Vitreous fluid quantification of opiates, cocaine, and benzoylecgonine: Comparison of calibration curves in both blood and vitreous matrices with corresponding concentrations in blood

Journal of Analytical Toxicology

Volumn 31, Issue 8, 2007, Pages 469-476

  Antonides, Heather M ^a   Kiely, Elizabeth R ^a   Marinetti, Laureen J ^a  

^a Montgomery County Coroner's Office   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; CODEINE; HYDROCODONE; MORPHINE; MORPHINE 6 ACETATE; OPIATE DERIVATIVE; OXYCODONE;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG DETERMINATION; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; VITREOUS BODY;

EID: 36448944723     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/31.8.469     Document Type: Article

References (14)

1. T.M. Montgomery. Anatomy, physiology, and pathology of the human eye. http://www.tedmontgomery.com/theeye/index.html, June 2007.
2. Forensic Toxicology Laboratory Guidelines. Society of Forensic Toxicology/American Academy of Forensic Science, 2006. 8.3.2
3. United Chemical Technologies (UCT) Worldwide Monitoring technical literature.
4. X.H. Chen, J.P. Franke, J. Wijsbeek, and R.A. de Zeeuw. Isolation of acidic, neutral, and basic drugs from whole blood using a single mixed-mode solid-phase extraction column. J. Anal. Toxicol. 16: 351-355 (1991).
5. Personal communication. Wayne County Medical Examiner's Office, Toxicology Lab, Detroit, MI.
6. D. Isenschmid, B. Levine, and Y. Caplan. A comprehensive study of the stability of cocaine and its metabolites. J. Anal. Toxicol. 13: 250-256 (1989).
7. D.S. Isenschmid. Cocaine - effects on human performance and behavior. Forensic Sci. Rev. 14: 62-100 (2002).
8. S. Mackey-Bojack, J. Kloss, and F. Apple. Cocaine, cocaine metabolite, and ethanol concentrations in postmortem blood and vitreous humor. J. Anal. Toxicol. 24: 59-65 (2000).
9. P.E. McKinney, S. Phillips, H.F. Gomez, J. Brent, M. MacIntyre, and W.A. Watson. Vitreous humor cocaine and metabolite concentrations: do postmortem specimens reflect blood levels at the time of death? J. Forensic Sci. 40: 102-107 (1995).
10. G. Skopp. Preanalytic aspects in postmortem toxicology. Forensic Sci. Int. 142: 75-100 (2004).
11. J. Wyman and S. Bultman. Postmortem distribution of heroin metabolites in femoral blood, liver, cerebrospinal fluid, and vitreous humor. J. Anal. Toxicol. 28: 260-263 (2004).
12. F. Pragst, K. Spiegel, U. Leuschner, and A. Hager. Detection of 6-acetylmorphine in vitreous humor and cerebrospinal fluid - comparison with urinary analysis for proving heroin administration in opiate fatalities. J. Anal. Toxicol. 23: 168-172 (1999).
13. J. Pearson and J. Saady. Utility of vitreous humor in investigations of heroin related deaths. Presented at the Society of Forensic Toxicology Meeting, Detroit, MI 2002.
14. R.C. Baselt. Disposition of Toxic Drugs and Chemicals in Man, 7th ed. Biomedical Publications, Foster City, CA, 2004, pp 532-536.