Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization

Forensic Science International

Volumn 174, Issue 2-3, 2008, Pages 189-196

  Zaitsu, Kei ^a   Miki, Akihiro ^a   Katagi, Munehiro ^a   Tsuchihashi, Hitoshi ^a  

^a NONE

Author keywords

Aseptic urine collection kit; Bacterial decomposition; Column switching LC MS; Long term stability; Sterilization

Indexed keywords

7 AMINOFLUNITRAZEPAM; AMPHETAMINE; COCAINE; ESTAZOLAM; METHAMPHETAMINE; MORPHINE 6 ACETATE; NITRAZEPAM; SODIUM AZIDE;

ADULT; ARTICLE; ASEPSIS; BACTERIUM CONTAMINATION; BIOFILTRATION; DRUG DECOMPOSITION; DRUG ELIMINATION; DRUG HYDROLYSIS; DRUG STABILITY; DRUG URINE LEVEL; FEMALE; HUMAN; MALE; METABOLITE; PRESERVATION AND STORAGE; PRIORITY JOURNAL; URINALYSIS;

EID: 37649006068     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2007.04.224     Document Type: Article

References (23)

1. Nishikawa M., and Tsuchihashi H. Applications of LC/MS in forensic chemistry. J. Toxicol. Toxin Rev. 17 (1998) 13-26
2. Kudo K., Tsuchihashi H., and Ikeda N. Meeting challenges in forensic toxicology in Japan by liquid chromatography/mass spectrometry. Anal. Chim. Acta 492 (2003) 83-104
3. Suzuki O., and Watanabe K. Drugs and Poisons in Humans. A Handbook of Practical Analysis (2005), Springer
4. Pharmaceutical Society of Japan. Standard methods of Chemical Analysis in Poisoning (2006), Tokyo Kagaku Dozin, Tokyo
5. Robertson M.D., and Drummer O.H. Postmortem drug metabolism by bacteria. J. Forensic Sci. 40 (1995) 382-386
6. Robertson M.D., and Drummer O.H. Postmortem distribution and redistribution of nitrobenzodiazepines in man. J. Forensic Sci. 43 (1998) 9-13
7. Levine B., Blanke R.V., and Valentour J.C. Postmortem stability of benzodiazepines in blood and tissues. J. Forensic Sci. 28 (1983) 102-115
8. Zaitsu K., Miki A., Katagi M., Kunimune N., and Tsuchihashi H. Development of an aseptic urine collection kit and its evaluation in preventing the bacterial decomposition of nitrazepam. J. Health Sci. 52 (2006) 724-729
9. Katagi M., Nishikawa M., Tatsuno M., Miki A., and Tsuchihashi H. Column-switching high-performance liquid chromatography/electrospray ionization mass spectrometry for the simultaneous microanalysis of herion metabolites in human urine. J. Chromatogr. B 751 (2001) 177-185
10. Miki A., Tatsuno M., Katagi M., Nishikawa M., and Tsuchihashi H. Simultaneous determination of eleven benzodiazepine hypnotics and eleven relevant metabolites in urine by column-switching liquid chromatography-mass spectrometry. J. Anal. Toxicol. 26 (2002) 87-93
11. Miki A., Katagi M., and Tsuchihashi H. Determination of methamphetamine and its metabolites incorporated in hair by column-switching liquid chromatography-mass spectrometry. J. Anal. Toxicol. 27 (2003) 95-102
12. Fehn J., and Megges G. Detection of O6-monoacetylmorphine in urine samples by GC-MS as evidence for heroin use. J. Anal. Toxicol. 9 (1985) 134-138
13. Pharmaceutical Society of Japan. Standard Methods of Analysis for Hygienic Chemists (2000), Kinbara Publisher, Tokyo
14. Miller M.W. The Pfizer Handbook of Microbial Metabolites (1961), McGraw-Hill, New York, NY
15. Isenschmid D.S., Levine B.S., and Caplan Y.H. A comprehensive study of the stability of cocaine and its metabolites. J. Anal. Toxicol. 13 (1989) 250-256
16. Clauwaert K.M., Van Bocxlaer J.F., and De Leenheer A.P. Stability study of the desighner drugs "MDA, MDMA and MDEA" in water, serum, whole blood, and urine under various storage temperatures. Forensic Sci. Int. 124 (2001) 36-42
17. Baba T., Yamada H., Oguri K., and Yoshimura H. Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine. Xenobiotica 18 5 (1988) 475-484
18. Robertson M.D., and Drummer O.H. Stability of nitrobenzodiazepines in postmortem blood. J. Forensic Sci. 43 (1998) 5-8
19. Kelly H., Huggett A., and Dawling S. Liquid-chromatographic measurement of nitrazepam in plasma. Clin. Chem. 28 (1982) 1478-1481
20. Stevens H.M. The stability of some drugs and poisons in putrefying human liver tissues. J. Forensic Sci. Soc. 24 (1984) 577-589
21. Rieder J., and Wendt G. Pharmacokinetics and metabolism of the hyponotic nitrazepam. In: Garattini S., Mussini E., and Randall L.O. (Eds). The Benzodiazepines (1973), Raven Press, New York
22. Rafii F., Franklin W., Heflich R.H., and Cerniglia C.E. Reduction of nitroaromatic compounds by anaerobic bacteria isolated from the human gastrointestinal tract. Appl. Environ. Microbiol. 57 (1991) 962-968
23. Fuller D.C., and Anderson W.H. A simplified procedure for the determination of free codeine, free morphine, and 6-acetylmorphine in urine. J. Anal. Toxicol. 16 (1992) 315-318