Core-binding factor β interacts with Runx2 and is required for skeletal development

Nature Genetics

Volumn 32, Issue 4, 2002, Pages 633-638

  Yoshida, Carolina A ^a,b   Furuichi, Tatsuya ^a   Fujita, Takashi ^c   Fukuyama, Ryo ^a,c   Kanatani, Naoko ^a   Kobayashi, Shinji ^a,d   Satake, Masanobu ^e   Takada, Kenji ^b   Komori, Toshihisa ^a,e,f  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c SETSUNAN UNIVERSITY   (Japan)

^d TEIJIN LTD   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORE BINDING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIRTH; BONE DEVELOPMENT; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DNA BINDING; ENCHONDRAL OSSIFICATION; GEL MOBILITY SHIFT ASSAY; GENE FUNCTION; GENE INTERACTION; HEMATOPOIESIS; MESENCHYME CELL; MOUSE; MOUSE STRAIN; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SURVIVAL;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR BETA SUBUNIT; CORE BINDING FACTORS; DIMERIZATION; DNA-BINDING PROTEINS; EMBRYO; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GATA1 TRANSCRIPTION FACTOR; GENES, LETHAL; HEMATOPOIESIS; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; OSTEOBLASTS; OSTEOGENESIS; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SKULL; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER; POLYOMAVIRUS;

EID: 0036900947     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1015     Document Type: Article

References (32)

1. Liu, R et al. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261, 1041-1044 (1993).
2. Okuda, T., Deursen, J., van Hiebert, S.W., Grosveld, G. and Downing, J.R. AML1, the target of multiple chromosomal translocation in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330 (1996).
3. Wang, Q. et al. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl. Acad. Sci. USA 93, 3444-3449 (1996).
4. Sasaki, K. et al. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor β. Proc. Natl. Acad. Sci. USA 93, 12359-12363 (1996).
5. Wang, Q. et al. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell 87, 697-708 (1996).
6. Niki, M. et al. Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc. Natl. Acad. Sci. USA 94, 5697-5702 (1997).
7. Mundlos, S. et al. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89, 773-779 (1997).
8. Komori, T. et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764 (1997).
9. Otto, F. et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771 (1997).
10. Ducy, R, Zhang, R., Geoffroy, V., Ridall, A.L. and Karsenty, G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754 (1997).
11. Inada, M. et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev. Dyn. 214, 279-290 (1999).
12. Kim, I.S., Otto, F., Zabel, B. and Mundlos, S. Regulation of chondrocyte differentiation by Cbfa1, Mech. Dev. 80, 159-170 (1999).
13. Enomoto, H. et al. Cbfa1 is a positive regulatory factor in chondrocyte maturation. J. Biol. Chem. 275, 8695-8702 (2000).
14. Ueta, C. et al. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J. Cell. Biol. 153, 87-99 (2001).
15. Takeda, S., Bonnamy, J.P., Owen, M.J., Ducy, P. and Karsenty, G. Continuous expression of Cbfa1 in non-hypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 15, 467-481 (2001).
16. Onodera, K. et al. GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis. Proc. Natl Acad. Sci. USA 94, 4487-4492 (1997).
17. Takakura, N. et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell 102, 199-209 (2000).
18. Tahirov, T.H. et al. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ. Cell 104, 755-767 (2001).
19. Thirunavukkarasu, K., Mahajan, M., Mclarren, K.W., Stifani, S. and Karsenty, G. Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfβ. Mol. Cell. Biol. 18, 4197-4208 (1998).
20. Huang, G. et al. Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 20, 723-733 (2001).
21. Ducy, P. et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 13, 1025-1036 (1999).
22. Drissi, H. et al. Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J. Cell. Physiol. 184, 341-350 (2000).
23. Miller, J. et al. The core-binding factor β subunit is required for bone formation and hematopoietic maturation. Nature Genet. 32, 645-649 (2002).
24. Kundu, M. et al. Cbfβ interacts with Runx2 and has a critical role in bone development. Nature Genet. 32, 639-644 (2002).
25. Lee, K.S. et al. Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell. Biol. 20, 8783-8792 (2000).
26. Chiba, N. et al. Differentiation-dependent expression and distinct subcellular localization of the protooncogene product, PEBP2β/CBFβ, in muscle development. Oncogene 14, 2543-2552 (1997).
27. Deguchi, K. et al. Excessive extramedullary hematopoiesis in Cbfa1-deficient mice with a congenital lack of bone marrow. Biochem. Biophys. Res. Commun. 255, 352-359 (1999).
28. Onishi, M. et al. Applications of retrovirus-mediated expression cloning. Exp. Hematol. 24, 324-329 (1996).
29. Morita, S., Kojima, T. and Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000).
30. Harada, H. et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J. Biol. Chem. 274, 6972-6978 (1999).
31. Herz, J. and Gerard, R.D. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl Acad. Sci. USA 90, 2812-2816 (1993).
32. Lu, J. et al. Subcellular localization of the α and β subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol. Cell. Biol. 3, 1651-1661 (1995).