The glucocorticoid receptor β isoform can mediate transcriptional repression by recruiting histone deacetylases

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 1, 2008, Pages

  Kelly, Audrey ^a   Bowen, Holly ^a   Jee, Young Koo ^b   Mahfiche, Nabila ^a   Soh, Cecilia ^a   Lee, Tak ^a   Hawrylowicz, Catherine ^a   Lavender, Paul ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Dankook University   (South Korea)

Author keywords

Cytokine gene regulation; glucocorticoid receptor; transcription

Indexed keywords

AMINO ACID; CYTOKINE; DNA; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HISTONE DEACETYLASE; HYDROCORTISONE; INTERLEUKIN 13; INTERLEUKIN 5;

ARTICLE; ASTHMA; DNA BINDING; EMBRYO; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 38149122816     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.09.010     Document Type: Article

References (31)

1. Hollenberg S.M., Weinberger C., Ong E.S., Cerelli G., Oro A., Lebo R., et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature 318 (1985) 635-641
2. Encio I.J., and Detera-Wadleigh S.D. The genomic structure of the human glucocorticoid receptor. J Biol Chem 266 (1991) 7182-7188
3. Bledsoe R.K., Montana V.G., Stanley T.B., Delves C.J., Apolito C.J., McKee D.D., et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 110 (2002) 93-105
4. Bamberger C.M., Bamberger A.M., de Castro M., and Chrousos G.P. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 95 (1995) 2435-2441
5. Oakley R.H., Jewell C.M., Yudt M.R., Bofetiado D.M., and Cidlowski J.A. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem 274 (1999) 27857-27866
6. Yudt M.R., Jewell C.M., Bienstock R.J., and Cidlowski J.A. Molecular origins for the dominant negative function of human glucocorticoid receptor beta. Mol Cell Biol 23 (2003) 4319-4330
7. Lu N.Z., and Cidlowski J.A. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 18 (2005) 331-342
8. Lewis-Tuffin L.J., Jewell C.M., Bienstock R.J., Collins J.B., and Cidlowski J.A. Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active. Mol Cell Biol 27 (2007) 2266-2282
9. Drouin J., Sun Y.L., Chamberland M., Gauthier Y., De Lean A., Nemer M., et al. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 12 (1993) 145-156
10. Jee Y.K., Gilmour J., Kelly A., Bowen H., Richards D., Soh C., et al. Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA-3 signaling and involves histone deacetylase recruitment. J Biol Chem 280 (2005) 23243-23250
11. Smith P.J., Cousins D.J., Jee Y.K., Staynov D.Z., Lee T.H., and Lavender P. Suppression of granulocyte-macrophage colony-stimulating factor expression by glucocorticoids involves inhibition of enhancer function by the glucocorticoid receptor binding to composite NF-AT/activator protein-1 elements. J Immunol 167 (2001) 2502-2510
12. Goleva E., Li L.B., Eves P.T., Strand M.J., Martin R.J., and Leung D.Y. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 173 (2006) 607-616
13. Strickland I., Kisich K., Hauk P.J., Vottero A., Chrousos G.P., Klemm D.J., et al. High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 193 (2001) 585-593
14. Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Wallaert B., Lafitte J.J., et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 159 (1999) 1600-1604
15. Honda M., Orii F., Ayabe T., Imai S., Ashida T., Obara T., et al. Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 118 (2000) 859-866
16. Leung D.Y., Hamid Q., Vottero A., Szefler S.J., Surs W., Minshall E., et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 186 (1997) 1567-1574
17. Sousa A.R., Lane S.J., Cidlowski J.A., Staynov D.Z., and Lee T.H. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol 105 (2000) 943-950
18. Brehm A., Miska E.A., McCance D.J., Reid J.L., Bannister A.J., and Kouzarides T. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391 (1998) 597-601
19. Codlin S., Soh C., Lee T., and Lavender P. Characterization of a palindromic enhancer element in the promoters of IL4, IL5, and IL13 cytokine genes. J Allergy Clin Immunol 111 (2003) 826-832
20. Lavender P., Vandel L., Bannister A.J., and Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene 14 (1997) 2721-2728
21. Scheidereit C., Geisse S., Westphal H.M., and Beato M. The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature 304 (1983) 749-752
22. Lefstin J.A., and Yamamoto K.R. Allosteric effects of DNA on transcriptional regulators. Nature 392 (1998) 885-888
23. Oakley R.H., Sar M., and Cidlowski J.A. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem 271 (1996) 9550-9559
24. Li L.B., Leung D.Y., Hall C.F., and Goleva E. Divergent expression and function of glucocorticoid receptor beta in human monocytes and T cells. J Leukoc Biol 79 (2006) 818-827
25. Cousins D.J., Lee T.H., and Staynov D.Z. Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. J Immunol 169 (2002) 2498-2506
26. Wallace A.D., and Cidlowski J.A. Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J Biol Chem 276 (2001) 42714-42721
27. Hawrylowicz C., Richards D., Loke T.K., Corrigan C., and Lee T. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 109 (2002) 369-370
28. Xystrakis E., Kusumakar S., Boswell S., Peek E., Urry Z., Richards D.F., et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 116 (2006) 146-155
29. Stevens A., Garside H., Berry A., Waters C., White A., and Ray D. Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735. Mol Endocrinol 17 (2003) 845-859
30. Bilodeau S., Vallette-Kasic S., Gauthier Y., Figarella-Branger D., Brue T., Berthelet F., et al. Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes Dev 20 (2006) 2871-2886
31. Ito K., Ito M., Elliott W.M., Cosio B., Caramori G., Kon O.M., et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med 352 (2005) 1967-1976