Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages

Journal of Allergy and Clinical Immunology

Volumn 122, Issue 3, 2008, Pages

  Goleva, Elena ^a   Hauk, Pia J ^a   Hall, Clifton F ^a   Liu, Andrew H ^a,b   Riches, David W H ^a,b   Martin, Richard J ^a,c   Leung, Donald Y M ^a,b  

^a DEPARTMENT OF MEDICINE   (United States)

^b Children's Hospital Colorado   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

asthma; Corticosteroids; endotoxin; genes; resistance

Indexed keywords

ARGINASE 1; CHEMOKINE; CORTICOSTEROID; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; DEXAMETHASONE; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED EXPIRATORY VOLUME; GAS CHROMATOGRAPHY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG LAVAGE; MACROPHAGE; MASS SPECTROMETRY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

EID: 50649101494     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.07.007     Document Type: Article

References (51)

1. National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma update on selected topics-2002. J Allergy Clin Immunol 110 suppl (2002) S141-S219
2. Szefler S.J., Martin R.J., King T.S., Boushey H.A., Cherniack R.M., Chinchilli V.M., et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 109 (2002) 410-418
3. Sher E.R., Leung D.Y., Surs W., Kam J.C., Zieg G., Kamada A.K., et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 93 (1994) 33-39
4. Leung D.Y., and Bloom J.W. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 111 (2003) 3-22
5. Ito K., Chung K.F., and Adcock I.M. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 117 (2006) 522-543
6. Drazen J.M., Silverman E.K., and Lee T.H. Heterogeneity of therapeutic responses in asthma. Br Med Bull 56 (2000) 1054-1070
7. Barnes P.J., Jonsson B., and Klim J.B. The costs of asthma. Eur Respir J 9 (1996) 636-642
8. Vollmer W.M., Markson L.E., O'Connor E., Frazier E.A., Berger M., and Buist A.S. Association of asthma control with health care utilization: a prospective evaluation. Am J Respir Crit Care Med 165 (2002) 195-199
9. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 136 (1987) 225-244
10. American Thoracic Society, Medical Section of the American Lung Association. Guidelines for fiberoptic bronchoscopy in adults. Am Rev Respir Dis 136 (1987) 1066
11. Nomura I., Goleva E., Howell M.D., Hamid Q.A., Ong P.Y., Hall C.F., et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171 (2003) 3262-3269
12. Nomura I., Gao B., Boguniewicz M., Darst M.A., Travers J.B., and Leung D.Y. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 112 (2003) 1195-1202
13. Goleva E., Li L.B., Eves P.T., Strand M.J., Martin R.J., and Leung D.Y. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 173 (2006) 607-616
14. Mantovani A., Sozzani S., Locati M., Allavena P., and Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23 (2002) 549-555
15. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 3 (2003) 23-35
16. Sweet M.J., and Hume D.A. Endotoxin signal transduction in macrophages. J Leukoc Biol 60 (1996) 8-26
17. Yao J., Mackman N., Edgington T.S., and Fan S.T. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J Biol Chem 272 (1997) 17795-17801
18. Guha M., O'Connell M.A., Pawlinski R., Hollis A., McGovern P., Yan S.F., et al. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 98 (2001) 1429-1439
19. Kitamura H., Kanehira K., Okita K., Morimatsu M., and Saito M.M.A.I.L. a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett 485 (2000) 53-56
20. Ito T., Morimatsu M., Oonuma T., Shiina T., Kitamura H., and Syuto B. Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages. Gene 342 (2004) 137-143
21. O'Reilly S.M., and Moynagh P.N. Regulation of Toll-like receptor 4 signaling by A20 zinc finger protein. Biochem Biophys Res Commun 303 (2003) 586-593
22. Stein M., Keshav S., Harris N., and Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 176 (1992) 287-292
23. Zimmermann N., King N.E., Laporte J., Yang M., Mishra A., Pope S.M., et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 111 (2003) 1863-1874
24. Reynolds S.J., Milton D.K., Heederik D., Thorne P.S., Donham K.J., Croteau E.A., et al. Interlaboratory evaluation of endotoxin analyses in agricultural dusts-comparison of LAL assay and mass spectrometry. J Environ Monit 7 (2005) 1371-1377
25. Alwis K.U., and Milton D.K. Recombinant factor C assay for measuring endotoxin in house dust: comparison with LAL, and (1→3)-beta-D-glucans. Am J Ind Med 49 (2006) 296-300
26. Chen Z.T., Li S.L., Cai E.Q., Wu W.L., Jin J.S., and Zhu B. LPS induces pulmonary intravascular macrophages producing inflammatory mediators via activating NF-kappaB. J Cell Biochem 89 (2003) 1206-1214
27. Locati M., Deuschle U., Massardi M.L., Martinez F.O., Sironi M., Sozzani S., et al. Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol 168 (2002) 3557-3562
28. Hakonarson H., Bjornsdottir U.S., Halapi E., Bradfield J., Zink F., Mouy M., et al. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci U S A 102 (2005) 14789-14794
29. Woodruff P.G., Boushey H.A., Dolganov G.M., Barker C.S., Yang Y.H., Donnelly S., et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A 104 (2007) 15858-15863
30. Berry M.A., Hargadon B., Shelley M., Parker D., Shaw D.E., Green R.H., et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 354 (2006) 697-708
31. Howarth P.H., Babu K.S., Arshad H.S., Lau L., Buckley M., McConnell W., et al. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 60 (2005) 1012-1018
32. Kiley J., Smith R., and Noel P. Asthma phenotypes. Curr Opin Pulm Med 13 (2007) 19-23
33. Moore W.C., Bleecker E.R., Curran-Everett D., Erzurum S.C., Ameredes B.T., Bacharier L., et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 119 (2007) 405-413
34. Moore W.C., and Peters S.P. Update in asthma 2006. Am J Respir Crit Care Med 175 (2007) 649-654
35. Doherty D.E., Zagarella L., Henson P.M., and Worthen G.S. Lipopolysaccharide stimulates monocyte adherence by effects on both the monocyte and the endothelial cell. J Immunol 143 (1989) 3673-3679
36. Liu A.H. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol 109 (2002) 379-392
37. Michel O., Ginanni R., Duchateau J., Vertongen F., Le Bon B., and Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 21 (1991) 441-448
38. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 154 (1996) 1641-1646
39. Rizzo M.C., Naspitz C.K., Fernandez-Caldas E., Lockey R.F., Mimica I., and Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 8 (1997) 121-126
40. Thorne P.S., Kulhankova K., Yin M., Cohn R., Arbes Jr. S.J., and Zeldin D.C. Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing. Am J Respir Crit Care Med 172 (2005) 1371-1377
41. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 (2004) 499-511
42. Bisgaard H., Hermansen M.N., Buchvald F., Loland L., Halkjaer L.B., Bonnelykke K., et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357 (2007) 1487-1495
43. Sutherland E.R., and Martin R.J. Asthma and atypical bacterial infection. Chest 132 (2007) 1962-1966
44. Platts-Mills J.A., Custis N.J., Woodfolk J.A., and Platts-Mills T.A. Airborne endotoxin in homes with domestic animals: implications for cat-specific tolerance. J Allergy Clin Immunol 116 (2005) 384-389
45. Gereda J.E., Klinnert M.D., Price M.R., Leung D.Y., and Liu A.H. Metropolitan home living conditions associated with indoor endotoxin levels. J Allergy Clin Immunol 107 (2001) 790-796
46. Spahn J.D., Fost D.A., Covar R., Martin R.J., Brown E.E., Szefler S.J., et al. Clarithromycin potentiates glucocorticoid responsiveness in patients with asthma: results of a pilot study. Ann Allergy Asthma Immunol 87 (2001) 501-505
47. Gotfried M.H. Macrolides for the treatment of chronic sinusitis, asthma, and COPD. Chest 125 (2004) 52S-60S
48. Simpson J.L., Powell H., Boyle M.J., Scott R.J., and Gibson P.G. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 177 (2008) 148-155
49. Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Wallaert B., Lafitte J.J., Chrousos G.P., Szefler S.J., and Leung D.Y. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 159 (1999) 1600-1604
50. Leung D.Y., Hamid Q., Vottero A., Szefler S.J., Surs W., Minshall E., et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med 186 (1997) 1567-1574
51. Hauk P., Goleva E., Liu A.H., Hall C.F., Martin R.J., and Leung D.Y.M. Dog ownership: a risk factor of corticosteroid-resistant (CR) asthma?. J Allergy Clin Immunol 119 suppl (2007) S164