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Volumn 136, Issue 24, 2009, Pages 4177-4185

The Gli2 transcriptional activator is a crucial effector for lhh signaling in osteoblast development and cartilage vascularization

Author keywords

Bone; Cartilage; Gli2; Gli3; Lhh; Mouse; Vascularization

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3;

EID: 71449101887     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.041624     Document Type: Article
Times cited : (88)

References (40)
  • 1
    • 0033761448 scopus 로고    scopus 로고
    • Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
    • Aza-Blanc, P., Lin, H. Y., Ruiz i Altaba, A. and Kornberg, T. B. (2000). Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127, 4293-4301.
    • (2000) Development , vol.127 , pp. 4293-4301
    • Aza-Blanc, P.1    Lin, H.Y.2    Ruiz i Altaba, A.3    Kornberg, T.B.4
  • 2
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic acbvation of the Shh pathway
    • Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D. and Joyner, A. L. (2002). Gli2, but not Gli1, is required for initial Shh signaling and ectopic acbvation of the Shh pathway. Development 129, 4753-4761.
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3    Stephen, D.4    Joyner, A.L.5
  • 3
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by hedgehog is gli dependent and involves an activator function of gli3
    • Bai, C. B., Stephen, D. and Joyner, A. L. (2004). All mouse ventral spinal cord patterning by hedgehog is gli dependent and involves an activator function of gli3. Dev. Cell 6, 103-115.
    • (2004) Dev. Cell , vol.6 , pp. 103-115
    • Bai, C.B.1    Stephen, D.2    Joyner, A.L.3
  • 4
    • 0346888543 scopus 로고    scopus 로고
    • Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
    • Buttitta, L., Mo, R., Hui, C. C. and Fan, C. M. (2003). Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130, 6233-6243.
    • (2003) Development , vol.130 , pp. 6233-6243
    • Buttitta, L.1    Mo, R.2    Hui, C.C.3    Fan, C.M.4
  • 5
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.
    • (1998) Development , vol.125 , pp. 2533-2543
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.C.7
  • 6
    • 27644467931 scopus 로고    scopus 로고
    • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development
    • Hilton, M. J., Tu, X., Cook, J., Hu, H. and Long, F. (2005). Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. Development 132, 4339-4351.
    • (2005) Development , vol.132 , pp. 4339-4351
    • Hilton, M.J.1    Tu, X.2    Cook, J.3    Hu, H.4    Long, F.5
  • 7
    • 34447639266 scopus 로고    scopus 로고
    • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage
    • Hilton, M. J., Tu, X. and Long, F. (2007). Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. Dev. Biol. 308, 93-105.
    • (2007) Dev. Biol , vol.308 , pp. 93-105
    • Hilton, M.J.1    Tu, X.2    Long, F.3
  • 8
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • Hu, H.. Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M. and Long, F. (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132, 49-60.
    • (2005) Development , vol.132 , pp. 49-60
    • Hu, H.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 9
    • 0018775237 scopus 로고
    • Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections
    • Junqueira, L. C., Bignolas, G. and Brentani, R. R. (1979). Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. J. 11, 447-455.
    • (1979) Histochem. J , vol.11 , pp. 447-455
    • Junqueira, L.C.1    Bignolas, G.2    Brentani, R.R.3
  • 10
    • 0033950445 scopus 로고    scopus 로고
    • Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
    • Karp, S. J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H. and McMahon, A. P. (2000). Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 127, 543-548.
    • (2000) Development , vol.127 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 11
    • 0033214946 scopus 로고    scopus 로고
    • Ubiquitous expression of marker transgenes in mice and rats
    • Kisseberth, W. C., Brettingen, N. T., Lohse. J. K. and Sandgren, E. P. (1999). Ubiquitous expression of marker transgenes in mice and rats. Dev. Biol. 214, 128-138.
    • (1999) Dev. Biol , vol.214 , pp. 128-138
    • Kisseberth, W.C.1    Brettingen, N.T.2    Lohse, J.K.3    Sandgren, E.P.4
  • 12
    • 22144436249 scopus 로고    scopus 로고
    • Indian hedgehog stimulates periarlicular chondrocyte differentiation to regulate growth plate length independently of PTHrP
    • Kobayashi, T., Soegiarto, D. W., Yang, Y., Lanske, B., Schipani, E., McMahon, A. P. and Kronenberg, H. M. (2005). Indian hedgehog stimulates periarlicular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J. Clin. Invest. 115, 1734-1742.
    • (2005) J. Clin. Invest , vol.115 , pp. 1734-1742
    • Kobayashi, T.1    Soegiarto, D.W.2    Yang, Y.3    Lanske, B.4    Schipani, E.5    McMahon, A.P.6    Kronenberg, H.M.7
  • 13
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. H., Inada, M. et al. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6    Shimizu, Y.7    Bronson, R.T.8    Gao, Y.H.9    Inada, M.10
  • 14
    • 29644447977 scopus 로고    scopus 로고
    • Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
    • Koziel, L., Wuelling, M., Schneider, S. and Vortkamp, A. (2005). Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132, 5249-5260.
    • (2005) Development , vol.132 , pp. 5249-5260
    • Koziel, L.1    Wuelling, M.2    Schneider, S.3    Vortkamp, A.4
  • 15
    • 33745129425 scopus 로고    scopus 로고
    • Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development
    • Lavine, K. J., White, A. C., Park, C., Smith, C. S., Choi, K., Long, E, Hui, C. C. and Ornitz, D. M. (2006). Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 20, 1651-1666.
    • (2006) Genes Dev , vol.20 , pp. 1651-1666
    • Lavine, K.J.1    White, A.C.2    Park, C.3    Smith, C.S.4    Choi, K.5    Long, E.6    Hui, C.C.7    Ornitz, D.M.8
  • 16
    • 67449152618 scopus 로고    scopus 로고
    • Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes
    • Li, Y. and Dudley, A. T. (2009). Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes. Development 136, 1083-1092.
    • (2009) Development , vol.136 , pp. 1083-1092
    • Li, Y.1    Dudley, A.T.2
  • 17
    • 2342481730 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
    • Li, Y., Zhang, H., Choi, S. C., Litingtung, Y. and Chiang, C. (2004). Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 270, 214-231.
    • (2004) Dev. Biol , vol.270 , pp. 214-231
    • Li, Y.1    Zhang, H.2    Choi, S.C.3    Litingtung, Y.4    Chiang, C.5
  • 18
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung, Y. and Chiang, C. (2000). Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3, 979-985.
    • (2000) Nat. Neurosci , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 19
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung, Y., Dahn, R. D., Li, Y., Fallon, J. F. and Chiang, C. (2002). Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418, 979-983.
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 20
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X. M., Karp, S., Yang, Y. and McMahon, A. P. (2001). Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099-5108.
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 21
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long, F., Chung, U. I., Ohba, S., McMahon, J., Kronenberg, H. M. and McMahon, A. P. (2004). Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131, 1309-1318.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 22
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.
    • (1998) Development , vol.125 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 23
    • 0036134643 scopus 로고    scopus 로고
    • High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion
    • Maynard, T. M., Jain, M. D., Balmer, C. W. and LaMantía, A. S. (2002). High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. Mamm. Genome 13, 58-61.
    • (2002) Mamm. Genome , vol.13 , pp. 58-61
    • Maynard, T.M.1    Jain, M.D.2    Balmer, C.W.3    LaMantía, A.S.4
  • 24
    • 0019126423 scopus 로고
    • Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S
    • McLeod, M. J. (1980). Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299-301.
    • (1980) Teratology , vol.22 , pp. 299-301
    • McLeod, M.J.1
  • 25
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason, S. G. and McMahon, A. P. (2002). A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129, 2087-2098.
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 26
    • 1242331822 scopus 로고    scopus 로고
    • Impaired endochondral bone development and osteopenia in Gli2-deficient mice
    • Miao, D., Liu, H., Plut, P., Niu, M., Huo, R., Goltzman, D. and Henderson, J. E. (2004). Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp. Cell Res. 294, 210-222.
    • (2004) Exp. Cell Res , vol.294 , pp. 210-222
    • Miao, D.1    Liu, H.2    Plut, P.3    Niu, M.4    Huo, R.5    Goltzman, D.6    Henderson, J.E.7
  • 27
    • 0037439152 scopus 로고    scopus 로고
    • Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    • Mill, P, Mo, R., Fu, H, Grachtchouk, M., Kim, P. C., Dlugosz, A. A. and Hui, C. C. (2003). Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 17, 282-294.
    • (2003) Genes Dev , vol.17 , pp. 282-294
    • Mill, P.1    Mo, R.2    Fu, H.3    Grachtchouk, M.4    Kim, P.C.5    Dlugosz, A.A.6    Hui, C.C.7
  • 29
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M. and Hui, C. C. (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 20, 54-57.
    • (1998) Nat Genet , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 30
    • 0034055649 scopus 로고    scopus 로고
    • Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    • Park H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M. and Joyner, A. L. (2000). Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605.
    • (2000) Development , vol.127 , pp. 1593-1605
    • Park, H.L.1    Bai, C.2    Platt, K.A.3    Matise, M.P.4    Beeghly, A.5    Hui, C.C.6    Nakashima, M.7    Joyner, A.L.8
  • 32
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. and Kondoh, H. (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 33
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71.
    • (1999) Nat. Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 35
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., Hammerschmidt, M. and McMahon, A. P. (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13, 2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 37
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    • Vokes, S. A., Ji, H., Wong, W. H. and McMahon, A. R (2008). A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 22, 2651-2663.
    • (2008) Genes Dev , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.R.4
  • 38
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J. (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 40
    • 33746987081 scopus 로고    scopus 로고
    • The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
    • Zhao, M., Qiao, M., Harris, S. E., Chen, D., Oyajobi, B. O. and Mundy, G. R. (2006). The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol. 26, 6197-6208.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 6197-6208
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Chen, D.4    Oyajobi, B.O.5    Mundy, G.R.6


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