Role of interleukin-17F in asthma

Inflammation and Allergy - Drug Targets

Volumn 8, Issue 5, 2009, Pages 383-389

  Kawaguchi, Mio ^a   Kokubu, Fumio ^b   Fujita, Junichi ^a   Huang, Shau Ku ^c   Hizawa, Nobuyuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Asthma; IL 17 family; IL 17A; IL 17F

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; INTERLEUKIN 17; INTERLEUKIN 17B; INTERLEUKIN 17C; INTERLEUKIN 17F; INTERLEUKIN 25; INTERLEUKIN 27; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; STEROID; UNCLASSIFIED DRUG;

AIRWAY; AIRWAY HYPERREACTIVITY; AIRWAY NEUTROPHILIA; ASTHMA; BASOPHIL; BIOLOGICAL ACTIVITY; BRONCHUS MUCOSA; CHROMOSOME 6P; CHROMOSOME 6P12; CORRELATIONAL STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; EOSINOPHIL; EPITHELIUM CELL; FIBROBLAST; GENE; GENE LOCATION; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG; MAST CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT DISEASE; REVIEW; TH17 CELL; WILD TYPE;

EID: 74849107906     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/1871528110908050383     Document Type: Review

References (52)

1. Yao, Z.; Painter, S. L.; Fanslow, W. C.; Ulrich, D.; Macduff, B. M.; Spriggs, M. K.; Armitage, R. J. Human IL-17: a novel cytokine derived from T cells. J. Immunol., 1995, 155, 5483-6.
2. Yao, Z.; Fanslow, W. C.; Seldin, M. F.; Rousseau, A. M.; Painter, S. L.; Comeau, M. R.; Cohen, J. I.; Spriggs, M. K. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity, 1995, 3, 811-21.
3. Kawaguchi, M.; Onuchic, L. F.; Li, X. D.; Essayan, D. M.; Schroeder, J.; Xiao, H. Q.; Liu, M. C.; Krishnaswamy, G.; Germino, G.; Huang, S. K. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J. Immunol., 2001, 167, 4430-5.
4. Shi, Y.; Ullrich, S. J.; Zhang, J.; Connolly, K.; Grzegorzewski, K. J.; Barber, M. C.; Wang, W.; Wathen, K.; Hodge, V.; Fisher, C. L.; Olsen, H.; Ruben, S. M.; Knyazev, I.; Cho, Y. H.; Kao, V.; Wilkinson, K. A.; Carrell, J. A.; Ebner, R. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem., 2000, 275, 19167-76.
5. Li, H.; Chen, J.; Huang, A.; Stinson, J.; Heldens, S.; Foster, J.; Dowd, P.; Gurney, A. L.; Wood, W. I. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc. Natl. Acad. Sci. USA, 2000, 97, 773-8.
6. Starnes, T.; Broxmeyer, H. E.; Robertson, M. J.; Hromas, R. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J. Immunol., 2002, 169, 642-6.
7. Lee, J.; Ho, W. H.; Maruoka, M.; Corpuz, R. T.; Baldwin, D. T.; Foster, J. S; Kelley, R. F.; Pan, G.; Gurney, A. L.; de Vos, A. M.; Starovasnik, M. A. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem., 2001, 276, 1660-4.
8. Starnes, T.; Robertson, M. J.; Sledge, G.; Kelich, S.; Nakshatri, H.; Broxmeyer, H. E.; Hromas, R. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol., 2001, 167, 4137-40.
9. Hymowitz, S. G.; Filvaroff, E. H.; Yin, J. P.; Lee, J.; Cai, L.; Risser, P.; Maruoka, M.; Mao, W.; Foster, J.; Kelley, R. F.; Pan, G.; Gurney, A. L.; de Vos, A. M.; Starovasnik, M. A. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J., 2001, 20, 5332-41.
10. Moseley, T. A.; Haudenschild, D. R.; Rose, L.; Reddi, A. H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev., 2003, 14, 155-74.
11. Wright, J. F.; Guo, Y.; Quazi, A.; Luxenberg, D. P.; Bennett, F.; Ross, J. F.; Qiu, Y.; Whitters, M. J.; Tomkinson, K. N.; Dunussi-Joannopoulos, K.; Carreno, B. M.; Collins, M.; Wolfman, N. M. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J. Biol. Chem., 2007, 282, 13447-55.
12. Bettelli, E.; Carrier, Y.; Gao, W.; Korn, T.; Strom, T. B.; Oukka, M.; Weiner, H. L.; Kuchroo, V. K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 2006, 441, 235-8.
13. Traves, S. L.; Donnelly, L. E. Th17 cells in airway diseases. Curr. Mol. Med., 2008, 8, 416-26.
14. Pène, J.; Chevalier, S.; Preisser, L.; Vénéreau, E.; Guilleux, M. H.; Ghannam, S.; Molès, J. P.; Danger, Y.; Ravon, E.; Lesaux, S.; Yssel, H.; Gascan, H. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol., 2008, 180, 7423-30.
15. Yang, X. O.; Nurieva, R.; Martinez, G. J.; Kang, H. S.; Chung, Y.; Pappu, B. P.; Shah, B.; Chang, S. H.; Schluns, K. S.; Watowich, S. S.; Feng, X. H.; Jetten, A. M.; Dong, C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity, 2008, 29, 44-56.
16. Ciric, B.; El-behi, M.; Cabrera, R.; Zhang, G. X.; Rostami, A. IL-23 drives pathogenic IL-17-producing CD8+ T cells. J. Immunol., 2009, 182, 5296-305.
17. Kawaguchi, M.; Onuchic, L. F.; Huang, S. K. Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1. J. Biol. Chem., 2002, 277, 15229-32.
18. Kawaguchi, M.; Kokubu, F.; Matsukura, S.; Ieki, K.; Odaka, M.; Watanabe, S.; Suzuki, S.; Adachi, M.; Huang, S. K. Induction of CX-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway. J. Pharmacol. Exp. Ther., 2003, 307, 1213-20.
19. Kawaguchi, M.; Adachi, M.; Oda, N.; Kokubu, F.; Huang, S. K. IL-17 cytokine family. J. Allergy Clin. Immunol., 2004, 114, 1265-73.
20. Kawaguchi, M.; Adachi, M.; Huang, S. K. Structural and functional analysis of a new cytokine, ML-1 (interleukin-17F). Allergol. Int., 2003, 52, 117-22.
21. Kawaguchi, M.; Kokubu, F.; Odaka, M.; Watanabe, S.; Suzuki, S.; Ieki, K.; Matsukura, S.; Kurokawa, M.; Adachi, M.; Huang, S. K. Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway. J. Allergy Clin. Immunol., 2004, 114, 444-50.
22. Kawaguchi, M.; Kokubu, F.; Huang, S. K.; Homma, T.; Odaka, M.; Watanabe, S.; Suzuki, S.; Ieki, K.; Matsukura, S.; Kurokawa, M.; Adachi, M. The IL-17F signaling pathway is involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells. J. Allergy Clin. Immunol., 2007, 119, 1408-14.
23. Jatakanon, A.; Uasuf, C.; Maziak, W.; Lim, S.; Chung, K. F.; Barnes, P. J. Neutrophilic inflammation in severe persistent asthma. Am. J. Respir. Crit. Care Med., 1999, 160, 1532-9.
24. Ordonez, C. L.; Shaughnessy, T. E.; Matthay, M. A.; Fahy, J. V. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am. J. Respir, Crit, Care Med., 2000, 161, 1185-90.
25. Lamblin, C.; Gosset, P.; Tillie-Leblond, I. Saulnier, F.; Marquette, C. H.; Wallaert, B.; Tonnel, A. B. Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am. J. Respir. Crit. Care Med., 1998, 157, 394-402.
26. Manolitsas, N. D.; Trigg, C. J.; McAulay, A. E.; Wang, J. H.; Jordan, S. E.; D'Ardenne, A. J.; Davies, R. J. The expression of intercellular adhesion molecule-1 and the beta1-integrins in asthma. Eur. Respir. J., 1994, 7, 1439-44.
27. Bentley, A. M.; Durham, S. R.; Robinson, D. S.; Menz, G.; Storz, C.; Cromwell, O.; Kay, A. B.; Wardlaw, A. J. Expression of endothelial and leukocyte adhesion molecules interacellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergeninduced asthma. J. Allergy Clin. Immunol., 1993, 92, 857-68.
28. Cox, G.; Ohtoshi, T.; Vancheri, C.; Denburg, J. A.; Dolovich, J.; Gauldie, J.; Jordana, M. Promotion of eosinophil survival by human bronchial epithelial cells and its modulation by steroids. Am. J. Respir. Cell Mol. Biol., 1991, 4, 525-31.
29. Masuda, T.; Suda, Y.; Shimura, S.; Maruyama, N.; Aizawa, T.; Tamura, G.; Sasaki, H.; Takishima, T. Airway epithelial cells enhance eosinophil survival. Respiration, 1992, 59, 238-422.
30. Kawaguchi, M.; Fujita, J.; Kokubu, F.; Huang, S. K.; Homma, T.; Matsukura, S.; Adachi, M.; Hizawa, N. IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway. Am. J. Physiol. Lung Cell Mol. Physiol., 2009, 296, L804-10.
31. Tang, W.; Geba, G. P.; Zheng, T.; Ray, P.; Homer, R. J.; Kuhn, 3rd C.; Flavell, R. A.; Elias, J. A. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J. Clin. Invest., 1996, 98, 2845-53.
32. Chakir, J.; Shannon, J.; Molet, S.; Fukakusa, M.; Elias, J.; Laviolette, M.; Boulet, L. P.; Hamid, Q. Airway remodelingassociated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J. Allergy Clin. Immunol., 2003, 111, 1293-8.
33. Cheung, P. F.; Wong, C. K.; Lam, C. W. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytesmediated allergic inflammation. J. Immunol., 2008, 180, 5625-35.
34. Suzuki, S.; Kokubu, F.; Kawaguchi, M.; Homma, T.; Odaka, M.; Watanabe, S.; Ieki, K.; Matsukura, S.; Kurokawa, M.; Takeuchi, H.; Sasaki, Y.; Huang, S. K.; Adachi, M.; Ota, H. Expression of interleukin-17F in a mouse model of allergic asthma. Int. Arch. Allergy Immunol., 2007, 143(Suppl 1), 89-94.
35. Oda, N.; Canelos, P. B.; Essayan, D. M.; Plunkett, B. A.; Myers, A. C.; Huang, S. K. Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am. J. Respir. Crit. Care Med., 2005, 171, 12-8.
36. Hurst, S. D.; Muchamuel, T.; Gorman, D. M.; Gilbert, J. M.; Clifford, T.; Kwan, S.; Menon, S.; Seymour, B.; Jackson, C.; Kung, T. T.; Brieland, J. K.; Zurawski, S. M.; Chapman, R. W.; Zurawski, G.; Coffman, R. L. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol., 2002, 169, 443-53.
37. Yang, X. O.; Chang, S. H.; Park, H.; Nurieva, R.; Shah, B.; Acero, L.; Wang, Y. H.; Schluns, K. S.; Broaddus, R. R.; Zhu, Z.; Dong, C. Regulation of inflammatory responses by IL-17F. J. Exp. Med., 2008, 205, 1063-75.
38. Gavett, S. H.; Chen, X.; Finkelman, F.; Wills-Karp, M. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol., 1994, 10, 587-93.
39. Renzi, P. M.; Yang, J. P.; Diamantstein, T.; Martin, J. G. Effects of depletion of cells bearing the interleukin-2 receptor on immunoglobulin production and allergic airway responses in the rat. Am. J. Respir. Crit. Care Med., 1996, 153, 1214-21.
40. McKinley, L.; Alcorn, J. F.; Peterson, A.; Dupont, R. B.; Kapadia, S.; Logar, A.; Henry, A.; Irvin, C. G.; Piganelli, J. D.; Ray, A.; Kolls, J. K. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008, 181, 4089-97.
41. Moseley, T. A.; Haudenschild, D. R.; Rose, L.; Reddi, A. H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev., 2003, 14, 155-74.
42. Yao, Z.; Spriggs, M. K.; Derry, J. M.; Strockbine, L.; Park, L. S.; VandenBos, T.; Zappone, J. D.; Painter, S. L.; Armitage, R. J. Molecular characterization of the human interleukin (IL)-17receptor. Cytokine, 1997, 9, 794-800.
43. Toy, D.; Kugler, D.; Wolfson, M.; Vanden Bos, T.; Gurgel, J.; Derry, J.; Tocker, J.; Peschon, J. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol., 2006, 177, 36-9.
44. Kuestner, R. E.; Taft, D. W.; Haran, A.; Brandt, C. S.; Brender, T.; Lum, K.; Harder, B.; Okada, S.; Ostrander, C. D.; Kreindler, J. L.; Aujla, S. J.; Reardon, B.; Moore, M.; Shea, P.; Schreckhise, R.; Bukowski, T. R.; Presnell, S.; Guerra-Lewis, P.; Parrish-Novak, J.; Ellsworth, JL.; Jaspers, S.; Lewis, K. E.; Appleby, M.; Kolls, J. K.; Rixon, M.; West, J. W.; Gao, Z.; Levin, S. D. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J. Immunol., 2007, 179, 5462-73.
45. Haudenschild, D.; Moseley, T.; Rose, L.; Reddi, A. H. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J. Biol. Chem., 2002, 277, 4309-16.
46. Rong, Z.; Cheng, L.; Ren, Y.; Li, Z.; Li, Y.; Li, X.; Li, H.; Fu, X. Y.; Chang, Z. Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. Cell Signal., 2007, 19, 1514-20.
47. Kawaguchi, M.; Kokubu, F.; Kuga, H.; Matsukura, S.; Hoshino, H.; Ieki, K.; Imai, T.; Adachi. M.; Huang, S. K. Modulation of bronchial epithelial cells by IL-17. J. Allergy Clin. Immunol., 2001, 108, 804-9.
48. Laan M, Lotvall J, Chung KF, Linden A. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: role of mitogenactivated protein (MAP) kinases. Br. J. Pharmacol., 2001, 133, 200-6.
49. Kokubu, F.; Matsukura, S.; Kawaguchi, M.; Osakabe, Y. Respiratory viruses and bronchial asthma. Arerugi., 2008, 57, 1117-23.
50. Al-Ramli, W.; Préfontaine, D.; Chouiali, F.; Martin, J. G.; Olivenstein, R.; Lemière, C.; Hamid, Q. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J. Allergy Clin. Immunol., 2009, 123, 1185-7.
51. Kawaguchi, M.; Takahashi, D.; Hizawa, N.; Suzuki, S.; Matsukura, S.; Kokubu, F.; Maeda, Y.; Fukui, Y.; Konno, S.; Huang, S. K.; Nishimura, M.; Adachi, M. Interleukin-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J. Allergy Clin. Immunol., 2006, 117, 795-801.
52. Hizawa, N.; Kawaguchi, M.; Huang, S. K.; Nishimura, M. Role of interleukin-17F in chronic inflammatory and allergic lung disease. Clin. Exp. Allergy, 2006, 36, 1109-14.