Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum

Journal of Analytical Toxicology

Volumn 26, Issue 8, 2002, Pages 547-553

  Lester, Laeben ^d   Uemura, Naoto ^d   Ademola, John ^a   Harkey, Martha R ^b   Nath, Rajneesh P ^d   Kim, Seong J ^a   Jerschow, Elena ^a   Henderson, Gary L ^b   Mendelson, John ^d   Jones, Reese T ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DEUTERIUM; BENZOYLECGONINE; DRUG DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; DISTRIBUTION VOLUME; DRUG DISPOSITION; GAS CHROMATOGRAPHY; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; INTERSTITIAL FLUID; MALE; MASS SPECTROMETRY; NORMAL HUMAN; SEBUM; SKIN; SOLID PHASE EXTRACTION; STRATUM CORNEUM; VOLUNTEER; CHEMISTRY; EPIDERMIS; EXTRACELLULAR SPACE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; TIME; TISSUE DISTRIBUTION;

ADULT; AREA UNDER CURVE; COCAINE; EPIDERMIS; EXTRACELLULAR SPACE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; SEBUM; SKIN; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 1842835866     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/26.8.547     Document Type: Article

References (33)

1. E.J. Cone, S.L. Menchen, B.D. Paul, L.D. Mell, and J. Mitchell. Validity testing of commercial urine cocaine metabolite assays: I. Assay detection times, individual excretion patterns, and kinetics after cocaine administration to humans. J. Forensic Sci. 34: 15-31 (1989).
2. K.L. Preston, M.A. Huestis, C.J. Wong, A. Umbricht, B.A. Goldberger, and E.J. Cone. Monitoring cocaine use in substance-abuse-treatment patients by sweat and urine testing. J. Anal. Toxicol. 23: 313-322 (1999).
3. S. Balabanova, E. Schneider, R. Wepler, B. Hermann, H.J. Boschek, and H. Scheitler. Significance of drug determination in pilocarpine sweat for detection of past drug abuse. Beitr. Gerichtl. Med. 50: 111-115 (1992).
4. G.L. Henderson. Mechanisms of drug incorporation into hair. Forensic Sci. Int. 63: 19-29 (1993).
5. E.J. Cone, M.J. Hillsgrove, A.J. Jenkins, R.M. Keenan, and W.D. Darwin. Sweat testing for heroin, cocaine, and metabolites. J. Anal. Toxicol. 18: 298-305 (1994).
6. M. Burns and R.C. Baselt. Monitoring drug use with a sweat patch: An experiment with cocaine. J. Anal. Toxicol. 19: 41-48 (1995).
7. G.L. Henderson, M.R. Harkey, C. Zhou, R.T. Jones, and P. Jacob, III. Incorporation of isotopically labeled cocaine and metabolites into human hair. I. Dose-response relationships. J. Anal. Toxicol. 20: 1-12 (1996).
8. R.E. Joseph, Jr., J.M. Oyler, A.T. Wstadik, C. Ohuoha, and E.J. Cone. Drug testing with alternative matrices I. Pharmacological effects and disposition of cocaine and codeine in plasma, sebum, and stratum corneum. J. Anal. Toxicol. 22: 6-17 (1998).
9. J.N. Bruun, N. Ostby, J.E. Bredesen, P. Kierulf, and P.K. Lunde. Sulfonamide and trimethoprim concentrations in human serum and skin blister fluid. Antimicrob. Agents Chemother. 19: 82-85 (1981).
10. E. Haneke. Fluconazole levels in human epidermis and blister fluid. Br. J. Dermatol. 123: 273-274 (1990).
11. J. Faergemann, H. Zehender, T. Jones, and I. Maibach. Terbinafine levels in serum, stratum corneum, dermis-epidermis (without stratum corneum), hair, sebum and eccrine sweat. Acta Derm. Venereol. 71: 322-326 (1991).
12. J. Faergemann and H. Laufen. Levels of fluconazole in serum, stratum corneum, epidermis-dermis (without stratum corneum) and eccrine sweat. Clin. Exp. Dermatol. 18: 102-106 (1993).
13. J.A. Levisky, D.L. Bowerman, W.W. Jenkins, and S.B. Karch. Drug deposition in adipose tissue and skin: Evidence for an alternative source of positive sweat patch tests. Forensic Sci. Int. 110: 35-46 (2000).
14. E. Johansson, K. Noren, J. Sjovall, and M.M. Halldin. Determination of delta 1-tetrahydrocannabinol in human fat biopsies from marihuana users by gas chromatography-mass spectrometry. Biomed. Chromatogr. 3: 35-38 (1989).
15. C. Surber, K.P. Wilhelm, D. Bermann, and H.I. Maibach. In vivo skin penetration of acitretin in volunteers using three sampling techniques. Pharm. Res. 10: 1291-1294 (1993).
16. M. Schafer-Korting, H.C. Korting, and E. Mutschler. Human plasma and skin blister fluid levels of griseofulvin following a single oral dose. Eur. J. Clin. Pharmacol. 29: 109-113 (1985).
17. E.T. Everhart, P. Jacob, III, J. Mendelson, and R.T. Jones. The synthesis of deuterium-labelled cocaine, cocaethylene and metabolites. J. Labelled Cpd. Radiopharm. 42: 1265-1275 (1999).
18. B.J. Vermeer, F.C. Reman, and C.M. van Gent. The determination of lipids and proteins in suction blister fluid. J. Invest. Dermatol. 73: 303-305 (1979).
19. G. Volden, A.K. Thorsrud, I. Bjornson, and E. Jellum. Biochemical composition of suction blister fluid determined by high resolution multicomponent analysis (capillary gas chromatography-mass spectrometry and two-dimensional electrophoresis). J. Invest. Dermatol. 75: 421-424 (1980).
20. H. Pinkus. Tape stripping in dermatological research. A review with emphasis on epidermal biology. G. Ital. Dermatol. Minerva Dermatol. 107: 1115-1126 (1966).
21. M.R. Harkey, G.L. Henderson, and C. Zhou. Simultaneous quantitation of cocaine and its major metabolites in human hair by gas chromatography/chemical ionization mass spectrometry. J. Anal. Toxicol. 15: 260-265 (1991).
22. P. Wilkinson, C. Van Dyke, P. Jatlow, P. Barash, and R. Byck. Intranasal and oral cocaine kinetics. Clin. Pharmacol. Ther. 27: 386-394 (1980).
23. M.J. Chow, J.J. Ambre, T.I. Ruo, A.J. Atkinson, Jr., D.J. Bowsher, and M.W. Fischman. Kinetics of cocaine distribution, elimination, and chronotropic effects. Clin. Pharmacol. Ther. 38: 318-324 (1985).
24. A.R. Jeffcoat, M. Perez-Reyes, J.M. Hill, B.M. Sadler, and C.E. Cook. Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. Drug Metab. Dispos. 17: 153-159 (1989).
25. D.S. Isenschmid, M.W. Fischman, R.W. Foltin, and Y.H. Caplan. Concentration of cocaine and metabolites in plasma of humans following intravenous administration and smoking of cocaine. J. Anal. Toxicol. 16: 311-314 (1992).
26. E.J. Cone. Pharmacokinetics and pharmacodynamics of cocaine. J. Anal. Toxicol. 19: 459-478 (1995).
27. S. Groth and B. Staberg. Suction blisters of the skin: A compartment with physiological, interstitium-like properties. Scand. J. Clin. Lab. Invest. 44: 311-316 (1984).
28. A. Trampuz, M. Wenk, Z. Rajacic, and W. Zimmerli. Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid. Antimicrob. Agents Chemother. 44: 1352-1355 (2000).
29. J.T. Sullivan, P.M. Becker, K.L. Preston, R.A. Wise, F.M. Wigely, M.P. Testa, and D.R. Jasinski. Cocaine effects on digital blood flow and diffusing capacity for carbon monoxide among chronic cocaine users. Am. J. Med. 102: 232-238 (1997).
30. J.P. Ortonne, C. Khatchadourian, C. Voulot, and Y. Menezo. Cholinesterases isoenzymes: A comparative study in the skin and plasma. J. Invest. Dermatol. 73: 239-242 (1979).
31. D.T. Downing and J.S. Strauss. On the mechanism of sebaceous secretion. Arch. Dermatol. Res. 272: 343-349 (1982).
32. G. Odland. Structure of the skin. In Physiology, Biochemistrry, and Molecular Biology of the Skin, L.A. Goldsmith, Ed. Oxford University Press, New York, NY, 1983, pp 3-63.
33. L. Potsch, G. Skopp, and M.R. Moeller. Biochemical approach on the conservation of drug molecules during hair fiber formation. Forensic Sci. Int. 84: 25-35 (1997).