A fatal overdose of cocaine associated with coingestion of marijuana, buprenorphine, and fluoxetine. Body fluid and tissue distribution of cocaine and its metabolites determined by hydrophilic interaction chromatography-mass spectrometry (HILIC-MS)

Journal of Analytical Toxicology

Volumn 28, Issue 6, 2004, Pages 464-474

  Giroud, Christian ^a   Michaud, Katarzyna ^a   Sporkert, Frank ^a   Eap, Chin ^b   Augsburger, Marc ^a   Cardinal, Pascal ^a   Mangin, Patrice ^a  

^a UNIVERSITY CENTER OF LEGAL MEDICINE   (Switzerland)

^b Hopital de Cery   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBENZOYLECGONINE; ANHYDROECGONINE METHYL ESTER; BENZOYLECGONINE; BUPRENORPHINE; CANNABIS; COCAINE; DEUTERIUM; DRONABINOL; DRUG METABOLITE; ECGONINE ETHYL ESTER; ECGONINE METHYL ESTER; FLUOXETINE; HOMOCOCAINE; NORCOCAETHYLENE; NORCOCAINE; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; BLOOD SAMPLING; BODY FLUID; CASE REPORT; CAUSE OF DEATH; CHROMATOGRAPHY; CONFERENCE PAPER; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG OVERDOSE; DRUG SCREENING; HAIR ANALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; MULTIPLE DRUG ABUSE; TISSUE DISTRIBUTION;

CANNABIS; CANNABIS SATIVA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 4344605615     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/28.6.464     Document Type: Conference Paper

References (68)

1. "Epidemiology" fact sheet from the "Swiss Drugs Policy" brochure, December 2002. Swiss Federal Office of Public Health, Drugs Section, CH-3003 Berne, Switzerland.
2. S. Hamadène, P. Charpentier, R. Stachel, O. Simon, P. Stephan, P-A. Michaud, and J. Besson. Systemic contributions in addiction care for the young consumer of psychoactive substances. Med. Hyg. 61:1457-1461 (2003).
3. L. Chinet, A. Meynard, and F. Marring. Cannabis use among adolescents and young adults, the visible iceberg? Facts and comments for primary care physicians. Med. Hyg. 61: 1786-1792 (2003).
4. L Chinet, M. Bernard, P Stephan, and A. Rubin. New patterns of substance use and access to health care: a survey in rave parties. Med. Hyg. 61: 631-634 (2003).
5. M. Croquette-Krokar, M. Marset, and F. Bourrit. Interest of cognitivo-behavioral therapies in the treatment of cocaine's dependance. Med. Hyg. 61:1445-1449 (2003).
6. D.S. Isenschmid. Cocaine-effects on human performance and behavior. Forensic Sci. Rev. 14: 61-100 (2002).
7. M.M. Knuepfer. Cardiovascular disorders associated with cocaine use: myths and truths. Pharmacol. Ther. 97: 181-222 (2003).
8. D.M. Grilly and P.J. Pistell: Fluoxetine alters the effects of cocaine on vigilance task performance of rats. Pharmacol. Biochem. Behav. 56: 515-522 (1996).
9. D.J. Schneider. Cardiac ramifications of cocaine abuse. Coron. Artery Dis. 2: 267-273 (1991).
10. A. Büttner, G. Mall, R. Penning, H. Sachs, and S. Weis. The neuropathology of cocaine abuse. Legal Med.5: 240-242 (2003).
11. C.M. Lathers, L.S.Y. Tyau, M.M. Spino, and I. Agarwal. Cocaine-induced seizures, arrhythmias and sudden death. J. Clin. Pharmacol. 28: 584-593 (1988).
12. S.M. Evans, E.J. Cone, and J.E. Hennigfield. Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects. J. Pharmacol. Exp. Ther. 279: 1345-1356 (1996).
13. G. Barnett, R. Hawks, and R. Resnick. Cocaine pharmacokinetics in humans J. Ethnopharmacol. 3: 353-366 (1981).
14. J.J. Ambre, S.M. Belkknap, J. Nelson, T.I. Ruo, S.G. Shin, and A.J. Atkinson. Acute tolerance to cocaine in humans. Clin. Pharmacol. Ther. 44: 1-8 (1988).
15. D.S. Isenschmid, B.S. Levine, and Y.H. Caplan. A comprehensive study of the stability of cocaine and its metabolites. J. Anal. Toxicol. 13: 250-256 (1989).
16. A. Warner, A.B. Norman. Mechanisms of cocaine hydrolysis and metabolism in vitro and in vivo: a clarification. Ther. Drug Monit. 22: 266-270 (2000).
17. B.R. Martin, L.P. Lue, and J.P. Boni. Pyrolysis and volatilization of cocaine. J. Anal. Toxicol. 13: 158-162 (1989).
18. M.W. Kloss, G.M. Rosen, and E.J. Rauckman. Cocaine-mediated hepatotoxicity. A critical review. Biochem. Pharmacol. 33: 169-173 (1984).
19. T. Randall. Cocaine, alcohol mix in body to form even longer lasting, more lethal drug. J. Am. Med. Assoc. 267: 1043-1044 (1992).
20. C. Giroud, T. Colassis, L. Rivier, and E. Ottinger. Cocaine and alcohol: a deadly mixture! Schweiz. Rundschau Med. (PRAXIS) 82: 441-446 (1993).
21. B.W. Steele, E.S. Bandstra, N.C. Wu, G. Hime, W.L. Hime, and W.L. Hearn. m-Hydroxybenzoylecgonine: an important contributor to the immuoreactivity in assays for benzoylecgonine in meconium. J. Anal. Toxicol. 17: 348-352 (1993).
22. J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, D.L. Deforce, E.G. Van den Eeckhout, and A.P. De Leenheer. Liquid chromatography-mass spectrometry in forensic toxicology. Mass Spectrom. Rev. 19: 165-214 (2000).
23. M. Tatsuno, M. Nishikawa, M. Katagi, and H. Tsuchihashi. Simultaneous determination of illicit drugs in human urine by liquid chromatography-mass spectrometry. J. Anal. Toxicol. 20: 281-286 (1996).
24. P. Marquet. Progress of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Ther. Drug Monit. 24: 255-276 (2002).
25. W. Weinmann and M. Svoboda. Fast screening for drugs of abuse by solid-phase extraction combined with flow-injection ionspray-tandem mass spectrometry. J. Anal. Toxicol. 22: 319-328 (1998).
26. S.D. Brown, C.A. White, and M.G. Bartlett. Hydrophilic interaction liquid chromatography/electrospray mass spectrometry determination of acyclovir in pregnant rat plasma and tissues. Rapid Comm. Mass Spectrom. 16: 1871-1876 (2002).
27. A. Eerkes, W.Z. Shou, and W. Naidong. Liquid/liquid extraction using 96-well plate format in conjunction with hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the analysis of fluconazole in human plasma. J. Pharm. Biomed. Anal. 31: 917-928 (2003).
28. R. Diams, C.M. Murphy, R.E. Choo, W.E. Lambert, A.P. De Leenheer, and M.A. Huestis. LC-atmospheric pressure chemical ionization-MS/MS analysis of multiple illicit drugs, methadone, and their metabolites in oral fluid following protein precipitation. Anal. Chem. 75: 798-804 (2003).
29. T.M. Annesley. Ion suppression in mass spectrometry. Clin. Chem. 49: 1041-1044 (2003).
30. N. Romain, C. Giroud, K. Michaud, M. Augsburger, and P. Mangin. Fatal flecainide intoxication. Forensic Sci. Int. 106: 115-123 (1999).
31. C. Girod and C. Staub. Analysis of drugs of abuse in hair by automated solid-phase extraction, GC/EI/MS and GC ion trap/CI/MS. Forensic Sci. Int. 107: 261-271 (2000).
32. A. Tracqui, P. Kintz, and P. Mangin. Buprenorphine-related deaths among drug addicts in France: a report on 20 fatalities. J. Anal. Toxicol. 22: 430-434 (1998).
33. J.A. Crifasi, N.X. Le, and C. Long. Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS. J. Anal. Toxicol. 01: 415-419 (1997).
34. 9-THCCOOH plasma or serum to whole blood concentrations distribution ratios in blood samples taken from living and dead people. Forensic Sci. Int. 123: 159-164 (2001).
35. A.H.B. Wu, N. Liu, Y.-J. Cho, K.G. Johnson, and S.S. Wong. Extraction and simultaneous elution and derivatization of 11-nor-9-carboxy-A9- tetrahydrocannabinol using Toxi-Lab SPEC prior to GC/MS analysis of urine. J. Anal. Toxicol. 17: 215-217 (1993).
36. R.D. Voyksner. Electrospray Ionization Mass Spectrometry, R.B. Cole, Ed. Wiley, New York, NY, 1997, p 323.
37. J.F. Casale and R.W. Waggoner. A Chromatographie impurity signature profile analysis for cocaine using capillary gas chromatography. J. Forensic Sci. 36: 1312-1330 (1991).
38. J.M. Moore and J.F. Casale. Cocaine profiling methodology-recent advances. Forensic Sci. Rev. 10: 14-45 (1998).
39. F.M. Ndikum-Moffor, IR. Schoeb, and S.M. Roberts. Liver toxicity from norcocaine nitroxide, an N-oxidative of cocaine. J. Pharmacol. Exp. Ther. 284: 413-418 (1998).
40. R. Pacifici, A.I. Fiaschi, L. Micheli, F. Centini, G. Giorgi, P. Zuccaro, S. Pichini, S. Di Carlo, A. Bacosi, and D. Cerretani. Immunosuppression and oxidative stress induced by acute and chronic exposure to cocaine in rat. Int. Immunopharmacol. 3: 581-592 (2003).
41. C.V. Wetli and R.K. Wright. Death caused by recreational cocaine use. J. Am. Med. Assoc. 241: 2519-2522 (1979).
42. O.H. Drummer and J. Gerostamoulos. Postmortem drug analysis: analytical and toxicological aspects. Ther. Drug Monit. 24: 199-209 (2002).
43. Al. Pélissier-Alicot, J.-P. Gaulier, P. Champsaur, and P. Marquet. Mechanisms underlying postmortem redistribution of drugs: a review. J. Anal. Toxicol. 27: 533-544 (2003).
44. W.L. Hearn, E.E. Keran, H. Wei, and G. Hime. Site-dependent postmortem changes in blood cocaine concentrations. J. Forensic Sci. 36: 673-684 (1991).
45. P.E. McKinney, S. Phillips, H.F. Gomez, J. Brent, M. Maclntyre, and W.A. Watson. Vitreous humor cocaine and metabolite concentrations: do postmortem specimens reflect blood levels at the time of death? Forensic Sci. 40: 102-107 (1995).
46. A.M. Langford, K.K. Taylor, and D.J. Pounder. Drug concentration in skeletal muscles. J. Forensic Sci. 43: 22-27 (1998).
47. V.R. Spiehler and D. Reed. Brain concentrations of cocaine and benzoylecgonine in fatal cases. J. Forensic Sci. 30: 1003-1011 (1985).
48. K.S. Kalasinsky, T.Z. Bosy, G.A. Schmunk, L.-A. Vernard Adams, S.B. Gore, J. Smialek, Y. Furukawa, M. Guttman, and S.J. Kish. Regional distribution of cocaine in postmortem brain of chronic human cocaine users. J. Forensic Sci. 45: 1041-1048 (2000).
49. P.K. Nayak, A.L. Misra, and S.J. Mule. Physiological disposition and biotransformation of 3H-cocaine in acutely and chronically treated rats. J. Pharm. Exp. Ther. 196: 556-569 (1976).
50. Narcotics. Legal procedures and recommendations for buprenorphine use. Bulletin 10/00 - 2000. Swiss Federal Office of Public Health, Drugs Section, CH-3003 Berne, Switzerland.
51. M. Schulz and A. Schmoldt. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58: 447-474 (2003).
52. A. Oliveto, T.R. Kosten, R. Shottenfeld, J. Falcioni, and D. Ziedonis. Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users. J. Subst. Abuse Treatment 12: 423-428 (1995).
53. C. Iribarne, D. Picart, Y. Dreano, and F. Berthou. In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine. Fund. Clin. Pharmacol. 12: 194-199 (1998).
54. D.J. Borys, S.C. Setzer, L.J. Ling, J.J. Reisdorf, L.C. Day, and E.P. Krenzelok. The effects of fluoxetine in the overdose patient. J. Toxicol. Clin. Toxicol. 28: 331-340 (1990).
55. K.E. Goeringer, L. Raymon, G.D. Christian, and B.K. Logan. Postmortem forensic toxicology of selective serotonin reuptake inhibitors: a review of pharmacology and report of 168 cases. J. Forensic Sci. 45: 633-648 (2000).
56. M. Appleby, A. Mbewu, and B. Clarke. Fluoxetine and ventricular torsade-is there a link? Int. J. Cardiol. 49: 178-180 (1995).
57. M. Hofman and J.K. Lin. Conduction abnormality and ventricular tachyarrhythmia associated with fluoxetine overdose. Vet. Hum. Toxicol. 36: 371 (1994).
58. G. Braitberg and S.C. Curry. Seizure after isolated fluoxetine overdose. Ann. Emerg. Ann. Emerg. 26: 234-237 (1995).
59. S.L. Walsh, K.L. Preston, J.T. Sullivan, R. Fromme, and G.E. Bigelow. Fluoxetine alters the effects of intravenous cocaine in humans. J. Clin. Psychopharmacol. 14: 396-407 (1994).
60. S.J. Heishman, M. Huestis, J. Henningfield, and E.J. Cone. Acute and residual effects of marijuana: profiles of plasma, THC levels, physiological, subjective, and performance measures. Pharmacol. Biochem. Behav. 37: 561-565 (1990).
61. 9-tetrahydrocannabinol (THCCOOH). J. Anal. Toxicol. 16: 283-290 (1992).
62. T. Hilberg, S. Rogde, and J. Morland. Postmortem drug redistribution-human cases related to results in experimental animals. J. Forensic Sci. 44: 3-9 (1999).
63. G. Chiu-Kai Chan, T.R. Hinds, S. Impey, and D.R. Storm. Hippocampal neurotoxicity of Δ9-tetrahydrocannabinol. J. Neurosci. 18: 5322-5332 (1998).
64. I.B. Adams and B.R. Martin. Cannabis: pharmacology and toxicology in animals and humans. Addiction 91: 1585-1614 (1996).
65. L. Bachs and H. Morland. Acute cardiovascular fatalities following cannabis use. Forensic Sci. Int. 124: 200-203 (2001).
66. R.W. Foltin, M.W. Fischman, J.J. Pedroso, and G.D. Pearlson. Marijuana and cocaine interactions in humans: cardiovascular consequences. Pharmacol. Biochem. Behav. 28: 459-464 (1987).
67. K. Sperry and E.S. Sweeney. Suicide by intravenous injection of cocaine. A report of three cases. J. Forensic Sci. 34: 244-248 (1989).
68. A. Poklis, M.A. Mackell, and M. Graham. Disposition of cocaine in fatal poisoning in man. J. Anal. Toxicol. 9: 227-229 (1985).