Determination of cocaine and heroin with their respective metabolites in meconium by gas chromatography-mass spectrometry

Journal of Applied Toxicology

Volumn 27, Issue 5, 2007, Pages 464-471

  Lopez P ^a   Bermejo, A M ^a   Tabernero, M J ^a   Fernandez P ^a   Alvarez I ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cocaine; GC MS; Meconium; Opiates; SPE

Indexed keywords

BENZOYLECGONINE; COCAINE; CODEINE; DIAMORPHINE; METHANOL; MORPHINE; MORPHINE 6 ACETATE;

ARTICLE; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; MECONIUM; METABOLITE; OSCILLATION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

COCAINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEROIN; HUMANS; MECONIUM;

EID: 34547912142     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1227     Document Type: Article

References (26)

1. Abusada GM, Abukhalaf IK, Alford DD, Vinzon-Bautista I, Pramanik AK, Ansari NA, Manno JE, Manno BR. 1993. Solid-phase extraction and GC/MS quantitation of cocaine, ecgonine methyl ester, benzoylecgonine, and cocaethylene from meconium, whole blood, and plasma. J. Anal. Toxicol. 17: 353-358.
2. Chan D, Klein J, Koren G. 2003. New methods for neonatal drug screening. NeoReviews 4: 236-244.
3. Clark GD, Rosenzweig IB, Raisys V, Callahan CM, Grant TM, Streissguth AP. 1992. The analysis of cocaine and benzoylecgonine in meconium. J. Anal. Toxicol. 16: 261-263.
4. ElSohly MA, Feng S, Murphy TP. 2001. Analysis of methadone and its metabolites in meconium by enzyme immunoassay (EMIT®) and GC-MS. J. Anal. Toxicol. 25: 40-44.
5. ElSohly MA, Kopycki W, Feng S, Murphy T. 1999. Identification and analysis of the major metabolites of cocaine in meconium. J. Anal. Toxicol. 23: 446-451.
6. Food and Drug Administration: U.S. Department of Health and Human Services, Guidance for Industry, Bioanalytical Method Validation. FDA [document on line] [cited 21 January 2003]. Available from URL: http://www.fda.gov/cder/ guidance/4252fnl.pdf.
7. Franke JP, de Zeeuw RA. 1998. Solid-phase extraction procedures in systematic toxicological analysis. J. Chromatogr. B 713: 51-59.
8. Franssen RME, Stolk LML, wan der Brand W, Smith BJ. 1994. Analysis of morphine and amphetamine in meconium with immunoassay and HPLC-diode array detection. J. Anal. Toxicol. 18: 294-295.
9. Howe T, Tsushima JH, Batra KK. 1994. Neonatal screening of meconium for drugs of abuse by abbot TDx with GC and GC/MS confirmation: comparison with urine EMIT results. Abstract Clin. Chem. 38: 1005.
10. Kwong TC, Ryan RM. 1997. Detection of intrauterine illicit drug exposure by newborn drug testing. Clin. Chem. 43: 235-242.
11. Lillusunde P, Korte T. 1991. Comprehensive drug screening in urine using solid phase extraction and combined TLC and GC/MS identification. J. Anal. Toxicol. 15: 71-78.
12. López P, Bermejo AM, Tabernero MJ, Fernández P, Álvarez I. 2006. Determination of cocaine and heroin with their respective metabolites in human hair using gas chromatography-mass spectrometry. Anal. Lett. 39: 2307-2316.
13. Moriya F, Chan KM, Noguchi TT, Wu PYK. 1994. Testing for drugs of abuse in meconium of newborn infants. J. Anal. Toxicol. 18: 41-45.
14. Murphey LJ, Olsen GD, Konkol RJ. 1993. Quantitation of benzoylnorecgonine and other cocaine metabolites in meconium by high-performance liquid chromatography. J. Chromatogr. 613: 330-335.
15. Ostrea EM Jr, Brady MJ, Parks PM, Asensio DC, Naluz A. 1989. Drug screening in infants of drug dependent mothers: an alternative to urine testing. J. Pediatr. 115: 474-477.
16. Ostrea EM Jr, Parks PM, Brady MJ. 1988. Rapid isolation and detection of drugs in meconium of infants of drug-dependent mothers. Clin. Chem. 34: 2372-2373.
17. Ostrea EM Jr, Romero A, Knapp DK, Ostrea AR, Lucena JE, Utarnachilt RB. 1994. Postmorten drug analysis of meconium in early-gestation human fetuses exposed to cocaine: Clinical implications. J. Pediatr. 124: 477-479.
18. Oyler J, Darwin WD, Preston KL, Suess P, Cone EJ. 1996. Cocaine disposition in meconium from newborns of cocaine-abusing mothers and urine of adult drug users. J. Anal. Toxicol. 20: 453-462.
19. Pichini S, Marchei E, Pacifici R, Pellegrini M, Lozano J, Garcia-Algar O. 2005. Application of a validated high performance liquid chromatography-mass spectrometry assay to analysis of meta-hydroxybenzoylecgonine and para hydroxybenzoylecgonine in meconium. J. Chromatogr. B 820: 151-156.
20. Pichini S, Pacifici R, Pellegrini M, Marchei E, Pérez-Alarcon E, Puig C, Vall O, García-Algar O. 2003. Development and validation of a liquid chromatography-mass spectrometry assay for the determination of opiates and cocaine in meconium. J. Chromatogr. B 794: 281-292.
21. Pichini S, Puig C, Zuccaro P, Marchei E, Pellegrini M, Murillo J, Vall O, Pacifici R, García-Algar O. 2005. Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city. Preliminary results of the 'Meconium Project'. Forensic Sci. Int. 153: 59-65.
22. Ryan RM, Wagner CL, Schultz JM, Varley J, DiPeta J, Sherer DM, Phelps DL, Kwong T. 1994. Meconium analysis for improved identification of infants exposed to cocaine in utero. J. Pediatr. 125: 435-440.
23. Salem MY, Ross SA, Murphy TP, ElSohly MA. 2001. GC-MS determination of heroin metabolites in meconium: evaluation of four solid-phase extraction cartridges. J. Anal. Toxicol. 25: 93-98.
24. Steele BW, Bandstra ES, Wu NC, Hime GW, Hearn WL. 1993. m-Hydroxybenzoylecgonine: an important contributor to the immunoreactivity in assays for benzoylecgonine in meconium. J. Anal. Toxicol. 17: 348-352.
25. Szeto H. 1993. Kinetics of drug transfer to the fetus. Clin. Obstet. Gynecol. 36: 246-254.
26. Xia Y, Wang P, Bartlett MG, Solomon HM, Busch KL. 2000. An LC/MS/MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium. Anal. Chem. 72: 764-771.