Rapid analysis of cocaine and metabolites in urine using a completely automated solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry method

Journal of Analytical Toxicology

Volumn 32, Issue 8, 2008, Pages 570-576

  Jagerdeo, Eshwar ^a,d   Montgomery, Madeline A ^a   Sibum, Martin ^b   Sasaki, Tania A ^c   LeBeau, Marc A ^a  

^a Federal Bureau of Investigation   (United States)

^b Spark Holland Inc ^*  (Netherlands)

^c APPLIED BIOSYSTEMS   (United States)

^d FBI LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; ECGONINE; ECGONINE METHYL ESTER; HOMOCOCAINE;

ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; QUALITY CONTROL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 56449084504     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.8.570     Document Type: Article

References (21)

1. K .Woff, M. Farrell, J. Marsden, M.G. Monteiro, R. Ali, S. Welch, and J. Strang. A review of biological indicators of illicit drug use, practical considerations and clinical usefulness. Addiction 94: 1279-1298 (1999).
2. H.H. Maurer, T. Kraemer, O. Ledvinka, C.J. Schmitt, and A.A. Weber. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicology analysis studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of α and β-amanitin in urine by atmospheric pressure ionization electrospray LC-MS. J. Chromatogr. B 689: 81-89 (1997).
3. H.H. Maurer. Screening procedure for simultaneous detection of several drug classes used for high throughput toxicological analyses and doping control. A review. Combi. Chem. High Throughput Screen. 3: 467-480 (2000).
4. M.A. Huestis, E.J. Cone, C.J.Wong, A. Umbricht, and K.L. Preston. Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testing. J. Anal. Toxicol. 24: 509-521 (2000).
5. K.L. Preston, M.A. Huestis, C.J. Wong, A. Umbricht, B.A. Goldberger, and E.J. Cone. Monitoring cocaine use in substance-abuse-treatment patient by sweat and urine testing. J. Anal. Toxicol. 23: 313-322 (1999).
6. R. Dams, C.M. Murphy, W.E. Lambert, and M.A. Huestis. Urine drug testing for opiates, cocaine, and metabolites by direct injection liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 17: 1665-1670 (2003).
7. N.L. Benowitz. Clinical pharmacology and toxicology of cocaine. Pharmacol. Toxicol. 72: 3-12 (1993).
8. K. Srinivasan, P. Wang, A.T. Eley, C.A. White, and M.G. Bartlett. Liquid chromatography-tandem mass spectrometry analysis of cocaine and its metabolites from blood, aminotic fluid, placental and fetal tissues: study of the metabolism and distribution of cocaine in pregnant rats. J. Chromatogr. B 745: 287-303 (2000).
9. E.J. Cone. Pharmacokinetics and pharmacodynamics of cocaine. J. Anal. Toxicol. 19: 459-478 (1995).
10. K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection. J. Chromatogr. Sci. 35: 321-328 (1997).
11. D.L. Philips, I.R. Tebbett, and R.L. Bertholf. Comparsion of HPLC and GC-MS for measurement of cocaine and metabolites in human urine. J. Anal. Toxicol. 20: 305-308 (1996).
12. L. Virag, B. Mets, and S. Jamdar. Determination of cocaine, norcocaine, benzoylecgonine and ecgonine in rat plasma by high performance liquid chromatography with ultraviolet detection. J. Chromatogr. B 681: 263-269 (1996).
13. P. Fernandez, L. Morales, C. Vazquez, A.M. Bermejo, and M.J. Tabernero. HPLC-DAD determination of opioids, cocaine and their metabolites in plasma. Forensic Sci. Int. 161: 31-35 (2006).
14. S.J. Mulé and G.A. Casella. Confirmation and quantitation of cocaine, benzoylecgonine, ecgonine methyl ester in human urine by GC-MS. J. Anal. Toxicol. 12: 153-155 (1988).
15. D.S. Isenschmid, B.S. Levine, and Y.H. Caplan. A method for the simultaneous determination of cocaine, benzoylecgonine, and ecgonine methyl ester in blood and urine using GC-EIMS with derivatization to produce high mass molecular ions. J. Anal. Toxicol. 12: 242-245 (1988).
16. D.M. Chinn, D.J. Crouch, M.A. Peat, B.S. Finkle, and T.A. Jennison. Gas chromatography-chemical ionization mass spectrometry of cocaine and its metabolites in biological fluids. J. Anal. Toxicol. 4: 37-42 (1980).
17. J. Gerlitis. GC-MS quantitation of benzoylecgonine following liquid-liquid extraction of urine. J. Forensic Sci. 38: 1210-1214 (1993).
18. S. Lin, D.E. Moody, G.E. Bigelow, and R.L. Foltz. A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry method for quantitation of cocaine and benzoylecgonine in human plasma. J. Anal. Toxicol. 25: 497-503 (2001).
19. M.J. Bogusz, R. Maier, K. Kruger, and U. Kohls. Determination of common drugs of abuse in body fluids one isolation procedure and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J. Anal. Toxicol. 22: 549-558 (1998).
20. Y. Xia, P.Wang, M.G. Barlett, H.M. Solomon, and K.L. Busch. An LC-MS-MS method for the comprehensive analysis of cocaine and cocaine metabolites in meconium. Anal. Chem. 72: 764-771 (2000).
21. P.M. Jeanville, E.S. Estape, I. Torres-Negron, and A. Marti. Rapid confirmation/quantitation of ecgonine methyl ester, benzoylecgonine, and cocaine in urine using online extraction coupled with fast HPLC and tandem mass spectrometry. J. Anal. Toxicol. 25: 69-75 (2001).