin and metabolites in extracts of sweat patches. J. Anal. Toxicol. 25, 190-197 (2001).
208. García-Algar O, Vall Combelles O, Puig Sola C et al. Prenatal exposure to drugs of abuse using meconium analysis in a low socioeconomic population in Barcelona. Na. Pediatr. 70, 145-152 (2009).
209. Kacinko SL, Jones HE, Johnson RE, Choo RE, Huestis MA. Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes. Clin. Pharmacol. Ther. 84, 604-612 (2008).
210. López P, Bermejo AM, Tabernero MJ, Fernández P, Alvarez I. Determination of cocaine and heroin with their respective metabolites in meconium by gas chromatography-mass spectrometry. J. Appl. Toxicol. 27, 464-471 (2007).
211. Pichini S, Puig C, Zuccaro P et al. Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project". Forensic Sci. Int. 153, 59-65 (2005).
212. Pichini S, Marchei E, Pacifci R, Pellegrini M, Lozano J, García-Algar O. Application of a validated high-performance liquid chromatography-mass spectrometry assay to the analysis of m-and p-hydroxybenzoylecgonine in meconium. J. Chromatogr. B 820, 151-156 (2005).
213. Hajnal BL, Ferriero DM, Partridge JC, Dempsey DA, Good W V. Is exposure to cocaine or cigarette smoke during pregnancy associated with infant visual abnormalities? Dev. Med. Child. Neurol. 46, 520-525 (2004).
214. Pichini S, Pacifci R, Pellegrini M et al. Development and validation of a liquid chromatography-mass spectrometry assay for the determination of opiates and cocaine in meconium. J. Chromatogr. B 794, 281-292 (2003).
215. Vinner E, Vignau J, Thibault D et al. Hair analysis of opiates in mothers and newborns for evaluating opiate exposure during pregnancy. Forensic Sci. Int. 133, 57-62 (2003).
216. Bar-Oz B, Klein J, Karaskov T, Koren G. Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Arch. Dis. Child. Fetal. Neonatal Ed. 88, F98-F100 (2003).
217. Lester BM, ElSohly M, Wright LL et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics 107, 309-317 (2001).
218. Xia Y, Wang P, Bartlett MG, Solomon HM, Busch KL. An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium. Anal. Chem. 72, 764-771 (2000).
219. ElSohly MA, Kopycki W, Feng S, Murphy TP. Identifcation and analysis of the major metabolites of cocaine in meconium. J. Anal. Toxicol. 23, 446-451 (1999).
220. ElSohly MA, Stanford DF, Murphy TP et al. Immunoassay and GC-MS procedures for the analysis of drugs of abuse in meconium. J. Anal. Toxicol. 23, 436-445 (1999).
221. Ali EM, Edwards HG, Hargreaves MD, Scowen IJ. Raman spectroscopic investigation of cocaine hydrochloride on human nail in a forensic context. Anal. Bioanal. Chem. 390, 1159-1166 (2008).
222. Stimpf T, Reichel S. Distribution of drugs of abuse within specifc regions of the human brain. Forensic Sci. Int. 170, 179-182 (2007).
223. Pellegrini M, Casá A, Marchei E et al. Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth. J. Pharm Biomed. Anal. 40, 662-668 (2006).