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Volumn 28, Issue 5, 2010, Pages 489-502

Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development

Author keywords

Endochondral ossification; Hypertrophic chondrocyte; Osteoblast; Signaling pathways; Transcriptional factors

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR; NOTCH RECEPTOR; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 77956927453     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-010-0199-7     Document Type: Review
Times cited : (26)

References (157)
  • 1
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • 1:CAS:528:DC%2BD3sXjs1ynu7s%3D
    • HM Kronenberg 2003 Developmental regulation of the growth plate Nature (Lond) 423 332 336 1:CAS:528:DC%2BD3sXjs1ynu7s%3D
    • (2003) Nature (Lond) , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 2
    • 1842766265 scopus 로고    scopus 로고
    • Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development
    • 15081357 1:CAS:528:DC%2BD2cXjtV2htb8%3D
    • C Colnot C Lu D Hu JA Helms 2004 Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development Dev Biol 269 55 69 15081357 1:CAS:528:DC%2BD2cXjtV2htb8%3D
    • (2004) Dev Biol , vol.269 , pp. 55-69
    • Colnot, C.1    Lu, C.2    Hu, D.3    Helms, J.A.4
  • 3
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • 1:CAS:528:DC%2BD3sXotlWqsbg%3D
    • J Zhang C Niu L Ye H Huang X He WG Tong J Ross J Haug T Johnson JQ Feng, et al. 2003 Identification of the haematopoietic stem cell niche and control of the niche size Nature (Lond) 425 836 841 1:CAS:528:DC%2BD3sXotlWqsbg%3D
    • (2003) Nature (Lond) , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3    Huang, H.4    He, X.5    Tong, W.G.6    Ross, J.7    Haug, J.8    Johnson, T.9    Feng, J.Q.10
  • 5
    • 0035135642 scopus 로고    scopus 로고
    • Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    • 11160153 1:CAS:528:DC%2BD3MXhtVGitL0%3D
    • UI Chung E Schipani AP McMahon HM Kronenberg 2001 Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development J Clin Invest 107 295 304 11160153 1:CAS:528:DC%2BD3MXhtVGitL0%3D
    • (2001) J Clin Invest , vol.107 , pp. 295-304
    • Chung, U.I.1    Schipani, E.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 6
    • 0028057743 scopus 로고
    • Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene
    • 8314082 1:CAS:528:DyaK2cXitlKlurw%3D
    • AC Karaplis A Luz J Glowacki RT Bronson VL Tybulewicz HM Kronenberg RC Mulligan 1994 Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene Genes Dev 8 277 289 8314082 1:CAS:528:DyaK2cXitlKlurw%3D
    • (1994) Genes Dev , vol.8 , pp. 277-289
    • Karaplis, A.C.1    Luz, A.2    Glowacki, J.3    Bronson, R.T.4    Tybulewicz, V.L.5    Kronenberg, H.M.6    Mulligan, R.C.7
  • 8
    • 0031442990 scopus 로고    scopus 로고
    • Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
    • 9391087 1:CAS:528:DyaK2sXotValtrc%3D
    • E Schipani B Lanske J Hunzelman A Luz CS Kovacs K Lee A Pirro HM Kronenberg H Juppner 1997 Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide Proc Natl Acad Sci USA 94 13689 13694 9391087 1:CAS:528:DyaK2sXotValtrc%3D
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13689-13694
    • Schipani, E.1    Lanske, B.2    Hunzelman, J.3    Luz, A.4    Kovacs, C.S.5    Lee, K.6    Pirro, A.7    Kronenberg, H.M.8    Juppner, H.9
  • 9
    • 0032573058 scopus 로고    scopus 로고
    • The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
    • 9789035 1:CAS:528:DyaK1cXntFWktbY%3D
    • UI Chung B Lanske K Lee E Li H Kronenberg 1998 The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation Proc Natl Acad Sci USA 95 13030 13035 9789035 1:CAS:528:DyaK1cXntFWktbY%3D
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13030-13035
    • Chung, U.I.1    Lanske, B.2    Lee, K.3    Li, E.4    Kronenberg, H.5
  • 10
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • 8662546 1:CAS:528:DyaK28Xks1yntL4%3D
    • A Vortkamp K Lee B Lanske GV Segre HM Kronenberg CJ Tabin 1996 Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein Science 273 613 622 8662546 1:CAS:528:DyaK28Xks1yntL4%3D
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 11
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • 10465785 1:CAS:528:DyaK1MXmtValsLY%3D
    • B St-Jacques M Hammerschmidt AP McMahon 1999 Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation Genes Dev 13 2072 2086 10465785 1:CAS:528:DyaK1MXmtValsLY%3D
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 12
    • 0036696005 scopus 로고    scopus 로고
    • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C
    • 12194850 1:CAS:528:DC%2BD38Xmtl2it7w%3D
    • J Guo UI Chung H Kondo FR Bringhurst HM Kronenberg 2002 The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C Dev Cell 3 183 194 12194850 1:CAS:528:DC%2BD38Xmtl2it7w%3D
    • (2002) Dev Cell , vol.3 , pp. 183-194
    • Guo, J.1    Chung, U.I.2    Kondo, H.3    Bringhurst, F.R.4    Kronenberg, H.M.5
  • 13
    • 6944221426 scopus 로고    scopus 로고
    • Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
    • 15459318 1:CAS:528:DC%2BD2cXovVyju70%3D
    • M Bastepe LS Weinstein N Ogata H Kawaguchi H Juppner HM Kronenberg UI Chung 2004 Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo Proc Natl Acad Sci USA 101 14794 14799 15459318 1:CAS:528:DC%2BD2cXovVyju70%3D
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14794-14799
    • Bastepe, M.1    Weinstein, L.S.2    Ogata, N.3    Kawaguchi, H.4    Juppner, H.5    Kronenberg, H.M.6    Chung, U.I.7
  • 15
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • 11731473 1:CAS:528:DC%2BD3MXptVKms7s%3D
    • PW Ingham AP McMahon 2001 Hedgehog signaling in animal development: paradigms and principles Genes Dev 15 3059 3087 11731473 1:CAS:528: DC%2BD3MXptVKms7s%3D
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 16
    • 29644447977 scopus 로고    scopus 로고
    • Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    • 1:CAS:528:DC%2BD28XktlehsQ%3D%3D
    • L Koziel M Wuelling S Schneider A Vortkamp 2005 Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation Development (Camb) 132 5249 5260 1:CAS:528: DC%2BD28XktlehsQ%3D%3D
    • (2005) Development (Camb) , vol.132 , pp. 5249-5260
    • Koziel, L.1    Wuelling, M.2    Schneider, S.3    Vortkamp, A.4
  • 17
    • 0035479835 scopus 로고    scopus 로고
    • New aspects of Wnt signaling pathways in higher vertebrates
    • 11532397 1:CAS:528:DC%2BD3MXmt1Krt7s%3D
    • J Huelsken W Birchmeier 2001 New aspects of Wnt signaling pathways in higher vertebrates Curr Opin Genet Dev 11 547 553 11532397 1:CAS:528: DC%2BD3MXmt1Krt7s%3D
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 547-553
    • Huelsken, J.1    Birchmeier, W.2
  • 18
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • 9891778 1:CAS:528:DyaK1cXnvFyju74%3D
    • A Wodarz R Nusse 1998 Mechanisms of Wnt signaling in development Annu Rev Cell Dev Biol 14 59 88 9891778 1:CAS:528:DyaK1cXnvFyju74%3D
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 19
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • 11336703 1:CAS:528:DC%2BD3MXjsVentL0%3D
    • J Mao J Wang B Liu W Pan GH Farr 3rd C Flynn H Yuan S Takada D Kimelman L Li, et al. 2001 Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway Mol Cell 7 801 809 11336703 1:CAS:528:DC%2BD3MXjsVentL0%3D
    • (2001) Mol Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr III, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.10
  • 20
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • 1:CAS:528:DC%2BD3cXntlSrtro%3D
    • KI Pinson J Brennan S Monkley BJ Avery WC Skarnes 2000 An LDL-receptor-related protein mediates Wnt signalling in mice Nature (Lond) 407 535 538 1:CAS:528:DC%2BD3cXntlSrtro%3D
    • (2000) Nature (Lond) , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 22
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • 1:CAS:528:DyaK1cXot1Glug%3D%3D
    • A Glinka W Wu H Delius AP Monaghan C Blumenstock C Niehrs 1998 Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction Nature (Lond) 391 357 362 1:CAS:528:DyaK1cXot1Glug%3D%3D
    • (1998) Nature (Lond) , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 23
    • 13244299109 scopus 로고    scopus 로고
    • FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    • 15592430 1:CAS:528:DC%2BD2MXlvVKmuw%3D%3D
    • MN Chamorro DR Schwartz A Vonica AH Brivanlou KR Cho HE Varmus 2005 FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development EMBO J 24 73 84 15592430 1:CAS:528:DC%2BD2MXlvVKmuw%3D%3D
    • (2005) EMBO J , vol.24 , pp. 73-84
    • Chamorro, M.N.1    Schwartz, D.R.2    Vonica, A.3    Brivanlou, A.H.4    Cho, K.R.5    Varmus, H.E.6
  • 24
    • 9144240010 scopus 로고    scopus 로고
    • DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway
    • 15378020 1:CAS:528:DC%2BD2cXpt1Omsb4%3D
    • A Niida T Hiroko M Kasai Y Furukawa Y Nakamura Y Suzuki S Sugano T Akiyama 2004 DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway Oncogene 23 8520 8526 15378020 1:CAS:528: DC%2BD2cXpt1Omsb4%3D
    • (2004) Oncogene , vol.23 , pp. 8520-8526
    • Niida, A.1    Hiroko, T.2    Kasai, M.3    Furukawa, Y.4    Nakamura, Y.5    Suzuki, Y.6    Sugano, S.7    Akiyama, T.8
  • 25
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • 11433302 1:CAS:528:DC%2BD3MXlt1Ojs7c%3D
    • A Bafico G Liu A Yaniv A Gazit SA Aaronson 2001 Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow Nat Cell Biol 3 683 686 11433302 1:CAS:528:DC%2BD3MXlt1Ojs7c%3D
    • (2001) Nat Cell Biol , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 26
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • 1:CAS:528:DC%2BD3MXjvF2qtbo%3D
    • B Mao W Wu Y Li D Hoppe P Stannek A Glinka C Niehrs 2001 LDL-receptor-related protein 6 is a receptor for Dickkopf proteins Nature (Lond) 411 321 325 1:CAS:528:DC%2BD3MXjvF2qtbo%3D
    • (2001) Nature (Lond) , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 27
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • 11448771 1:CAS:528:DC%2BD3MXltVGjtb8%3D
    • MV Semenov K Tamai BK Brott M Kuhl S Sokol X He 2001 Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 Curr Biol 11 951 961 11448771 1:CAS:528:DC%2BD3MXltVGjtb8%3D
    • (2001) Curr Biol , vol.11 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5    He, X.6
  • 28
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • 12967557 1:CAS:528:DC%2BD3sXnsFKlsbg%3D
    • MT Veeman JD Axelrod RT Moon 2003 A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling Dev Cell 5 367 377 12967557 1:CAS:528:DC%2BD3sXnsFKlsbg%3D
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 29
    • 34047250505 scopus 로고    scopus 로고
    • Wnt gene expression in the post-natal growth plate: Regulation with chondrocyte differentiation
    • DOI 10.1016/j.bone.2007.01.005, PII S8756328207000294
    • AC Andrade O Nilsson KM Barnes J Baron 2007 Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation Bone (NY) 40 1361 1369 1:CAS:528:DC%2BD2sXktF2ns7o%3D (Pubitemid 46550985)
    • (2007) Bone , vol.40 , Issue.5 , pp. 1361-1369
    • Andrade, A.C.1    Nilsson, O.2    Barnes, K.M.3    Baron, J.4
  • 31
    • 21444439296 scopus 로고    scopus 로고
    • Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
    • 15760903 1:CAS:528:DC%2BD2MXjvFers7Y%3D
    • Y Tamamura T Otani N Kanatani E Koyama J Kitagaki T Komori Y Yamada F Costantini S Wakisaka M Pacifici, et al. 2005 Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification J Biol Chem 280 19185 19195 15760903 1:CAS:528:DC%2BD2MXjvFers7Y%3D
    • (2005) J Biol Chem , vol.280 , pp. 19185-19195
    • Tamamura, Y.1    Otani, T.2    Kanatani, N.3    Koyama, E.4    Kitagaki, J.5    Komori, T.6    Yamada, Y.7    Costantini, F.8    Wakisaka, S.9    Pacifici, M.10
  • 32
    • 18744391368 scopus 로고    scopus 로고
    • The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis
    • 12413904 1:CAS:528:DC%2BD38XotFGgsb8%3D
    • M Enomoto-Iwamoto J Kitagaki E Koyama Y Tamamura C Wu N Kanatani T Koike H Okada T Komori T Yoneda, et al. 2002 The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis Dev Biol 251 142 156 12413904 1:CAS:528:DC%2BD38XotFGgsb8%3D
    • (2002) Dev Biol , vol.251 , pp. 142-156
    • Enomoto-Iwamoto, M.1    Kitagaki, J.2    Koyama, E.3    Tamamura, Y.4    Wu, C.5    Kanatani, N.6    Koike, T.7    Okada, H.8    Komori, T.9    Yoneda, T.10
  • 33
    • 17844372752 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    • 15866164 1:CAS:528:DC%2BD2MXkslentbc%3D
    • TF Day X Guo L Garrett-Beal Y Yang 2005 Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis Dev Cell 8 739 750 15866164 1:CAS:528:DC%2BD2MXkslentbc%3D
    • (2005) Dev Cell , vol.8 , pp. 739-750
    • Day, T.F.1    Guo, X.2    Garrett-Beal, L.3    Yang, Y.4
  • 34
    • 33750301324 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
    • 1:CAS:528:DC%2BD28XhtFels7rI
    • KK Mak MH Chen TF Day PT Chuang Y Yang 2006 Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation Development (Camb) 133 3695 3707 1:CAS:528: DC%2BD28XhtFels7rI
    • (2006) Development (Camb) , vol.133 , pp. 3695-3707
    • Mak, K.K.1    Chen, M.H.2    Day, T.F.3    Chuang, P.T.4    Yang, Y.5
  • 35
    • 0037347909 scopus 로고    scopus 로고
    • Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation
    • 1:CAS:528:DC%2BD3sXisVeltLg%3D
    • Y Yang L Topol H Lee J Wu 2003 Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation Development (Camb) 130 1003 1015 1:CAS:528:DC%2BD3sXisVeltLg%3D
    • (2003) Development (Camb) , vol.130 , pp. 1003-1015
    • Yang, Y.1    Topol, L.2    Lee, H.3    Wu, J.4
  • 36
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • 9759503 1:CAS:528:DyaK1cXlsFOmsbY%3D
    • J Massague 1998 TGF-beta signal transduction Annu Rev Biochem 67 753 791 9759503 1:CAS:528:DyaK1cXlsFOmsbY%3D
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 37
    • 33751069567 scopus 로고    scopus 로고
    • BMP signaling in the cartilage growth plate
    • 17118262 1:CAS:528:DC%2BD2sXmsFOms74%3D
    • R Pogue K Lyons 2006 BMP signaling in the cartilage growth plate Curr Top Dev Biol 76 1 48 17118262 1:CAS:528:DC%2BD2sXmsFOms74%3D
    • (2006) Curr Top Dev Biol , vol.76 , pp. 1-48
    • Pogue, R.1    Lyons, K.2
  • 38
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • 1:CAS:528:DC%2BD3sXnvV2hs7c%3D
    • R Derynck YE Zhang 2003 Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature (Lond) 425 577 584 1:CAS:528: DC%2BD3sXnvV2hs7c%3D
    • (2003) Nature (Lond) , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 39
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • 16322555 1:CAS:528:DC%2BD2MXhtlWqsrnI
    • J Massague J Seoane D Wotton 2005 Smad transcription factors Genes Dev 19 2783 2810 16322555 1:CAS:528:DC%2BD2MXhtlWqsrnI
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 40
    • 0033562850 scopus 로고    scopus 로고
    • Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation
    • 10328918 1:CAS:528:DyaK1MXislOhsrg%3D
    • S Pathi JB Rutenberg RL Johnson A Vortkamp 1999 Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation Dev Biol 209 239 253 10328918 1:CAS:528:DyaK1MXislOhsrg%3D
    • (1999) Dev Biol , vol.209 , pp. 239-253
    • Pathi, S.1    Rutenberg, J.B.2    Johnson, R.L.3    Vortkamp, A.4
  • 41
    • 0030955344 scopus 로고    scopus 로고
    • Distinct roles of type i bone morphogenetic protein receptors in the formation and differentiation of cartilage
    • 9303535 1:CAS:528:DyaK2sXmtVertbc%3D
    • H Zou R Wieser J Massague L Niswander 1997 Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes Dev 11 2191 2203 9303535 1:CAS:528:DyaK2sXmtVertbc%3D
    • (1997) Genes Dev , vol.11 , pp. 2191-2203
    • Zou, H.1    Wieser, R.2    Massague, J.3    Niswander, L.4
  • 43
    • 0033981112 scopus 로고    scopus 로고
    • Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments
    • 10705576 1:STN:280:DC%2BD3c7mvFOmtg%3D%3D
    • A Haaijman EH Burger SW Goei L Nelles P ten Dijke D Huylebroeck AL Bronckers 2000 Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments Growth Factors 17 177 192 10705576 1:STN:280:DC%2BD3c7mvFOmtg%3D%3D
    • (2000) Growth Factors , vol.17 , pp. 177-192
    • Haaijman, A.1    Burger, E.H.2    Goei, S.W.3    Nelles, L.4    Ten Dijke, P.5    Huylebroeck, D.6    Bronckers, A.L.7
  • 44
    • 0024991197 scopus 로고
    • Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)
    • 1:CAS:528:DyaK3cXmtVyrtr0%3D
    • KM Lyons RW Pelton BL Hogan 1990 Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A) Development (Camb) 109 833 844 1:CAS:528:DyaK3cXmtVyrtr0%3D
    • (1990) Development (Camb) , vol.109 , pp. 833-844
    • Lyons, K.M.1    Pelton, R.W.2    Hogan, B.L.3
  • 45
    • 0028960753 scopus 로고
    • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development
    • 7605753 1:CAS:528:DyaK2MXktFCiuro%3D
    • KM Lyons BL Hogan EJ Robertson 1995 Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development Mech Dev 50 71 83 7605753 1:CAS:528:DyaK2MXktFCiuro%3D
    • (1995) Mech Dev , vol.50 , pp. 71-83
    • Lyons, K.M.1    Hogan, B.L.2    Robertson, E.J.3
  • 46
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • 1:CAS:528:DC%2BD3MXptVGlurc%3D
    • E Minina HM Wenzel C Kreschel S Karp W Gaffield AP McMahon A Vortkamp 2001 BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation Development (Camb) 128 4523 4534 1:CAS:528:DC%2BD3MXptVGlurc%3D
    • (2001) Development (Camb) , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 47
    • 0032970436 scopus 로고    scopus 로고
    • Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification
    • 10404014 1:CAS:528:DyaK1MXkvVyjsLk%3D
    • T Sakou T Onishi T Yamamoto T Nagamine T Sampath P Ten Dijke 1999 Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification J Bone Miner Res 14 1145 1152 10404014 1:CAS:528:DyaK1MXkvVyjsLk%3D
    • (1999) J Bone Miner Res , vol.14 , pp. 1145-1152
    • Sakou, T.1    Onishi, T.2    Yamamoto, T.3    Nagamine, T.4    Sampath, T.5    Ten Dijke, P.6
  • 48
    • 0034933839 scopus 로고    scopus 로고
    • The type i BMP receptor BmprIB is essential for female reproductive function
    • 11416163 1:CAS:528:DC%2BD3MXlt1Kntb8%3D
    • SE Yi PS LaPolt BS Yoon JY Chen JK Lu KM Lyons 2001 The type I BMP receptor BmprIB is essential for female reproductive function Proc Natl Acad Sci USA 98 7994 7999 11416163 1:CAS:528:DC%2BD3MXlt1Kntb8%3D
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7994-7999
    • Yi, S.E.1    Lapolt, P.S.2    Yoon, B.S.3    Chen, J.Y.4    Lu, J.K.5    Lyons, K.M.6
  • 49
    • 17044364765 scopus 로고    scopus 로고
    • Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
    • 15781876 1:CAS:528:DC%2BD2MXjsFemt70%3D
    • BS Yoon DA Ovchinnikov I Yoshii Y Mishina RR Behringer KM Lyons 2005 Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo Proc Natl Acad Sci USA 102 5062 5067 15781876 1:CAS:528:DC%2BD2MXjsFemt70%3D
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5062-5067
    • Yoon, B.S.1    Ovchinnikov, D.A.2    Yoshii, I.3    Mishina, Y.4    Behringer, R.R.5    Lyons, K.M.6
  • 50
    • 66349117431 scopus 로고    scopus 로고
    • BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
    • 1:CAS:528:DC%2BD1MXlt1Oqt7c%3D
    • KN Retting B Song BS Yoon KM Lyons 2009 BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation Development (Camb) 136 1093 1104 1:CAS:528:DC%2BD1MXlt1Oqt7c%3D
    • (2009) Development (Camb) , vol.136 , pp. 1093-1104
    • Retting, K.N.1    Song, B.2    Yoon, B.S.3    Lyons, K.M.4
  • 52
    • 29144529005 scopus 로고    scopus 로고
    • BMP signaling stimulates cellular differentiation at multiple steps during cartilage development
    • 16322106 1:CAS:528:DC%2BD2MXhtlersrzK
    • T Kobayashi KM Lyons AP McMahon HM Kronenberg 2005 BMP signaling stimulates cellular differentiation at multiple steps during cartilage development Proc Natl Acad Sci USA 102 18023 18027 16322106 1:CAS:528: DC%2BD2MXhtlersrzK
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18023-18027
    • Kobayashi, T.1    Lyons, K.M.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 53
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • 17194222
    • A Bandyopadhyay K Tsuji K Cox BD Harfe V Rosen CJ Tabin 2006 Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis PLoS Genet 2 e216 17194222
    • (2006) PLoS Genet , vol.2 , pp. 216
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3    Harfe, B.D.4    Rosen, V.5    Tabin, C.J.6
  • 54
    • 33846067098 scopus 로고    scopus 로고
    • BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    • 1:CAS:528:DC%2BD2sXivFeqsA%3D%3D
    • BS Yoon R Pogue DA Ovchinnikov I Yoshii Y Mishina RR Behringer KM Lyons 2006 BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways Development (Camb) 133 4667 4678 1:CAS:528:DC%2BD2sXivFeqsA%3D%3D
    • (2006) Development (Camb) , vol.133 , pp. 4667-4678
    • Yoon, B.S.1    Pogue, R.2    Ovchinnikov, D.A.3    Yoshii, I.4    Mishina, Y.5    Behringer, R.R.6    Lyons, K.M.7
  • 55
    • 0022998254 scopus 로고
    • Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells
    • 3528157 1:CAS:528:DyaL28Xls1Grtrw%3D
    • LR Ellingsworth JE Brennan K Fok DM Rosen H Bentz KA Piez SM Seyedin 1986 Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells J Biol Chem 261 12362 12367 3528157 1:CAS:528:DyaL28Xls1Grtrw%3D
    • (1986) J Biol Chem , vol.261 , pp. 12362-12367
    • Ellingsworth, L.R.1    Brennan, J.E.2    Fok, K.3    Rosen, D.M.4    Bentz, H.5    Piez, K.A.6    Seyedin, S.M.7
  • 56
    • 0025864662 scopus 로고
    • Transforming growth factor-beta in calf articular cartilage organ cultures: Synthesis and distribution
    • 1716871 1:CAS:528:DyaK3MXksVaksLc%3D
    • TI Morales ME Joyce ME Sobel D Danielpour AB Roberts 1991 Transforming growth factor-beta in calf articular cartilage organ cultures: synthesis and distribution Arch Biochem Biophys 288 397 405 1716871 1:CAS:528: DyaK3MXksVaksLc%3D
    • (1991) Arch Biochem Biophys , vol.288 , pp. 397-405
    • Morales, T.I.1    Joyce, M.E.2    Sobel, M.E.3    Danielpour, D.4    Roberts, A.B.5
  • 57
    • 0033577851 scopus 로고    scopus 로고
    • Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation
    • 10330406 1:CAS:528:DyaK1MXjt1WgsLc%3D
    • R Serra A Karaplis P Sohn 1999 Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation J Cell Biol 145 783 794 10330406 1:CAS:528:DyaK1MXjt1WgsLc%3D
    • (1999) J Cell Biol , vol.145 , pp. 783-794
    • Serra, R.1    Karaplis, A.2    Sohn, P.3
  • 58
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • 11285272 1:CAS:528:DC%2BD3MXisVyhtLw%3D
    • X Yang L Chen X Xu C Li C Huang CX Deng 2001 TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage J Cell Biol 153 35 46 11285272 1:CAS:528:DC%2BD3MXisVyhtLw%3D
    • (2001) J Cell Biol , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6
  • 59
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • 9334355 1:CAS:528:DyaK2sXmvV2gu7k%3D
    • R Serra M Johnson EH Filvaroff J LaBorde DM Sheehan R Derynck HL Moses 1997 Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis J Cell Biol 139 541 552 9334355 1:CAS:528:DyaK2sXmvV2gu7k%3D
    • (1997) J Cell Biol , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    Laborde, J.4    Sheehan, D.M.5    Derynck, R.6    Moses, H.L.7
  • 60
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • 16105881 1:CAS:528:DC%2BD2MXhtVaktrvK
    • A Moustakas CH Heldin 2005 Non-Smad TGF-beta signals J Cell Sci 118 3573 3584 16105881 1:CAS:528:DC%2BD2MXhtVaktrvK
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 61
    • 18144391965 scopus 로고    scopus 로고
    • FGF signaling in the developing endochondral skeleton
    • 15863035 1:CAS:528:DC%2BD2MXjvVOnsLw%3D
    • DM Ornitz 2005 FGF signaling in the developing endochondral skeleton Cytokine Growth Factor Rev 16 205 213 15863035 1:CAS:528:DC%2BD2MXjvVOnsLw%3D
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 205-213
    • Ornitz, D.M.1
  • 62
    • 0033958379 scopus 로고    scopus 로고
    • Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells
    • 10646125 1:CAS:528:DC%2BD3cXmsVyntw%3D%3D
    • JE Henderson MC Naski MM Aarts D Wang L Cheng D Goltzman DM Ornitz 2000 Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells J Bone Miner Res 15 155 165 10646125 1:CAS:528:DC%2BD3cXmsVyntw%3D%3D
    • (2000) J Bone Miner Res , vol.15 , pp. 155-165
    • Henderson, J.E.1    Naski, M.C.2    Aarts, M.M.3    Wang, D.4    Cheng, L.5    Goltzman, D.6    Ornitz, D.M.7
  • 63
    • 0032413011 scopus 로고    scopus 로고
    • Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    • 1:CAS:528:DyaK1MXjs1CmtA%3D%3D
    • MC Naski JS Colvin JD Coffin DM Ornitz 1998 Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3 Development (Camb) 125 4977 4988 1:CAS:528: DyaK1MXjs1CmtA%3D%3D
    • (1998) Development (Camb) , vol.125 , pp. 4977-4988
    • Naski, M.C.1    Colvin, J.S.2    Coffin, J.D.3    Ornitz, D.M.4
  • 64
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • 8630492 1:CAS:528:DyaK28XjtFaju7c%3D
    • JS Colvin BA Bohne GW Harding DG McEwen DM Ornitz 1996 Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3 Nat Genet 12 390 397 8630492 1:CAS:528:DyaK28XjtFaju7c%3D
    • (1996) Nat Genet , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 65
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • 14871928 1:CAS:528:DC%2BD2cXhsFalt78%3D
    • S Murakami G Balmes S McKinney Z Zhang D Givol B de Crombrugghe 2004 Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype Genes Dev 18 290 305 14871928 1:CAS:528:DC%2BD2cXhsFalt78%3D
    • (2004) Genes Dev , vol.18 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    De Crombrugghe, B.6
  • 66
    • 11144358656 scopus 로고    scopus 로고
    • Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
    • 14702637 1:CAS:528:DC%2BD2cXlsFCq
    • A Yasoda Y Komatsu H Chusho T Miyazawa A Ozasa M Miura T Kurihara T Rogi S Tanaka M Suda, et al. 2004 Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway Nat Med 10 80 86 14702637 1:CAS:528:DC%2BD2cXlsFCq
    • (2004) Nat Med , vol.10 , pp. 80-86
    • Yasoda, A.1    Komatsu, Y.2    Chusho, H.3    Miyazawa, T.4    Ozasa, A.5    Miura, M.6    Kurihara, T.7    Rogi, T.8    Tanaka, S.9    Suda, M.10
  • 67
    • 33846214070 scopus 로고    scopus 로고
    • FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
    • 17014841 1:CAS:528:DC%2BD2sXntlOktQ%3D%3D
    • Z Liu KJ Lavine IH Hung DM Ornitz 2007 FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate Dev Biol 302 80 91 17014841 1:CAS:528:DC%2BD2sXntlOktQ%3D%3D
    • (2007) Dev Biol , vol.302 , pp. 80-91
    • Liu, Z.1    Lavine, K.J.2    Hung, I.H.3    Ornitz, D.M.4
  • 68
    • 0345711458 scopus 로고    scopus 로고
    • Sox9 is required for cartilage formation
    • 10319868 1:CAS:528:DyaK1MXjtVagsLw%3D
    • W Bi JM Deng Z Zhang RR Behringer B de Crombrugghe 1999 Sox9 is required for cartilage formation Nat Genet 22 85 89 10319868 1:CAS:528:DyaK1MXjtVagsLw%3D
    • (1999) Nat Genet , vol.22 , pp. 85-89
    • Bi, W.1    Deng, J.M.2    Zhang, Z.3    Behringer, R.R.4    De Crombrugghe, B.5
  • 69
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • 12414734 1:CAS:528:DC%2BD38Xos1Sisr0%3D
    • H Akiyama MC Chaboissier JF Martin A Schedl B de Crombrugghe 2002 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 Genes Dev 16 2813 2828 12414734 1:CAS:528:DC%2BD38Xos1Sisr0%3D
    • (2002) Genes Dev , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3    Schedl, A.4    De Crombrugghe, B.5
  • 70
    • 0032189223 scopus 로고    scopus 로고
    • A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene
    • DOI 10.1093/emboj/17.19.5718
    • V Lefebvre P Li B de Crombrugghe 1998 A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene EMBO J 17 5718 5733 9755172 1:CAS:528:DyaK1cXmvVyjsLs%3D (Pubitemid 28445983)
    • (1998) EMBO Journal , vol.17 , Issue.19 , pp. 5718-5733
    • Lefebvre, V.1    Li, P.2    De Crombrugghe, B.3
  • 71
    • 0035431807 scopus 로고    scopus 로고
    • The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    • 11702786 1:CAS:528:DC%2BD3MXntVGrsLs%3D
    • P Smits P Li J Mandel Z Zhang JM Deng RR Behringer B de Crombrugghe V Lefebvre 2001 The transcription factors L-Sox5 and Sox6 are essential for cartilage formation Dev Cell 1 277 290 11702786 1:CAS:528:DC%2BD3MXntVGrsLs%3D
    • (2001) Dev Cell , vol.1 , pp. 277-290
    • Smits, P.1    Li, P.2    Mandel, J.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7    Lefebvre, V.8
  • 72
    • 34247859295 scopus 로고    scopus 로고
    • S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes
    • 17396138 1:CAS:528:DC%2BD2sXkslCksr0%3D
    • T Saito T Ikeda K Nakamura UI Chung H Kawaguchi 2007 S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes EMBO Rep 8 504 509 17396138 1:CAS:528:DC%2BD2sXkslCksr0%3D
    • (2007) EMBO Rep , vol.8 , pp. 504-509
    • Saito, T.1    Ikeda, T.2    Nakamura, K.3    Chung, U.I.4    Kawaguchi, H.5
  • 73
    • 67349120238 scopus 로고    scopus 로고
    • Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes
    • 19306868 1:CAS:528:DC%2BD1MXnt1yitLo%3D
    • S Yamashita M Andoh H Ueno-Kudoh T Sato S Miyaki H Asahara 2009 Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes Exp Cell Res 315 2231 2240 19306868 1:CAS:528:DC%2BD1MXnt1yitLo%3D
    • (2009) Exp Cell Res , vol.315 , pp. 2231-2240
    • Yamashita, S.1    Andoh, M.2    Ueno-Kudoh, H.3    Sato, T.4    Miyaki, S.5    Asahara, H.6
  • 74
    • 8444233948 scopus 로고    scopus 로고
    • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    • 15529345 1:CAS:528:DC%2BD2cXhtVOqtrjI
    • T Ikeda S Kamekura A Mabuchi I Kou S Seki T Takato K Nakamura H Kawaguchi S Ikegawa UI Chung 2004 The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage Arthritis Rheum 50 3561 3573 15529345 1:CAS:528:DC%2BD2cXhtVOqtrjI
    • (2004) Arthritis Rheum , vol.50 , pp. 3561-3573
    • Ikeda, T.1    Kamekura, S.2    Mabuchi, A.3    Kou, I.4    Seki, S.5    Takato, T.6    Nakamura, K.7    Kawaguchi, H.8    Ikegawa, S.9    Chung, U.I.10
  • 76
    • 0035810951 scopus 로고    scopus 로고
    • Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization
    • 11371614 1:CAS:528:DC%2BD3MXksVOkurw%3D
    • W Bi W Huang DJ Whitworth JM Deng Z Zhang RR Behringer B de Crombrugghe 2001 Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization Proc Natl Acad Sci USA 98 6698 6703 11371614 1:CAS:528:DC%2BD3MXksVOkurw%3D
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6698-6703
    • Bi, W.1    Huang, W.2    Whitworth, D.J.3    Deng, J.M.4    Zhang, Z.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 77
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • 9182763 1:CAS:528:DyaK2sXjs1ejtr4%3D
    • T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu RT Bronson YH Gao M Inada, et al. 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Cell 89 755 764 9182763 1:CAS:528:DyaK2sXjs1ejtr4%3D
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6    Shimizu, Y.7    Bronson, R.T.8    Gao, Y.H.9    Inada, M.10
  • 78
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • 9182764 1:CAS:528:DyaK2sXjs1ejtrk%3D
    • F Otto AP Thornell T Crompton A Denzel KC Gilmour IR Rosewell GW Stamp RS Beddington S Mundlos BR Olsen, et al. 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development Cell 89 765 771 9182764 1:CAS:528:DyaK2sXjs1ejtrk%3D
    • (1997) Cell , vol.89 , pp. 765-771
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3    Denzel, A.4    Gilmour, K.C.5    Rosewell, I.R.6    Stamp, G.W.7    Beddington, R.S.8    Mundlos, S.9    Olsen, B.R.10
  • 80
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3 K-Akt signaling
    • 15226309 1:CAS:528:DC%2BD2cXlslWqtLg%3D
    • T Fujita Y Azuma R Fukuyama Y Hattori C Yoshida M Koida K Ogita T Komori 2004 Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3 K-Akt signaling J Cell Biol 166 85 95 15226309 1:CAS:528:DC%2BD2cXlslWqtLg%3D
    • (2004) J Cell Biol , vol.166 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5    Koida, M.6    Ogita, K.7    Komori, T.8
  • 81
    • 58249109359 scopus 로고    scopus 로고
    • Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene
    • 19116917 1:CAS:528:DC%2BD1MXhvFequ7g%3D
    • A Higashikawa T Saito T Ikeda S Kamekura N Kawamura A Kan Y Oshima S Ohba N Ogata K Takeshita, et al. 2009 Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene Arthritis Rheum 60 166 178 19116917 1:CAS:528:DC%2BD1MXhvFequ7g%3D
    • (2009) Arthritis Rheum , vol.60 , pp. 166-178
    • Higashikawa, A.1    Saito, T.2    Ikeda, T.3    Kamekura, S.4    Kawamura, N.5    Kan, A.6    Oshima, Y.7    Ohba, S.8    Ogata, N.9    Takeshita, K.10
  • 82
    • 0035118709 scopus 로고    scopus 로고
    • Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    • 11230154 1:CAS:528:DC%2BD3MXhvVOisr8%3D
    • S Takeda JP Bonnamy MJ Owen P Ducy G Karsenty 2001 Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice Genes Dev 15 467 481 11230154 1:CAS:528:DC%2BD3MXhvVOisr8%3D
    • (2001) Genes Dev , vol.15 , pp. 467-481
    • Takeda, S.1    Bonnamy, J.P.2    Owen, M.J.3    Ducy, P.4    Karsenty, G.5
  • 84
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • 15107406 1:CAS:528:DC%2BD2cXjsFKksLg%3D
    • CA Yoshida H Yamamoto T Fujita T Furuichi K Ito K Inoue K Yamana A Zanma K Takada Y Ito, et al. 2004 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog Genes Dev 18 952 963 15107406 1:CAS:528:DC%2BD2cXjsFKksLg%3D
    • (2004) Genes Dev , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5    Inoue, K.6    Yamana, K.7    Zanma, A.8    Takada, K.9    Ito, Y.10
  • 87
    • 23044448510 scopus 로고    scopus 로고
    • Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    • 15990875 1:CAS:528:DC%2BD2MXmt1ynu70%3D
    • JS Kang T Alliston R Delston R Derynck 2005 Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3 EMBO J 24 2543 2555 15990875 1:CAS:528:DC%2BD2MXmt1ynu70%3D
    • (2005) EMBO J , vol.24 , pp. 2543-2555
    • Kang, J.S.1    Alliston, T.2    Delston, R.3    Derynck, R.4
  • 89
    • 69249155244 scopus 로고    scopus 로고
    • HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity
    • 19509297 1:CAS:528:DC%2BD1MXpsFymtr0%3D
    • X Sun L Wei Q Chen RM Terek 2009 HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity J Biol Chem 284 21881 21890 19509297 1:CAS:528:DC%2BD1MXpsFymtr0%3D
    • (2009) J Biol Chem , vol.284 , pp. 21881-21890
    • Sun, X.1    Wei, L.2    Chen, Q.3    Terek, R.M.4
  • 90
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • 1:CAS:528:DC%2BD2cXivF2nu7s%3D
    • F Long UI Chung S Ohba J McMahon HM Kronenberg AP McMahon 2004 Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton Development (Camb) 131 1309 1318 1:CAS:528:DC%2BD2cXivF2nu7s%3D
    • (2004) Development (Camb) , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 92
    • 0346996354 scopus 로고    scopus 로고
    • Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells
    • G van der Horst H Farih-Sips CW Lowik M Karperien 2003 Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells Bone (NY) 33 899 910
    • (2003) Bone (NY) , vol.33 , pp. 899-910
    • Van Der Horst, G.1    Farih-Sips, H.2    Lowik, C.W.3    Karperien, M.4
  • 93
    • 33748768971 scopus 로고    scopus 로고
    • Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
    • 1:CAS:528:DC%2BD28XhtVart7zI
    • SJ Rodda AP McMahon 2006 Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors Development (Camb) 133 3231 3244 1:CAS:528:DC%2BD28XhtVart7zI
    • (2006) Development (Camb) , vol.133 , pp. 3231-3244
    • Rodda, S.J.1    McMahon, A.P.2
  • 94
  • 96
    • 71449101887 scopus 로고    scopus 로고
    • The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization
    • 1:CAS:528:DC%2BC3cXptValsw%3D%3D
    • KS Joeng F Long 2009 The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization Development (Camb) 136 4177 4185 1:CAS:528: DC%2BC3cXptValsw%3D%3D
    • (2009) Development (Camb) , vol.136 , pp. 4177-4185
    • Joeng, K.S.1    Long, F.2
  • 97
    • 34250801612 scopus 로고    scopus 로고
    • Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone
    • 17409191 1:CAS:528:DC%2BD2sXks1Shu7o%3D
    • Y Maeda E Nakamura MT Nguyen LJ Suva FL Swain MS Razzaque S Mackem B Lanske 2007 Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone Proc Natl Acad Sci USA 104 6382 6387 17409191 1:CAS:528:DC%2BD2sXks1Shu7o%3D
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6382-6387
    • Maeda, Y.1    Nakamura, E.2    Nguyen, M.T.3    Suva, L.J.4    Swain, F.L.5    Razzaque, M.S.6    MacKem, S.7    Lanske, B.8
  • 98
    • 40149091426 scopus 로고    scopus 로고
    • Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    • 18328428 1:CAS:528:DC%2BD1cXjsVKgs70%3D
    • H Kimura JM Ng T Curran 2008 Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure Cancer Cell 13 249 260 18328428 1:CAS:528:DC%2BD1cXjsVKgs70%3D
    • (2008) Cancer Cell , vol.13 , pp. 249-260
    • Kimura, H.1    Ng, J.M.2    Curran, T.3
  • 100
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • 14584895 1:CAS:528:DC%2BD3sXosFynsrk%3D
    • G Rawadi B Vayssiere F Dunn R Baron S Roman-Roman 2003 BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop J Bone Miner Res 18 1842 1853 14584895 1:CAS:528:DC%2BD3sXosFynsrk%3D
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 101
    • 8744271562 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 in insulin and Wnt signalling: A double-edged sword?
    • 15494020 1:CAS:528:DC%2BD2cXptVSlsLo%3D
    • S Patel B Doble JR Woodgett 2004 Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? Biochem Soc Trans 32 803 808 15494020 1:CAS:528:DC%2BD2cXptVSlsLo%3D
    • (2004) Biochem Soc Trans , vol.32 , pp. 803-808
    • Patel, S.1    Doble, B.2    Woodgett, J.R.3
  • 103
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • 1:CAS:528:DC%2BD2MXhtVSru70%3D
    • H Hu MJ Hilton X Tu K Yu DM Ornitz F Long 2005 Sequential roles of Hedgehog and Wnt signaling in osteoblast development Development (Camb) 132 49 60 1:CAS:528:DC%2BD2MXhtVSru70%3D
    • (2005) Development (Camb) , vol.132 , pp. 49-60
    • Hu, H.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 104
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • 15866163 1:CAS:528:DC%2BD2MXkslentbY%3D
    • TP Hill D Spater MM Taketo W Birchmeier C Hartmann 2005 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes Dev Cell 8 727 738 15866163 1:CAS:528:DC%2BD2MXkslentbY%3D
    • (2005) Dev Cell , vol.8 , pp. 727-738
    • Hill, T.P.1    Spater, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 106
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • 11956231 1:CAS:528:DC%2BD38XivFKktLk%3D
    • M Kato MS Patel R Levasseur I Lobov BH Chang DA Glass 2nd C Hartmann L Li TH Hwang CF Brayton, et al. 2002 Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor J Cell Biol 157 303 314 11956231 1:CAS:528:DC%2BD38XivFKktLk%3D
    • (2002) J Cell Biol , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.S.2    Levasseur, R.3    Lobov, I.4    Chang, B.H.5    Glass II, D.A.6    Hartmann, C.7    Li, L.8    Hwang, T.H.9    Brayton, C.F.10
  • 109
    • 2342529836 scopus 로고    scopus 로고
    • The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    • 14976225 1:CAS:528:DC%2BD2cXjvVOkt70%3D
    • PV Bodine W Zhao YP Kharode FJ Bex AJ Lambert MB Goad T Gaur GS Stein JB Lian BS Komm 2004 The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice Mol Endocrinol 18 1222 1237 14976225 1:CAS:528:DC%2BD2cXjvVOkt70%3D
    • (2004) Mol Endocrinol , vol.18 , pp. 1222-1237
    • Bodine, P.V.1    Zhao, W.2    Kharode, Y.P.3    Bex, F.J.4    Lambert, A.J.5    Goad, M.B.6    Gaur, T.7    Stein, G.S.8    Lian, J.B.9    Komm, B.S.10
  • 110
    • 33845802651 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation
    • 17199045 1:CAS:528:DC%2BD2sXpt1Witw%3D%3D
    • X Tu KS Joeng KI Nakayama K Nakayama J Rajagopal TJ Carroll AP McMahon F Long 2007 Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation Dev Cell 12 113 127 17199045 1:CAS:528:DC%2BD2sXpt1Witw%3D%3D
    • (2007) Dev Cell , vol.12 , pp. 113-127
    • Tu, X.1    Joeng, K.S.2    Nakayama, K.I.3    Nakayama, K.4    Rajagopal, J.5    Carroll, T.J.6    McMahon, A.P.7    Long, F.8
  • 111
    • 35748960839 scopus 로고    scopus 로고
    • A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation
    • 17952062 1:CAS:528:DC%2BD2sXht1Cgu7fM
    • I Takada M Mihara M Suzawa F Ohtake S Kobayashi M Igarashi MY Youn K Takeyama T Nakamura Y Mezaki, et al. 2007 A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation Nat Cell Biol 9 1273 1285 17952062 1:CAS:528:DC%2BD2sXht1Cgu7fM
    • (2007) Nat Cell Biol , vol.9 , pp. 1273-1285
    • Takada, I.1    Mihara, M.2    Suzawa, M.3    Ohtake, F.4    Kobayashi, S.5    Igarashi, M.6    Youn, M.Y.7    Takeyama, K.8    Nakamura, T.9    Mezaki, Y.10
  • 113
    • 33846004405 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and their antagonists
    • 17029022 1:CAS:528:DC%2BD2sXht12muw%3D%3D
    • E Gazzerro E Canalis 2006 Bone morphogenetic proteins and their antagonists Rev Endocr Metab Disord 7 51 65 17029022 1:CAS:528: DC%2BD2sXht12muw%3D%3D
    • (2006) Rev Endocr Metab Disord , vol.7 , pp. 51-65
    • Gazzerro, E.1    Canalis, E.2
  • 115
    • 33745501153 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development
    • 16813523 1:CAS:528:DC%2BD28XntlWqtbc%3D
    • M Okamoto J Murai H Yoshikawa N Tsumaki 2006 Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development J Bone Miner Res 21 1022 1033 16813523 1:CAS:528:DC%2BD28XntlWqtbc%3D
    • (2006) J Bone Miner Res , vol.21 , pp. 1022-1033
    • Okamoto, M.1    Murai, J.2    Yoshikawa, H.3    Tsumaki, N.4
  • 118
    • 0032574993 scopus 로고    scopus 로고
    • Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    • 1:CAS:528:DyaK1cXjsFKgt78%3D
    • EH Schroeter JA Kisslinger R Kopan 1998 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Nature (Lond) 393 382 386 1:CAS:528:DyaK1cXjsFKgt78%3D
    • (1998) Nature (Lond) , vol.393 , pp. 382-386
    • Schroeter, E.H.1    Kisslinger, J.A.2    Kopan, R.3
  • 119
    • 0029678250 scopus 로고    scopus 로고
    • The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor
    • 9078362 1:CAS:528:DyaK28XisFSitbw%3D
    • T Honjo 1996 The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor Genes Cells 1 1 9 9078362 1:CAS:528: DyaK28XisFSitbw%3D
    • (1996) Genes Cells , vol.1 , pp. 1-9
    • Honjo, T.1
  • 120
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects notch signaling and Alzheimer's disease
    • 11090127 1:CAS:528:DC%2BD3cXos1ehsLw%3D
    • R Kopan A Goate 2000 A common enzyme connects notch signaling and Alzheimer's disease Genes Dev 14 2799 2806 11090127 1:CAS:528: DC%2BD3cXos1ehsLw%3D
    • (2000) Genes Dev , vol.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 121
    • 0032728957 scopus 로고    scopus 로고
    • Mice lacking both presenilin genes exhibit early embryonic patterning defects
    • 10557208 1:CAS:528:DyaK1MXnsVGgtL0%3D
    • DB Donoviel AK Hadjantonakis M Ikeda H Zheng PS Hyslop A Bernstein 1999 Mice lacking both presenilin genes exhibit early embryonic patterning defects Genes Dev 13 2801 2810 10557208 1:CAS:528:DyaK1MXnsVGgtL0%3D
    • (1999) Genes Dev , vol.13 , pp. 2801-2810
    • Donoviel, D.B.1    Hadjantonakis, A.K.2    Ikeda, M.3    Zheng, H.4    Hyslop, P.S.5    Bernstein, A.6
  • 122
    • 13044278313 scopus 로고    scopus 로고
    • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
    • 10518543 1:CAS:528:DyaK1MXmvVGjsrg%3D
    • A Herreman D Hartmann W Annaert P Saftig K Craessaerts L Serneels L Umans V Schrijvers F Checler H Vanderstichele, et al. 1999 Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency Proc Natl Acad Sci USA 96 11872 11877 10518543 1:CAS:528: DyaK1MXmvVGjsrg%3D
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11872-11877
    • Herreman, A.1    Hartmann, D.2    Annaert, W.3    Saftig, P.4    Craessaerts, K.5    Serneels, L.6    Umans, L.7    Schrijvers, V.8    Checler, F.9    Vanderstichele, H.10
  • 123
    • 0032915458 scopus 로고    scopus 로고
    • Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
    • 1:CAS:528:DyaK1MXjtVeisro%3D
    • D Nofziger A Miyamoto KM Lyons G Weinmaster 1999 Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts Development (Camb) 126 1689 1702 1:CAS:528:DyaK1MXjtVeisro%3D
    • (1999) Development (Camb) , vol.126 , pp. 1689-1702
    • Nofziger, D.1    Miyamoto, A.2    Lyons, K.M.3    Weinmaster, G.4
  • 124
    • 33646550902 scopus 로고    scopus 로고
    • Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling
    • 16407293 1:CAS:528:DC%2BD28XhvFOhtbk%3D
    • V Deregowski E Gazzerro L Priest S Rydziel E Canalis 2006 Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling J Biol Chem 281 6203 6210 16407293 1:CAS:528:DC%2BD28XhvFOhtbk%3D
    • (2006) J Biol Chem , vol.281 , pp. 6203-6210
    • Deregowski, V.1    Gazzerro, E.2    Priest, L.3    Rydziel, S.4    Canalis, E.5
  • 125
    • 0345688655 scopus 로고    scopus 로고
    • Notch 1 impairs osteoblastic cell differentiation
    • 12960086 1:CAS:528:DC%2BD3sXpsV2ns7w%3D
    • M Sciaudone E Gazzerro L Priest AM Delany E Canalis 2003 Notch 1 impairs osteoblastic cell differentiation Endocrinology 144 5631 5639 12960086 1:CAS:528:DC%2BD3sXpsV2ns7w%3D
    • (2003) Endocrinology , vol.144 , pp. 5631-5639
    • Sciaudone, M.1    Gazzerro, E.2    Priest, L.3    Delany, A.M.4    Canalis, E.5
  • 126
    • 40449084522 scopus 로고    scopus 로고
    • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    • 18297083 1:CAS:528:DC%2BD1cXivFOrtL8%3D
    • MJ Hilton X Tu X Wu S Bai H Zhao T Kobayashi HM Kronenberg SL Teitelbaum FP Ross R Kopan, et al. 2008 Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation Nat Med 14 306 314 18297083 1:CAS:528:DC%2BD1cXivFOrtL8%3D
    • (2008) Nat Med , vol.14 , pp. 306-314
    • Hilton, M.J.1    Tu, X.2    Wu, X.3    Bai, S.4    Zhao, H.5    Kobayashi, T.6    Kronenberg, H.M.7    Teitelbaum, S.L.8    Ross, F.P.9    Kopan, R.10
  • 128
    • 18144384703 scopus 로고    scopus 로고
    • Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling
    • 15695512 1:CAS:528:DC%2BD2MXjtleisLk%3D
    • M Nobta T Tsukazaki Y Shibata C Xin T Moriishi S Sakano H Shindo A Yamaguchi 2005 Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling J Biol Chem 280 15842 15848 15695512 1:CAS:528:DC%2BD2MXjtleisLk%3D
    • (2005) J Biol Chem , vol.280 , pp. 15842-15848
    • Nobta, M.1    Tsukazaki, T.2    Shibata, Y.3    Xin, C.4    Moriishi, T.5    Sakano, S.6    Shindo, H.7    Yamaguchi, A.8
  • 130
    • 0034614616 scopus 로고    scopus 로고
    • The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1
    • 10617648 1:CAS:528:DC%2BD3cXjvVKhtA%3D%3D
    • KW McLarren R Lo D Grbavec K Thirunavukkarasu G Karsenty S Stifani 2000 The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1 J Biol Chem 275 530 538 10617648 1:CAS:528:DC%2BD3cXjvVKhtA%3D%3D
    • (2000) J Biol Chem , vol.275 , pp. 530-538
    • McLarren, K.W.1    Lo, R.2    Grbavec, D.3    Thirunavukkarasu, K.4    Karsenty, G.5    Stifani, S.6
  • 131
    • 28844466310 scopus 로고    scopus 로고
    • The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin
    • 16195230 1:CAS:528:DC%2BD2MXht1OqtrbJ
    • Q Shen S Christakos 2005 The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin J Biol Chem 280 40589 40598 16195230 1:CAS:528:DC%2BD2MXht1OqtrbJ
    • (2005) J Biol Chem , vol.280 , pp. 40589-40598
    • Shen, Q.1    Christakos, S.2
  • 132
    • 4444246433 scopus 로고    scopus 로고
    • Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity
    • 15178686 1:CAS:528:DC%2BD2cXntFSnsL8%3D
    • N Zamurovic D Cappellen D Rohner M Susa 2004 Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity J Biol Chem 279 37704 37715 15178686 1:CAS:528:DC%2BD2cXntFSnsL8%3D
    • (2004) J Biol Chem , vol.279 , pp. 37704-37715
    • Zamurovic, N.1    Cappellen, D.2    Rohner, D.3    Susa, M.4
  • 133
    • 70350170420 scopus 로고    scopus 로고
    • The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells
    • 19670267 1:CAS:528:DC%2BD1MXhtFyntLfM
    • Y Zhang JB Lian JL Stein AJ van Wijnen GS Stein 2009 The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells J Cell Biochem 108 651 659 19670267 1:CAS:528: DC%2BD1MXhtFyntLfM
    • (2009) J Cell Biochem , vol.108 , pp. 651-659
    • Zhang, Y.1    Lian, J.B.2    Stein, J.L.3    Van Wijnen, A.J.4    Stein, G.S.5
  • 134
    • 47949130093 scopus 로고    scopus 로고
    • Notch inhibits osteoblast differentiation and causes osteopenia
    • 18420737 1:CAS:528:DC%2BD1cXptlamsbg%3D
    • S Zanotti A Smerdel-Ramoya L Stadmeyer D Durant F Radtke E Canalis 2008 Notch inhibits osteoblast differentiation and causes osteopenia Endocrinology 149 3890 3899 18420737 1:CAS:528:DC%2BD1cXptlamsbg%3D
    • (2008) Endocrinology , vol.149 , pp. 3890-3899
    • Zanotti, S.1    Smerdel-Ramoya, A.2    Stadmeyer, L.3    Durant, D.4    Radtke, F.5    Canalis, E.6
  • 135
    • 0028927556 scopus 로고
    • Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    • 7891679 1:CAS:528:DyaK2MXksFWjsb4%3D
    • P Ducy G Karsenty 1995 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene Mol Cell Biol 15 1858 1869 7891679 1:CAS:528:DyaK2MXksFWjsb4%3D
    • (1995) Mol Cell Biol , vol.15 , pp. 1858-1869
    • Ducy, P.1    Karsenty, G.2
  • 136
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • 9182762 1:CAS:528:DyaK2sXjs1ejsbg%3D
    • P Ducy R Zhang V Geoffroy AL Ridall G Karsenty 1997 Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation Cell 89 747 754 9182762 1:CAS:528:DyaK2sXjs1ejsbg%3D
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 137
    • 0036352427 scopus 로고    scopus 로고
    • Runx2, a multifunctional transcription factor in skeletal development
    • 12210716 1:CAS:528:DC%2BD38XmvFOnsLo%3D
    • T Komori 2002 Runx2, a multifunctional transcription factor in skeletal development J Cell Biochem 87 1 8 12210716 1:CAS:528:DC%2BD38XmvFOnsLo%3D
    • (2002) J Cell Biochem , vol.87 , pp. 1-8
    • Komori, T.1
  • 138
    • 34249815830 scopus 로고    scopus 로고
    • Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor
    • 17317722 1:CAS:528:DC%2BD2sXmsVWksro%3D
    • S Ohba T Ikeda F Kugimiya F Yano AC Lichtler K Nakamura T Takato H Kawaguchi UI Chung 2007 Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor FASEB J 21 1777 1787 17317722 1:CAS:528:DC%2BD2sXmsVWksro%3D
    • (2007) FASEB J , vol.21 , pp. 1777-1787
    • Ohba, S.1    Ikeda, T.2    Kugimiya, F.3    Yano, F.4    Lichtler, A.C.5    Nakamura, K.6    Takato, T.7    Kawaguchi, H.8    Chung, U.I.9
  • 139
    • 0033876760 scopus 로고    scopus 로고
    • Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro
    • 10873656 1:CAS:528:DC%2BD3cXkt1KmtLY%3D
    • H Kobayashi Y Gao C Ueta A Yamaguchi T Komori 2000 Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro Biochem Biophys Res Commun 273 630 636 10873656 1:CAS:528:DC%2BD3cXkt1KmtLY%3D
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 630-636
    • Kobayashi, H.1    Gao, Y.2    Ueta, C.3    Yamaguchi, A.4    Komori, T.5
  • 140
    • 0035902565 scopus 로고    scopus 로고
    • Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
    • 11438701 1:CAS:528:DC%2BD3MXls1Wit70%3D
    • JY Choi J Pratap A Javed SK Zaidi L Xing E Balint S Dalamangas B Boyce AJ van Wijnen JB Lian, et al. 2001 Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development Proc Natl Acad Sci USA 98 8650 8655 11438701 1:CAS:528:DC%2BD3MXls1Wit70%3D
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8650-8655
    • Choi, J.Y.1    Pratap, J.2    Javed, A.3    Zaidi, S.K.4    Xing, L.5    Balint, E.6    Dalamangas, S.7    Boyce, B.8    Van Wijnen, A.J.9    Lian, J.B.10
  • 141
    • 0033560784 scopus 로고    scopus 로고
    • A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    • 10215629 1:CAS:528:DyaK1MXivFGkurc%3D
    • P Ducy M Starbuck M Priemel J Shen G Pinero V Geoffroy M Amling G Karsenty 1999 A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development Genes Dev 13 1025 1036 10215629 1:CAS:528: DyaK1MXivFGkurc%3D
    • (1999) Genes Dev , vol.13 , pp. 1025-1036
    • Ducy, P.1    Starbuck, M.2    Priemel, M.3    Shen, J.4    Pinero, G.5    Geoffroy, V.6    Amling, M.7    Karsenty, G.8
  • 142
    • 0035494469 scopus 로고    scopus 로고
    • Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    • 11581292 1:CAS:528:DC%2BD3MXnsVelt7c%3D
    • W Liu S Toyosawa T Furuichi N Kanatani C Yoshida Y Liu M Himeno S Narai A Yamaguchi T Komori 2001 Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures J Cell Biol 155 157 166 11581292 1:CAS:528:DC%2BD3MXnsVelt7c%3D
    • (2001) J Cell Biol , vol.155 , pp. 157-166
    • Liu, W.1    Toyosawa, S.2    Furuichi, T.3    Kanatani, N.4    Yoshida, C.5    Liu, Y.6    Himeno, M.7    Narai, S.8    Yamaguchi, A.9    Komori, T.10
  • 143
    • 0036333736 scopus 로고    scopus 로고
    • High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage
    • 12167715 1:CAS:528:DC%2BD38Xmt1ent7c%3D
    • V Geoffroy M Kneissel B Fournier A Boyde P Matthias 2002 High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage Mol Cell Biol 22 6222 6233 12167715 1:CAS:528:DC%2BD38Xmt1ent7c%3D
    • (2002) Mol Cell Biol , vol.22 , pp. 6222-6233
    • Geoffroy, V.1    Kneissel, M.2    Fournier, B.3    Boyde, A.4    Matthias, P.5
  • 144
    • 18744394030 scopus 로고    scopus 로고
    • The core-binding factor beta subunit is required for bone formation and hematopoietic maturation
    • 12434155 1:CAS:528:DC%2BD38XptVShurY%3D
    • J Miller A Horner T Stacy C Lowrey JB Lian G Stein GH Nuckolls NA Speck 2002 The core-binding factor beta subunit is required for bone formation and hematopoietic maturation Nat Genet 32 645 649 12434155 1:CAS:528: DC%2BD38XptVShurY%3D
    • (2002) Nat Genet , vol.32 , pp. 645-649
    • Miller, J.1    Horner, A.2    Stacy, T.3    Lowrey, C.4    Lian, J.B.5    Stein, G.6    Nuckolls, G.H.7    Speck, N.A.8
  • 147
    • 33744536200 scopus 로고    scopus 로고
    • SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    • 16751105 1:CAS:528:DC%2BD28Xls1Shtrg%3D
    • G Dobreva M Chahrour M Dautzenberg L Chirivella B Kanzler I Farinas G Karsenty R Grosschedl 2006 SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation Cell 125 971 986 16751105 1:CAS:528:DC%2BD28Xls1Shtrg%3D
    • (2006) Cell , vol.125 , pp. 971-986
    • Dobreva, G.1    Chahrour, M.2    Dautzenberg, M.3    Chirivella, L.4    Kanzler, B.5    Farinas, I.6    Karsenty, G.7    Grosschedl, R.8
  • 151
    • 33744454653 scopus 로고    scopus 로고
    • Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
    • 16728642 1:CAS:528:DC%2BD28XkvVOhs74%3D
    • DC Jones MN Wein M Oukka JG Hofstaetter MJ Glimcher LH Glimcher 2006 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3 Science 312 1223 1227 16728642 1:CAS:528:DC%2BD28XkvVOhs74%3D
    • (2006) Science , vol.312 , pp. 1223-1227
    • Jones, D.C.1    Wein, M.N.2    Oukka, M.3    Hofstaetter, J.G.4    Glimcher, M.J.5    Glimcher, L.H.6
  • 152
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • 12738770 1:CAS:528:DC%2BD3sXlsFKku78%3D
    • M Zhao M Qiao BO Oyajobi GR Mundy D Chen 2003 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation J Biol Chem 278 27939 27944 12738770 1:CAS:528:DC%2BD3sXlsFKku78%3D
    • (2003) J Biol Chem , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 153
    • 45349097474 scopus 로고    scopus 로고
    • CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
    • 18541707 1:CAS:528:DC%2BD1cXns1ymsL0%3D
    • X Li M Huang H Zheng Y Wang F Ren Y Shang Y Zhai DM Irwin Y Shi D Chen, et al. 2008 CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation J Cell Biol 181 959 972 18541707 1:CAS:528:DC%2BD1cXns1ymsL0%3D
    • (2008) J Cell Biol , vol.181 , pp. 959-972
    • Li, X.1    Huang, M.2    Zheng, H.3    Wang, Y.4    Ren, F.5    Shang, Y.6    Zhai, Y.7    Irwin, D.M.8    Shi, Y.9    Chen, D.10
  • 154
    • 0042662937 scopus 로고    scopus 로고
    • Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
    • 12923053 1:CAS:528:DC%2BD3sXms1Kntr4%3D
    • S Kim T Koga M Isobe BE Kern T Yokochi YE Chin G Karsenty T Taniguchi H Takayanagi 2003 Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation Genes Dev 17 1979 1991 12923053 1:CAS:528:DC%2BD3sXms1Kntr4%3D
    • (2003) Genes Dev , vol.17 , pp. 1979-1991
    • Kim, S.1    Koga, T.2    Isobe, M.3    Kern, B.E.4    Yokochi, T.5    Chin, Y.E.6    Karsenty, G.7    Taniguchi, T.8    Takayanagi, H.9
  • 155
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • 11792318 1:CAS:528:DC%2BD38XosF2hsg%3D%3D
    • K Nakashima X Zhou G Kunkel Z Zhang JM Deng RR Behringer B de Crombrugghe 2002 The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation Cell 108 17 29 11792318 1:CAS:528:DC%2BD38XosF2hsg%3D%3D
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 157
    • 29944437296 scopus 로고    scopus 로고
    • P53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
    • 16380437 1:CAS:528:DC%2BD28Xlt1ajuw%3D%3D
    • X Wang HY Kua Y Hu K Guo Q Zeng Q Wu HH Ng G Karsenty B de Crombrugghe J Yeh, et al. 2006 p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling J Cell Biol 172 115 125 16380437 1:CAS:528:DC%2BD28Xlt1ajuw%3D%3D
    • (2006) J Cell Biol , vol.172 , pp. 115-125
    • Wang, X.1    Kua, H.Y.2    Hu, Y.3    Guo, K.4    Zeng, Q.5    Wu, Q.6    Ng, H.H.7    Karsenty, G.8    De Crombrugghe, B.9    Yeh, J.10


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