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Volumn 4, Issue 18, 2002, Pages 3103-3106

Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; LOBATAMIDE C; MACROLIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SALICYLIC ACID DERIVATIVE; SALICYLIHALAMIDE A;

EID: 0037026562     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol026391z     Document Type: Article
Times cited : (42)

References (38)
  • 19
    • 0442263443 scopus 로고    scopus 로고
    • African Pat. 1968 ZA 6802187; CAN 70: 106224
    • Sherlock, M. H. S. African Pat. 1968 ZA 6802187; CAN 70: 106224
    • Sherlock, M.H.S.1
  • 22
    • 4944231040 scopus 로고
    • Analogue 9 was synthesized from (E,E)-2,4-hexadienamide (Pellegata, R.; Italia, A.; Villa, M. Synthesis 1985, 517) according to the general procedure used to prepare analogue 5.
    • (1985) Synthesis , pp. 517
    • Pellegata, R.1    Italia, A.2    Villa, M.3
  • 26
    • 0442265003 scopus 로고    scopus 로고
    • A conformational search was performed using PC Spartan Pro version 1.0.7 Wavefunction, Irvine, CA
    • A conformational search was performed using PC Spartan Pro version 1.0.7 (Wavefunction, Irvine, CA).
  • 33
    • 0442268059 scopus 로고    scopus 로고
    • Prepared by DIC coupling of o-anisic acid and 4-iodo-3-buten-1-ol. See Supporting Information for details
    • Prepared by DIC coupling of o-anisic acid and 4-iodo-3-buten-1-ol. See Supporting Information for details.
  • 36
    • 0442266564 scopus 로고    scopus 로고
    • note
    • ATPase activity was determined as described in Supporting Information. The assay measures turnover of ATP, which includes ATPase activity of the vacuolar ATPase and other potential ATPase activity present in the membrane preparations. In these assays more than 90% of the activity was inhibited by lobatamide C or by concanamycin A, specific inhibitors of the vacuolar ATPase.
  • 37
    • 0038365096 scopus 로고
    • Cf. (a) Pinkus, A. G.; Lin, Ellen Y. J. Mol. Struct. 1975, 24, 9. (b) Decouzon, M.; Ertl, P.; Exner, O.; Gal, J. F.; Maria, P. C. J. Am. Chem. Soc. 1993, 115, 12071.
    • (1975) J. Mol. Struct. , vol.24 , pp. 9
    • Pinkus, A.G.1    Lin, E.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.